CN101698017A - Antiphlogosis and sterilizing ointment - Google Patents
Antiphlogosis and sterilizing ointment Download PDFInfo
- Publication number
- CN101698017A CN101698017A CN200710156738A CN200710156738A CN101698017A CN 101698017 A CN101698017 A CN 101698017A CN 200710156738 A CN200710156738 A CN 200710156738A CN 200710156738 A CN200710156738 A CN 200710156738A CN 101698017 A CN101698017 A CN 101698017A
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- Prior art keywords
- ethanol
- thick paste
- supernatant
- condensed
- cinnabaris
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 12
- 239000002674 ointment Substances 0.000 title claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 14
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- 229910021538 borax Inorganic materials 0.000 claims abstract description 12
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 12
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 12
- 206010061218 Inflammation Diseases 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
- 238000001556 precipitation Methods 0.000 claims description 12
- 239000006228 supernatant Substances 0.000 claims description 12
- 229910052957 realgar Inorganic materials 0.000 claims description 11
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 4
- 201000004624 Dermatitis Diseases 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 6
- 208000002193 Pain Diseases 0.000 abstract description 5
- 230000036407 pain Effects 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 5
- 208000003251 Pruritus Diseases 0.000 abstract description 4
- 208000010668 atopic eczema Diseases 0.000 abstract description 4
- 239000002904 solvent Substances 0.000 abstract description 4
- 208000017520 skin disease Diseases 0.000 abstract description 3
- 230000000975 bioactive effect Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 230000002349 favourable effect Effects 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 240000000774 Cunila origanoides Species 0.000 abstract 1
- 235000018274 Cunila origanoides Nutrition 0.000 abstract 1
- 241000218691 Cupressaceae Species 0.000 abstract 1
- 235000014866 Dictamnus albus Nutrition 0.000 abstract 1
- 201000005866 Exanthema Subitum Diseases 0.000 abstract 1
- 241000972672 Phellodendron Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 240000001745 Rheum palmatum Species 0.000 abstract 1
- 208000036485 Roseola Diseases 0.000 abstract 1
- 244000007853 Sarothamnus scoparius Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 230000009982 effect on human Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 229910052958 orpiment Inorganic materials 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- GJPYYNMJTJNYTO-UHFFFAOYSA-J sodium aluminium sulfate Chemical compound [Na+].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GJPYYNMJTJNYTO-UHFFFAOYSA-J 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 8
- 230000001139 anti-pruritic effect Effects 0.000 description 4
- 239000003908 antipruritic agent Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 230000035618 desquamation Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010048245 Yellow skin Diseases 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an antiphlogosis and sterilizing ointment with favorable effects of treating eczema, dermatitis and other intractable skin diseases. The antiphlogosis and sterilizing ointment is prepared by the following steps: using red orpiment, Cinnabaris, borneol, borax (stir-fried), natrii sulfas exsiccatus, dittany bark, broom cypress fruit, angelica dahurica, Chinese rhubarb, Fructus Forsythiae and phellodendron as the raw materials, leaching the effective components from the drugs by using a proper solvent, and evaporating all or part of the solvent until the concentration of glycerin reaches the specified standard and the water content reaches 15-20%. The bioactive components not only can effectively improve the symptoms of skin itch, gall, furfuration, roseola and the like, but also has the effects of relieving itching and pains, clearing heat for detoxication, diminishing inflammation, sterilizing and removing tumescence, and has favorable curative effects for most severe skin diseases. Compared with the prior art, the invention is safe and effective and does not have any side effect on human body.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of refractory skins such as eczema, dermatitis, especially have the ointment of effects such as antipruritic pain relieving, heat-clearing and toxic substances removing, anti-inflammation and sterilization, detumescence.
Background technology
The medicine of general treatment refractory skin has following general character:
1., itch pain unbearably: drug effect is slow, and effective ingredient is difficult to arrive at ill skin rapidly, does not reach antipruritic analgesic effect;
2., skin lesion taking place: treats singlely, can only improve a certain symptom, can not change heat in blood, dry, the blood stasis phenomenon of blood, cause the skin hardening, fester, erythema, desquamation etc.;
3., dermatitis takes place repeatedly: only treat at the dermatitis superficial phenomenon, can only relief of symptoms, can not remove dysentery, blood poison, cause dermatitis to be shown effect repeatedly;
4., side effect: the drug variety of treatment refractory skin is single, a lot of patients select for use for oral administration or the injection corticosteroid hormone, not only do not cure dermatitis, side effect such as face is swollen, hypertension, dizziness, head necrosis also appear, cause the state of an illness to increase the weight of, in addition, conventional medicament is long the course of treatment, the curative effect effect is slow, can't check spreading of inflammation.
Summary of the invention
The purpose of this invention is to provide a kind of ointment for the treatment of the effective anti-inflammation and sterilization of refractory skins such as eczema, dermatitis.
For realizing that technical scheme provided by the present invention is:
A kind of ointment of anti-inflammation and sterilization, it is characterized in that Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus is dry down at 105 ℃, grind to the powder, the ethanol that adds 7 times of amounts, the heating continuous backflow is extracted 12h, perhaps gets the extracting solution of 1ml, add and stop reflux when 10% alcoholic solution does not show the purple yellow, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, with Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri decocts with water, and decocting liquid filters, and filtrate concentrates, add ethanol, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), the Matrii Sulfas Exsiccatus thick paste adds mixing in proportion, adjusts content, the ointment that obtains behind the finished product.
The present invention adopts appropriate solvent that the effective ingredient of medical material is leached, boil off part or all of solvent, with the dosage form of glycerol concentration to required standard, water content is at 15%-20%, symptoms such as bioactive ingredients can not only effectively improve skin pruritus, swells and ache, desquamation, erythema, add Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae etc., antipruritic pain relieving, heat-clearing and toxic substances removing, anti-inflammation and sterilization, repercussive effect are arranged, for most serious symptom dermatosis curative effect is preferably arranged all, compared with prior art, the present invention is safe and effective, and is without any side effects to human body.
Specific embodiments
In the actual production, with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus is dry under 105 ℃, grinds to the powder, the ethanol that adds 7 times of amounts, the heating continuous backflow is extracted 12h, perhaps gets the extracting solution of 1ml, add and stop reflux when 10% alcoholic solution does not show the purple yellow, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, with Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri decocts with water, and decocting liquid filters, and filtrate concentrates, add ethanol, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), the Matrii Sulfas Exsiccatus thick paste adds mixing in proportion, adjusts content, the ointment that obtains behind the finished product.
Preparation method of the present invention is following steps:
Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri decocts with water, and decocting liquid filters, and filtrate concentrates, add ethanol, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, again with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus 105 ℃ down dry, 100 mesh sieves that ground to the powder add the ethanol of 7 times of amounts, the heating continuous backflow is extracted 12h, perhaps get the extracting solution of 1ml, add 10% alcoholic solution and do not show purple and stop reflux when yellow, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, two kinds of thick pastes and an amount of glycerol are adjusted content in proportion, mixing, finished product.
Below in conjunction with embodiment content of the present invention is described further:
Embodiment one
Batching: Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus, Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri;
Preparation method:
Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri decocts with water, and decocting liquid filters, and filtrate concentrates, add ethanol, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, again with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus 105 ℃ down dry, 100 mesh sieves that ground to the powder add the ethanol of 7 times of amounts, the heating continuous backflow is extracted 12h, perhaps get the extracting solution of 1ml, add 10% alcoholic solution and do not show purple and stop reflux when yellow, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, two kinds of thick pastes and an amount of glycerol are adjusted content in proportion, mixing, finished product;
Embodiment two
Batching: Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus, Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri, Radix Sophorae Flavescentis, its preparation method are with embodiment one, and difference is to add Radix Sophorae Flavescentis and is used as medicine.
In sum, the ointment of anti-inflammation and sterilization of the present invention, yellow skin is put on the skin and the affected part after cleaning every day, and 3 times on the one, have antipruritic pain relieving, heat-clearing and toxic substances removing, anti-inflammation and sterilization, repercussive effect, reach the purpose of refractory skins such as treatment eczema, dermatitis.
Claims (2)
1. the ointment of an anti-inflammation and sterilization, it is characterized in that: with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus is dry down at 105 ℃, grind to the powder, the ethanol that adds 7 times of amounts, the heating continuous backflow is extracted 12h, perhaps gets the extracting solution of 1ml, add and stop reflux when 10% alcoholic solution does not show the purple yellow, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, with Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri decocts with water, and decocting liquid filters, and filtrate concentrates, add ethanol, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), the Matrii Sulfas Exsiccatus thick paste adds mixing in proportion, adjusts content, the product that obtains behind the finished product.
2. according to claim 1, it is characterized in that preparation method is following steps: Cortex Dictamni, the Fructus Kochiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Cortex Phellodendri decocts with water, decocting liquid filters, filtrate concentrates, and adds ethanol, leaves standstill and makes precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, again with Realgar, Cinnabaris, Borneolum Syntheticum, Borax (stir-fry), Matrii Sulfas Exsiccatus is dry down at 105 ℃, 100 mesh sieves ground to the powder, the ethanol that adds 7 times of amounts, the heating continuous backflow is extracted 12h, perhaps gets the extracting solution of 1ml, add and stop reflux when 10% alcoholic solution does not show the purple yellow, leave standstill and make precipitation, get supernatant, reclaim ethanol, be condensed into thick paste, two kinds of thick pastes and an amount of glycerol are adjusted content, mixing, finished product in proportion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710156738A CN101698017A (en) | 2007-11-28 | 2007-11-28 | Antiphlogosis and sterilizing ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710156738A CN101698017A (en) | 2007-11-28 | 2007-11-28 | Antiphlogosis and sterilizing ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101698017A true CN101698017A (en) | 2010-04-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710156738A Pending CN101698017A (en) | 2007-11-28 | 2007-11-28 | Antiphlogosis and sterilizing ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101698017A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007120A (en) * | 2012-12-03 | 2013-04-03 | 周比玥 | Traditional Chinese medicine for treating beriberi |
| CN103110747A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | External traditional Chinese medicine preparation for treating contact dermatitis |
| CN103356890A (en) * | 2013-07-31 | 2013-10-23 | 徐冰娜 | Externally-applied traditional Chinese medicinal preparation for treating skin allergy and pruritus, and preparation method thereof |
| CN104116799A (en) * | 2014-07-21 | 2014-10-29 | 董宝珍 | Medicated wine for preventing and treating miliaria |
| CN104435208A (en) * | 2013-09-16 | 2015-03-25 | 青岛锦涟鑫商贸有限公司 | Face cream for treating dermatitis |
| CN105641133A (en) * | 2014-11-13 | 2016-06-08 | 扬子江药业集团上海海尼药业有限公司 | Composition for prevention and treatment of children eczema and preparation method thereof |
| CN106074758A (en) * | 2016-08-15 | 2016-11-09 | 欧明宇 | Dermatitis medicinal liquid, dermatitis cleanout fluid and its prepare, using method |
| CN107497396A (en) * | 2017-09-13 | 2017-12-22 | 浙江玉智德新材料科技有限公司 | A kind of antibacterial filter material and its anhydrous method preparation technology |
-
2007
- 2007-11-28 CN CN200710156738A patent/CN101698017A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007120A (en) * | 2012-12-03 | 2013-04-03 | 周比玥 | Traditional Chinese medicine for treating beriberi |
| CN103110747A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | External traditional Chinese medicine preparation for treating contact dermatitis |
| CN103356890A (en) * | 2013-07-31 | 2013-10-23 | 徐冰娜 | Externally-applied traditional Chinese medicinal preparation for treating skin allergy and pruritus, and preparation method thereof |
| CN103356890B (en) * | 2013-07-31 | 2014-08-13 | 徐冰娜 | Externally-applied traditional Chinese medicinal preparation for treating skin allergy and pruritus, and preparation method thereof |
| CN104435208A (en) * | 2013-09-16 | 2015-03-25 | 青岛锦涟鑫商贸有限公司 | Face cream for treating dermatitis |
| CN104116799A (en) * | 2014-07-21 | 2014-10-29 | 董宝珍 | Medicated wine for preventing and treating miliaria |
| CN105641133A (en) * | 2014-11-13 | 2016-06-08 | 扬子江药业集团上海海尼药业有限公司 | Composition for prevention and treatment of children eczema and preparation method thereof |
| CN106074758A (en) * | 2016-08-15 | 2016-11-09 | 欧明宇 | Dermatitis medicinal liquid, dermatitis cleanout fluid and its prepare, using method |
| CN107497396A (en) * | 2017-09-13 | 2017-12-22 | 浙江玉智德新材料科技有限公司 | A kind of antibacterial filter material and its anhydrous method preparation technology |
| CN107497396B (en) * | 2017-09-13 | 2019-08-09 | 浙江玉智德新材料科技有限公司 | A kind of antibacterial filter material and its anhydrous method preparation process |
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| C06 | Publication | ||
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Open date: 20100428 |