CN1055398C - Medicament for treatment of hyerosteogeny and its prepn. - Google Patents

Abstract

The present invention relates to a novel medicament for treating hyperosteogeny, which comprises Chinese medicinal herbs with functions of removing stasis, softening hard masses, clearing heat and toxic materials, activating blood, dissolving stasis, diminishing inflammation, alleviating pain, etc. The medicament is prepared according to the Chinese medicine theory and the medicinal characteristics of each medicinal material. The medicinal materials are respectively pretreated by different methods, and are milled and prepared into a capsule for treating hyperosteogeny according to a certain proportion through the comprehensive effect of the Chinese medicinal herbs. The medicament has unique formula, unique preparation method, obvious therapeutic effect, and obvious economic and social benefits.

Description

Hyperosteogeny treating medicament and compound method thereof

The present invention relates to the pharmaceutical product field, more specifically say so about the prepared from traditional Chinese medicines product of treatment hyperosteogeny.

Hyperosteogeny is the aged a kind of performance of skeleton, also is one of common frequently-occurring disease of old people.Present domestic medical circle treatment hyperosteogeny main method has: traction, massage, surgical operation etc., these Therapeutic Method cause very big misery to the patient, the treatment condition has certain limitation, and dangerous big, the course of treatment is long, human mechanism there is certain damage, weak effect, cure rate is low, easily recurrence, and stay sequela easily even cause other diseases, cause health paralysis or fatal.

Traditional endo-medicine healing potion has bony spur tablet, bony spur pill, GUXIAN PIAN and GUXIANLING etc.These medicines can only be controlled table, can not effect a permanent cure.Can only easing pain and diminishing inflammation, mitigate the disease, disease controlling worsens, and can not remove misery.The cycle course of treatment is long, and dosage is big, and effect is very little, and certain effect of paying is arranged.

The object of the present invention is to provide a kind of good medicament and preparation technique thereof of new treatment hyperosteogeny.

The present invention is based on motherland's medical science to pathogenetic understanding of hyperosteogeny and Therapeutic Principle, mechanism and Chinese herbal medicine to human body have been done to study intensively, collection clinical treatment experience for many years, the Chinese herbal medicine that filters out some eliminating stagnation softening the hard mass, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic from motherland's medicine treasure-house is the principal agent component, be equipped with an amount of accessory drugs component again, by the theory of Chinese medical science prescription, skim the cream off milk, the constituent content of the hyperosteogeny treating medicament of Zu Chenging is the eliminating stagnation softening the hard mass medical material of (weight %): 30-45 thus, and it is selected from Concha Arcae, Membrana Follicularis ovi, Ovum crusta Gallus domesticus; The heat-clearing and toxic substances removing medical material of 15--30, it is selected from Radix Glycyrrhizae, Rhizoma Zingiberis Recens; The blood circulation promoting and blood stasis dispelling medical material of 10-30, it is selected from Radix Angelicae Sinensis, Herba Eleusines Indicae, the Radix Paeoniae Alba, Radix Luffae, Rhizoma Imperatae, Radix Serissae; And the anti-inflammatory analgetic medical material of 7-30, it is selected from green grapes, Radix vitis viniferae, Rhizoma Chuanxiong, Rhizoma Dioscoreae Nipponicae.In prescription, also be equipped with an amount of accessory drugs according to patient, said in the present invention accessory drugs component comprises: Rhizoma Dioscoreae Nipponicae, Flos Rosae Chinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Rosae Laevigatae, Pericarpium Citri Reticulatae, green grapes, Fructus Crataegi (parched to brown), Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Angelicae Sinensis, Radix Adenophorae (Radix Glehniae) and Rhizoma Zingiberis powder etc., suitably select to use according to different prescriptions.

According to the theory of traditional Chinese medical science prescription, can form several different prescriptions, be used for the treatment of several dissimilar hyperosteogeny diseases.A kind of preferred prescription is to be principal agent with Concha Arcae, green grapes, Radix Angelicae Sinensis, Radix Glycyrrhizae, its constituent content is green grapes or Radix vitis viniferae, the Radix Angelicae Sinensis of 10-25 or Radix Glycyrrhizae or the Rhizoma Zingiberis Recens of the Radix Paeoniae Alba and 15-27 of the Concha Arcae of (weight %): 30-40 or Membrana Follicularis ovi, 10-25, and being equipped with an amount of accessory drugs, it is selected from Rhizoma Dioscoreae Nipponicae, Flos Rosae Chinensis, the Rhizoma Atractylodis Macrocephalae and Rhizoma Dioscoreae.This prescription is mainly used in the treatment hyperosteogeny of cervical vertebra, and bony spur is eliminated in the inside of human body chemotherapy, is not subjected to any misery, and seven days is a course of treatment, and general 2-3 days can take effect, and can cure no any pair of effect three courses of treatment.Using dosage is secondary every day, and each one (2 gram) is oral.

Another kind of preferred prescription is to be principal agent with Concha Arcae, Membrana Follicularis ovi, Radix Angelicae Sinensis, Radix Glycyrrhizae and Rhizoma Chuanxiong, its constituent content is the Concha Arcae of (weight %): 30-35, the Membrana Follicularis ovi of 3-10 or Ovum crusta Gallus domesticus, the Radix Angelicae Sinensis of 10-25 or the Radix Paeoniae Alba, the Rhizoma Chuanxiong of 15-27 Radix Glycyrrhizae or Rhizoma Zingiberis Recens and 10-30 or Rhizoma Dioscoreae Nipponicae, and being equipped with an amount of accessory drugs, it is selected from Fructus Rosae Laevigatae, Pericarpium Citri Reticulatae, green grapes and Fructus Crataegi (parched to brown).This prescription has obvious curative effects to each joint part hyperosteogeny of treatment upper limb, can make bony spur dissolve elimination at inside of human body, does not have any misery.15 days is a course of treatment, and can cure no any pair of effect general four courses of treatment.

Also having a preferred prescription is with Concha Arcae, Membrana Follicularis ovi, Radix Angelicae Sinensis, Radix Glycyrrhizae, Rhizoma Chuanxiong and Rhizoma Dioscoreae Nipponicae are principal agent, being equipped with suitable accessory drugs makes, its constituent content is the Concha Arcae of (weight %): 25-33, the Membrana Follicularis ovi of 5-10 or Ovum crusta Gallus domesticus, the Radix Angelicae Sinensis of 10-20 or the Radix Paeoniae Alba, the Radix Glycyrrhizae of 20-25 or Rhizoma Zingiberis Recens, the Rhizoma Chuanxiong of 10-15, the 10-15 Rhizoma Dioscoreae Nipponicae, it is selected from Fructus Rosae Laevigatae used accessory drugs, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Ophiopogonis, Cortex Zingiberis etc., the prescription of Zu Chenging is mainly used in the treatment lumbar vertebra thus, knee joint, hyperosteogeny diseases such as heel thorn have significant curative effect to the hyperosteogeny in each joint of lower limb, can make bony spur dissolve elimination, there is no any misery at inside of human body.20 days is a course of treatment, and can cure general three courses of treatment.State of an illness especially severe, can cure no any pair of effect in three months fully.

Another preferably fills a prescription is with Concha Arcae, green grapes, Radix Glycyrrhizae, Radix Serissae and Herba Eleusines Indicae are principal agent, being equipped with suitable accessory drugs makes, its constituent content is Concha Arcae or the Membrana Follicularis ovi of (weight %): 30-45, the green grapes of 10-25 or Radix vitis viniferae, the Radix Glycyrrhizae of 15-27 or Rhizoma Zingiberis Recens, the Herba Eleusines Indicae of the Radix Serissae of 10-15 or Radix Luffae and 10-15 or Rhizoma Imperatae, used accessory drugs then is selected from Rhizoma Dioscoreae Nipponicae, Fructus Rosae Laevigatae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Angelicae Sinensis, Radix Adenophorae (Radix Glehniae) and Rhizoma Zingiberis powder, the medicament made of compositing formula thus, be mainly used in the after treatment after above-mentioned hyperosteogeny disease is cured, play stable and healing effect, return to one's perfect health, do not recur to reach, no any pair of effect, can suit the remedy to the case according to patient's the state of an illness, take in right amount.

Medicine for treating osteoproliferation provided by the invention, aspect manufacture method, also be different from general Chinese medicine manufacture method, it is the medicinal characteristic according to each flavor medical material, respectively with the distinct methods pretreatment, thereafter levigate, be mixed with the capsule of said treatment hyperosteogeny in proportion, its main making step comprises:

1, the pretreatment of special medical material.Some medical material need be done special pretreatment in the present invention.As Concha Arcae, membrana follicularis ovi and the green grapes that uses in the prescription, before processing, to flood, spray wine or stifling with vinegar, then oven dry or parch.In addition, Rhizoma Dioscoreae Nipponicae of using in the prescription and Fructus Rosae Laevigatae then need to fumigate with Chinese liquor earlier, then oven dry and parch.The duration and degree of heating of parch, medicinal for different medical materials also has specific (special) requirements certainly.

2, the pretreatment of general medical material, for other general medical materials that use among the present invention, then need with after the distilled water sprinkling, oven dry or stir-fry are done under suitable high temperature again, the temperature of parch is also inequality for each flavor medical material, and generally oven dry or parch temperature are 100-200 ℃.

3, the pretreated medical material pulverize separately of respectively distinguishing the flavor of, be finely ground to 120 order fine powders;

4, pressing after proportional quantity preparation mixes, incapsulate by doses, generally is every 2 gram, makes said treatment hyperosteogeny medicament.

The treatment hyperosteogeny medicament of so making is a kind of Chinese patent medicine for oral administration, twice of oral every day (early, evening each once), each one (every 2 gram).

The present invention treats multiple hyperosteogeny patient's 400 many cases through clinical trial for many years, and through Weifang Yidu Central Hospital, Qingzhou City the People's Hospital clinical trial checking, effective percentage reaches 100%, and cure rate reaches more than 50%.No any pair of effect, and do not find any recurrent cases.

Concrete instance of following reuse is described further manufacture method of the present invention.

1, get Concha Arcae 200 gram, through high temperature forge fry red, be called in the present invention forge red.Forging Concha Arcae after red takes advantage of hot dipping to go into to take out oven dry in the vinegar then.

2, get Rhizoma Dioscoreae Nipponicae 150 grams, with oven dry after the stifling appropriate time of Chinese liquor, fry to sending out crisp more earlier.

3, get green grapes 50 grams, after fumigating with vinegar, fry again and do.

4, get Membrana Follicularis ovi 25 grams, spray vinegar earlier, mix the back oven dry thoroughly.

5, get Fructus Rosae Laevigatae 50 grams, after fumigating with Chinese liquor, fry again to yellow standby.

6, get Radix Angelicae Sinensis 75 grams, Rhizoma Chuanxiong 75 grams, Radix Glycyrrhizae 125 grams, Pericarpium Citri Reticulatae 50 restrains, Fructus Crataegi (parched to brown) 60 grams, spray earlier is with distilled water, and oven dry thereafter or stir-fry are done standby.

7, the above-mentioned pulverizing medicinal materials of respectively distinguishing the flavor of is worn into 120 order fine powders, be mixed in proportion during the back incapsulates with prescribed dose, promptly make the Chinese patent medicine that is used for the treatment of each joint part hyperosteogeny of upper limb.

The several examples of following reuse further specify effect of the present invention.

Example 1: fourth * *, man, 46 years old, the workman of Qingzhou valve plant.Before the treatment, have a pain in the leg suddenly unbearably at work, can not walk upright, film making is checked through the Qingzhou City the People's Hospital, determines knee joint hyperosteogeny, serious pressuring nerve, no special therapeutic method, the commentaries on classics of also not getting better.Bring into use the treatment of this medicine in November, 93, take the fruit that takes effect after three days, can walk upright, activity returns to one's perfect health after 20 days freely after seven days, and any pair of effect do not found in not recurrence yet up to now.

Example 2, poplar * *, the woman, 58 years old, Qingzhou City land administration bureau families of workers and staff, because of double-legged root long bone thorn can not be walked, morbidity identified that through Weifang Yidu Central Hospital film making bony spur has the Semen Juglandis size more than 3 years, through how tame hospital with multiple medicine (GUXIAN PIAN, bony spur spirit and various folk prescriptions) treatment, lose effect.Begin to take this medicine in February, 91, treat the fruit that takes effect after seven days, return to one's perfect health after 50 days, bony spur is all eliminated on inspection, and cure does not have rebound phenomenon 3 years, finds no any pair of effect yet.

Example 3, Korea Spro * *, the man, 46 years old, raw material workshop, ironworks, Yidu worker, in June, 92 morbidity, health is paralysed substantially during morbidity, identifies lumbar vertebra dislocation, obstructive hyperosteogeny at the CT of Weifang Yidu Central Hospital sheet, Qingzhou City institute of traditional Chinese medicine hospitalization three months, through artificial traction, the location acupuncture-moxibustion were used GUXIAN PIAN, medicines such as ZHUANGGU GUANJIE WAN are not all cured.The amyotrophy of buttocks portion can not be sat when leaving hospital, and can not squat, and sleep can not be stood up, and can not walk upright for a long time.Begin to take this medicine in October, 92, takes effect after three days, and take three months each symptoms altogether and eliminate fully, rehabilitation, now normal working, and can often participate in heavy physical labour such as maintenance of equipment.So far do not find recurrent pathological changes and other pairs effect.

Example 4: Zhao * *, the man, 46 years old, ironworks, Yidu pelletizing workshop workman identified lumbar vertebra, cervical spine injury hyperosteogeny through hospital, causes the one leg atrophy, with several different methods and Drug therapy, loses effect through how tame hospital.Begin to take this medicine in July, 85, symptom was eliminated in three months, returned to one's perfect health.

Show that from above clinical use result advantage of the present invention is clearly, prescription of the present invention and manufacture method uniqueness, drug use dosage is little, human body is not had medicine pay effect, and is safe in utilization, evident in efficacy.The present invention provides a kind of both convenient, safety for the hyperosteogeny patient, and Jing Ji new healing potion has improved the hyperosteogeny treating effect again, has reduced patient's misery.This drug manufacture technology is simple, and the raw material abundance has tangible economic benefit and social benefit.

The several actual prescriptions of following reuse further specify the present invention; certainly be not confined among these several examples, each Formulation Example all can be done suitably to adjust by patient's concrete condition according to the traditional Chinese medical science principles of formulating prescriptions; the increase and decrease accessory drugs is so this adjustment all is included among protection scope of the present invention.

Example 1: Concha Arcae 200 grams, green grapes 75 grams, Radix Angelicae Sinensis 100 grams, Radix Glycyrrhizae 125 grams, Rhizoma Dioscoreae Nipponicae 90 grams, the Rhizoma Atractylodis Macrocephalae 70 grams.

Be mixed with Chinese patent medicine by above-mentioned compound method.Show that through clinical use symptom can very fast elimination, and is evident in efficacy.

Example 2, Concha Arcae 200 grams, Membrana Follicularis ovi 25 grams, Radix Angelicae Sinensis 75 grams, Rhizoma Chuanxiong 75 grams, Radix Glycyrrhizae 125 grams, Pericarpium Citri Reticulatae 25 grams, Rhizoma Dioscoreae Nipponicae 90 grams, Fructus Crataegi (parched to brown) 60 grams.

Pei Zhi Chinese patent medicine shows that through clinical trial the hyperosteogeny to each joint part of upper limb has obvious curative effects as stated above.

Example 3, Radix Angelicae Sinensis 100 restrains, Membrana Follicularis ovi 50 grams, Concha Arcae 200 grams, Radix Glycyrrhizae 150 grams, Rhizoma Dioscoreae Nipponicae 75 grams, restrain Radix Ophiopogonis 30, the Rhizoma Atractylodis Macrocephalae 30 grams, Rhizoma Chuanxiong 75 grams.

The Chinese patent medicine that is mixed with as stated above shows that through clinical trial all there is apparent curative effect in each joints of lower limb such as lumbar vertebra, knee joint, bony spur of foot root.

Example 4, Concha Arcae 200 grams, green grapes 25 grams, Radix Glycyrrhizae 125 grams, Radix Serissae 75 grams, Herba Eleusines Indicae 75 grams, Radix Angelicae Sinensis 10 grams, Rhizoma Dioscoreae Nipponicae 75 grams, Radix Adenophorae (Radix Glehniae) 50 grams, the Rhizoma Atractylodis Macrocephalae 25 grams.

The Chinese patent medicine that is mixed with as stated above, show that through clinical trial all kinds of hyperosteogenys are all had positive effect, be mainly used in consolidation and healing effect after the state of an illness is cured, return to one's perfect health to reach, no longer recurrence, more than prescription can be suited the remedy to the case according to different patients, the state of an illness.

Claims (1)

1, a kind of medicament for the treatment of hyperosteogeny, it is characterized in that by Concha Arcae, membrana follicularis ovi, Radix Angelicae Sinensis, Radix Glycyrrhizae, Rhizoma Chuanxiong, Rhizoma Dioscoreae Nipponicae, Radix Ophiopogonis, components such as the Rhizoma Atractylodis Macrocephalae are formed, each medical material of distinguishing the flavor of is respectively earlier with preparing after the following distinct methods pretreatment, said Rhizoma Dioscoreae Nipponicae should be stifling with Chinese liquor earlier, and Concha Arcae, membrana follicularis ovi floods with vinegar earlier respectively, sprinkling or stifling, other medical materials: Radix Angelicae Sinensis, Radix Glycyrrhizae, Rhizoma Chuanxiong, the Radix Ophiopogonis and the Rhizoma Atractylodis Macrocephalae etc. then spray with distilled water earlier, thereafter dry down or fry and do at 100～200 ℃ respectively, and be finely ground to 120 order fine powders respectively, be mixed in proportion and be mixed with said treatment hyperosteogeny medicament, its constituent content (weight portion %) is: 28.2 parts of Concha Arcaes, 7.0 parts of membrana follicularis ovis, 14.1 parts of Radix Angelicae Sinensis, 21.1 parts in Radix Glycyrrhizae, 10.6 parts of Rhizoma Chuanxiongs, 10.6 parts of Rhizoma Dioscoreae Nipponicae, 4.2 parts of 4.2 parts of the Radix Ophiopogonis and the Rhizoma Atractylodis Macrocephalaes.