CN101606530B - Pesticide containing hexaflumuron and malathion and application thereof - Google Patents

Abstract

The invention discloses an insecticide containing hexaflumuron and malathion, which uses hexaflumuron and malathion as active ingredients, and the weight ratio of the two is 2-10:5-40. In the present invention, the combination of hexaflumuron and malathion can give full play to their respective advantages, and the combination of the two active ingredients has a significant synergistic effect, which can achieve the effects of enhancing the control effect and delaying drug resistance. It is used to control pests such as mirid bugs and cotton bollworms.

Description

Insecticides containing hexaflumuron and malathion and uses thereof

technical field

The invention relates to an insecticide containing hexaflumuron and malathion and its application, belonging to the field of pesticides.

Background technique

Mirid bugs, including Apolygus lucorum, Adelphocoris suturelis, Adelphocoris lineolatus and Adelphocorisfasciaticollis, are important pests to cotton. At present, there are many kinds of medicaments for the prevention and control of mirid bugs in production, such as imidacloprid, cypermethrin, chlorpyrifos, fipronil, etc. The current problem is that due to long-term single drug use, mirid gnats have developed resistance to some chemicals, and the control effect is reduced. It is necessary to increase the amount used in production to control its occurrence and damage. A large amount of chemical insecticides are sprayed into crops and farmland, causing pollution to cotton products and the environment. Therefore, there is an urgent need for efficient and environmentally friendly new pesticide varieties in production.

Hexaflumuron (hexaflumuron), a benzoylurea insecticide, is a chitin synthesis inhibitor with high insecticidal and ovicidal activity, and can be used for cotton and fruit trees to control various Coleoptera, Diptera, Homoptera insects. It is characterized by low toxicity, safety to humans and animals, effective on a variety of pests, and can control a variety of pests.

Malathion, also known as marathon, is one of the representative varieties of organophosphorus pesticides, which has contact killing, stomach poisoning and fumigation effects on pests. It is characterized by low toxicity, cheap price, wide spectrum of action, effective on most pests and mites, and can control many kinds of pests at the same time. Its disadvantage is that the dosage is relatively large.

Therefore, researchers are currently working on an insecticide that can not only improve drug efficacy and reduce costs, but also avoid and delay the emergence of drug resistance.

Contents of the invention

The purpose of the present invention is to provide a kind of insecticide containing hexaflumuron and malathion, combining the two can give full play to their respective advantages, and the combination of the two active ingredients has a significant synergistic effect, which can To achieve the effect of enhancing the control effect and delaying drug resistance.

Another object of the present invention is to provide an application of an insecticide containing hexaflumuron and malathion in the control of mirid bugs or cotton bollworm pests.

In order to achieve the purpose of the present invention, the researchers of the present invention selected hexaflumuron and malathion for compounding according to the biological assay results based on the equivalence principle of reasonable compounding of pesticides and different compounding ratios.

Pesticide of the present invention contains the active ingredient of following weight portion:

Hexaflumuron: 2～10

Malathion: 5-40.

Preferably, the insecticide of the present invention contains the following active ingredients in parts by weight:

Hexaflumuron: 4～8

Malathion: 10-40.

More preferably, the insecticide of the present invention contains the following active ingredients in parts by weight:

Hexaflumuron: 5～7

Malathion: 25-35.

According to methods well known to those skilled in the art, the above-mentioned active ingredients and appropriate auxiliary materials can be prepared into emulsifiable concentrates, suspension concentrates, emulsions in water or dispersible granules.

A preferred solution is to prepare emulsifiable concentrate, and the auxiliary materials include emulsifier and solvent, wherein the emulsifier accounts for 5% to 30% of the total weight of the emulsifiable concentrate, and the solvent accounts for 40% to 70% of the total weight of the emulsifiable concentrate.

The emulsifier is selected from: Nongru 600#, Nongru 700#, 2201, OP-21, OP-10, AEO (condensation of fatty alcohol and ethylene oxide) or JFC (polyoxyethylene ether compound) one or more of . Preferred is: OP-21 or AEO.

Described solvent is selected from: dimethylformamide, methanol, benzyl alcohol, ethanol, ethylene glycol, dimethyl sulfoxide, glycerol, isopropanol, n-butanol, N-methylpyrrolidone, cyclohexane Any one or more of ketone or xylene. It is preferably any one or more of dimethylformamide, ethanol, N-methylpyrrolidone, xylene or cyclohexanone.

The components of the emulsifiable concentrate containing hexaflumuron and malathion can all be obtained from the market, and processed into an emulsifiable concentrate formulation using techniques known in the art.

Specifically, above-mentioned emulsifiable concentrate can adopt following method to prepare:

In a container equipped with a thermometer and a stirrer, add hexaflumuron, malathion and solvent, heat to 30°C-50°C, stir for 30-90 minutes, then evenly add emulsifier at a temperature of 40°C and stir, Stir for 60 minutes, and when the temperature drops to 20°C, the medicinal solution is a transparent substance solution, and after filtration, it becomes the emulsifiable concentrate of fluflumuron and malathion.

The emulsifiable concentrate containing hexaflumuron and malathion can be used for preventing and controlling pests such as mirid bugs or cotton bollworms.

The dosage of the emulsifiable concentrate containing hexaflumuron and malathion in the field to prevent and control mirid bugs is generally 200-600 g/ha of active ingredients (the amount of active ingredients per hectare) for spraying. The application method of the emulsifiable concentrate containing hexaflumuron and malathion of the present invention is: according to the recommended dosage, it is diluted with water in a sprayer and then sprayed.

Insecticide of the present invention has the following advantages:

1. Hexaflumuron and malathion have different mechanisms of action on insects, and their modes of action are complementary to a certain extent. In addition, the combination of the two has a very high synergistic effect, so it is an ideal insecticide. Insecticide binary combination.

2. The combination of hexaflumuron and malathion of the present invention achieves complementary advantages, improves drug efficacy, reduces costs, delays resistance, and reduces the amount of chemical pesticides used.

3. The emulsifiable concentrate containing hexaflumuron and malathion described in the present invention can be applied to control pests such as mirid bugs and cotton bollworms.

Detailed ways

The present invention will be further described below in conjunction with specific examples. Unless otherwise specified, the experimental methods and reagents used in the present invention are methods and reagents known to those skilled in the art. It should be understood that these examples are only used to illustrate the present invention, but not to limit the protection scope of the present invention. For those skilled in the art, on the premise of not departing from the spirit and essence of the present invention, various changes or modifications to the details of these embodiments also fall within the protection scope of the present invention.

Example 1

The purpose of this experimental example is to study the synergistic effect of the mixed use of hexaflumuron and malathion.

The indoor toxicity of the tested pesticides to the 3rd instar larvae of Lygus lucidum was determined by leaf dipping method. Dissolve each test agent with acetone and prepare a mother solution with a certain concentration. Dilute each of the above mother liquors with an aqueous solution containing 0.1% Tween 80 into 5 to 7 series of mass concentrations in an equiproportional gradient. Immerse fresh cotton leaves of the same size in the liquid medicine for 30 seconds, dry them naturally at room temperature, put them into a plastic box (8 cm in diameter, 5 cm in height), and insert lively, healthy, and 3rd instar larvae of the same size. , 15 heads per box, covered with a lid with a small hole. Distilled water containing 0.1% Tween 80 and 0.1% acetone was used as blank control, and repeated 3 times. Place them under the conditions of temperature 24-26° C., relative humidity 70-80%, and photoperiod of L:D=14:10 for observation. The test is investigated once, and after 2 days (48 hours), the death situation of the test insects is checked. The experimental results are shown in Table 1.

Table 1 Determination results of co-toxicity coefficient of malathion, hexaflumuron and their different ratios

The test method adopts leaf dipping method. A co-toxicity coefficient > 120 indicates synergy.

It can be seen that the mixture of hexaflumuron and malathion in the composition of the present invention has a significant synergistic effect.

Example 2

The purpose of this experimental example is to study 36% hexaflumuron. Field efficacy test of malathion EC for controlling Lygus japonica.

Preparation of emulsifiable agents:

Weigh the raw materials with the following weight ratio

Hexaflumuron: 6%

Malathion: 30%

Emulsifier JFC: 15%

Emulsifier Nongru 500# 5%

Solvent 1N-Methylpyrrolidone 10%

Solvent 2 Xylene: The remainder.

In a container equipped with a thermometer and a stirrer, add hexaflumuron and malathion, ethanol and xylene, heat to 40°C, stir for 60 minutes, then gradually add emulsifier OP-21 and stir for 60 minutes, When the temperature drops to 30°C, it becomes 36% emulsifiable oil after filtration.

The prepared agent was sprayed on cotton, and the number of adults and nymphs of Lygus aeruginosa were investigated before and after spraying. Mark 50 cotton plants per plot, and count the number of living insects on the whole plant.

Table 2 36% hexaflumuron · malathion EC test statistical results for the control of Cotton Lygus Lygus

Note: *The control effects in the table were analyzed by variance after arcsine transformation, and Duncan’s new multiple range method was used for multiple comparisons. Those with the same letter in the same column have no significant difference at the 0.05 level.

Control effect (%)=(1-the number of insects in the control area before the drug × the number of insects in the post-treatment area/the number of insects in the control area after the drug × the number of insects in the pre-treatment area) × 100

Find out by test result, 36% hexaflumuron and malathion emulsifiable concentrate 200ai.g/ha. and 300ai.g/ha.(1350 times and 900 times) two treatments are all in 79 % or more, its control effect on the 1st and 3rd day was not significantly different from that of the control agent 5% hexaflumuron EC 312.5 times, but the control effect on the seventh day was significantly higher than that of the control agent treatment, and after treatment 1, The control effects of 3 and 7 days were significantly higher than 600 times of 45% malathion emulsifiable concentrate treatment, indicating that its quick-acting and long-lasting effects were better.

Example 3

To prepare 20% EC:

First take the following raw materials by weight:

Hexaflumuron: 1.0%

Malathion: 19.0%

Emulsifier OP-21: 25%

Solvent 1 Ethanol: 35%

Solvent 2 xylene: balance

Then, in a container equipped with a thermometer and a stirrer, add hexaflumuron, malathion, ethanol and xylene, heat to 40°C, stir for 60 minutes, then gradually add emulsifier OP-21 and stir for 60 minutes , when the temperature drops to 30°C, it becomes 20% emulsifiable oil after filtration.

Example 4

To prepare 20% EC:

First take the following raw materials by weight:

Hexaflumuron: 2%

Malathion: 18%

Emulsifier AEO: 25%

Solvent 1 Benzyl Alcohol: 15%

Solvent 2 dimethylformamide The balance.

Then add hexaflumuron, malathion, solvent benzyl alcohol and dimethylformamide into the container, heat to 30°C, stir for 60 minutes, then add emulsifier AEO and stir for 90 minutes, cool down to 15°C, filter Serve as an emulsifiable concentrate containing hexaflumuron and malathion.

Example 5

To prepare 20% EC:

First take the following raw materials by weight:

Hexaflumuron: 3%

Malathion: 17%

Emulsifier JFC: 20%

Solvent 1N-Methylpyrrolidone: 15%

Solvent 2 Ethylene Glycol: Balance

Add hexaflumuron, malathion, solvent N-methylpyrrolidone, and ethylene glycol into the container, heat to 50°C, stir for 90 minutes, then add emulsifier and stir for 60 minutes, cool down to 30°C, and filter Serve as an emulsifiable concentrate containing hexaflumuron and malathion.

Example 6

Preparation method is the same as Example 1, and difference is that composition and content are as follows:

Hexaflumuron: 5%

Malathion: 25%

Emulsifier OP-10: 15%

Emulsifier Nongru 600: 10%

Solvent 1 Cyclohexanone: 10%

Solvent 2 dimethylformamide: the remainder.

Example 7

Preparation method is the same as Example 1, and difference is that composition and content are as follows:

Hexaflumuron: 10%

Malathion: 5%

Emulsifier 2201: 10%

Emulsifier OP-10: 10%

Solvent 1 DMF: 15%

Solvent 2 dimethyl sulfoxide: balance.

Example 8

Preparation method is the same as Example 1, and difference is that composition and content are as follows:

Hexaflumuron: 5%

Malathion: 45%

Emulsifier AEO: 20%

Solvent 1 DMF: 10%

Solvent 2N-methylpyrrolidone: balance

Example 9

Preparation method is the same as Example 1, and difference is that composition and content are as follows:

Hexaflumuron: 6%

Malathion: 30%

Emulsifier JFC: 15%

Emulsifier Nongru 500# 5%

Solvent 1N-Methylpyrrolidone 10%

Solvent 2 Xylene: The remainder.

Example 10

Preparation method is the same as Example 1, and difference is that composition and content are as follows:

Hexaflumuron: 4%

Malathion: 35%

Emulsifier JFC: 15%

Emulsifier Nongru 500# 5%

Solvent 1N-Methylpyrrolidone 10%

Solvent 2 Xylene: The remainder.

Example 11

Preparation method is the same as Example 1, and difference is that composition and content are as follows:

Hexaflumuron: 5%

Malathion: 10%

Emulsifier JFC: 15%

Emulsifier Nongru 500# 5%

Solvent 1N-Methylpyrrolidone 10%

Solvent 2 Xylene: The remainder.

Example 12

According to the method of Example 2, 50 plants of cotton were marked for each plot, and the numbers of Lygus and cotton bollworms were counted. The insecticides of the above-mentioned Example 3 to Example 11 were sprayed respectively (three repetitions in each group), and the spraying rate was 300ai·g/ha. Count the number of Lygus and cotton bollworm in each plot after spraying. The results are shown in Table 3 and Table 4 below.

Table 3 The number of Lygus aeruginosa after mixed treatment with different proportions of hexaflumuron and malathion

Table 4 The number of cotton bollworms after the mixed treatment of hexaflumuron and malathion in different proportions

From the results of Table 2 and Table 3, the dosage of each mixed preparation of hexaflumuron and malathion is 300g/ha. concurrent therapeutic effect.

Control effect (%)=(1-the number of insects in the pre-drug control area×the number of insects in the post-drug treatment area/the number of insects in the post-drug control area×the number of insects in the pre-drug treatment area)×100.

Claims (10)

1. an insecticide that contains fluorine bell urea and malathion is characterized in that, this insecticide contains the active ingredient of following weight portion:

Fluorine bell urea: 2～10

Malathion: 5～40.

2. insecticide as claimed in claim 1 is characterized in that, this insecticide contains the active ingredient of following weight portion:

Fluorine bell urea: 4～8

Malathion: 10～40.

3. insecticide as claimed in claim 1 is characterized in that, this insecticide contains the active ingredient of following weight portion:

Fluorine bell urea: 5～7

Malathion: 25～35.

4. like each described insecticide of claim 1～3, it is characterized in that it is the missible oil that active ingredient and suitable auxiliary material are prepared into.

5. insecticide as claimed in claim 4 is characterized in that, said insecticide is a missible oil, and said auxiliary material comprises emulsifier and solvent, and wherein emulsifier accounts for 5%～30% of missible oil gross weight, and solvent accounts for 40%～70% of missible oil gross weight.

6. insecticide as claimed in claim 5 is characterized in that, described emulsifier is selected from one or more in agricultural newborn 600#, Nongru-700 #, 2201, OP-21, OP-10, fatty alcohol and ethylene oxide condensate or the APEO.

7. insecticide as claimed in claim 6 is characterized in that: described emulsifier is: OP-21 or fatty alcohol and ethylene oxide condensate.

8. insecticide according to claim 5 is characterized in that: described solvent be in dimethyl formamide, methyl alcohol, phenmethylol, ethanol, ethylene glycol, dimethyl sulfoxide (DMSO), glycerine, isopropyl alcohol, n-butanol, N-Methyl pyrrolidone, cyclohexanone or the xylol any one or multiple.

9. insecticide as claimed in claim 8 is characterized in that, said solvent be in dimethyl formamide, ethanol, N-Methyl pyrrolidone, xylol or the cyclohexanone any one or multiple.

10. the application of any described insecticide of claim 1～9 on control fleahopper silk worm or cotton bollworm insect.