CN101357181B - Medicine for treating diabetes containing Radix Bupleurum and preparation method thereof - Google Patents
Medicine for treating diabetes containing Radix Bupleurum and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine containing bupleurum root and used for treating diabetes and a preparation method thereof. The medicine is made by the following method: (1) medicinal materials are selected, and the medicinal materials comprise the following crude drugs by weight portions: 5-40 portions of trichosanthes root, 10-30 portions of bupleurum root, 3-15 portions of fruit of immature bitter orange, 1-6 portions of Chinese rhubarb, 1-12 portions of pinellia tuber, 3-15 portions of baikal skullcap root, 1-12 portions of Chinese goldthread, 3-15 portions of white peony root and 5-20 portions of dark plum; (2) refluxing extraction is carried out on the Bupleurum root, the white peony root, the fruit of immature bitter orange, the Chinese rhubarb, the baikal skullcap root and Chinese goldthread by ethanol with a certain concentration to obtain extracting solutions, and then the obtained extracting solutions are cooled, filtered and mixed to obtain a filtrate; (3) dregs obtained from the refluxing extraction are added with other medicinal materials and water for refluxing extraction to obtain an extracting solution, the extracting solution is condensed by decompression to obtain a concentrated solution, the concentrated solution is added with the ethanol until the ethanol content reaches 65-75% to obtain a mixture, and the mixture is filtered to obtain a filtrate; (4) the filtrates obtained from (2) and (3) are mixed and condensed into an extractum. The medicinal materials of the medicine can be further added with hawthorn fruit.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of medicine for the treatment of diabetes and preparation method thereof.
Background technology
Diabetes are the lifelong diseases of a kind of chronic progressive external that caused by sugar, protein and fat metabolic disturbance in the body, and its characteristic shows as hyperglycemia and glycosuria.This disease will cause heart and renal complication, blind and amputation.From observing clinically, the sickness rate of diabetes is being ascendant trend year by year in recent years.At present, the whole world has 1.5 hundred million diabeticss approximately, and the present diabetes number of China surpasses 4,000 ten thousand.In diabetes cases, minority is insulin dependent diabetes mellitus (IDDM) (an I type), and great majority are non-insulin-dependent diabetes mellitus (II type).Most diabetics need be taken medicine all the life.
Treating diabetes is still based on chemical synthetic drug, as sulfonamides, biguanides, glucosidase inhibitor, Lie Nai and euglycemic agent etc. at present.But it is all bigger that these medicines are taken side effect for a long time.
Chinese medicine has long history aspect the diabetes preventing and treating, and the practice through several thousand has accumulated a large amount of invaluable experiences, has formed the unique academic system.The Chinese medicine ancient books and records have been put down in writing the Chinese medicine that much has the blood sugar lowering curative effect, as Rhizoma Alismatis, the Rhizoma Anemarrhenae, Radix Panacis Quinquefolii, Radix Puerariae, Radix Rehmanniae, pollen etc.Traditional TCM treatment of diabetes is to carry out the three types of diabetes opinion according to clinical symptoms to control.But there is not good treatment way in early days at impaired glucose tolerance phase and onset diabetes.
The clearing stomach of Therapeutic Method dissipating depression of QI, nourishing YIN to lower pathogenic fire, purging FU-organs rushes down turbid.
The inventor is a theoretical foundation with the traditional Chinese medical science " hot and suffocating " theory, discovers that the compositions of being made up of medical materials such as Radix Trichosanthis, Radix Bupleuri, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, the Rhizoma Pinelliae, Radix Scutellariae, Rhizoma Coptidis, the Radix Paeoniae Alba, Fructus Mumes has good therapeutical effect to diabetes.But the extract by traditional pure extracting method obtains has lost a large amount of aqueous soluble active constituents; Not only yield is low, and content of effective is very little, so dosage is very big, corresponding side effect also can increase.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of diabetes, adopt following method to be prepared from:
(1) material of getting it filled, described medical material contains the raw medicinal herbs of following weight portion: Radix Trichosanthis 5-40 part, Radix Bupleuri 10-30 part, Fructus Aurantii Immaturus 3-15 part, Radix Et Rhizoma Rhei 1-6 part, Rhizoma Pinelliae 1-12 part, Radix Scutellariae 3-15 part, Rhizoma Coptidis 1-12 part, Radix Paeoniae Alba 3-15 part, Fructus Mume 5-20 part;
(2) wherein Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis are used certain density alcohol reflux, extracting solution cools, filters, merges;
(3) add other medical materials in the medicinal residues, add the water reflux, extract,, the extracting solution concentrating under reduced pressure, it is 65-75% to containing pure weight that concentrated solution adds ethanol, filters;
(4) (2) and (3) gained filtrate is merged, be condensed into extractum.
In the step (2), concentration of alcohol is preferably 75-90%, and more preferably 80%; Preferred reflux, extract, twice, each 10 times of medical material weight were extracted 1.5 hours at every turn.
In the step (3), preferred reflux, extract, twice, each 10 times of medical material weight were extracted 1.5 hours at every turn.The ratio that preferred extracting solution is concentrated into the volume of initial medical material weight and concentrated solution is 1:1.The concentration of alcohol that adds is preferably 90-100%, and more preferably 95%.Contain pure weight and be preferably 70%.
Described medicine, the weight ratio of each raw medicinal herbs is preferably: 9 parts of Radix Trichosanthis, 12 parts of Radix Bupleuri, 9 parts of Fructus Aurantii Immaturuss, 3 parts of Radix Et Rhizoma Rhei, 6 parts of the Rhizoma Pinelliaes, 9 parts of Radix Scutellariaes, 6 parts of Rhizoma Coptidis, 9 parts of the Radix Paeoniae Albas, 9 parts of Fructus Mumes.
Better, the present invention can also add Fructus Crataegi on the basis of described medicine, and this is because the Fructus Crataegi sour and sweet drugs can transforme into YIN, both can be in case the hot too impairment of YIN of loosing, but picric acid system is sweet again.The heat clearing away of compatibility dissipating depression of QI has better curative effect.The weight portion of each raw medicinal herbs is: Radix Trichosanthis 5-40 part, Radix Bupleuri 10-30 part, Fructus Aurantii Immaturus 3-15 part, Radix Et Rhizoma Rhei 1-6 part, Rhizoma Pinelliae 1-12 part, Radix Scutellariae 3-15 part, Rhizoma Coptidis 1-12 part, Radix Paeoniae Alba 3-15 part, Fructus Mume 5-20 part, Fructus Crataegi 3-15 part.
Be preferably: Radix Trichosanthis 10-30 part, Radix Bupleuri 10-30 part, Fructus Aurantii Immaturus 3-15 part, Radix Et Rhizoma Rhei 1-6 part, Rhizoma Pinelliae 1-12 part, Radix Scutellariae 3-15 part, Rhizoma Coptidis 1-12 part, Radix Paeoniae Alba 3-15 part, Fructus Mume 5-20 part, Fructus Crataegi 3-15 part.
More preferably: 30 parts of Radix Trichosanthis, 12 parts of Radix Bupleuri, 9 parts of Fructus Aurantii Immaturuss, 3 parts of Radix Et Rhizoma Rhei, 6 parts of the Rhizoma Pinelliaes, 9 parts of Radix Scutellariaes, 6 parts of Rhizoma Coptidis, 9 parts of the Radix Paeoniae Albas, 15 parts of Fructus Mumes, 9 parts of Fructus Crataegis; Perhaps 15 parts of Radix Trichosanthis, 12 parts of Radix Bupleuri, 9 parts of Fructus Aurantii Immaturuss, 3 parts of Radix Et Rhizoma Rhei, 6 parts of the Rhizoma Pinelliaes, 9 parts of Radix Scutellariaes, 6 parts of Rhizoma Coptidis, 9 parts of the Radix Paeoniae Albas, 15 parts of Fructus Mumes, 9 parts of Fructus Crataegis.
Preparation method of the present invention, the alcohol extraction of raw medicinal herbs such as Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis elder generation, residue merges water with other medical materials again to be carried, and has guaranteed that this Six-element medical material effective ingredient is fully extracted; The effective ingredient of other medical materials during only water is carried, this is because effective ingredient wherein all is a water solublity.Content of effective obviously improves in the Chinese medicine composition of the present invention, and the content of impurity significantly reduces, thereby has reduced the dosage of administration.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the preparation of any routine.For example the above-mentioned raw materials medicine is ground into powder and takes after mixing it with water, or make tablet or capsule oral, perhaps make injection etc.But these can not be used to limit protection scope of the present invention.
The specific embodiment
Further specify medicine of the present invention and beneficial effect thereof below by embodiment and test example, but not as limitation of the present invention.
Embodiment 1
Radix Trichosanthis 750g, Radix Bupleuri 1500g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 150g, Rhizoma Pinelliae 150g, Radix Scutellariae 450g, Rhizoma Coptidis 150g, Radix Paeoniae Alba 450g, Fructus Mume 750g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 75% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add 90% ethanol to containing alcohol amount 65%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 2
Radix Trichosanthis 1200g, Radix Bupleuri 900g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 180g, Rhizoma Pinelliae 360g, Radix Scutellariae 450g, Rhizoma Coptidis 360g, Radix Paeoniae Alba 450g, Fructus Mume 600g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 90% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add dehydrated alcohol to containing alcohol amount 75%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 3
Radix Trichosanthis 630g Radix Bupleuri 840g Fructus Aurantii Immaturus 630g Radix Et Rhizoma Rhei 210g Rhizoma Pinelliae 420g Radix Scutellariae 630g Rhizoma Coptidis 420g Radix Paeoniae Alba 630g Fructus Mume 630g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 80% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add 95% ethanol to containing alcohol amount 70%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 4
Radix Trichosanthis 750g, Radix Bupleuri 1500g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 150g, Rhizoma Pinelliae 150g, Radix Scutellariae 450g, Rhizoma Coptidis 150g, Radix Paeoniae Alba 450g, Fructus Mume 750g, Fructus Crataegi 450g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 75% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, Fructus Crataegi, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add 90% alcohol to containing alcohol amount 65%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 5
Radix Trichosanthis 1200g, Radix Bupleuri 900g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 180g, Rhizoma Pinelliae 360g, Radix Scutellariae 450g, Rhizoma Coptidis 360g, Radix Paeoniae Alba 450g, Fructus Mume 600g, Fructus Crataegi 450g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 90% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, Fructus Crataegi, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add dehydrated alcohol to containing alcohol amount 75%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 6
Radix Trichosanthis 833g Radix Bupleuri 667g Fructus Aurantii Immaturus 500g Radix Et Rhizoma Rhei 167g Rhizoma Pinelliae 333g Radix Scutellariae 500g Rhizoma Coptidis 333g Radix Paeoniae Alba 500g Fructus Mume 833g Fructus Crataegi 500g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 80% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, Fructus Crataegi, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add 95% ethanol to containing alcohol amount 70%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 7
Radix Trichosanthis 500g, Radix Bupleuri 750g, Fructus Aurantii Immaturus 500g, Radix Et Rhizoma Rhei 250g, Rhizoma Pinelliae 500g part, Radix Scutellariae 500g, Rhizoma Coptidis 500g, Radix Paeoniae Alba 500g, Fructus Mume 500g, Fructus Crataegi 500g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 80% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, Fructus Crataegi, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add 95% ethanol to containing alcohol amount 70%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 8
Radix Trichosanthis 1200g, Radix Bupleuri 800g, Fructus Aurantii Immaturus 600g, Radix Et Rhizoma Rhei 200g, Rhizoma Pinelliae 400g, Radix Scutellariae 400g, Rhizoma Coptidis 200g, Radix Paeoniae Alba 400g, Fructus Mume 400g, Fructus Crataegi 400g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 85% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, Fructus Crataegi, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add 90% ethanol to containing alcohol amount 68%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Embodiment 9
Radix Trichosanthis 1000g, Radix Bupleuri 600g, Fructus Aurantii Immaturus 600g, Radix Et Rhizoma Rhei 250g, Rhizoma Pinelliae 300g, Radix Scutellariae 500g, Rhizoma Coptidis 300g, Radix Paeoniae Alba 500g, Fructus Mume 500g, Fructus Crataegi 300g
Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis were measured 90% alcohol reflux 2 times each 1.5 hours with 10 times, and extracting solution filters, and is standby; Medicinal residues add Radix Trichosanthis, Fructus Mume, the Rhizoma Pinelliae, Fructus Crataegi, and with 10 times of water gaging reflux, extract, 2 times each 1.5 hours, extracting solution was evaporated to 1:1, add 99% ethanol to containing alcohol amount 74%, and filtration is standby; Two extracting solution are mixed, and concentrating under reduced pressure becomes thick paste.
Test example 1
1) laboratory animal:
SPF level male SD rat, body weight 200-220g.
2) main agents and medicine:
Streptozotocin (Streptozotocin, STZ): U.S. sigma company, lot number 024K1211;
Steady milli type blood glucose meter (One-Touch Ultra): U.S. Lifescan company, number of registration 20032400735;
Anhydrous citric acid (C
6H
8O
7.H
2O): Tianjin chemical reagent one factory, lot number 011121;
Sodium citrate (Na
3C
6H
5O
7.2H
2O): Tianjin chemical reagent one factory, lot number 011219;
Metformin: the 250mg/ sheet, Tianjin Pacific Pharmaceutical Co., Ltd. produces, lot number 040121;
The difference prescription group medicine of test example is respectively the extract powder according to embodiment 3, embodiment 8 and embodiment 9 preparations, and numbering is respectively TL-1, TL-2 and TL-3.
3) model preparation:
The SD rat adapts to the back fasting overnight of 1 week, and through lumbar injection STZ65mg/Kg (0.1mmol/l, PH4.4 citrate buffer solution are made the solution of 2% (W/V)), the tail vein is got blood to survey blood glucose 〉=16.7mmol/L be the modeling success after 3 days.
4) medication and observation index:
The diabetes rat of Cheng Mo is divided into model group, metformin 125mg/Kg group and different prescription groups (crude drug 15.5g/Kg) at random.Adapt to a week, detect gastric infusion behind the blood glucose, once a day, medicine all is mixed with the suspension administration with normal saline, the experimental session drinking-water of all freely ingesting, 15 days experimental periods.Administration the 7th, 14 days, fasting was 2 hours after the administration, and the tail vein is got blood one-touchultra blood glucose meter and measured blood glucose, detected the body weight of rat simultaneously.
5) statistical procedures:
(X ± SD) expression, two group difference significances adopt the t check to experimental data with mean ± standard deviation.
6) result
By table 1 as seen, different prescription groups are when 15.5g/Kg dosage, and administration all made the blood glucose of STZ hyperglycemic rat obviously descend (P＜0.01) after 7,14 days.
Table 1. is respectively organized changes of blood glucose and comparison (X ± SDn=10)
Annotate: compare with matched group
*P＜0.01; Compare with model group
▲P＜0.01
Claims (4)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100585725A CN101357181B (en) | 2007-08-02 | 2007-08-02 | Medicine for treating diabetes containing Radix Bupleurum and preparation method thereof |
| PCT/CN2008/001383 WO2009015557A1 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| MYPI20094878A MY154567A (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| KR1020107003490A KR101462984B1 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| DK08783574.0T DK2172207T3 (en) | 2007-08-02 | 2008-07-28 | Pharmaceutical composition for the treatment of diabetes and its method of preparation |
| JP2010518477A JP5508264B2 (en) | 2007-08-02 | 2008-07-28 | PHARMACEUTICAL COMPOSITION FOR DIABETES TREATMENT AND METHOD FOR PRODUCING THE SAME |
| HK10104520.9A HK1138206B (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| BRPI0812792A BRPI0812792B8 (en) | 2007-08-02 | 2008-07-28 | method for preparing a pharmaceutical composition for the treatment of diabetes mellitus and said pharmaceutical composition |
| NZ581525A NZ581525A (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| EP08783574A EP2172207B1 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| AU2008281227A AU2008281227B2 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| CA2687492A CA2687492C (en) | 2007-08-02 | 2008-07-28 | A herbal composition, method for preparing the same and use thereof for treating diabetes mellitus |
| RU2009144878/15A RU2485968C2 (en) | 2007-08-02 | 2008-07-28 | Drug preparation for treating diabetes and method for preparing it |
| US12/601,236 US8637092B2 (en) | 2007-08-02 | 2008-07-28 | Pharmaceutical composition for treating diabetes and its process for preparation |
| ARP080103309A AR070306A1 (en) | 2007-08-02 | 2008-07-30 | A PHARMACEUTICAL COMPOSITION TO TREAT MELLITUS DIABETES AND THE METHOD TO PREPARE THE SAME |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100585725A CN101357181B (en) | 2007-08-02 | 2007-08-02 | Medicine for treating diabetes containing Radix Bupleurum and preparation method thereof |
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| CN101357181A CN101357181A (en) | 2009-02-04 |
| CN101357181B true CN101357181B (en) | 2011-09-21 |
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| CN105943860A (en) * | 2016-06-21 | 2016-09-21 | 青岛辰达生物科技有限公司 | Medicine preparation for treating diabetes mellitus and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376495A (en) * | 2002-01-31 | 2002-10-30 | 刘惠生 | Chinese medicine for treating diabetes and its complication |
| CN1726929A (en) * | 2004-07-30 | 2006-02-01 | 天津天士力制药股份有限公司 | Compsn. of medication for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376495A (en) * | 2002-01-31 | 2002-10-30 | 刘惠生 | Chinese medicine for treating diabetes and its complication |
| CN1726929A (en) * | 2004-07-30 | 2006-02-01 | 天津天士力制药股份有限公司 | Compsn. of medication for treating diabetes |
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Effective date of registration: 20220607 Address after: 101-1032, F1, building 3, No. 103, Beiqing Road, Haidian District, Beijing 100081 Patentee after: Beijing zhongyitang Technology Co.,Ltd. Address before: 300410 Tianjin Beichen District Huaihe road and Ting Jiang West Road intersection heaven proud of the park Legal Center Intellectual Property Department Patentee before: TASLY PHARMACEUTICAL GROUP Co.,Ltd. |
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Granted publication date: 20110921 |