CN101336077B - Use of 25-hydroxy vitamin D3 to improve vitality of animals - Google Patents
Use of 25-hydroxy vitamin D3 to improve vitality of animals Download PDFInfo
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Abstract
The present invention relates to the use of 25-hydroxy-vitamin D3 to improve the general health status of female animals at least during gestation and/or lactation. The invention also relates to the use of 25-hydroxy-vitamin D3 in animal breeding. More particular, the invention relates to the use of 25-hydroxy-vitamin D3 for improving litter size and vitality of piglets in pig breeding and for providing better body frame and increasing gestation backfat gain, reducing lactation backfat loss and increasing lactation feed intake of sows and gilts.
Description
The present invention relates to 25-hydroxyl-vitamin D
3Be used for improving the purposes of general health status of the jenny of the gestational period and/or lactation.
The invention still further relates to 25-hydroxyl-vitamin D
3Purposes in the animal reproduction process.More specifically, the present invention relates to 25-hydroxyl-vitamin D
3Be used for to improve in the purposes of the litter size of pig reproductive process and porkling vitality and be used for providing sow and better physique, the raising gestational period back fat recruitment of the sow that do not produce, the purposes of lactation backfat loss reduction and increase feed intake lactation of reducing.
The main purpose of feeding mother pig is, every sow every year is with the wean pig of the maximum quantity of least cost production.Any small improvement of sow productivity all can cause significant positive impact to the reproductive performance of whole reproducting herd and can cause significant positive impact to total benefit factor on pig farm.For example, in childbirth-feeding plant (farrow-to-finish operation) of 1000 sows, 0.2 wean pig that every sow only increases every year is converted into extra 200 commercial pigs.
Between each countries and regions, there is very big-difference in the productivity of the sow in the pig reproducting herd, and this point has fully been accepted.The productivity of reproducting herd from low to high, every nest life birth pig is in 7 to 13 scope, every nest wean pig is in 5 12 scope.Therefore, the productivity of improving sow has suitable potentiality.
In pregnant process, breeding potential obviously is subjected to the influence of the alterable height loss of potential porkling.15% to 20% fetus loses between the 30th day of gestation was to 50 days, and other 5 to 10% loss occurrence was at the 90th day to 114 days.The loss at gestation initial stage can be facilitated by each factor of influence implantation implantation (interaction between embryo and the uterus), and those losses of latter half of gestation are subject to the available uterine space of every porkling, and this more may become a restrictive factor in younger sow.
Litter size is the important parameter of every sow of influence annual life birth porkling number and wean porkling number.Progress from the heredity, the novel sow management method of not producing and modern production control technology are for increasing the method for litter size and reproducting herd productivity in the practice.From the viewpoint of breeding physiologic, the rational method that produces the porkling number for increasing every nest must and can be kept pregnancy and with the growth by cornua uteri length in pregnant process the uterus capacity be increased and adapt with the implantation implantation of success.In addition, the sow that every nest is produced more porkling must have good milk in the lactation process, thereby can raise extra porkling and can support them and nutritionally grow up healthy and sound, thereby the quantity that can realize every nest wean porkling increases.
According to the present invention, have been found that and bestow jenny (for example sow and the sow that do not produce) 25-hydroxyl-vitamin D
3Can improve the quantity of every nest life birth porkling and the quantity of every nest wean porkling, thereby improve the vitality of the porkling that the sow that do not produced by the pregnancy of raising like this and sow produce.Under the situation that litter size improves, the increase by life birth porkling number and wean porkling number reflects the vitality of porkling.On the other hand, use 25-hydroxyl-vitamin D
3The survival rate of the more healthy porkling that make to produce is higher than by without feeding 25-hydroxyl-vitamin D
3The survival rate of the porkling that produces of sow, this by lactation the porkling death rate reduction show.Also find, with 25-hydroxyl-vitamin D
3Bestowing respectively to sow and the sow that do not produce can provide sow and better physique, the raising gestational period back fat recruitment of the sow that do not produce, reduce the lactation backfat loss reduction and increase feed intake lactation.
Therefore, on the one hand, the present invention relates to 25-hydroxyl-vitamin D
3The purposes that is used for the litter size of raising animal reproduction (for example pig breeding).On the other hand, the present invention relates to 25-hydroxyl-vitamin D
325-hydroxyl-vitamin D by the sow effective dose bestowing sow and do not produce
3Improve the purposes of young animal (for example porkling) vitality.
On the other hand, the present invention relates to 25-hydroxyl-vitamin D
3Be used for improving the purposes of general health status of the jenny of gestational period at least and/or lactation, this means the better physique that jenny is provided, and/or improve gestational period back fat recruitment, and/or reduce the lactation backfat loss reduction and/or increase feed intake lactation.
On the other hand, the present invention relates to improve litter size in the animal reproduction process and the method for young animal (for example porkling) vitality, described method comprises, bestows sow and the 25-hydroxyl-vitamin D of the sow effective dose of not producing
3
On the other hand, the present invention relates to provide female prime of life animal (for example sow and the sow that do not produce) better physique, raising gestational period back fat recruitment, reduce the lactation backfat loss reduction and increase the method for feed intake lactation, described method comprises the 25-hydroxyl-vitamin D of the sow effective dose of bestowing sow and not producing
3
In the context of the present invention, animal comprises mammal, and its example comprises the mankind.Except the mankind, mammiferous preferred example is ruminant and non-ruminant animal, for example tame ox, the pet animals as dog and cat, horse, camel, sheep, goat and pig.
Used term " sow " comprising herein: the sow that did not produce, namely want pregnancy and be not fertilized by boar or with the sow of boar mating; And the sow (being also referred to as first farrowing sow) and the multiparity sow (namely having produced the sow of a brood of above porkling) that have produced a tire porkling.
Term " better physique " expression, as according to " Guidelines for Uniform SwineImprovement Programs " (National Swine Improvement Federation, NSIF, 1996), assessment (the PorkIndustry Handbook of " the hoof leg health of sow (Feed and Leg Soundness in Swine) ", PIH 101) and the assessment of hoof point and hoof by after the performance test and assessment weighed for assessment of the points-scoring system of hoof leg structure, satisfy the quantity increase of the sow that did not produce of physical qualification standard.
Term " food " refers to food or the feed of any mankind of being suitable for or animal edible herein.Food can be through the human food of preparation and packing or food supplement or animal feed (animal feed that for example, extrude or granulating, thick mixed feed or pet food composition).Term " food " comprises food and liquid food, and drinkable liquid (such as drinking water).
In order to be used for humanly consuming improving gestation and/or mother's general health status between lactation, food supplement of the present invention can give with the form of unit dosage forms (for example tablet, capsule, quantitatively powder or quantitative liquid part, described liquid part if desired can by filling CO 2).
And food supplement of the present invention can also comprise on conventional inertia, the physiology can accept supporting agent, flavor enhancement, colouring agent and calcium.For example, tablet can adopt consumption to satisfy 25-hydroxyl-vitamin D
3Daily dose be the 25-hydroxyl-vitamin D of 5 to 15mcg every kg body weight
3Replenish, wherein, conventional daily dose is 1 or 2.
Followingly according to animal reproduction the present invention is explained in more detail.
In order to realize purpose of the present invention, 25-hydroxyl-vitamin D
3Be suitable for adding in the food with the form of replenishers.Food can come to replenish in the following way, with 25-hydroxyl-vitamin D
3(for example with trade mark ROVIMIX Hy-D
The 1.25% commercial preparation that obtains) is mixed in the conventional food, perhaps at first prepares food component and 25-hydroxyl-vitamin D
3Pre-composition, subsequently pre-composition is mixed with other food component.Food can be any conventional pig food.Term used herein " food " comprises food and liquid food, and drinkable liquid (such as drinking water).Particularly, 25-hydroxyl-vitamin D
3Can be added in the pre-composition that contains other mineral matter, vitamin, amino acid and trace element with the preparation form of powder, wherein this pre-composition is added in the conventional animal food, and fully stirs, thereby is evenly distributed in the animal food.
In order to realize purpose of the present invention, at least one stage of cyclostage (gestational period and lactation), bestow 25-hydroxyl-vitamin D
3, also can in the growth course (namely being selected in the growth course that substitutes the sow of disallowable sow in the reproducting herd) of the pig that reserve was not produced, suitably bestow.
Generally speaking, 25-hydroxyl-vitamin D
3Add in the sow food with institute's expense, thereby bestow about 0.1mcg to about 3.0mcg, especially about 0.5mcg is to 25-hydroxyl-vitamin D of about 2.0mcg
3The body weight every day of the single animal of every kg.
More specifically, in the manufacture process according to sow/sow food of not producing of the present invention, be suitable for the 25-hydroxyl-vitamin D to about 100mcg/kg with about 10mcg/kg
3Add in the conventional pig food.Perhaps, can be that the basis prepares the food pre-composition as follows with the conventional food component: with higher concentration active component is added in the above-mentioned food component, for example with about 10mg/kg to about 100mg/kg 25-hydroxyl-vitamin D
3Concentration.If add the above-mentioned pre-composition of 1kg in every 1000kg conventional food, just can satisfy the individual need of animal by consuming conventional food so usually.
The sow that did not produce according to individuality and the pregnancy period sow needs, be suitable for about 0.125mcg to about 1.25mcg, especially with about 0.625mcg extremely the consumption of the every kg body weight of about 1.000mcg every day bestow 25-hydroxyl-vitamin D
3Thereby, realize purpose of the present invention.Therefore, 25-hydroxyl-vitamin D
3The consumption that is suitable for satisfying above-mentioned dosage requirement adds in the food.Usually, can comprise about 10mcg in the sow that did not produce and the pregnancy period sow food to about 100mcg, especially about 50mcg is to 25-hydroxyl-vitamin D of about 80mcg
3Every kg food.
And, according to the needs of single milking sow, be suitable for about 0.250mcg to about 2.50mcg, especially with about 1.250mcg extremely the consumption of the every kg body weight of about 2.000mcg every day bestow 25-hydroxyl-vitamin D
3Thereby, realize purpose of the present invention.Therefore, 25-hydroxyl-vitamin D
3The consumption that is suitable for satisfying above-mentioned dosage requirement adds in the food.Usually, can comprise about 10mcg in the sow in lactation food to about 100mcg, especially about 50mcg is to 25-hydroxyl-vitamin D of about 80mcg
3Every kg food.
The sow that can adopt the average of 200kg body weight and 2.5kg food every day to calculate not produce and the pregnancy period sow body weight and feed intake.Can adopt the average of 200kg body weight and 5kg food every day to calculate body weight and the feed intake of sow in lactation.
Test the present invention as can be seen to the effect of the sow that do not produce by following two.
Experiment 1
In commercial pig farm, select 27 sows (Landrace * white) that June, big reserve was not produced altogether.There are two kinds of meals treatment in different phase (puberty of replacement gilt, the gestational period, lactation) in the cyclostage.Control diet is the standard pig feed, does not replenish 25-hydroxyl-vitamin D
3Experimental diet is to have replenished 50mcg 25-hydroxyl-vitamin D in every kg meals
3The standard pig feed.
Select ten four (14) sows that only do not produce to organize in contrast at random, other 13 sows that do not produce are as ROVIMIX
HyD
1.25% group.When the sow that did not produce 7 months is big, begin to feed.Sow after feeding is placed pregnant hurdle (gestating stall), and make it remain in wherein up to the expected date of childbirth preceding 14 days.Then, sow is weighed and be transferred to and produce in the hurdle.Porkling wean in 28 days.
Experiment 2
In another commercial pig farm, select 43 sows (Landrace * white) that June, big replacement was not produced altogether.There are two kinds of meals treatment in different phase (puberty of replacement gilt, the gestational period, lactation) in the cyclostage.Control diet is the standard pig feed, does not replenish 25-hydroxyl-vitamin D
3Experimental diet is to have replenished 50mcg 25-hydroxyl-vitamin D in every kg meals
3The standard pig feed.
Select 22 (22) sows that only do not produce to organize in contrast at random, other 21 sows that do not produce are bestowed ROVIMIX
HyD
1.25% as experimental group.When the sow that did not produce 7 months is big, begin to feed.Sow after feeding is placed pregnant hurdle, and make it remain in wherein up to the expected date of childbirth preceding 14 days.Then, sow is weighed and be transferred to and produce in the hurdle.Porkling wean in 28 days.
Following data are collected in the product hurdle in experiment 1 and 2
1. every nest birth number
A. Chu Sheng sum
B. life birth porkling
C. stillborn foetus porkling
D. shrivelled pig tire
2. porkling weight when being born
3. the porkling number when every nest weans
4. the death rate
5. porkling weight when weaning
Table 1 (experiment 1) shows, feeds 25-hydroxyl-vitamin D
3The reproductive performance of sow of product first tire than quantitative nursing but replenish 25-hydroxyl-vitamin D
3The sow that did not produce of (control group), (birth porkling sum (10.46vs.9.00 with regard to every nest birth porkling number; + 1.46) and live hog son (9.77vs.7.93; + 1.84) both) want high.For 25-hydroxyl-vitamin D
3Processed group, the porkling number the during wean of every nest also is higher than control group (9.46vs.7.64; + 1.82).Yet control group has heavier birth weight (1.64vs.1.45kg).Weanling weight does not have difference to each other.Yet, by feeding 25-hydroxyl-vitamin D
3Porkling weightening finish 5.5kg when wean in 28 days of producing of the sow that did not produce, and the porkling that is produced by the sow that did not produce of control group weightening finish 5.33kg when wean in 28 days.
Table 1. is fed 25-hydroxyl-vitamin D
3The reproductive performance (experiment 1) of sow of product first tire
Every nest porkling sum during the LSBT=birth; The every nest life birth of LSBA=porkling number; Porkling body weight during the BWT=birth; Every nest wean porkling number during wean in LSW=28 days; Body weight during wean in WWT=28 days
Table 2. is fed 25-hydroxyl-vitamin D
3The reproductive performance (experiment 2) of sow of product first tire
Every nest porkling sum during the LSBT=birth; The every nest life birth of LSBA=porkling number; Porkling body weight during the BWT=birth; Every nest wean porkling number during wean in LSW=28 days; Body weight during wean in WWT=28 days
Table 2 (experiment 2) shows, feeds 25-hydroxyl-vitamin D
3The reproductive performance of sow of product first tire than quantitatively feeding but replenish 25-hydroxyl-vitamin D
3Every nest life birth porkling number of the sow that did not produce of (control group) is wanted high (9.62vs.9.18; + 0.44).For 25-hydroxyl-vitamin D
3Processed group, the every nest porkling number during wean also is higher than control group (8.48vs.7.82; + 0.66).
Further set forth the present invention by following examples.
Embodiment 1
To be adopted the 25-hydroxyl-vitamin D of every kg feed 50 to 80mcg by the feed that each component shown in the table 3 is formed
3Replenish.
Table 3
| Composition | The sow meals kg/1000kg that reserve was not produced | Pregnancy period sow meals kg/1000kg | Sow in lactation meals kg/1000kg |
| Yellow maize | 398.12 | 432.17 | 404.47 |
| Dregs of beans (Argentina) | 110.00 | 108.10 | 151.20 |
| Rough cupu oil | 0.00 | 0.00 | 10.20 |
| Rice bran | 250.00 | 250.00 | 220.00 |
| Copra meal | 150.00 | 150.00 | 150.00 |
| Molasses | 50.00 | 14.00 | 20.00 |
| Calcium monohydrogen phosphate | 16.50 | 21.50 | 21.50 |
| Lime stone | 15.20 | 13.80 | 13.20 |
| L-lysine | 2.10 | 2.00 | 2.20 |
| Choline chloride | 1.00 | 1.00 | 1.00 |
| Toxin binders | 1.00 | 1.00 | 1.00 |
| The trace mineral pre-composition *) | 0.80 | 1.00 | 1.00 |
| Salt | 5.00 | 5.00 | 5.00 |
| Vitamin premix *) | 0.15 | 0.30 | 0.30 |
| Antioxidant | 0.13 | 0.13 | 0.13 |
| **) composition of vitamin premix | The IU of vitamin premix or mg/kg |
| Vitamin A | 50’000’000 |
| Vitamin D 3 | 9’000’000 |
| Vitamin E | 200’000 |
| Prokeyvit | 9’000 |
| Vitamin B1 | 9’000 |
| Vitamin B2 | 22’000 |
| Vitamin B6 | 14’000 |
| Cobalamin | 100 |
| Nicotinic acid | 150’000 |
| Pantothenic acid | 70’000 |
| Biotin | 1’000 |
| Folic acid | 10’000 |
| **) composition of trace mineral pre-composition | The mg/kg of trace mineral pre-composition |
| Iron | 125’000 |
| Copper | 7’500 |
| Manganese | 25’000 |
| Zinc | 125’000 |
| Cobalt | 500 |
| Iodine | 175 |
| Selenium | 300 |
Adopt 25-hydroxyl-vitamin D by the following method
3Above-mentioned feed is replenished: with 50 to 80mg 25-hydroxyl-vitamin Ds
3(4 to 6.4g by DSM Nutritional Products, the ROVIMIX that Kaiseraugst, Switzerland provide
Hy D
1.25%) mixes with remaining every feed.Can make gained feed mud granulating if desired.
Embodiment 2
Prepare feed shown in embodiment 1, difference is, adds about 50 to 80mg 25-hydroxyl-vitamin Ds in every kg vitamin and the mineral pre-mix
3
Embodiment 3
Contain 25-hydroxyl-vitamin D following can the preparation
3The sow that did not produce or sow feed feed pre-composition:
Above-mentioned all components is carefully mixed, add this pre-composition of 0.5% (5kg/1000kg feed) to conventional sow then or the sow feed do not produced in.
Perhaps, also can add 25-hydroxyl-vitamin D with the form of 1% dilution pre-composition (containing suitable supporting agent)
3Above-mentioned supporting agent can be independent wheat flour, inferior powder, maize cob, rice husk, apricot shell or calcium carbonate, or is several the various mixtures in these supporting agents.Representative formula is:
Composition [%]
Rice husk 64.20
Calcium carbonate 35.00
ROVIMIX
Hy-D
1.25％ 0.80
Above-mentioned all components is carefully mixed, add this pre-composition of 0.05% (0.5kg/1000kg feed) to conventional sow then or the sow feed do not produced in, thereby obtain 50mcg 25-hydroxyl-vitamin D
3Every kg feed.
Claims (5)
1.25-hydroxyl-vitamin D
3Purposes in the feed of the jenny of making pregnancy period and/or lactation, wherein said 25-hydroxyl-vitamin D
3Improve litter size and porkling vitality, and in sow, described 25-hydroxyl-vitamin D
3Better physique is provided, reduces the lactation backfat loss reduction or increases feed intake lactation, wherein, 25-hydroxyl-vitamin D
3Form with feed additive is bestowed sow, and wherein, 25-hydroxyl-vitamin D
3Add in the described feed with institute's expense, thereby bestow 25-hydroxyl-vitamin D of 0.1mcg to 3.0mcg
3The body weight every day of every kg individual animals.
2.25-hydroxyl-vitamin D
3Purposes in the feed of the jenny of making pregnancy period and/or lactation, wherein, 25-hydroxyl-vitamin D
3Improve litter size and porkling vitality, and in sow, described 25-hydroxyl-vitamin D
3Better physique is provided, reduces the lactation backfat loss reduction or increases feed intake lactation, wherein, 25-hydroxyl-vitamin D
3Form with feed additive is bestowed sow, and wherein, 25-hydroxyl-vitamin D
3Consumption with the every kg feed of 10mcg to 100mcg adds in the described feed.
3. purposes as claimed in claim 1, wherein, described sow is sow in lactation.
4. one kind was improved litter size and porkling vitality and better physique is provided in sow, reduces the lactation backfat loss reduction or increases the method for feed intake lactation in pregnancy period and/or lactation, and described method comprises 25-hydroxyl-vitamin D of bestowing the sow effective dose
3, wherein bestow 25-hydroxyl-vitamin D with the consumption of the every kg body weight of 0.1mcg to 3.0mcg every day
3
5. one kind was improved litter size and porkling vitality and better physique is provided in sow, reduces the lactation backfat loss reduction or increases the method for feed intake lactation in pregnancy period and/or lactation, and described method comprises 25-hydroxyl-vitamin D of bestowing the sow effective dose
3Wherein, bestow 25-hydroxyl-vitamin D with the form of feed additive
3, described feed comprises 25-hydroxyl-vitamin D that consumption is the every kg feed of 10mcg to 100mcg
3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05025723.7 | 2005-11-25 | ||
| EP05025723 | 2005-11-25 | ||
| EP06005440 | 2006-03-17 | ||
| EP06005440.0 | 2006-03-17 | ||
| PCT/EP2006/011236 WO2007059960A1 (en) | 2005-11-25 | 2006-11-23 | Use of 25-hydroxy vitamin d3 to improve vitality of animals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101336077A CN101336077A (en) | 2008-12-31 |
| CN101336077B true CN101336077B (en) | 2013-08-14 |
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|---|---|---|---|
| CN2006800518353A Active CN101336077B (en) | 2005-11-25 | 2006-11-23 | Use of 25-hydroxy vitamin D3 to improve vitality of animals |
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| ES (1) | ES2352101T3 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102640877A (en) * | 2012-05-23 | 2012-08-22 | 贵阳正邦畜牧有限公司 | Pregnant sow feed capable of reducing sand crack |
| CN104431482A (en) * | 2014-11-28 | 2015-03-25 | 新津邦得科技有限公司 | Vitamin premix feed for pregnant sows |
| CN106721422A (en) * | 2016-11-30 | 2017-05-31 | 浙江播恩生物技术有限公司 | The chicken feed of hydroxyl Methionine calcium salt and 25 hydroxycholecalciferols, mixed fodder and application |
| CN107183378A (en) * | 2017-05-19 | 2017-09-22 | 赣州八维生物科技有限公司 | Methionine hydroxy calcium and 25 hydroxy-vitamine Ds3Improving the application of pig growth performance and reproductive performance |
| CN110613051A (en) * | 2019-09-18 | 2019-12-27 | 中国农业大学 | Livestock and poultry feed additive and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
| CN1615139A (en) * | 2002-01-15 | 2005-05-11 | Dsmip资产有限公司 | 25-hydroxy vitamin D3 compositions |
-
2006
- 2006-11-23 CN CN2006800518353A patent/CN101336077B/en active Active
- 2006-11-23 ES ES06818759T patent/ES2352101T3/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
| CN1615139A (en) * | 2002-01-15 | 2005-05-11 | Dsmip资产有限公司 | 25-hydroxy vitamin D3 compositions |
Non-Patent Citations (1)
| Title |
|---|
| 李元生.维生素D的生物学功能及合理使用.《饲料与畜牧》.1990,(第5期),32-34. * |
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| CN101336077A (en) | 2008-12-31 |
| ES2352101T3 (en) | 2011-02-15 |
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