CN101129817A - Chinese medicine formulation for treating hypertension and method of producing the same - Google Patents
Chinese medicine formulation for treating hypertension and method of producing the same Download PDFInfo
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- CN101129817A CN101129817A CNA2007101523266A CN200710152326A CN101129817A CN 101129817 A CN101129817 A CN 101129817A CN A2007101523266 A CNA2007101523266 A CN A2007101523266A CN 200710152326 A CN200710152326 A CN 200710152326A CN 101129817 A CN101129817 A CN 101129817A
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating hypertension, which is prepared from ginseng, Chinese angelica root, epimeddium, wolferry fruit, root of red rooted saliva, tetrandra root, selfheal, bark of peony root, buthus martensi karsch, wild jujuba seeds and haw. The invention also provides the process for preparing the medicament.
Description
Technical field
The present invention relates to the hypertensive Chinese medicine preparation of a kind of treatment, relate in particular to a kind of Chinese medicine preparation for the treatment of essential hypertension, and preparation method thereof.
Background technology
Hypertension claims essential hypertension again, is a kind of by factor reciprocal actions such as polygenic inheritance and environment, emotions and what produce is the systemic disease of feature with the arteriotony rising.Along with its M ﹠ M increasing day by day and more and more be subjected to extensive concern worldwide.
At present, because pathogenesis and influence factor's more complicated of hypertension still can not find a kind of method or medicine to make it obtain radical cure.The medicine of treatment hypertension often can only work to small part blood pressure influence factor based on symptomatic treatment in the prior art, regulates and can not produce body comprehensively, and therapeutical effect is more unilateral.The hyperpietic reduces complication for controlling blood pressure, often needs to take medicine for a long time, and this not only brings heavy financial burden to the patient, and internal organs such as Liver and kidney are brought grievous injury, the more important thing is, even if so also can not obtain significant curative effect.
Based on above-mentioned background, the invention provides a kind of Chinese medicine preparation for the treatment of hypertension, body is regulated comprehensively, control influences the factor of blood pressure to greatest extent, can effectively control various complication when significantly bringing high blood pressure down.
Summary of the invention
The objective of the invention is to: a kind of Chinese medicine preparation for the treatment of hypertension is provided, body is regulated comprehensively, control influences the factor of blood pressure to greatest extent, can effectively control various complication when significantly bringing high blood pressure down.The objective of the invention is to be achieved through the following technical solutions:
A kind of Chinese medicine preparation for the treatment of hypertension is provided, and its raw material comprises following bulk drugs:
Radix Ginseng 6-10 part, Radix Astragali 15-30 part, Radix Rhodiolae 10-15 part, Radix Glycyrrhizae 5-10 part, Fructus Schisandrae Chinensis 10-15 part, Radix Angelicae Sinensis 20-30 part, Radix Rehmanniae Preparata 30-50 part, Radix Polygoni Multiflori 15-20 part, Herba Epimedii 5-15 part, Cortex Eucommiae 6-12 part, Cordyceps 3-6 part, Fructus Corni 10-15 part, Ootheca Mantidis 10-15 part, Fructus Lycii 10-15 part, Fructus Ligustri Lucidi 6-12 part, Tremella 10-15 part, Auricularia 15-25 part, Plumula Nelumbinis 10-15 part, Radix Salviae Miltiorrhizae 15-30 part, Rhizoma Chuanxiong 10-20 part, Hirudo 15-30 part, Eupolyphaga Seu Steleophaga 15-20 part, Radix Ilicis Pubescentis 15-30 part, Flos Carthami 5-10 part, Rhizoma Corydalis Decumbentis 6-15 part, Radix Notoginseng 6-10 part, Radix Stephaniae Tetrandrae 10-15 part Herba Siegesbeckiae 10-15 part, Folium et Ramulus Clerodendri Trichotomi 10-15 part, Agkistrodon halys 6-12 part, Poria 10-15 part, Rhizoma Alismatis 10-15 part, Gryllotalpa 10-15 part, Flos Chrysanthemi 10-15 part, Radix Puerariae 15-30 part, Radix Bupleuri 6-12 part, Spica Prunellae 15-30 part, Radix Rehmanniae 15-30 part, Radix Scrophulariae 15-20 part, Cortex Moutan 10-15 part, Radix Gentianae 10-15 part, Cortex Phellodendri 10-15 part, Radix Scutellariae 10-15 part, Radix Et Rhizoma Rhei 6-12 part, Scorpio 6-10 part, Pheretima 10-15 part, Rhizoma Gastrodiae 6-10 part, Concha Haliotidis 15-20 part, Folium Apocyni Veneti 20-30 part, Fructus Tribuli 10-15 part, Semen Ziziphi Spinosae 20-30 part, Radix Polygalae 6-10 part, Ganoderma 20-30 part, Borneolum Syntheticum 6-10 part, Rhizoma Acori Graminei 6-12 part, Fructus Crataegi (parched to brown) 30-50 part, Semen Raphani 20-30 part, Folium Camelliae sinensis 10-15 part.
Described crude drug preferably comprises following parts by weight of Chinese traditional medicine material:
6 parts of Radix Ginsengs, 20 parts of the Radixs Astragali, 15 parts of Radix Rhodiolaes, 6 parts in Radix Glycyrrhizae, 12 parts of Fructus Schisandrae Chinensis, 20 parts of Radix Angelicae Sinensis, 50 parts of Radix Rehmanniae Preparata, 15 parts of Radix Polygoni Multiflori, 12 parts of Herba Epimedii, 12 parts of the Cortexs Eucommiae, 6 parts of Cordyceps, 15 parts of Fructus Corni, 12 parts of Ootheca Mantidiss, 15 parts of Fructus Lycii, 12 parts of Fructus Ligustri Lucidi, 15 parts in Tremella, 20 parts of Auricularia, 12 parts of Plumula Nelumbiniss, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Chuanxiongs, 20 parts of Hirudos, 15 parts of Eupolyphaga Seu Steleophagas, 30 parts of Radix Ilicis Pubescentiss, 10 parts on Flos Carthami, 10 parts of Rhizoma Corydalis Decumbentiss, 6 parts of Radix Notoginseng, 15 parts of 12 parts of Herba Siegesbeckiaes of Radix Stephaniae Tetrandrae, 15 parts of Folium et Ramulus Clerodendri Trichotomis, 10 parts of Agkistrodon halyss, 15 parts in Poria, 12 parts of Rhizoma Alismatis, 10 parts of Gryllotalpas, 15 parts of Flos Chrysanthemis, 20 parts of Radix Puerariaes, 10 parts of Radix Bupleuri, 30 parts of Spica Prunellaes, 30 parts of Radix Rehmanniae, 20 parts of Radix Scrophulariaes, 12 parts of Cortex Moutans, 12 parts of Radix Gentianae, 15 parts of Cortex Phellodendris, 15 parts of Radix Scutellariaes, 10 parts of Radix Et Rhizoma Rhei, 6 parts of Scorpios, 15 parts of Pheretimas, 10 parts in Rhizoma Gastrodiae, 20 parts of Concha Haliotidis, 30 parts of Folium Apocyni Venetves, 15 parts of Fructus Tribulis, 30 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Polygalaes, 30 parts of Ganodermas, 10 parts of Borneolum Syntheticums, 10 parts of Rhizoma Acori Graminei, 30 parts of Fructus Crataegi (parched to brown)s, 30 parts of Semen Raphanis, 10 parts of Folium Camelliae sinensis.
Described crude drug further preferably comprises the Chinese crude drug of following weight:
Radix Ginseng 6g, Radix Astragali 20g, Radix Rhodiolae 15g, Radix Glycyrrhizae 6g, Fructus Schisandrae Chinensis 12g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Radix Polygoni Multiflori 15g, Herba Epimedii 12g, Cortex Eucommiae 12g, Cordyceps 6g, Fructus Corni 15g, Ootheca Mantidis 12g, Fructus Lycii 15g, Fructus Ligustri Lucidi 12g, Tremella 15g, Auricularia 20g, Plumula Nelumbinis 12g, Radix Salviae Miltiorrhizae 30g, Rhizoma Chuanxiong 15g, Hirudo 20g, Eupolyphaga Seu Steleophaga 15g, Radix Ilicis Pubescentis 30g, Flos Carthami 10g, Rhizoma Corydalis Decumbentis 10g, Radix Notoginseng 6g, Radix Stephaniae Tetrandrae 12g Herba Siegesbeckiae 15g, Folium et Ramulus Clerodendri Trichotomi 15g, Agkistrodon halys 10g, Poria 15g, Rhizoma Alismatis 12g, Gryllotalpa 10g, Flos Chrysanthemi 15g, Radix Puerariae 20g, Radix Bupleuri 10g, Spica Prunellae 30g, Radix Rehmanniae 30g, Radix Scrophulariae 20g, Cortex Moutan 12g, Radix Gentianae 12g, Cortex Phellodendri 15g, Radix Scutellariae 15g, Radix Et Rhizoma Rhei 10g, Scorpio 6g, Pheretima 15g, Rhizoma Gastrodiae 10g, Concha Haliotidis 20g, Folium Apocyni Veneti 30g, Fructus Tribuli 15g, Semen Ziziphi Spinosae 30g, Radix Polygalae 10g, Ganoderma 30g, Borneolum Syntheticum 10g, Rhizoma Acori Graminei 10g, Fructus Crataegi (parched to brown) 30g, Semen Raphani 30g, Folium Camelliae sinensis 10g.
Folium et Ramulus Clerodendri Trichotomi is twig and the leaf of Verenaceae plant Folium et Ramulus Clerodendri Trichotomi described in the present invention's prescription.
Folium et Ramulus Clerodendri Trichotomi (Clerodendron lricholomum Thunb) is born in roadside, mountain valley, mountain region, small stream limit.Be widely distributed, effluent north reaches Zhejiang, Fujian in the south, to Hubei, Sichuan and other places.The glue juice that the flower of this plant, fruit, root and root bark are smash is hyoscine also.
[collection] 8-10 month adopts after blooming, or adopts before blooming in the 6-7 month, extracts spray and leaf, ties up bunchy, dries.
[composition] leaf contains clerodendron trichotomum element, meso inositol, alkaloid, acacetin-7-glucosulfone aldehydic acid glycoside.This product still contains clerodendronin A, clerodendronin B, clerodendrin A and clerodendrin B.
[process of preparing Chinese medicine] chooses the roguing grass, slightly soaks with clear water, runs through, and is cut into the segment of 1 centimeter length, dries, and gives birth to and uses.
[nature and flavor] " modern practical Chinese medicine ": " the bitter in the mouth band is sweet ".
[function cures mainly] wind-damp dispelling, blood pressure lowering.The dispelling the wind and dampness pathogens arthralgia pain, hemiplegia.
Gryllotalpa is the dry Scorpio of Gryllotalpidae insecticide Gryllotalpa described in the present invention's prescription.
Gryllotalpa body Long Circle, khaki or crineous, whole body is close by short and small fur.Move in the moist warm sand.
Plough between [collection] summer, autumn and catch when digging, or the trapping of lighting a lamp evening.Catch back boiling hot deadly, dry or dry with boiling water.
Free amino acid has 13 kinds in [composition] hemolymph, and wherein alanine, histidine, valine content are higher.Free amino acid in the testis has alanine, aspartic acid, glutamic acid, glycine, histidine, isoleucine, leucine, proline, serine, tyrosine, valine, wherein with concentration of proline for the highest.
[process of preparing Chinese medicine] chooses clean impurity, removes wing foot, or bakes to yellowish-brown and use.
[nature and flavor] are salty, cold.
[function cures mainly] diuretic, relieving constipation.Harness the river swollen, stranguria caused by urinary stone, dysuria, scrofula, carbuncle malignant boil.
Agkistrodon halys described in the present invention's prescription is that Viperidae animal Agkistrodon halys is removed all of internal organs.
Agkistrodon halys inhabits Plain or lower mountain area, often coils into discoid or is twisted into wavy.Predation Mus, the frog, Eremiatis argi, bird, insecticide etc. have severe toxicity.All there is distribution at China the north and middle part.The skin of this animal (Dermis Agkistrodon halys), bone (Os Agkistrodon halys), gallbladder (Fel Agkistrodon halys), fat (Adeps Agkistrodon halys Agkistrodon halys), (Periostracum Agkistrodonhalys) the also hyoscine of casting off a skin.
Catch between [collection] spring, summer.Catch after, cut open the belly and remove internal organs, the oven dry.
[chemical constituent] separated the following composition of purifying from agkistrodon halyx pallas venom: homorrhagic factor HR-I and HR-II, protease b, a kind of Kallidin I release enzyme and two kinds of Kallidin I destructive enzymes and potentiator E.HR-I may be its main malicious rope, contains 12% neutral sugar, and isoelectric point, IP 4.70 is a kind of tart glycoproteins, and molecular weight is about 85000.HR-I is highly purified; But b is inseparable with protease, also is glycoprotein, molecular weight 95000.Protease b is a disconnected enzyme in a kind of peptide bond, contains 2 gram atom Ca/mol; After removing Ca, molecular configuration changes, the forfeiture proteinase activity; React irreversible.Potentiator E is 11 peptides, and its primary structure chemosynthesis proves.
[process of preparing Chinese medicine] Agkistrodon halys frost: get Agkistrodon halys calcining sustainability, pulverize.
[nature and flavor] are sweet, and temperature is poisonous.1. supplement to the Herbal: slightly poisonous.2. " detailed outline ": sweet, temperature, poisonous.3. " herbal classic is met former ": big heat, poisonous.
[function cures mainly] dispels the wind, counteracting toxic substances.Control leprosy, leprosy disease, skin insensitive impediment, scrofula, haemorrhoids.1. " not Lu ": make and make wine and treat leprosy disease, all fistulas, cardiac and abdominal pain, following stagnation of QI.2. " property of medicine opinion ": control five hemorrhoid, hemorrhoidal hamorrhage rushes down blood.3. " detailed outline is picked up any lost article from the road ": control migratory arthralgia.
Described Folium Camelliae sinensis is QINGCHAYE.
Described crude drug also comprises the Haematitum of 30-60 weight portion, preferably includes the Haematitum of 60 weight portions.
The present invention also provides the preparation method of the Chinese medicine preparation of described treatment hypertension, may further comprise the steps:
1) crude drug with described ratio cleans, dries according to conventional method;
2) Semen Ziziphi Spinosae that step 1) was handled and Semen Raphani fry;
3) will be through step 1) and 2) crude drug pulverize separately under aseptic, dustless condition of handling;
4) the crude drug mix homogeneously that step 3) is pulverized further is prepared into the process of Chinese medicine preparation acceptable forms according to conventional method.
The fineness of the described pulverizing of step 3) is to make medicated powder cross 120 mesh sieves.
The described process of Chinese medicine preparation acceptable forms of step 4) is powder, capsule, tablet or pill.
Among the side of the present invention:
Radix Ginseng, the Radix Astragali, Radix Rhodiolae, Radix Glycyrrhizae and Fructus Schisandrae Chinensis benefiting qi and nourishing blood, Radix Angelicae Sinensis, Radix Rehmanniae Preparata and Radix Polygoni Multiflori promote QI-blood circulation, Herba Epimedii, the Cortex Eucommiae, Cordyceps, Fructus Corni and Ootheca Mantidis nourishing liver and kidney, Fructus Lycii, Fructus Ligustri Lucidi, Tremella, Auricularia and Plumula Nelumbinis are mended Yin and Yang, are monarch drug;
Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Hirudo, Eupolyphaga Seu Steleophaga, Radix Ilicis Pubescentis, Flos Carthami, Rhizoma Corydalis Decumbentis and pseudo-ginseng blood-circulation-invigovating blood stasis dispelling, vessel softening, the clear stasis of blood blowdown of Radix Stephaniae Tetrandrae, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi, Agkistrodon halys, Poria, Rhizoma Alismatis and Gryllotalpa, expelling wind and removing dampness are ministerial drug;
Flos Chrysanthemi, Radix Puerariae, Radix Bupleuri, Spica Prunellae, the Radix Rehmanniae and Radix Scrophulariae clearing away heat and cooling blood, Cortex Moutan, Radix Gentianae, Cortex Phellodendri, Radix Scutellariae and the blood pressure lowering of Radix Et Rhizoma Rhei dampness are adjuvant drug;
Scorpio, Pheretima, Rhizoma Gastrodiae, Concha Haliotidis, Folium Apocyni Veneti and Fructus Tribuli suppressing the hyperactive liver to relieve the wind syndrome, Semen Ziziphi Spinosae, Radix Polygalae, Ganoderma, Borneolum Syntheticum and Rhizoma Acori Graminei tranquillizing and allaying excitement are messenger drug;
In addition, Fructus Crataegi (parched to brown) and Semen Raphani invigorating the stomach and promoting digestion also play certain assosting effect.
The hypertension therapeutic principle that the inventor proposes is different from the Therapeutic Principle of many existing depressor, thinks that treatment to hypertension is not will get blood pressure that The faster the better, but need one secular, to the therapeutic process of the progressive adjusting of whole body arteriovenous.Because the cause of disease of hypertension is comparatively complicated, think on the traditional Chinese medical science to arise from imbalance of YIN and YANG, cause excess in the upper and deficiency in the lower, the wind-fire expectorant stasis of blood.Therefore the proposition of Chinese medicine of the present invention is guiding principle with the deficiency and excess, in the process of whole treatment hypertension, human body is regarded as an organic whole, by the compatibility relationship of monarch between crude drug among the above-mentioned side, at first regulating YIN and YANG, nourishing liver and kidney, further on this basis blood circulation promoting and blood stasis dispelling, promote QI-blood circulation, further based on this again brain-benefiting blood pressure-reducing, expelling wind and removing dampness, reach tranquillizing and allaying excitement, make the patient be able to consciousness-restoring and orifice-opening, finally reverse pathomechanism, prevent that complication from producing, to reach the optimal treatment boundary of basic treatment, whole recovery and treating both the principal and secondary aspects of a disease.
Instructions of taking of the present invention: everyone 3 times on the 1st, each 4-6g, 3 months is a course of treatment, on average takes onset in 10-15 days.
The clinical effectiveness of Chinese medicine of the present invention is observed:
Diagnostic criteria: World Health Organization (WHO)/international hypertension alliance (WHO-ISH) hypertension was controlled in 1999
Treat person's Evaluation of Diagnostic Criteria of Hypertension and the classification more than 18 years old worked out in the guide, see the following form 1.
The definition of table 1. blood pressure level and classification (mmHg)
| Classification | Systolic pressure | Diastolic pressure |
| Normal high value 1 grade of hypertension (slightly) subgroup of ideal bp normal arterial pressure: 3 grades of hypertension of 2 grades of hypertension of borderline hypertension (moderate) (severe) isolated systolic hypertension subgroup: borderline hypertension | ＜120 ＜130 130～139 140～159 140～149 160～179 ≥180 ≥140 140～90 | ＜80 ＜85 85～89 90～99 90～94 100～109 ≥110 ＜90 ＜90 |
Observational technique:
Make a definite diagnosis 150 routine patients with hypertension according to above diagnostic criteria, its mild or moderate 84 examples, moderate 44 examples, severe 22 examples.According to the difference of blood pressure classification, allow the patient take a Chinese medicine 1-4 course of treatment of the embodiment of the invention 4 preparations according to above-mentioned instructions of taking.
Curative effect determinate standard:
Produce effects: 1. more than the diastolic pressure decline 10mmHg, and reach normal range; Though 2. diastolic pressure do not reduce to normally descended 20mmHg or more than;
Effectively: 1. diastolic pressure descends not as good as 10mmHg, but has reached normal range; 2. decline 10-19mmHg before diastolic pressure is treated, but do not reach normal range; 3. systolic pressure is more than the preceding decline 30mmHg of treatment; Must possess wherein 1.
Invalid: as not reach above standard.
The therapeutic effect statistics:
Obvious effective rate 80%
Effective percentage 15%
Inefficiency 5%
Above-mentioned presentation of results to clinical observation on the therapeutic effect, Chinese medicine of the present invention has remarkable result to the treatment of hypertension.
Compared with prior art, Chinese medicine of the present invention also has following beneficial effect:
1. treating both the principal and secondary aspects of a disease, conditioning comprehensively
A lot of depressor of the prior art, its drug effect is often unilateral at certain single blood pressure influence factors such as vascular resistance, blood vessel elasticity or calcium ion concentrations, though the patient takes the falling that blood pressure can be realized in the back, but cause unbalance between the various functions of body easily, need to take other drug thus and correct.Perhaps, rebound easily owing to simple symptomatic treatment makes blood pressure can not really recover normally.
Chinese medicine of the present invention is said as aforementioned part, be to regard human body as organic whole, concern by the reasonable compatibility between each crude drug, each system of body, many organs are nursed one's health comprehensively, not only from essence hypertensive pathogenic factors being exerted an influence, bring high blood pressure down, and the recovery of each systematic function of health is tended to balance, thereby reach treating both the principal and secondary aspects of a disease.
2. steadily blood pressure lowering
In view of the cause of disease complexity of hypertension, the influence factor is numerous, and Chinese medicine of the present invention is not target with quick blood pressure lowering, but the patient is carried out progressive, multiple conditioning treatment, thereby realizes steady blood pressure lowering.So not only be difficult for making the blood pressure bounce-back, and can not bring the danger of blood pressure rapid drawdown to the patient.
3. effectively suppress the generation and the development of complication
Chinese medicine of the present invention is principle with comprehensive conditioning, based on nourishing liver and kidney, in blood pressure lowering, not only can not bring infringement to each internal organs, can effectively nurse one's health and safeguard by nourishing liver and kidney, blood circulation promoting and blood stasis dispelling, cephalocathartic target organ that drug effect injures easily to hypertension such as calm the nerves on the contrary, suppress the generation and the development of various complication.
4. Chinese medicine of the present invention has certain effect in other all many-sides such as defying age, adjusting immunity and inhibition tumors.
The specific embodiment
Embodiment 1
Get the raw materials ready:
Radix Ginseng 6g, Radix Astragali 20g, Radix Rhodiolae 15g, Radix Glycyrrhizae 6g, Fructus Schisandrae Chinensis 12g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Radix Polygoni Multiflori 15g, Herba Epimedii 12g, Cortex Eucommiae 12g, Cordyceps 6g, Fructus Corni 15g, Ootheca Mantidis 12g, Fructus Lycii 15g, Fructus Ligustri Lucidi 12g, Tremella 15g, Auricularia 20g, Plumula Nelumbinis 12g, Radix Salviae Miltiorrhizae 30g, Rhizoma Chuanxiong 15g, Hirudo 20g, Eupolyphaga Seu Steleophaga 15g, Radix Ilicis Pubescentis 30g, Flos Carthami 10g, Rhizoma Corydalis Decumbentis 10g, Radix Notoginseng 6g, Radix Stephaniae Tetrandrae 12g Herba Siegesbeckiae 15g, Folium et Ramulus Clerodendri Trichotomi 15g, Agkistrodon halys 10g, Poria 15g, Rhizoma Alismatis 12g, Gryllotalpa 10g, Flos Chrysanthemi 15g, Radix Puerariae 20g, Radix Bupleuri 10g, Spica Prunellae 30g, Radix Rehmanniae 30g, Radix Scrophulariae 20g, Cortex Moutan 12g, Radix Gentianae 12g, Cortex Phellodendri 15g, Radix Scutellariae 15g, Radix Et Rhizoma Rhei 10g, Scorpio 6g, Pheretima 15g, Rhizoma Gastrodiae 10g, Concha Haliotidis 20g, Folium Apocyni Veneti 30g, Fructus Tribuli 15g, Semen Ziziphi Spinosae 30g, Radix Polygalae 10g, Ganoderma 30g, Borneolum Syntheticum 10g, Rhizoma Acori Graminei 10g, Fructus Crataegi (parched to brown) 30g, Semen Raphani 30g, Folium Camelliae sinensis 10g.
Pharmacy:
1) the above-mentioned raw materials medicine is cleaned the back oven dry;
2) wherein Semen Ziziphi Spinosae and Semen Raphani are fried;
3) will through the crude drug of above-mentioned processing under aseptic, the dustless condition with the Universalpulverizer pulverize separately after, cross 120 mesh sieves, obtain medicated powder;
4) above-mentioned various medicated powder are mixed through mixer, Chinese powder medicine of the present invention is made in packing.
Embodiment 2
Get the raw materials ready:
Radix Ginseng 10g, Radix Astragali 20g, Radix Rhodiolae 10g, Radix Glycyrrhizae 8g, Fructus Schisandrae Chinensis 15g, Radix Angelicae Sinensis 25g, Radix Rehmanniae Preparata 40g, Radix Polygoni Multiflori 18g, Herba Epimedii 15g, Cortex Eucommiae 10g, Cordyceps 5g, Fructus Corni 12g, Ootheca Mantidis 15g, Fructus Lycii 10g, Fructus Ligustri Lucidi 10g, Tremella 12g, Auricularia 20g, Plumula Nelumbinis 10g, Radix Salviae Miltiorrhizae 25g, Rhizoma Chuanxiong 10g, Hirudo 30g, Eupolyphaga Seu Steleophaga 10g, Radix Ilicis Pubescentis 20g, Flos Carthami 10g, Rhizoma Corydalis Decumbentis 12g, Radix Notoginseng 10g, Radix Stephaniae Tetrandrae 10g Herba Siegesbeckiae 12g, Folium et Ramulus Clerodendri Trichotomi 10g, Agkistrodon halys 10g, Poria 10g, Rhizoma Alismatis 10g, Gryllotalpa 15g, Flos Chrysanthemi 12g, Radix Puerariae 30g, Radix Bupleuri 8g, Spica Prunellae 20g, Radix Rehmanniae 20g, Radix Scrophulariae 15g, Cortex Moutan 15g, Radix Gentianae 15g, Cortex Phellodendri 12g, Radix Scutellariae 12g, Radix Et Rhizoma Rhei 8g, Scorpio 8g, Pheretima 12g, Rhizoma Gastrodiae 8g, Concha Haliotidis 18g, Folium Apocyni Veneti 25g, Fructus Tribuli 15g, Haematitum 50g, Semen Ziziphi Spinosae 20g, Radix Polygalae 8g, Ganoderma 20g, Borneolum Syntheticum 8g, Rhizoma Acori Graminei 12g, Fructus Crataegi (parched to brown) 40g, Semen Raphani 30g, Folium Camelliae sinensis 15g.
Pharmacy:
1) the above-mentioned raw materials medicine is cleaned the back oven dry;
2) wherein Semen Ziziphi Spinosae and Semen Raphani are fried;
3) will through the crude drug of above-mentioned processing under aseptic, the dustless condition with the Universalpulverizer pulverize separately after, cross 120 mesh sieves, obtain medicated powder;
4) above-mentioned various medicated powder are mixed through mixer, make Chinese medicine pill of the present invention with general method for making.
Embodiment 3
With the medicated powder direct compression of mix homogeneously in embodiment 1 step 4), make the tablet of Chinese medicine of the present invention.
Embodiment 4
With the medicated powder of mix homogeneously in embodiment 2 step 4) capsule of packing into No. 3, make the capsule of Chinese medicine of the present invention.
Application Example
Case 1
The male, 49 years old, 22 years hypertension histories, obstinate is with hyperlipidemia, fatty liver, serum creatinine level height, headache, dizziness, insomnia, weak, symptom such as diet is depressed.Take the capsule 1 year of the embodiment of the invention 4 preparation, above-mentioned symptom disappears, and it is normal that every clinical indices is recovered.
Case 2
The male 55 years old, suffers from hypertension, with hyperlipemia, headache, dizziness, insomnia forgetfulness, cardiac blood supply deficiency, numb limbs and tense tendons.Accepted Drug therapy of the present invention in 2005, and took nearly 1 year of the capsule of the embodiment of the invention 4 preparation, above-mentioned symptom disappears substantially, and it is normal that every clinical indices is recovered.
Case 3.
The male, 61 years old, nineteen ninety-five began to suffer from hypertension, with hyperlipemia and heart disease.Accepting the preceding blood pressure level of Drug therapy of the present invention is about the 170/100mmHg.Worked the capsule after 1 year of taking the embodiment of the invention 4 preparation in 2006, above-mentioned symptom disappears, and the every index of clinical examination is near normal.
Case 4.
The women, 54 years old, accept before the Drug therapy of the present invention blood pressure level about 175/105mmHg, and with headache, dizziness, tinnitus, cardiopalmus, breathe hard, symptoms such as edema of lower limbs, numb hand and foot, sore waist and aching in the waist and the back, obesity.The capsule of taking the embodiment of the invention 4 preparation is after two courses of treatment, and body weight is reduced to 65 kilograms by original 75 kilograms, and above-mentioned symptom significantly goes down.After the treatment of two courses of treatment, the every index result of clinical detection of health all recovers normal again.After paying a return visit the affirmation withdrawal state of an illness did not appear repeatedly in 3 years.
Claims (9)
1. Chinese medicine preparation for the treatment of hypertension, its crude drug comprises following parts by weight of Chinese traditional medicine material:
Radix Ginseng 6-10 part, Radix Astragali 15-30 part, Radix Rhodiolae 10-15 part, Radix Glycyrrhizae 5-10 part, Fructus Schisandrae Chinensis 10-15 part, Radix Angelicae Sinensis 20-30 part, Radix Rehmanniae Preparata 30-50 part, Radix Polygoni Multiflori 15-20 part, Herba Epimedii 5-15 part, Cortex Eucommiae 6-12 part, Cordyceps 3-6 part, Fructus Corni 10-15 part, Ootheca Mantidis 10-15 part, Fructus Lycii 10-15 part, Fructus Ligustri Lucidi 6-12 part, Tremella 10-15 part, Auricularia 15-25 part, Plumula Nelumbinis 10-15 part, Radix Salviae Miltiorrhizae 15-30 part, Rhizoma Chuanxiong 10-20 part, Hirudo 15-30 part, Eupolyphaga Seu Steleophaga 15-20 part, Radix Ilicis Pubescentis 15-30 part, Flos Carthami 5-10 part, Rhizoma Corydalis Decumbentis 6-15 part, Radix Notoginseng 6-10 part, Radix Stephaniae Tetrandrae 10-15 part Herba Siegesbeckiae 10-15 part, Folium et Ramulus Clerodendri Trichotomi 10-15 part, Agkistrodon halys 6-12 part, Poria 10-15 part, Rhizoma Alismatis 10-15 part, Gryllotalpa 10-15 part, Flos Chrysanthemi 10-15 part, Radix Puerariae 15-30 part, Radix Bupleuri 6-12 part, Spica Prunellae 15-30 part, Radix Rehmanniae 15-30 part, Radix Scrophulariae 15-20 part, Cortex Moutan 10-15 part, Radix Gentianae 10-15 part, Cortex Phellodendri 10-15 part, Radix Scutellariae 10-15 part, Radix Et Rhizoma Rhei 6-12 part, Scorpio 6-10 part, Pheretima 10-15 part, Rhizoma Gastrodiae 6-10 part, Concha Haliotidis 15-20 part, Folium Apocyni Veneti 20-30 part, Fructus Tribuli 10-15 part, Semen Ziziphi Spinosae 20-30 part, Radix Polygalae 6-10 part, Ganoderma 20-30 part, Borneolum Syntheticum 6-10 part, Rhizoma Acori Graminei 6-12 part, Fructus Crataegi (parched to brown) 30-50 part, Semen Raphani 20-30 part, Folium Camelliae sinensis 10-15 part.
2. the Chinese medicine preparation of the described treatment hypertension of claim 1, it is characterized in that: described crude drug comprises following parts by weight of Chinese traditional medicine material:
6 parts of Radix Ginsengs, 20 parts of the Radixs Astragali, 15 parts of Radix Rhodiolaes, 6 parts in Radix Glycyrrhizae, 12 parts of Fructus Schisandrae Chinensis, 20 parts of Radix Angelicae Sinensis, 50 parts of Radix Rehmanniae Preparata, 15 parts of Radix Polygoni Multiflori, 12 parts of Herba Epimedii, 12 parts of the Cortexs Eucommiae, 6 parts of Cordyceps, 15 parts of Fructus Corni, 12 parts of Ootheca Mantidiss, 15 parts of Fructus Lycii, 12 parts of Fructus Ligustri Lucidi, 15 parts in Tremella, 20 parts of Auricularia, 12 parts of Plumula Nelumbiniss, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Chuanxiongs, 20 parts of Hirudos, 15 parts of Eupolyphaga Seu Steleophagas, 30 parts of Radix Ilicis Pubescentiss, 10 parts on Flos Carthami, 10 parts of Rhizoma Corydalis Decumbentiss, 6 parts of Radix Notoginseng, 15 parts of 12 parts of Herba Siegesbeckiaes of Radix Stephaniae Tetrandrae, 15 parts of Folium et Ramulus Clerodendri Trichotomis, 10 parts of Agkistrodon halyss, 15 parts in Poria, 12 parts of Rhizoma Alismatis, 10 parts of Gryllotalpas, 15 parts of Flos Chrysanthemis, 20 parts of Radix Puerariaes, 10 parts of Radix Bupleuri, 30 parts of Spica Prunellaes, 30 parts of Radix Rehmanniae, 20 parts of Radix Scrophulariaes, 12 parts of Cortex Moutans, 12 parts of Radix Gentianae, 15 parts of Cortex Phellodendris, 15 parts of Radix Scutellariaes, 10 parts of Radix Et Rhizoma Rhei, 6 parts of Scorpios, 15 parts of Pheretimas, 10 parts in Rhizoma Gastrodiae, 20 parts of Concha Haliotidis, 30 parts of Folium Apocyni Venetves, 15 parts of Fructus Tribulis, 30 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Polygalaes, 30 parts of Ganodermas, 10 parts of Borneolum Syntheticums, 10 parts of Rhizoma Acori Graminei, 30 parts of Fructus Crataegi (parched to brown)s, 30 parts of Semen Raphanis, 10 parts of Folium Camelliae sinensis.
3. the Chinese medicine preparation of the described treatment hypertension of claim 2, it is characterized in that: described crude drug comprises the Chinese crude drug of following weight:
Radix Ginseng 6g, Radix Astragali 20g, Radix Rhodiolae 15g, Radix Glycyrrhizae 6g, Fructus Schisandrae Chinensis 12g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Radix Polygoni Multiflori 15g, Herba Epimedii 12g, Cortex Eucommiae 12g, Cordyceps 6g, Fructus Corni 15g, Ootheca Mantidis 12g, Fructus Lycii 15g, Fructus Ligustri Lucidi 12g, Tremella 15g, Auricularia 20g, Plumula Nelumbinis 12g, Radix Salviae Miltiorrhizae 30g, Rhizoma Chuanxiong 15g, Hirudo 20g, Eupolyphaga Seu Steleophaga 15g, Radix Ilicis Pubescentis 30g, Flos Carthami 10g, Rhizoma Corydalis Decumbentis 10g, Radix Notoginseng 6g, Radix Stephaniae Tetrandrae 12g Herba Siegesbeckiae 15g, Folium et Ramulus Clerodendri Trichotomi 15g, Agkistrodon halys 10g, Poria 15g, Rhizoma Alismatis 12g, Gryllotalpa 10g, Flos Chrysanthemi 15g, Radix Puerariae 20g, Radix Bupleuri 10g, Spica Prunellae 30g, Radix Rehmanniae 30g, Radix Scrophulariae 20g, Cortex Moutan 12g, Radix Gentianae 12g, Cortex Phellodendri 15g, Radix Scutellariae 15g, Radix Et Rhizoma Rhei 10g, Scorpio 6g, Pheretima 15g, Rhizoma Gastrodiae 10g, Concha Haliotidis 20g, Folium Apocyni Veneti 30g, Fructus Tribuli 15g, Semen Ziziphi Spinosae 30g, Radix Polygalae 10g, Ganoderma 30g, Borneolum Syntheticum 10g, Rhizoma Acori Graminei 10g, Fructus Crataegi (parched to brown) 30g, Semen Raphani 30g, Folium Camelliae sinensis 10g.
4. the Chinese medicine preparation of claim 1,2 or 3 described arbitrary treatment hypertension, it is characterized in that: described Folium Camelliae sinensis is QINGCHAYE.
5. the Chinese medicine preparation of claim 1,2 or 3 described arbitrary treatment hypertension, it is characterized in that: described crude drug also comprises the Haematitum of 30-60 weight portion.
6. the Chinese medicine preparation of the described treatment hypertension of claim 5, it is characterized in that: described crude drug also comprises the Haematitum of 60 weight portions.
7. the preparation method of the Chinese medicine preparation of the described treatment hypertension of claim 1 may further comprise the steps:
1) crude drug with described ratio cleans, dries according to conventional method;
2) Semen Ziziphi Spinosae that step 1) was handled and Semen Raphani fry;
3) will be through step 1) and 2) crude drug pulverize separately under aseptic, dustless condition of handling;
4) the crude drug mix homogeneously that step 3) is pulverized further is prepared into the process of Chinese medicine preparation acceptable forms according to conventional method.
8. the preparation method of the Chinese medicine preparation of the described treatment hypertension of claim 7, it is characterized in that: the fineness of the described pulverizing of step 3) is to make medicated powder cross 120 mesh sieves.
9. the preparation method of the Chinese medicine preparation of the described treatment hypertension of claim 7, it is characterized in that: the described process of Chinese medicine preparation acceptable forms of step 4) comprises powder, capsule, tablet or pill.
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