CN101057942A - External applied medicine ointment for treating diabetes foot and its preparing method - Google Patents
External applied medicine ointment for treating diabetes foot and its preparing method Download PDFInfo
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Abstract
The invention relates to an externally used medical ointment for treating diabetes feet and process for preparation, wherein the medicinal ointment is prepared from Chinese caterpillar fungus, saffron, pangolin scales, flavescent sophora root, astragalus root, frankincense, Chinese honey locust, dragon's blood resin, root of red rooted saliva, Ligusticum wallichii, pseudo-ginseng, campeachy wood, Chinese angelica root, ginseng, capsule of weeping forsythia, ganoderma lucidum, corn stigma, schisandra fruit and auxiliary materials.
Description
Technical field
The present invention relates to a kind of external Chinese medicine, particularly relate to a kind of external-applied ointment for the treatment of diabetic foot and preparation method thereof.
Background technology
At present along with the globalization development of economy and the change of people's lives mode, and the appearance of aged tendency of population, the quantity of suffering from diabetics increases sharply, and its sickness rate has the trend that increases gradually in the world, especially in developing country, the speed of increase presents popular situation sooner.Diabetes have become the commonly encountered diseases that threatens human health, frequently-occurring disease, and fester by the brothers that diabetes cause, suppurate, threaten people's health more, bring great misery to the patient, and bad radical cure does not have any good treatment measure at present, and the patient is in ill process, after brothers are festered, often have no alternative but take the way in excision affected part, bring great misery at heart for patient and household, therefore, people press for a kind of medicine that can fine treatment diabetic foot, satisfy patient's demand.
Summary of the invention
Purpose of the present invention overcomes the deficiencies in the prior art exactly, and a kind of external-applied ointment evident in efficacy is provided, and makes it to be fit to clinical practice.
An object of the present invention is to provide a kind of external-applied ointment for the treatment of diabetic foot.
Another object of the present invention provides the preparation method of the external-applied ointment of described treatment diabetic foot.
The objective of the invention is to be achieved through the following technical solutions:
A kind of external-applied ointment for the treatment of diabetic foot is by comprising that following parts by weight of traditional Chinese medicines feedstock production forms;
Radix Sophorae Flavescentis 4-10 Radix Angelicae Sinensis 4-9 Rhizoma Chuanxiong 1-5
Lignum Sappan 3-8 Stigma Croci 4-10 Olibanum 4-10
Radix Astragali 3-9 Fructus Forsythiae 2-8 Radix Notoginseng 4-9
Radix Ginseng 2-9 Ganoderma 3-9 Stigma Maydis 2-8
Squama Manis 3-7 Cordyceps 1-2 Fructus Schisandrae Chinensis 2-7
Spina Gleditsiae 4-8 Sanguis Draxonis 4-9 Radix Salviae Miltiorrhizae 9-12
The sour glycerol fat of single 18 (alkane) 2-6 Tween 80 1-3
Preferably, a kind of external-applied ointment for the treatment of diabetic foot is by comprising that following parts by weight of traditional Chinese medicines feedstock production forms;
Radix Sophorae Flavescentis 4-8 Radix Angelicae Sinensis 4-7 Rhizoma Chuanxiong 1-3
Lignum Sappan 4-7 Stigma Croci 4-8 Olibanum 5-8
Radix Astragali 5-9 Fructus Forsythiae 2-6 Radix Notoginseng 4-9
Radix Ginseng 2-8 Ganoderma 5-9 Stigma Maydis 2-6
Squama Manis 5-7 Cordyceps 1-2 Fructus Schisandrae Chinensis 2-6
Spina Gleditsiae 4-8 Sanguis Draxonis 4-7 Radix Salviae Miltiorrhizae 9-12
The sour glycerol fat of single 18 (alkane) 2-5 Tween 80 1-2
A kind of preparation method for the treatment of the external-applied ointment of diabetic foot of the present invention, it may further comprise the steps;
1) takes by weighing each raw material by formula ratio, 13 Chinese medicines such as Cordyceps, Stigma Croci, Squama Manis, Radix Sophorae Flavescentis, the Radix Astragali, Olibanum, Spina Gleditsiae, Sanguis Draxonis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Notoginseng, Lignum Sappan, Radix Angelicae Sinensis are put into an extractor, five Chinese medicines such as Radix Ginseng, Fructus Forsythiae, Ganoderma, Stigma Maydis, Fructus Schisandrae Chinensis are put into another extractor, adding suitable water extracts simultaneously, to add carbon dioxide in the extraction process, the extraction time is 95-105 minute, and temperature is controlled at about 45 ℃;
2) after extraction finished, merging filtrate carries out filtering residue to be separated, and the filtrate that obtains is concentrated;
3) with single sour glycerol fat of 18 (alkane) and Tween 80, add in the concentrated solution, stir into paste.
External-applied ointment of the present invention, usage: to wound face carry out disinfection clean after, be applied in the affected part uniformly, need not wrap up, every day three times, 30 days is a course of treatment, can fully recover general 3-4 course of treatment.
A kind of external-applied ointment for the treatment of diabetic foot of the present invention, it is monarch drug with the Radix Sophorae Flavescentis, with the Radix Astragali, Olibanum, Spina Gleditsiae, Rhizoma Chuanxiong, Sanguis Draxonis, Radix Salviae Miltiorrhizae, Squama Manis, Stigma Croci, Lignum Sappan, Radix Notoginseng, Radix Angelicae Sinensis, Cordyceps totally ten two Chinese medicines be ministerial drug, be adjuvant drug with Radix Ginseng, Fructus Forsythiae, Ganoderma, Stigma Maydis, Fructus Schisandrae Chinensis.
One, monarch drug
Radix Sophorae Flavescentis: nature and flavor bitter cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel.Effect with heat clearing away, dampness, parasite killing cures mainly toxic-heat and blood stasis, dispelling wind for relieving itching, anti-dermatophyte, and modern medicine studies show that Radix Sophorae Flavescentis also has antiinflammatory, and antivirus action is particularly aspect the anti-gangrenous pathogenic bacterium obvious effects being arranged, so be monarch drug.
Two, ministerial drug
The Radix Astragali: warm in nature, sweet in the mouth, go into lung, spleen channel.The effect of have tonifying Qi and lifting yang, eliminating stasis and resolving masses, inducing diuresis to remove edema, refusing pus and growing muscle.Curing mainly arthralgia due to stagnation of blood, edema, carbuncle bursts and does not hold back for a long time.
Olibanum; Nature and flavor suffering, hardship, temperature.GUIXIN, liver, spleen channel.It has regulating QI, pain relieving, invigorating blood circulation chases after the effect of poison.Cure mainly vim and vigour and stagnate, the pain pyogenic infections from tumour or sore.
Spina Gleditsiae: property suffering, flavor temperature.Go into liver, stomach warp.The effect that has promoting blood circulation and detumescence, refuses malicious toxin expelling.Cure mainly carbuncle, sore, specialize in detumescence and apocenosis.
The Radix Astragali, Olibanum, three Chinese medicines of Spina Gleditsiae mainly play toxin expelling, clear pus, repercussive effect in this side, so be ministerial drug.
Rhizoma Chuanxiong: warm in nature, acrid in the mouth, go into liver, gallbladder, pericardium channel.Has activating QI to alleviate the depression, the effect of dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain.Cure mainly arthralgia due to cold clonic spasm of the muscle, ulcer sores.
Sanguis Draxonis: warm in nature, flat, sweet in the mouth.Go into the heart, liver, spleen channel.Have promoting blood circulation to remove blood stasis, analgesic therapy hemostasia and promoting granulation, hold back skin ulcer.Cure mainly ecchymoma due to internal injury, continuous bleeding due to traumatic injury, numbness infections, ecthyma unhealed for long time.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.Go into the heart, Liver Channel.Has blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, the effect of eliminating carbuncle pain relieving.Cure mainly hematogenous blockage, diseases such as ulcer sore pain.
Rhizoma Chuanxiong, Sanguis Draxonis, three Chinese medicines of Radix Salviae Miltiorrhizae mainly play blood sugar lowering, antiinflammatory, analgesic effect in this side, particularly in 15 days diabetic foot initial stages of treatment, blood sugar lowering is fairly obvious.
Squama Manis: salty in the mouth, cold nature, go into liver, stomach two warps.The effect of have secret lean gas, protecting lung the kidney invigorating, hemostasia and dissipation blood stasis.Cure mainly the lung kidney deficiency, anti-inflammation is regulated body immunity.
Stigma Croci: the nature and flavor bitterness, little sweet.Go into the heart, liver, kidney channel.It has thin channels and activating collaterals, the effect of the blood stasis dispelling of stimulating the menstrual flow, dissipating blood stasis relieving accumulation of pathogens, reducing swelling and alleviating pain, removing pathogenic heat from blood and toxic substance from the body, raising body immunity.Cure mainly cerebral thrombosis, vasculitis, the high body weight of blood, etc. disease.
Lignum Sappan: the little suffering of property, sweet in the mouth, salty.Go into the heart, liver, spleen channel.Effect with promoting the circulation of blood, removing blood stasis with potent drugs, reducing swelling and alleviating pain cures mainly skin sore, traumatic injury.
Squama Manis, Stigma Croci, three Chinese medicines of Lignum Sappan main rising in this side chases after poison, the promoting the circulation of blood of stimulating the menstrual flow, gets rid of vivotoxin, impels that other is antibiotic, the pharmaceutical compositions of antiinflammatory, blood sugar lowering is penetrated in the body, to reach the effect of healing, so be ministerial drug.
Radix Notoginseng: it is little sweet and bitter to distinguish the flavor of, and goes into liver, stomach, large intestine channel.It has the effect of hemostasis, dissipating blood stasis, subduing swelling and relieving pain.Cure mainly traumatic injury congestion, carbuncle pain.
Radix Angelicae Sinensis: warm in nature, acrid-sweet flavor, little hardship.Go into liver, the heart, spleen channel.Have and enrich blood, invigorate blood circulation, menstruction regulating and pain relieving is moisturized laxation, and ulcer sores cures mainly carbuncle, evacuation of pus pain relieving.
Cordyceps: sweet in the mouth is warm in nature, go into lung, kidney channel.Have secret lean gas, protect the lung the kidney invigorating, the effect of hemostasia and dissipation blood stasis cures mainly lung kidney deficiency, antimicrobial antiphlogistic, regulates body immunity.
Radix Notoginseng, Radix Angelicae Sinensis, Cordyceps mainly play granulation promoting and promote wound healing in this side, so be ministerial drug.
Three, adjuvant drug
Radix Ginseng: warm in nature, sweet in the mouth, bitter in the mouth, go into spleen, stomach, lung meridian, have strongly invigorating primordial QI, take off the effect of promoting the production of body fluid, calming the nerves admittedly, cure mainly that impairment caused by overstrain is deficient, frequent micturition, quench one's thirst and the disease of all qi-blood-body fluid deficiencies.
Fructus Forsythiae: nature and flavor, bitter cool, go into the heart, liver, gallbladder meridian, have heat-clearing and toxic substances removing, the dispersing swelling and dissipating binds effect.Cure mainly that sweating is smooth, xerostomia is thirsty, the disease of laryngopharynx swelling and pain.
Ganoderma: warm in nature, mildly bitter flavor, go into spleen, kidney channel, have calmness, blood pressure lowering, blood sugar lowering, regulate the effect of immunity, cure mainly dysuria, diuresis, kidney tonifying gas, logical nine orifices promotes that the blood blood circulation is unimpeded.
Stigma Maydis: nature and flavor are sweet, hot, flat, go into liver, spleen two warps, have diuresis, detumescence, blood pressure lowering, hypoglycemic activity, cure mainly diseases such as nephritis, diabetes edema.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, salty, have supplementing QI for promoting the production of body fluid, astringe the lung and grow stomach, unsmoothing the sperm and stopping bleeding, mind tranquilizing and the heart calming effect, cure mainly chronic cough of deficiency lung, lung is suffered from a deficiency of the kidney and coughed, disease such as quench one's thirst.
Radix Ginseng, Fructus Forsythiae, Ganoderma, Stigma Maydis, five adjuvant drugs of Fructus Schisandrae Chinensis mainly play skin moistening, blood sugar lowering in this side, the effect of quenching one's thirst, and make more back skin smooth of gangrenous wound surface, do not stay obvious cicatrix.
Modern medicine studies show that diabetic foot is that the diabetes nerve sexually transmitted disease (STD) becomes, and ischemic vascular disease becomes and infects due to three factor combineds effect.Its pathogeny is relevant with gangrenous pathogenic bacterium, clinical pedal skin drying, the keratinization of mainly showing as, amyotrophy, blackout, chronic ulcer, toes heel gangrene, diseases such as vascular lesion.Diabetic foot also is an ancient disease." Ling Shu Miraculous Pivot or Divine Axis, a carbuncle piece of writing " said: send out in toe (toe) name and say necrosis, its shape is red black, stubbornly refuses to control.Its characteristic of disease often is " simulataneous insufficiency and excessive ", and congestion, stagnation of liver-QI, deficiency of vital energy while also deposit.
The present invention is according to the theory of Chinese medical science of inner disease outer treat treating both the principal and secondary aspects of a disease, three big pathogenic factors and clinical manifestation symptoms at diabetic foot, 18 Chinese medicines of new screening, according to their pharmacological effect separately, in the process of treatment diabetic foot, realize sterilization, antiinflammatory, toxin expelling, blood stasis dispelling, granulation promoting, blood sugar lowering curative effect successively, gangrenous wound surface is healed fully and newborn skin smooth smooth, do not have obvious cicatrix.
The specific embodiment
Below adopt embodiment to specify a kind of external-applied ointment for the treatment of diabetic foot of the present invention and preparation method thereof.
Embodiment 1
Radix Sophorae Flavescentis 9kg Radix Angelicae Sinensis 4kg Rhizoma Chuanxiong 3kg
Lignum Sappan 3kg Stigma Croci 5kg Olibanum 6kg
Radix Astragali 9kg Fructus Forsythiae 5kg Radix Notoginseng 4kg
Radix Ginseng 7kg Ganoderma 8kg Stigma Maydis 3kg
Squama Manis 5kg Cordyceps 2kg Fructus Schisandrae Chinensis 2kg
Spina Gleditsiae 4kg Sanguis Draxonis 6kg Radix Salviae Miltiorrhizae 9kg
The sour glycerol fat of single 18 (alkane) 5kg Tween 80 2kg
Its preparation method is as follows:
1) takes by weighing each raw material by formula ratio, 13 Chinese medicines such as Cordyceps, Stigma Croci, Squama Manis, Radix Sophorae Flavescentis, the Radix Astragali, Olibanum, Spina Gleditsiae, Sanguis Draxonis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Notoginseng, Lignum Sappan, Radix Angelicae Sinensis are put into an extractor add 160kg water, five Chinese medicines such as Radix Ginseng, Fructus Forsythiae, Ganoderma, Stigma Maydis, Fructus Schisandrae Chinensis are put into another extractor add 50kg water, extraction simultaneously, to add carbon dioxide in the extraction process, the extraction time is 100 minutes, and temperature is controlled at about 45 ℃;
2) after extraction finished, merging filtrate carries out filtering residue to be separated, and the filtrate that obtains is concentrated;
3) with single sour glycerol fat of 18 (alkane) and Tween 80, add in the concentrated solution, stir 120 minutes one-tenth pastes.
Embodiment 2
Radix Sophorae Flavescentis 6kg Radix Angelicae Sinensis 7kg Rhizoma Chuanxiong 4kg
Lignum Sappan 5kg Stigma Croci 9kg Olibanum 9kg
Radix Astragali 6kg Fructus Forsythiae 3kg Radix Notoginseng 7kg
Radix Ginseng 9kg Ganoderma 5kg Stigma Maydis 2kg
Squama Manis 3kg Cordyceps 1.5kg Fructus Schisandrae Chinensis 6kg
Spina Gleditsiae 5kg Sanguis Draxonis 5kg Radix Salviae Miltiorrhizae 10kg
The sour glycerol fat of single 18 (alkane) 4kg Tween 80 2.5kg
Its preparation method is as follows:
1) takes by weighing each raw material by formula ratio, 13 Chinese medicines such as Cordyceps, Stigma Croci, Squama Manis, Radix Sophorae Flavescentis, the Radix Astragali, Olibanum, Spina Gleditsiae, Sanguis Draxonis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Notoginseng, Lignum Sappan, Radix Angelicae Sinensis are put into an extractor add 150kg water, five Chinese medicines such as Radix Ginseng, Fructus Forsythiae, Ganoderma, Stigma Maydis, Fructus Schisandrae Chinensis are put into another extractor add 55kg water, extraction simultaneously, to add carbon dioxide in the extraction process, the extraction time is 100 minutes, and temperature is controlled at about 45 ℃;
2) after extraction finished, merging filtrate carries out filtering residue to be separated, and the filtrate that obtains is concentrated;
3) with single sour glycerol fat of 18 (alkane) and Tween 80, add in the concentrated solution, stir 120 minutes one-tenth pastes.
Below be the present invention treat diabetic foot external-applied ointment over 3 years to 109 patients' clinical experiment, received quite satisfied effect, this clinical observation of curative effect for details see attached table 1.
Subordinate list 1
| State of an illness classification clinical setting | Diabetic foot | Add up to | |||
| Case load | 109 | 109 | |||
| Drug treatment | 3 | 4-5 | 6-7 | 8 | 3-8 |
| Cure | 21 | 26 | 33 | 18 | 98 |
| Effectively | 6 | 6 | |||
| Invalid | 5 | 5 | |||
Above experimental data shows that this external-applied ointment has the effect of obvious treatment diabetic foot, for extensive patients has been removed misery.
Claims (3)
1. external-applied ointment for the treatment of diabetic foot is by comprising that following parts by weight of traditional Chinese medicines feedstock production forms;
Radix Sophorae Flavescentis 4-10 Radix Angelicae Sinensis 4-9 Rhizoma Chuanxiong 1-5
Lignum Sappan 3-8 Stigma Croci 4-10 Olibanum 4-10
Radix Astragali 3-9 Fructus Forsythiae 2-8 Radix Notoginseng 4-9
Radix Ginseng 2-9 Ganoderma 3-9 Stigma Maydis 2-8
Squama Manis 3-7 Cordyceps 1-2 Fructus Schisandrae Chinensis 2-7
Spina Gleditsiae 4-8 Sanguis Draxonis 4-9 Radix Salviae Miltiorrhizae 9-12
The sour glycerol fat of single 18 (alkane) 2-6 Tween 80 1-3
2. a kind of external-applied ointment for the treatment of diabetic foot according to claim 1 is by comprising that following parts by weight of traditional Chinese medicines feedstock production forms;
Radix Sophorae Flavescentis 4-8 Radix Angelicae Sinensis 4-7 Rhizoma Chuanxiong 1-3
Lignum Sappan 4-7 Stigma Croci 4-8 Olibanum 5-8
Radix Astragali 5-9 Fructus Forsythiae 2-6 Radix Notoginseng 4-9
Radix Ginseng 2-8 Ganoderma 5-9 Stigma Maydis 2-6
Squama Manis 5-7 Cordyceps 1-2 Fructus Schisandrae Chinensis 2-6
Spina Gleditsiae 4-8 Sanguis Draxonis 4-7 Radix Salviae Miltiorrhizae 9-12
The sour glycerol fat of single 18 (alkane) 2-5 Tween 80 1-2
3. according to the described a kind of external-applied ointment for the treatment of diabetic foot of claim 1-2, its preparation method may further comprise the steps;
1) takes by weighing each raw material by formula ratio, 13 Chinese medicines such as Cordyceps, Stigma Croci, Squama Manis, Radix Sophorae Flavescentis, the Radix Astragali, Olibanum, Spina Gleditsiae, Sanguis Draxonis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Notoginseng, Lignum Sappan, Radix Angelicae Sinensis are put into an extractor, five Chinese medicines such as Radix Ginseng, Fructus Forsythiae, Ganoderma, Stigma Maydis, Fructus Schisandrae Chinensis are put into another extractor, adding suitable water extracts simultaneously, to add carbon dioxide in the extraction process, the extraction time is 95-105 minute, and temperature is controlled at about 45 ℃;
2) after extraction finished, merging filtrate carries out filtering residue to be separated, and the filtrate that obtains is concentrated;
3) with single sour glycerol fat of 18 (alkane) and Tween 80, add in the concentrated solution, stir into paste.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006100868096A CN101057942B (en) | 2006-06-19 | 2006-06-19 | External applied medicine ointment for treating diabetes foot and its preparing method |
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| CN2006100868096A CN101057942B (en) | 2006-06-19 | 2006-06-19 | External applied medicine ointment for treating diabetes foot and its preparing method |
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| CN101057942A true CN101057942A (en) | 2007-10-24 |
| CN101057942B CN101057942B (en) | 2010-10-06 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263606A (en) * | 2013-06-17 | 2013-08-28 | 李伟丽 | Traditional Chinese medicine composition for treating diabetic foot by foot bath nursing and application of traditional Chinese medicine composition |
| CN104623126A (en) * | 2015-01-12 | 2015-05-20 | 上海应用技术学院 | Medicine for treating diabetic foot and preparation method of medicine |
| CN104784243A (en) * | 2015-03-23 | 2015-07-22 | 北京协和药厂 | Application of traditional Chinese medicinal composition capable of effectively treating frostbite rhagadia to prevention and treatment of diabetic foot |
| CN105560325A (en) * | 2015-12-31 | 2016-05-11 | 李秋 | Foamed emulsion for protecting skin of foot of diabetes patients and preparation method thereof |
| CN112546168A (en) * | 2020-12-29 | 2021-03-26 | 管晓坤 | External medicament for reducing blood sugar and preparation method thereof |
| CN114042094A (en) * | 2021-11-19 | 2022-02-15 | 北京佑三药业有限公司 | External traditional Chinese medicine compound ointment for treating diabetic wound disunion and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1155405C (en) * | 2001-06-05 | 2004-06-30 | 刘建宁 | Recipe and prepn. of medicine for treating diabetes and ulcer |
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2006
- 2006-06-19 CN CN2006100868096A patent/CN101057942B/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263606A (en) * | 2013-06-17 | 2013-08-28 | 李伟丽 | Traditional Chinese medicine composition for treating diabetic foot by foot bath nursing and application of traditional Chinese medicine composition |
| CN103263606B (en) * | 2013-06-17 | 2014-06-04 | 李伟丽 | Traditional Chinese medicine composition for treating diabetic foot by foot bath nursing and application of traditional Chinese medicine composition |
| CN104623126A (en) * | 2015-01-12 | 2015-05-20 | 上海应用技术学院 | Medicine for treating diabetic foot and preparation method of medicine |
| CN104784243A (en) * | 2015-03-23 | 2015-07-22 | 北京协和药厂 | Application of traditional Chinese medicinal composition capable of effectively treating frostbite rhagadia to prevention and treatment of diabetic foot |
| CN104784243B (en) * | 2015-03-23 | 2018-06-26 | 北京协和药厂 | A kind of application of Chinese medicine composition that can effectively treat frostbite rhagadia in prevention, treatment diabetes |
| CN105560325A (en) * | 2015-12-31 | 2016-05-11 | 李秋 | Foamed emulsion for protecting skin of foot of diabetes patients and preparation method thereof |
| CN112546168A (en) * | 2020-12-29 | 2021-03-26 | 管晓坤 | External medicament for reducing blood sugar and preparation method thereof |
| CN114042094A (en) * | 2021-11-19 | 2022-02-15 | 北京佑三药业有限公司 | External traditional Chinese medicine compound ointment for treating diabetic wound disunion and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101057942B (en) | 2010-10-06 |
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