CN1899500A

CN1899500A - Acne clearing decoction

Info

Publication number: CN1899500A
Application number: CN 200610045395
Authority: CN
Inventors: 丛吉兵
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-07-03
Filing date: 2006-07-03
Publication date: 2007-01-24
Anticipated expiration: 2026-07-03
Also published as: CN100434107C

Abstract

The present invention belongs to the field of Chinese medicine preparation technology, and is especially acne clearing decoction prepared with honeysuckle, dandelion, skullcap root, phellodendron bark, cape jasmine, anemarrhena and other nine kinds of Chinese medicinal materials in certain weight proportion. The acne clearing decoction can heal acne effectively, and has high effective rate, unique recipe, no toxic side effect and less recurrence.

Description

Acne clearing decoction

Technical field

The invention belongs to the field of Chinese medicines, the medicine of the treatment acne whelks that particularly a kind of pure Chinese medicine is made.

Background technology

Along with the raising of people's living standard, the increase of high oils and fats, higher fatty acid, high protein and maror intake adds irregular, the oily skin of life, easily causes hair follicle to block, and causes the chronic skin infringement of sebaceous gland, is common in adolescence.Its skin lesion is the pleomorphism performance, generally is divided into inflammatory and non-inflammatory lesions two big classes.Cutaneous inflammatory lesion comprises: pimple, pustule, tuberosity and cyst; The non-inflammatory skin lesion comprises: hoary hair's acne and blackhead.It is documented, in two kinds of skin lesion of the acne of acne vulgaris and pustule, the Separation Research result of antibacterial shows: with Cuo bleb propionibacterium, staphylococcus aureus, staphylococcus epidermidis and white pityrosporum furfur serves as that wherein propionibacterium acnes is main pathogenic bacterium at most.Chinese medicine also early has description for acne, and " General Treatise on the Cause and Symptoms of Diseases " said: " the acne vulgaris person has wind heat gas to give birth to skin ulcer on the meaning face, head as rice are big, and also big as paddy, white person is." say in " medical science gold mirror rosacea caused by lung-wind " for another example: " this card is formed by the lung meridian heat in blood, and every is played broken pimple in the face nose, and shape such as broomcorn millet are considered to be worth doing, and red complexion swells and ache, and breaks out white lead juice, with the passing of time all becomes white scales, shape such as Semen Panici miliacei white scales------.”

In the western medical treatment, adopt spironolactone, metronidazole, minocycline to treat at present mostly, but curative effect is not remarkable.

Summary of the invention

The object of the present invention is to provide a kind of acne clearing decoction that is made by pure Chinese medicine, evident in efficacy, the cure rate height.

The present invention realizes like this:

Acne clearing decoction is characterized in that it is that component by the following weight proportioning is made: Flos Lonicerae 20-30, Herba Taraxaci 20-40, Radix Scutellariae 6-20, Cortex Phellodendri 6-20, cupboard 6-20, Rhizoma Anemarrhenae 6-20, Radix Rehmanniae 10-20, Radix Salviae Miltiorrhizae 10-20, Pericarpium Citri Reticulatae 10-20, Radix Arnebiae (Radix Lithospermi) 10-20, Spina Gleditsiae 10-20, Radix Angelicae Dahuricae 10-20, Rhizoma Atractylodis 10-20, Cortex Moutan 10-20 and Radix Glycyrrhizae 10-20.

Modern western medicine is thought, primary disease main and androgen and sebaceous gland hyperfunctioning, and the growing of microorganism in the hair follicle sebum, it is relevant that host's immunologic function is low etc.Chinese medicine thinks, lung-wind syndrome, acne, three of rosaceas are of the same race, and acne belong to lung, the slag nose belongs to spleen, always belongs to due to heat in blood stasis do not loose.Modern Chinese medicine is learned and is thought that the face nose belongs to lung, and wind and heat in the lung meridian, fumigation can cause the generation of acne in skin; Most of patients sweet tooth and greasy pungent product easily cause accumulateing in the damp-heat in the spleen and stomach, gastrointestinal dysfunction, and accumulation of heat becomes the stasis of blood to become poison, and the extrernal resistance skin then is an erythra, so work as lung taste intestinal in the treatment with clear.

Therapeutic scheme of the present invention is based on motherland's traditional medicine to pathogenetic understanding of acne and Therapeutic Principle, selected Chinese medicinal material, adopt unique formula, in conjunction with the modern pharmacological research achievement, form according to theory of Chinese medical science science compatibility, compatibility is reasonable, the selection science, and each Chinese medicine of distinguishing the flavor of is collaborative, to reach optimum curative effect.

After the present invention adopts such scheme, be pure Chinese medicinal preparation, the medication uniqueness can effectively be treated acne whelks, and is evident in efficacy, has no side effect, and obvious effective rate reaches more than 76%, and total effective rate reaches more than 94%, and is difficult for recurrence.

Modern pharmacological research proves:

Flos Lonicerae, Radix Scutellariae, Radix Salviae Miltiorrhizae, heat clearing away accompanies, dampness, invigorating blood circulation is monarch drug.Wherein, cold in nature, the heat-clearing and toxic substances removing of Flos Lonicerae sweet in the mouth, single swollen with treating the treatment furuncle; The Radix Scutellariae sweet in the mouth is cold in nature, heat clearing and damp drying, eliminating fire and detoxication; Radix Salviae Miltiorrhizae bitter in the mouth cold nature is invigorated blood circulation, blood stasis dispelling, the removing heat from blood eliminating carbuncle.

Herba Taraxaci, Cortex Phellodendri, Fructus Gardeniae heat-clearing and toxic substances removing, Radix Arnebiae (Radix Lithospermi), Radix Rehmanniae, Cortex Moutan removing heat from blood and promoting blood circulation are ministerial drug altogether.Wherein, the Herba Taraxaci bitter but sweet flavor is cold in nature, and the effect of heat-clearing and toxic substances removing, dampness removing is arranged, and associates with Flos Lonicerae, can strengthen the effect of Flos Lonicerae heat-clearing and toxic substances removing; The Cortex Phellodendri bitter in the mouth is cold in nature, and clearing away damp-heat, pathogenic fire purging poison are associated with Rhizoma Atractylodis, the Rhizoma Anemarrhenae, and heat clearing and damp drying brings out the best in each other; The Fructus Gardeniae bitter in the mouth is cold in nature, clearing away heat-damp and promoting diuresis, pathogenic fire purging relieving restlessness, removing pathogenic heat from blood and toxic substance from the body; The Radix Arnebiae (Radix Lithospermi) sweet in the mouth is cold in nature, and removing heat from blood and promoting blood circulation, detoxifcation rash are associated with Radix Salviae Miltiorrhizae, can strengthen the removing heat from blood and promoting blood circulation effect of Radix Salviae Miltiorrhizae.The Radix Rehmanniae bitter but sweet flavor is cold in nature, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Cortex Moutan bitter in the mouth suffering, cold nature, clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, normal and Flos Lonicerae, Herba Taraxaci are associated with, and it is flourishing to control fire-toxin, carbuncle sore tumefacting virus.

Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae, Rhizoma Atractylodis invigorating the spleen and regulating the stomach, drying dampness to eliminate phlegm; Rhizoma Anemarrhenae Chong and Ren Meridians regulating is adjuvant drug altogether.Wherein, Pericarpium Citri Reticulatae bitter in the mouth suffering, warm in nature, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Rhizoma Atractylodis acrid in the mouth bitterness temperature, drying damp and strengthening spleen, expelling wind and removing dampness is associated with Cortex Phellodendri, can strengthen the effect of monarch drug heat clearing and damp drying, and its property that can help the cold medicine of system warm in nature; Radix Angelicae Dahuricae acrid in the mouth is warm in nature, expelling pathogenic wind from the body surface, evacuation of pus, reducing swelling and alleviating pain.The Radix Angelicae Dahuricae is the many usefulness of a medicine in the side, and its acrid in the mouth and walk table has priming to reach the meaning of table, is to be messenger drug; It is warm in nature, and the property of the cold medicine of assistant system is arranged, and is again adjuvant drug; Control the skin ulcer rash, from the beginning of dissipating, can evacuation of pus after bursting.Rhizoma Anemarrhenae bitter but sweet flavor, cold in nature, clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, Chong and Ren Meridians regulating.

The Radix Glycyrrhizae detoxifcation, coordinating the actions of various ingredients in a prescription is messenger drug.The Radix Glycyrrhizae sweet in the mouth is flat, QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, relieving spasm to stop pain, the mediation property of medicine.

We adopt traditional Chinese medical science combination principle, and monarch is made a distinction between the important and the lesser one, and plays the effect of heat clearing away noxious dryness, dampness, removing heat from blood and promoting blood circulation altogether, reaches the purpose of effective treatment acne whelks.

The specific embodiment

Below in conjunction with embodiment the present invention is elaborated.

Embodiment 1.Choose Flos Lonicerae 25 grams, Herba Taraxaci 30 grams, Radix Scutellariae 9 grams, Cortex Phellodendri 9 grams, Fructus Gardeniae 9 grams, the Rhizoma Anemarrhenae 9 grams, Radix Rehmanniae 15 grams, Radix Salviae Miltiorrhizae 15 grams, Pericarpium Citri Reticulatae 15 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Spina Gleditsiae 9 grams, the Radix Angelicae Dahuricae 9 grams, Rhizoma Atractylodis 9 grams, Cortex Moutan 15 grams and Radix Glycyrrhizae 9 grams respectively, with being decocted in water for oral dose, filter the about 400ml of stock solution, one twice-daily, a 200ml, one month is a course of treatment, can effectively treat acne whelks.

Embodiment 2.Choose Flos Lonicerae 20 grams, Herba Taraxaci 40 grams, Radix Scutellariae 6 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 6 grams, the Rhizoma Anemarrhenae 20 grams, Radix Rehmanniae 10 grams, Radix Salviae Miltiorrhizae 20 grams, Pericarpium Citri Reticulatae 10 grams, Radix Arnebiae (Radix Lithospermi) 20 grams, Spina Gleditsiae 10 grams, the Radix Angelicae Dahuricae 20 grams, Rhizoma Atractylodis 10 grams, Cortex Moutan 20 grams and Radix Glycyrrhizae 10 grams respectively, with being decocted in water for oral dose, filter the about 400ml of stock solution, one twice-daily, a 200ml, one month is a course of treatment, can effectively treat acne whelks.

Embodiment 3.Choose Flos Lonicerae 30 grams, Herba Taraxaci 20 grams, Radix Scutellariae 20 grams, Cortex Phellodendri 6 grams, Fructus Gardeniae 20 grams, the Rhizoma Anemarrhenae 6 grams, Radix Rehmanniae 20 grams, Radix Salviae Miltiorrhizae 100 grams, Pericarpium Citri Reticulatae 20 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Spina Gleditsiae 20 grams, the Radix Angelicae Dahuricae 10 grams, Rhizoma Atractylodis 20 grams, Cortex Moutan 10 grams and Radix Glycyrrhizae 20 grams respectively, with being decocted in water for oral dose, filter the about 400ml of stock solution, one twice-daily, a 200ml, one month is a course of treatment, can effectively treat acne whelks.

Clinical trial

For verifying curative effect of the present invention, the inventor has carried out following clinical trial in 2000-2004 in Donga, Shandong Province county institute of traditional Chinese medicine:

1, clinical data

Select tardy property patients with acne 69 examples of age 〉=20 year old, be divided into two groups at random.One group is the treatment group, amounts to 39 examples; Another group is matched group, amounts to 30 examples.

The treatment group, the age is at 20-37 between year, and average 28.2 years old, course of disease 1-9.Wherein male 14 examples, women 25 examples.

Table one, treatment group state of an illness situation

The slight state of an illness		The moderate state of an illness		The severe state of an illness		Add up to
The slight state of an illness		The moderate state of an illness		The severe state of an illness		Add up to	Number (example)	Ratio (%)	Number (example)	Ratio (%)	Number (example)	Ratio (%)	39 examples
21	53.8	17	43.6	1	2.6		Number (example)	Ratio (%)	Number (example)	Ratio (%)	Number (example)	Ratio (%)

Matched group, the age is at 20-38 between year, and average 28.7 years old, course of disease 1-10.Wherein male 12 examples, women 18 examples.

Table two, matched group state of an illness situation

The slight state of an illness		The moderate state of an illness		The severe state of an illness		Add up to
The slight state of an illness		The moderate state of an illness		The severe state of an illness		Add up to	Number (example)	Ratio (%)	Number (example)	Ratio (%)	Number (example)	Ratio (%)	30 examples
17	56.7	12	40	1	3.3		Number (example)	Ratio (%)	Number (example)	Ratio (%)	Number (example)	Ratio (%)

From table one, table two as can be seen, the treatment group is compared with the matched group state of an illness, and there was no significant difference has comparability.

2, Therapeutic Method

The treatment group adopts medicine of the present invention, the usefulness that is decocted in water for oral dose, and potion on the one, potion 400ml divides secondary to take, and be a course of treatment January.

Matched group adopts spironolactone 20mg, metronidazole 20mg, minocycline 50mg, and oral, every day, secondary was oral, and be a course of treatment January.

3, curative effect judging standard

Produce effects: clinical cure, skin lesion all disappears, and subjective symptoms disappears or leaves pigmentation and cicatrix;

Effectively: skin lesion disappears more than 30%, and subjective symptoms obviously alleviates;

Invalid: the equal no change of skin lesion and symptom, the skin lesion less than 30% that disappears.

4, therapeutic outcome

Table three, therapeutic outcome

	Produce effects	Effectively	Invalid	Add up to
	Produce effects	Effectively	Invalid	Add up to	The treatment group	30	7	2	39
Matched group	10	9	11	30	The treatment group	30	7	2	39

As can be seen from Table III:

One, treatment group obvious effective rate is 76.9%, and effective percentage is 17.9%, and total effective rate is 94.9%;

Two, the matched group obvious effective rate is 33.3%, and effective percentage is 30%, and total effective rate is 63.3%.

5, testing data

Serum sex hormone level relatively before and after table four, the treatment

		Estradiol (E2)	Testosterone (T)	Progesterone (P)	Lactotropin (PRL)	Follicule-stimulating hormone (FSH) (FSH)	Lutropin (LH)
		Estradiol (E2)	Testosterone (T)	Progesterone (P)	Lactotropin (PRL)	Follicule-stimulating hormone (FSH) (FSH)	Lutropin (LH)	The treatment group	Before the treatment	253.61± 181.33	2.97± 1.49	3.12± 4.93	12.22± 11.23	13.10± 9.87	18.9± 15.15
After the treatment	249.56± 178	1.36± 0.72	2.96± 4.87	11.95± 10.73	12.61± 8.91	19.05± 14.21			Before the treatment	253.61± 181.33	2.97± 1.49	3.12± 4.93	12.22± 11.23	13.10± 9.87	18.9± 15.15
After the treatment	249.56± 178	1.36± 0.72	2.96± 4.87	11.95± 10.73	12.61± 8.91	19.05± 14.21	P		＞0.05	＜0.01	＞0.05	＞0.05	＞0.05	＞0.05
Matched group	Before the treatment	248.33± 131.10	2.94± 1.42	3.16± 4.73	13.12± 12.26	13.40± 9.91	P		＞0.05	＜0.01	＞0.05	＞0.05	＞0.05	＞0.05	18.71± 15.32
	Before the treatment	248.33± 131.10	2.94± 1.42	3.16± 4.73	13.12± 12.26	13.40± 9.91	After the treatment	246.91± 129.6	1.52± 0.78	3.11± 4.55	12.72± 11.14	13.14± 8.97	18.41± 15.17		18.71± 15.32
	P	＞0.05	＜0.01	＞0.05	＞0.05	＞0.05	After the treatment	246.91± 129.6	1.52± 0.78	3.11± 4.55	12.72± 11.14	13.14± 8.97	18.41± 15.17	＞0.05

As can be seen from Table IV:

One, treatment group, matched group are compared, and serum sex hormone level there are no significant difference has comparability before the treatment;

Two, treatment group, matched group are compared, and after the treatment, treatment group level obviously is better than matched group.

6, conclusion

Medicine of the present invention can effectively be treated acne whelks, and is evident in efficacy, obvious effective rate and total effective rate height.

7, concrete case

Below for to utilize the present invention to treat the concrete case of acne:

Example 1. Korea Spro * *, the woman, 22 years old, in JIUYUE, 2003 first visit, the patient has a liking for sweet food, over nearly 3 months, facial area and chest and back etc. locates often to distribute pimple as thorn, the adularescent that the squeezes sample opaque of cracking rice, irrelevant with menstrual cycle, go to a doctor in Donga County institute of traditional Chinese medicine, be diagnosed as acne whelks, adopt Drug therapy of the present invention.Took 10 days, symptom obviously disappears, and continues and obeys 20 days, clinical cure.Follow up a case by regular visits to and do not have the recurrence sign in 1 year.

Example 2. kings * *, the man, 21 years old, in February, 2003 morbidity, face portion, cervical region cover with acne, and band pus born of the same parents go to a doctor in Donga County institute of traditional Chinese medicine, are diagnosed as acne whelks, adopt Drug therapy of the present invention 10 days, and symptom is obviously improved, and continues and obeys 15 days, the symptom complete obiteration.Follow up a case by regular visits to and do not have recurrence in 1 year.

Example 3. Chu * *, the woman, 24 years old, in February, 2000 morbidity, forehead chin length has acne, the twinge of pinprick formula, red and swollen uncomfortable, go to a doctor in Donga County institute of traditional Chinese medicine, be diagnosed as acne whelks, adopted Drug therapy of the present invention 10 days, sx continues and obeyed 1 month, transference cure, clinical cure.Followed up a case by regular visits to 2 years, all normal.

Claims

1, acne clearing decoction is characterized in that it is that component by the following weight proportioning is made:

Flos Lonicerae 20-30, Herba Taraxaci 20-40, Radix Scutellariae 6-20, Cortex Phellodendri 6-20, Fructus Gardeniae 6-20, Rhizoma Anemarrhenae 6-20, Radix Rehmanniae 10-20, Radix Salviae Miltiorrhizae 10-20, Pericarpium Citri Reticulatae 10-20, Radix Arnebiae (Radix Lithospermi) 10-20, Spina Gleditsiae 10-20, Radix Angelicae Dahuricae 10-20, Rhizoma Atractylodis 10-20, Cortex Moutan 10-20 and Radix Glycyrrhizae 10-20.

2, acne clearing decoction according to claim 1 is characterized in that the weight proportion of above-mentioned component is:

Flos Lonicerae 25, Herba Taraxaci 30, Radix Scutellariae 9, Cortex Phellodendri 9, Fructus Gardeniae 9, the Rhizoma Anemarrhenae 9, Radix Rehmanniae 15, Radix Salviae Miltiorrhizae 15, Pericarpium Citri Reticulatae 15, Radix Arnebiae (Radix Lithospermi) 15, Spina Gleditsiae 9, the Radix Angelicae Dahuricae 9, Rhizoma Atractylodis 9, Cortex Moutan 15 and Radix Glycyrrhizae 9.