CN101036721A - Deer fetus capsule and its production process - Google Patents
Deer fetus capsule and its production process Download PDFInfo
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- CN101036721A CN101036721A CNA2007100720106A CN200710072010A CN101036721A CN 101036721 A CN101036721 A CN 101036721A CN A2007100720106 A CNA2007100720106 A CN A2007100720106A CN 200710072010 A CN200710072010 A CN 200710072010A CN 101036721 A CN101036721 A CN 101036721A
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Abstract
Soft capsule of deer fetus and a preparing method therefore are disclosed. The invention relates to a health product of deer fetus and a preparing method therefor, due to existing deer fetus soft capsule has on curative effect for diseases of male kidney-qi deficiency, cough and sputum, etc. The deer fetus soft capsule of the invention is formed, based on weight ratio, by 600-800 deer fetus and 30-40 Chinese herbal medicine which comprises 5-10 panax ginseng, 5-10 tuckahoe, 10-15 prepared radix rehmanniae, 10-15 hemlock parsley, 10-15 radix paeoniae alba, 10-15 liquorice, 5-10 herba gynostemae, 10-15 cistanche salsa, 10-15 fructus lycii and 10-15 deerhorn glue, based on weight ratio. The preparing method includes: adding NaCl solution into minced deer fetus to obtain supernatant fluid thereof; adding edible alcohol into the deposit, separating the filtrate and the residue; adding phosphate buffer solution jordaning and papain into the residue, taking out the supernatant fluid; mixing the Chinese herbal medicine filtrate and the supernatant fluid filtrate to form micropowder and suspension, finally pelleting. The soft capsule of deer fetus has high bioavailability and exact content, and the preparing method is easy for operating.
Description
Technical field
The present invention relates to a kind of Embryo cervi health product and manufacture method thereof.
Background technology
The history that Embryo cervi is used as medicine is of long duration, and ancient Chinese prescription just once had relevant record, and deer is according to record in " Mingyi Bielu ", and Embryo cervi is the in love product of flesh and blood, the most nourishing.Modern medicine study proves: contain the Embryo cervi polypeptide protein in the Embryo cervi, embryonic stem cell, special dietary composition and bioactive substances such as natural placenta factor also are rich in 18 seed amino acids, 22 kinds of trace element, vitamin A, B1, B2, estrone, estradiol and 6 kinds of specific liposoluble acid and ketoestradiol, glutathione and deer cell active factor etc.Embryo cervi is sweet, and Wen Wusu goes into three of livers, stomach, the heart, kidney-reinforcing Yang-strengthening, tonify deficiency spermatogenesis are arranged, control deficient, congestion does not go out, the effect of women frigid zone, bleeding not during menses, menoxenia, blood deficiency cold in blood, is the key medicine of temperature compensation essence and blood.In recent years, the relevant pharmaceuticals industry and the Producers of aquaculture are started with from the research and development of Embryo cervi goods and have been done a large amount of work, and have developed products such as deer fetus capsule, BAZHEN LUTAI KELI, deer fetus-pearl capsule, Embryo cervi paste.And patent publication No. is CN 1799590A, patent disclosure day to be that 30 days application for a patent for invention of December in 2004 discloses a kind of " deer fetus capsule and manufacture method thereof ", because this deer fetus capsule adopts Six-element Chinese herbal medicine and Embryo cervi compatibility, be mainly used in the treatment gynaecopathia, and diseases such as male's deficiency of kidney-QI, eliminating phlegm and stopping cough be there is no the obvious treatment effect.
Summary of the invention
The purpose of this invention is to provide a kind of deer fetus capsule and manufacture method thereof, it can solve existing deer fetus capsule there is no the obvious treatment effect to diseases such as male's deficiency of kidney-QI, eliminating phlegm and stopping cough problem.
Deer fetus capsule of the present invention is made up of according to ratio of weight and number following component: 600～800 parts of Embryo cervi, 30～40 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 5～10 parts of Radix Ginsengs, 5～10 parts in Poria, 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts in Radix Glycyrrhizae, 5～10 parts of Herb Gynostemmae Pentaphyllis, 10～15 parts of Herba Cistanches, 10～15 parts of Fructus Lycii, 10～15 parts of Colla cornus cervis; The manufacture method of deer fetus capsule of the present invention is finished by following steps: one, get 600～800 parts of Embryo cervi, 30～40 parts of Chinese herbal medicine according to ratio of weight and number; Earlier described Embryo cervi is cleaned, it is rotten that the unhairing post processing becomes, and adds the NaCl solution of 4～7 times of weight in the Embryo cervi gruel, and the concentration of NaCl solution is 8～10%, lixiviate 10～30min, and centrifugalize then, rotating speed is 4000～6000r/min, it is standby to get supernatant; Two, add the edible ethanol and the lixiviate 60～120h of 4～9 times of weight in the precipitate that step 1 obtains, the concentration of edible ethanol is 50～70%, filters, isolates filtrate and residue, filtrate for later use; Three, the phosphate buffer solution jordaning that in resulting residue, adds 4～7 times of weight, the concentration of phosphate buffer is 5～7%, in serosity, add papain again, make and contain 120～180I.U/g albumen in the serosity, and, be warmed up to 90～100 ℃ through behind 55～70 ℃ of constant temperature hydrolysis 3～7h, lixiviate 30～50min, centrifugalize then, rotating speed is 4000～6000r/min, it is standby to get supernatant; Four, the ratio of weight and number of Embryo cervi described in one and Chinese herbal medicine is chosen 30～40 parts of Chinese herbal medicine set by step, and described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 5～10 parts of Radix Ginsengs, 5～10 parts in Poria, 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts in Radix Glycyrrhizae, 5～10 parts of Herb Gynostemmae Pentaphyllis, 10～15 parts of Herba Cistanches, 10～15 parts of Fructus Lycii, 10～15 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 25～45: 55～75 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, when falling liquid film is concentrated into mixing preparation 1/2～1/3 of volume, be spray dried to micropowder then again; Five, be that 1: 0.25～0.45 ratio is made suspension with soybean oil and described micropowder according to ratio of weight and number, adhesive tape is made in the gelatin allotment, adds on adhesive tape that suspension is filled pelleting, drying is made.
The present invention has following beneficial effect: one, the present invention is in conjunction with modern biochemical technology on the basis of motherland's tradition Chinese medicine theory, adopt enzymatic isolation method water-soluble with in the Embryo cervi, the liposoluble component extracts to greatest extent, effectively kept its physiologically active ingredient, zoopery shows, the biological activity of so resulting product of extracting mode is higher, can promote the growth promoter and the metabolism of body, enhancing body's immunological function, to healthy skin care, nervous system, cardiovascular system all has good regulating action, help to recover and keep body health, especially in resisting fatigue, aspects such as human body immunity improving power obviously are better than the product that adopts traditional handicraft to make.Two, the Radix Paeoniae Alba in Embryo cervi extracting solution and the Chinese herbal medicine, Radix Rehmanniae Preparata, Fructus Lycii, the compatible synergism of Colla cornus cervi extracting solution have extremely strong nourishing YIN and supplementing blood, warming the liver the kidney invigorating, the effect of regulating menstruation analgesic, especially symptoms such as women's deficiency-cold of uterus, bleeding not during menses, blood deficiency and yellow complexion, dizzy, cardiopalmus, insomnia and male's deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, night sweat, seminal emission are had splendid therapeutic efficiency.Three, the Radix Ginseng in Embryo cervi extracting solution and the Chinese herbal medicine, the compatible synergism of Herba Cistanches extracting solution have stronger resisting fatigue, antitonic, cold-resistant, the content that increases blood plasma thyroliberin (ACTH) under appetite, fat-reducing, the increase emergency rating, have tangible defying age, antiulcer action.Four, the compatible synergism of Poria extracting solution in Embryo cervi extracting solution and the Chinese herbal medicine have stronger reduce phlegm, mind tranquilizing and the heart calming, diuretic actions.Five, the Rhizoma Chuanxiong in Embryo cervi extracting solution and the Chinese herbal medicine, Radix Glycyrrhizae, the compatible synergism of Herb Gynostemmae Pentaphylli extracting solution have the effect of stronger heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, calmness, beauty treatment, promoting blood circulation and stopping pain.Six, Embryo cervi is the important pharmaceutical raw material of traditional Chinese medicine, Embryo cervi comprises curing bag (fetus, Placenta Hominis and amniotic fluid) and the nascent fetus of obtaining from the doe abdomen of gestation intermediary and later stages, Embryo cervi has spleen invigorating spermatogenesis, emerging positive tonification, controls effects such as deficient tuberculosis, blood deficiency damage of essence, menoxenia, deficiency and coldness, bleeding not during menses.Modern medicine study proves: contain 18 seed amino acids and zinc, selenium and other trace elements in the Embryo cervi, available it nourish appearance, health invigorating, often protect the youth.The compatible synergism of extracts of Chinese herbal medicine that Embryo cervi extracting solution and Radix Ginseng, Poria, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Glycyrrhizae, Herb Gynostemmae Pentaphylli, Herba Cistanches, Fructus Lycii, Colla cornus cervi boil gained through decocting has the effect of stronger nourishing YIN and supplementing blood, warming the liver the kidney invigorating, regulating menstruation analgesia, promoting blood circulation to restore menstrual flow, deficiency of kidney-QI, asthenia weakness and emaciation, be middle-aged and elderly people, the empty many patients group's of body first-selected nutrient health particularly.Seven, manufacture method of the present invention simply, operate, be easy to large-scale industrial production easily, deer fetus capsule by manufacture method production of the present invention, its bioavailability height, content are accurate, every deer fetus capsule weighs 0.5～1g, and the raw material good uniformity, and taking convenience, be easy to preserve.
The specific embodiment
The specific embodiment one: the deer fetus capsule of present embodiment is made up of according to ratio of weight and number following component: 600～800 parts of Embryo cervi, 30～40 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 5～10 parts of Radix Ginsengs, 5～10 parts in Poria, 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts in Radix Glycyrrhizae, 5～10 parts of Herb Gynostemmae Pentaphyllis, 10～15 parts of Herba Cistanches, 10～15 parts of Fructus Lycii, 10～15 parts of Colla cornus cervis
The specific embodiment two: the difference of the present embodiment and the specific embodiment one is: the deer fetus capsule of present embodiment is made up of according to ratio of weight and number following component: 700 parts of Embryo cervi, 35 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 7 parts of Radix Ginsengs, 8 parts in Poria, 13 parts of Radix Rehmanniae Preparata, 13 parts of Rhizoma Chuanxiongs, 12 parts of the Radix Paeoniae Albas, 12 parts in Radix Glycyrrhizae, 8 parts of Herb Gynostemmae Pentaphyllis, 13 parts of Herba Cistanches, 12 parts of Fructus Lycii, 13 parts of Colla cornus cervis.Take the deer fetus capsule of this kind combination, it is effective, and effective percentage is best of breed up to 90%.
The specific embodiment three: the difference of the present embodiment and the specific embodiment one is: the deer fetus capsule of present embodiment is made up of according to ratio of weight and number following component: 600 parts of Embryo cervi, 30 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 5 parts of Radix Ginsengs, 5 parts in Poria, 10 parts of Radix Rehmanniae Preparata, 10 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 10 parts in Radix Glycyrrhizae, 5 parts of Herb Gynostemmae Pentaphyllis, 10 parts of Herba Cistanches, 10 parts of Fructus Lycii, 10 parts of Colla cornus cervis.Take the deer fetus capsule of this kind combination, effective percentage reaches 50%.
The specific embodiment four: the difference of the present embodiment and the specific embodiment one is: the deer fetus capsule of present embodiment is made up of according to ratio of weight and number following component: 800 parts of Embryo cervi, 40 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 10 parts of Radix Ginsengs, 10 parts in Poria, 15 parts of Radix Rehmanniae Preparata, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radix Paeoniae Albas, 15 parts in Radix Glycyrrhizae, 10 parts of Herb Gynostemmae Pentaphyllis, 15 parts of Herba Cistanches, 15 parts of Fructus Lycii, 15 parts of Colla cornus cervis.The deer fetus capsule effect of taking this kind combination is better, and effective percentage reaches 70%, is preferable combination.
The specific embodiment five: the manufacture method of the deer fetus capsule of present embodiment is finished by following steps: one, get 600～800 parts of Embryo cervi, 30～40 parts of Chinese herbal medicine according to ratio of weight and number; Earlier described Embryo cervi is cleaned, it is rotten that the unhairing post processing becomes, and adds the NaCl solution of 4～7 times of weight in the Embryo cervi gruel, and the concentration of NaCl solution is 8～10%, lixiviate 10～30min, and centrifugalize then, rotating speed is 4000～6000r/min, it is standby to get supernatant; Two, add the edible ethanol and the lixiviate 60～120h of 4～9 times of weight in the precipitate that step 1 obtains, the concentration of edible ethanol is 50～70%, filters, isolates filtrate and residue, filtrate for later use; Three, the phosphate buffer solution jordaning that in resulting residue, adds 4～7 times of weight, the concentration of phosphate buffer is 5～7%, in serosity, add papain again, make and contain 120～180I.U/g albumen in the serosity, and, be warmed up to 90～100 ℃ through behind 55～70 ℃ of constant temperature hydrolysis 3～7h, lixiviate 30～50min, centrifugalize then, rotating speed is 4000～6000r/min, it is standby to get supernatant; Four, the ratio of weight and number of Embryo cervi described in one and Chinese herbal medicine is chosen 30～40 parts of Chinese herbal medicine set by step, and described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 5～10 parts of Radix Ginsengs, 5～10 parts in Poria, 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts in Radix Glycyrrhizae, 5～10 parts of Herb Gynostemmae Pentaphyllis, 10～15 parts of Herba Cistanches, 10～15 parts of Fructus Lycii, 10～15 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 25～45: 55～75 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, when falling liquid film is concentrated into mixing preparation 1/2～1/3 of volume, be spray dried to micropowder then again; Five, be that 1: 0.25～0.45 ratio is made suspension with soybean oil and described micropowder according to ratio of weight and number, adhesive tape is made in the gelatin allotment, adds suspension and fill pelleting on adhesive tape, and drying, check, packing are made finished product.
The specific embodiment six: the difference of the present embodiment and the specific embodiment five is: present embodiment is got 700 parts of Embryo cervi, 35 parts of Chinese herbal medicine according to ratio of weight and number in step 1; Add the NaCl solution of 5.5 times of weight in the Embryo cervi gruel of making, the concentration of NaCl solution is 10%, lixiviate 20min, and centrifugalize then, rotating speed is 5000r/min, it is standby to get supernatant; In step 2, in the precipitate that step 1 obtains, add the edible ethanol and the lixiviate 90h of 6.5 times of weight, the concentration of edible ethanol is 60%, filters, isolates filtrate and residue, filtrate for later use; In step 3, the phosphate buffer solution jordaning that in resulting residue, adds 5.5 times of weight, the concentration of phosphate buffer is 6%, adds papain again in serosity, makes and contains 150I.U/g albumen in the serosity, and through behind 60 ℃ of constant temperature hydrolysis 5h, be warmed up to 95 ℃, lixiviate 40min, centrifugalize then, rotating speed is 5000r/min, and it is standby to get supernatant; In step 4, the ratio of weight and number of Embryo cervi described in one and Chinese herbal medicine is chosen 35 parts of Chinese herbal medicine set by step, and described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 7 parts of Radix Ginsengs, 8 parts in Poria, 13 parts of Radix Rehmanniae Preparata, 13 parts of Rhizoma Chuanxiongs, 12 parts of the Radix Paeoniae Albas, 12 parts in Radix Glycyrrhizae, 8 parts of Herb Gynostemmae Pentaphyllis, 13 parts of Herba Cistanches, 12 parts of Fructus Lycii, 13 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 35: 65 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, again when falling liquid film is concentrated into mixing preparation 40% of volume; In step 5, be that 1: 0.35 ratio is made suspension according to ratio of weight and number with soybean oil and described micropowder.This kind extracting method is the best approach, and extract purity is up to 95%, less wastage, effective.
Table 1 is the deer fetus capsule treatment Deficiency and coldness of spleen and stomach in the present embodiment, the clinical pharmacodynamics report of asthenia weakness and emaciation.
Deficiency and coldness of spleen and stomach, asthenia weakness and emaciation person to 30 16～62 years old age of example treat, and taking 15～30 days symptoms of deer fetus capsule can have clear improvement, and only need take 1～2 every day, and its effective percentage is up to 100%, and cure rate reaches 95%.The effect of deer fetus capsule treatment Deficiency and coldness of spleen and stomach, asthenia weakness and emaciation is as shown in table 1, and wherein the diagnosis that regular hospital provides is accepted and believed in state of an illness diagnosis.
Table 1
| Sequence number | Age | Sex | Disease or symptom | The use capsule (my god) | Therapeutic effect |
| 1 | 55 | The man | Deficiency and coldness of spleen and stomach | 26 | Cure |
| 2 | 42 | The woman | Deficiency and coldness of spleen and stomach | 25 | Cure |
| 3 | 26 | The woman | Deficiency and coldness of spleen and stomach | 26 | Cure |
| 4 | 29 | The woman | Deficiency and coldness of spleen and stomach | 24 | Cure |
| 5 | 38 | The woman | The asthenia weakness and emaciation | 25 | Cure |
| 6 | 16 | The woman | Deficiency and coldness of spleen and stomach | 18 | Cure |
| 7 | 60 | The man | Deficiency and coldness of spleen and stomach | 27 | Effectively |
| 8 | 18 | The woman | Deficiency and coldness of spleen and stomach | 15 | Cure |
| 9 | 60 | The man | Deficiency and coldness of spleen and stomach | 28 | Cure |
| 10 | 58 | The man | Deficiency and coldness of spleen and stomach | 30 | Cure |
| 11 | 49 | The man | Deficiency and coldness of spleen and stomach | 30 | Cure |
| 12 | 49 | The woman | Deficiency and coldness of spleen and stomach | 26 | Cure |
| 13 | 50 | The man | The asthenia weakness and emaciation | 28 | Cure |
| 14 | 56 | The man | The asthenia weakness and emaciation | 27 | Effectively |
| 15 | 44 | The man | The asthenia weakness and emaciation | 26 | Cure |
| 16 | 48 | The man | The asthenia weakness and emaciation | 28 | Cure |
| 17 | 44 | The man | Deficiency and coldness of spleen and stomach | 29 | Cure |
| 18 | 38 | The man | Deficiency and coldness of spleen and stomach | 29 | Cure |
| 19 | 58 | The woman | Deficiency and coldness of spleen and stomach | 30 | Cure |
| 20 | 54 | The man | Deficiency and coldness of spleen and stomach | 28 | Cure |
| 21 | 55 | The woman | Deficiency and coldness of spleen and stomach | 27 | Cure |
| 22 | 51 | The man | Deficiency and coldness of spleen and stomach | 26 | Cure |
| 23 | 49 | The man | Deficiency and coldness of spleen and stomach | 29 | Cure |
| 24 | 53 | The man | Deficiency and coldness of spleen and stomach | 29 | Cure |
| 25 | 53 | The woman | The asthenia weakness and emaciation | 25 | Cure |
| 26 | 42 | The man | The asthenia weakness and emaciation | 26 | Cure |
| 27 | 58 | The man | The asthenia weakness and emaciation | 28 | Cure |
| 28 | 49 | The man | The asthenia weakness and emaciation | 29 | Cure |
| 29 | 47 | The woman | The asthenia weakness and emaciation | 27 | Cure |
| 30 | 62 | The man | The asthenia weakness and emaciation | 30 | Cure |
Table 2 is the deer fetus capsule treatment menoxenia in the present embodiment, women deficiency and coldness person's clinical pharmacodynamics report.
To 20 the example 25～60 years old age menoxenia, women deficiency and coldness person treat, take 30～45 days symptoms of deer fetus capsule and have bigger improvement, only need take 2 every day, every day secondary, each 1, its effective percentage is up to 100%, cure rate is higher than 70%.The effect of deer fetus capsule treatment menoxenia, women's deficiency and coldness is as shown in table 2, and wherein the diagnosis that regular hospital provides is accepted and believed in state of an illness diagnosis.
Table 2
| Sequence number | Age | Sex | Disease or symptom | The use capsule (my god) | Therapeutic effect |
| 1 | 35 | The woman | Menoxenia | 35 | Cure |
| 2 | 42 | The woman | Menoxenia | 45 | Cure |
| 3 | 26 | The woman | Women's deficiency and coldness | 35 | Cure |
| 4 | 29 | The woman | Menoxenia | 34 | Cure |
| 5 | 38 | The woman | Menoxenia | 33 | Cure |
| 6 | 25 | The woman | Menoxenia | 31 | Cure |
| 7 | 60 | The woman | Women's deficiency and coldness | 40 | Effectively |
| 8 | 25 | The woman | Menoxenia | 30 | Cure |
| 9 | 60 | The woman | Women's deficiency and coldness | 45 | Cure |
| 10 | 58 | The woman | Women's deficiency and coldness | 42 | Cure |
| 11 | 49 | The woman | Menoxenia | 40 | Effectively |
| 12 | 49 | The woman | Women's deficiency and coldness | 38 | Effectively |
| 13 | 50 | The woman | Women's deficiency and coldness | 42 | Effectively |
| 14 | 56 | The woman | Women's deficiency and coldness | 43 | Effectively |
| 15 | 44 | The woman | Women's deficiency and coldness | 39 | Effectively |
| 16 | 28 | The woman | Menoxenia | 34 | Cure |
| 17 | 34 | The woman | Menoxenia | 30 | Cure |
| 18 | 38 | The woman | Menoxenia | 36 | Cure |
| 19 | 58 | The woman | Women's deficiency and coldness | 41 | Cure |
| 20 | 54 | The woman | Women's deficiency and coldness | 42 | Cure |
Table 3 is clinical pharmacodynamics reports that the deer fetus capsule in the present embodiment is treated male's deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, night sweat, insomnia, seminal emission person.
Male's deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, night sweat insomnia, seminal emission person to 30 23～55 years old age of example treat, take 30～45 days symptoms of deer fetus capsule and have bigger improvement, only need take 4 every day, every day secondary, each 2, its effective percentage is up to 100%.The effect of deer fetus capsule treatment male deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, night sweat, insomnia, seminal emission is as shown in table 3, and wherein the diagnosis that regular hospital provides is accepted and believed in state of an illness diagnosis.
Table 3
| Sequence number | Age | Sex | Disease or symptom | The use capsule (my god) | Therapeutic effect |
| 1 | 31 | The man | Deficiency of kidney-QI | 37 | Cure |
| 2 | 41 | The man | Night sweat | 37 | Cure |
| 3 | 26 | The man | Deficiency of kidney-QI | 43 | Cure |
| 4 | 27 | The man | Night sweat | 38 | Cure |
| 5 | 39 | The man | Night sweat | 39 | Cure |
| 6 | 55 | The man | Deficiency of kidney-QI | 45 | Cure |
| 7 | 34 | The man | Seminal emission | 36 | Effectively |
| 8 | 53 | The man | Insomnia | 42 | Cure |
| 9 | 55 | The man | Deficiency of kidney-QI | 44 | Cure |
| 10 | 55 | The man | Insomnia | 45 | Cure |
| 11 | 49 | The man | Night sweat | 40 | Effectively |
| 12 | 29 | The man | Seminal emission | 35 | Effectively |
| 13 | 30 | The man | Seminal emission | 32 | Cure |
| 14 | 54 | The man | Night sweat | 41 | Cure |
| 15 | 24 | The man | Seminal emission | 30 | Cure |
| 16 | 28 | The man | Seminal emission | 33 | Cure |
| 17 | 23 | The man | Night sweat | 32 | Cure |
| 18 | 28 | The man | Seminal emission | 40 | Cure |
| 19 | 55 | The man | Lumbago, carbuncle of yin nature | 43 | Cure |
| 20 | 54 | The man | Night sweat | 42 | Cure |
| 21 | 31 | The man | Night sweat | 31 | Effectively |
| 22 | 41 | The man | Lumbago, carbuncle of yin nature | 39 | Effectively |
| 23 | 26 | The man | Seminal emission | 33 | Cure |
| 24 | 27 | The man | Seminal emission | 35 | Cure |
| 25 | 39 | The man | Insomnia | 40 | Cure |
| 26 | 55 | The man | Night sweat | 44 | Cure |
| 27 | 54 | The man | Lumbago, carbuncle of yin nature | 45 | Effectively |
| 28 | 53 | The man | Lumbago, carbuncle of yin nature | 42 | Cure |
| 29 | 55 | The man | Night sweat | 44 | Cure |
| 30 | 55 | The man | Night sweat | 45 | Cure |
The specific embodiment seven: the difference of the present embodiment and the specific embodiment five is: present embodiment is got 600 parts of Embryo cervi, 30 parts of Chinese herbal medicine according to ratio of weight and number in step 1; Add the NaCl solution of 4 times of weight in the Embryo cervi gruel of making, the concentration of NaCl solution is 10%, lixiviate 10min, and centrifugalize then, rotating speed is 4000r/min, it is standby to get supernatant; In step 2, in the precipitate that step 1 obtains, add the edible ethanol and the lixiviate 60h of 4 times of weight, the concentration of edible ethanol is 50%, filters, isolates filtrate and residue, filtrate for later use; In step 3, the phosphate buffer solution jordaning that in resulting residue, adds 4 times of weight, the concentration of phosphate buffer is 5%, adds papain again in serosity, makes and contains 120I.U/g albumen in the serosity, and through behind 55 ℃ of constant temperature hydrolysis 3h, be warmed up to 90 ℃, lixiviate 30min, centrifugalize then, rotating speed is 4000r/min, and it is standby to get supernatant; In step 4, choose 30 parts of Chinese herbal medicine according to the ratio of weight and number of Embryo cervi described in the step 1 and Chinese herbal medicine, described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 5 parts of Radix Ginsengs, 5 parts in Poria, 10. parts of Radix Rehmanniae Preparata, 10 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 10 parts in Radix Glycyrrhizae, 5 parts of Herb Gynostemmae Pentaphyllis, 10 parts of Herba Cistanches, 10 parts of Fructus Lycii, 10 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 25: 75 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, again when falling liquid film is concentrated into mixing preparation 1/2 of volume; In step 5, be that 1: 0.25 ratio is made suspension according to ratio of weight and number with soybean oil and described micropowder.This kind extracting method, extract purity reaches 65%.
The specific embodiment eight: the difference of the present embodiment and the specific embodiment five is: present embodiment is got 800 parts of Embryo cervi, 40 parts of Chinese herbal medicine according to ratio of weight and number in step 1; Add the NaCl solution of 7 times of weight in the Embryo cervi gruel of making, the concentration of NaCl solution is 10%, lixiviate 30min, and centrifugalize then, rotating speed is 6000r/min, it is standby to get supernatant; In step 2, in the precipitate that step 1 obtains, add the edible ethanol and the lixiviate 120h of 9 times of weight, the concentration of edible ethanol is 70%, filters, isolates filtrate and residue, filtrate for later use; In step 3, the phosphate buffer solution jordaning that in resulting residue, adds 7 times of weight, the concentration of phosphate buffer is 7%, adds papain again in serosity, makes and contains 180I.U/g albumen in the serosity, and through behind 70 ℃ of constant temperature hydrolysis 7h, be warmed up to 100 ℃, lixiviate 50min, centrifugalize then, rotating speed is 6000r/min, and it is standby to get supernatant; In step 4, choose 40 parts of Chinese herbal medicine according to the ratio of weight and number of Embryo cervi described in the step 1 and Chinese herbal medicine, described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 10 parts of Radix Ginsengs, 10 parts in Poria, 15 parts of Radix Rehmanniae Preparata, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radix Paeoniae Albas, 15 parts in Radix Glycyrrhizae, 10 parts of Herb Gynostemmae Pentaphyllis, 15 parts of Herba Cistanches, 15 parts of Fructus Lycii, 15 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 45: 55 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, again when falling liquid film is concentrated into mixing preparation 1/3 of volume; In step 5, be that 1: 0.45 ratio is made suspension according to ratio of weight and number with soybean oil and described micropowder.This kind extracting method is inferior best method, and extract purity reaches 80%.
The specific embodiment nine: the difference of the present embodiment and the specific embodiment five is: present embodiment is in step 4, the water logging bubble 2～4h that in described Chinese herbal medicine, adds 10～18 times of Chinese herbal medicine weight, decoct 40～120min, filter, decoct 3～5 times, collect filtrate, obtain Chinese herbal medicine filtrate.Adopt this decoction method, 60%～90% of Chinese herbal medicine composition can be extracted less wastage.
The specific embodiment ten: the difference of the present embodiment and the specific embodiment six is: present embodiment adds the water logging bubble 2～4h of 14 times of Chinese herbal medicine weight in described Chinese herbal medicine in step 4, decoct 80min, filter, decoct 4 times, collect filtrate, obtain extracts of Chinese herbal medicine.Adopt this decoction method best results, 90% of Chinese herbal medicine composition can be extracted less wastage.
The specific embodiment 11: the difference of the present embodiment and the specific embodiment seven is: present embodiment adds the water logging bubble 2h of 10 times of Chinese herbal medicine weight in described Chinese herbal medicine in step 4, decoct 40min, filter, decoct 3 times, collect filtrate, obtain extracts of Chinese herbal medicine.Adopt this decoction method 60% of Chinese herbal medicine composition can be extracted.
The specific embodiment 12: the difference of the present embodiment and the specific embodiment eight is: present embodiment adds the water logging bubble 4h of 18 times of Chinese herbal medicine weight in described Chinese herbal medicine in step 4, decoct 120min, filter, decoct 5 times, collect filtrate, obtain extracts of Chinese herbal medicine.Adopt this decoction method 75% of Chinese herbal medicine composition can be extracted.
Claims (10)
1, a kind of deer fetus capsule is characterized in that it is made up of according to ratio of weight and number following component: 600～800 parts of Embryo cervi, 30～40 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 5～10 parts of Radix Ginsengs, 5～10 parts in Poria, 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts in Radix Glycyrrhizae, 5～10 parts of Herb Gynostemmae Pentaphyllis, 10～15 parts of Herba Cistanches, 10～15 parts of Fructus Lycii, 10～15 parts of Colla cornus cervis.
2, deer fetus capsule according to claim 1 is characterized in that it is made up of according to ratio of weight and number following component: 700 parts of Embryo cervi, 35 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 7 parts of Radix Ginsengs, 8 parts in Poria, 13 parts of Radix Rehmanniae Preparata, 13 parts of Rhizoma Chuanxiongs, 12 parts of the Radix Paeoniae Albas, 12 parts in Radix Glycyrrhizae, 8 parts of Herb Gynostemmae Pentaphyllis, 13 parts of Herba Cistanches, 12 parts of Fructus Lycii, 13 parts of Colla cornus cervis.
3, deer fetus capsule according to claim 1 is characterized in that it is made up of according to ratio of weight and number following component: 600 parts of Embryo cervi, 30 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 5 parts of Radix Ginsengs, 5 parts in Poria, 10 parts of Radix Rehmanniae Preparata, 10 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 10 parts in Radix Glycyrrhizae, 5 parts of Herb Gynostemmae Pentaphyllis, 10 parts of Herba Cistanches, 10 parts of Fructus Lycii, 10 parts of Colla cornus cervis.
4, deer fetus capsule according to claim 1 is characterized in that it is made up of according to ratio of weight and number following component: 800 parts of Embryo cervi, 40 parts of Chinese herbal medicine; Described Chinese herbal medicine is made up of according to ratio of weight and number following component: 10 parts of Radix Ginsengs, 10 parts in Poria, 15 parts of Radix Rehmanniae Preparata, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radix Paeoniae Albas, 15 parts in Radix Glycyrrhizae, 10 parts of Herb Gynostemmae Pentaphyllis, 15 parts of Herba Cistanches, 15 parts of Fructus Lycii, 15 parts of Colla cornus cervis.
5, a kind of manufacture method of deer fetus capsule is characterized in that it is finished by following steps: one, get 600～800 parts of Embryo cervi, 30～40 parts of Chinese herbal medicine according to ratio of weight and number; Earlier described Embryo cervi is cleaned, it is rotten that the unhairing post processing becomes, and adds the NaCl solution of 4～7 times of weight in the Embryo cervi gruel, and the concentration of NaCl solution is 8～10%, lixiviate 10～30min, and centrifugalize then, rotating speed is 4000～6000r/min, it is standby to get supernatant; Two, add the edible ethanol and the lixiviate 60～120h of 4～9 times of weight in the precipitate that step 1 obtains, the concentration of edible ethanol is 50～70%, filters, isolates filtrate and residue, filtrate for later use; Three, the phosphate buffer solution jordaning that in resulting residue, adds 4～7 times of weight, the concentration of phosphate buffer is 5～7%, in serosity, add papain again, make and contain 120～180I.U/g albumen in the serosity, and, be warmed up to 90～100 ℃ through behind 55～70 ℃ of constant temperature hydrolysis 3～7h, lixiviate 30～50min, centrifugalize then, rotating speed is 4000～6000r/min, it is standby to get supernatant; Four, the ratio of weight and number of Embryo cervi described in one and Chinese herbal medicine is chosen 30～40 parts of Chinese herbal medicine set by step, and described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 5～10 parts of Radix Ginsengs, 5～10 parts in Poria, 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts in Radix Glycyrrhizae, 5～10 parts of Herb Gynostemmae Pentaphyllis, 10～15 parts of Herba Cistanches, 10～15 parts of Fructus Lycii, 10～15 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 25～45: 55～75 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, when falling liquid film is concentrated into mixing preparation 1/2～1/3 of volume, be spray dried to micropowder then again; Five, be that 1: 0.25～0.45 ratio is made suspension with soybean oil and described micropowder according to ratio of weight and number, adhesive tape is made in the gelatin allotment, adds on adhesive tape that suspension is filled pelleting, drying is made.
6, the manufacture method of a kind of deer fetus capsule according to claim 5 is characterized in that in step 1, gets 700 parts of Embryo cervi, 35 parts of Chinese herbal medicine according to ratio of weight and number; Add the NaCl solution of 5.5 times of weight in the Embryo cervi gruel of making, the concentration of NaCl solution is 10%, lixiviate 20min, and centrifugalize then, rotating speed is 5000r/min, it is standby to get supernatant; In step 2, in the precipitate that step 1 obtains, add the edible ethanol and the lixiviate 90h of 6.5 times of weight, the concentration of edible ethanol is 60%, filters, isolates filtrate and residue, filtrate for later use; In step 3, the phosphate buffer solution jordaning that in resulting residue, adds 5.5 times of weight, the concentration of phosphate buffer is 6%, adds papain again in serosity, makes and contains 150I.U/g albumen in the serosity, and through behind 60 ℃ of constant temperature hydrolysis 5h, be warmed up to 95 ℃, lixiviate 40min, centrifugalize then, rotating speed is 5000r/min, and it is standby to get supernatant; In step 4, the ratio of weight and number of Embryo cervi described in one and Chinese herbal medicine is chosen 35 parts of Chinese herbal medicine set by step, and described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 7 parts of Radix Ginsengs, 8 parts in Poria, 13 parts of Radix Rehmanniae Preparata, 13 parts of Rhizoma Chuanxiongs, 12 parts of the Radix Paeoniae Albas, 12 parts in Radix Glycyrrhizae, 8 parts of Herb Gynostemmae Pentaphyllis, 13 parts of Herba Cistanches, 12 parts of Fructus Lycii, 13 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 35: 65 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, again when falling liquid film is concentrated into mixing preparation 40% of volume; In step 5, be that 1: 0.35 ratio is made suspension according to ratio of weight and number with soybean oil and described micropowder.
7, the manufacture method of a kind of deer fetus capsule according to claim 5 is characterized in that in step 1, gets 600 parts of Embryo cervi, 30 parts of Chinese herbal medicine according to ratio of weight and number; Add the NaCl solution of 4 times of weight in the Embryo cervi gruel of making, the concentration of NaCl solution is 10%, lixiviate 10min, and centrifugalize then, rotating speed is 4000r/min, it is standby to get supernatant; In step 2, in the precipitate that step 1 obtains, add the edible ethanol and the lixiviate 60h of 4 times of weight, the concentration of edible ethanol is 50%, filters, isolates filtrate and residue, filtrate for later use; In step 3, the phosphate buffer solution jordaning that in resulting residue, adds 4 times of weight, the concentration of phosphate buffer is 5%, adds papain again in serosity, makes and contains 120I.U/g albumen in the serosity, and through behind 55 ℃ of constant temperature hydrolysis 3h, be warmed up to 90 ℃, lixiviate 30min, centrifugalize then, rotating speed is 4000r/min, and it is standby to get supernatant; In step 4, the ratio of weight and number of Embryo cervi described in one and Chinese herbal medicine is chosen 30 parts of Chinese herbal medicine set by step, and described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 5 parts of Radix Ginsengs, 5 parts in Poria, 10 parts of Radix Rehmanniae Preparata, 10 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 10 parts in Radix Glycyrrhizae, 5 parts of Herb Gynostemmae Pentaphyllis, 10 parts of Herba Cistanches, 10 parts of Fructus Lycii, 10 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 25: 75 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, again when falling liquid film is concentrated into mixing preparation 1/2 of volume; In step 5, be that 1: 0.25 ratio is made suspension according to ratio of weight and number with soybean oil and described micropowder.
8, the manufacture method of a kind of deer fetus capsule according to claim 5 is characterized in that in step 1, gets 800 parts of Embryo cervi, 40 parts of Chinese herbal medicine according to ratio of weight and number; Add the NaCl solution of 7 times of weight in the Embryo cervi gruel of making, the concentration of NaCl solution is 10%, lixiviate 30min, and centrifugalize then, rotating speed is 6000r/min, it is standby to get supernatant; In step 2, in the precipitate that step 1 obtains, add the edible ethanol and the lixiviate 120h of 9 times of weight, the concentration of edible ethanol is 70%, filters, isolates filtrate and residue, filtrate for later use; In step 3, the phosphate buffer solution jordaning that in resulting residue, adds 7 times of weight, the concentration of phosphate buffer is 7%, adds papain again in serosity, makes and contains 180I.U/g albumen in the serosity, and through behind 70 ℃ of constant temperature hydrolysis 7h, be warmed up to 100 ℃, lixiviate 50min, centrifugalize then, rotating speed is 6000r/min, and it is standby to get supernatant; In step 4, the ratio of weight and number of Embryo cervi described in one and Chinese herbal medicine is chosen 40 parts of Chinese herbal medicine set by step, and described every part of Chinese herbal medicine is made up of according to ratio of weight and number following component: 10 parts of Radix Ginsengs, 10 parts in Poria, 15 parts of Radix Rehmanniae Preparata, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radix Paeoniae Albas, 15 parts in Radix Glycyrrhizae, 10 parts of Herb Gynostemmae Pentaphyllis, 15 parts of Herba Cistanches, 15 parts of Fructus Lycii, 15 parts of Colla cornus cervis; With the above-mentioned Chinese herbal medicine water boiling and extraction Chinese herbal medicine filtrate of respectively distinguishing the flavor of, is that 45: 55 ratio is carried out mixing preparation with the mixed liquor of resulting extracts of Chinese herbal medicine and the resulting supernatant of step 1, the resulting filtrate of step 2 and the resulting supernatant of step 3 according to ratio of weight and number, again when falling liquid film is concentrated into mixing preparation 1/3 of volume; In step 5, be that 1: 0.45 ratio is made suspension according to ratio of weight and number with soybean oil and described micropowder.
9, the manufacture method of a kind of deer fetus capsule according to claim 5 is characterized in that in step 4, adds the water logging bubble 2～4h of 10～18 times of Chinese herbal medicine weight in described Chinese herbal medicine, decoct 40～120min, filter, decoct 3～5 times, collect filtrate, obtain Chinese herbal medicine filtrate.
10, the manufacture method of a kind of deer fetus capsule according to claim 9 is characterized in that in step 4, adds the water logging bubble 2～4h of 14 times of Chinese herbal medicine weight in described Chinese herbal medicine, decoct 80min, filter, decoct 4 times, collect filtrate, obtain extracts of Chinese herbal medicine.
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| CNA2007100720106A CN101036721A (en) | 2007-04-09 | 2007-04-09 | Deer fetus capsule and its production process |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101836737A (en) * | 2010-03-24 | 2010-09-22 | 郑彬 | Method for preparing deer fetus dry powder by ultrasonic degradation |
| CN101670008B (en) * | 2008-09-11 | 2012-01-18 | 诸葛树华 | Deer fetus film and manufacturing method thereof |
| CN101564465B (en) * | 2009-06-12 | 2012-07-04 | 陕西东泰制药有限公司 | Chinese medicinal composition for nourishing blood, benefiting vital energy, regulating menstruation and dissipating cold |
| CN105079047A (en) * | 2015-08-17 | 2015-11-25 | 农九师161团天麓鹿业有限责任公司 | Deer placenta capsule and preparation method thereof |
| CN106234826A (en) * | 2016-08-04 | 2016-12-21 | 袁玥 | A kind of ecological feed cultivating Gallus jabouillei and preparation method thereof |
-
2007
- 2007-04-09 CN CNA2007100720106A patent/CN101036721A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670008B (en) * | 2008-09-11 | 2012-01-18 | 诸葛树华 | Deer fetus film and manufacturing method thereof |
| CN101564465B (en) * | 2009-06-12 | 2012-07-04 | 陕西东泰制药有限公司 | Chinese medicinal composition for nourishing blood, benefiting vital energy, regulating menstruation and dissipating cold |
| CN101836737A (en) * | 2010-03-24 | 2010-09-22 | 郑彬 | Method for preparing deer fetus dry powder by ultrasonic degradation |
| CN101836737B (en) * | 2010-03-24 | 2012-10-03 | 郑彬 | Method for preparing deer fetus dry powder by ultrasonic degradation |
| CN105079047A (en) * | 2015-08-17 | 2015-11-25 | 农九师161团天麓鹿业有限责任公司 | Deer placenta capsule and preparation method thereof |
| CN106234826A (en) * | 2016-08-04 | 2016-12-21 | 袁玥 | A kind of ecological feed cultivating Gallus jabouillei and preparation method thereof |
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