CN100445254C - Method of synthesizing glutaraldehyde by oxidation of cyclo amylene - Google Patents
Method of synthesizing glutaraldehyde by oxidation of cyclo amylene Download PDFInfo
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- CN100445254C CN100445254C CNB2005100286033A CN200510028603A CN100445254C CN 100445254 C CN100445254 C CN 100445254C CN B2005100286033 A CNB2005100286033 A CN B2005100286033A CN 200510028603 A CN200510028603 A CN 200510028603A CN 100445254 C CN100445254 C CN 100445254C
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Abstract
The cyclopentene oxidizing process to synthesize glutaraldehyde has hydrogen peroxide as oxidant and reaction in the presence of catalyst and in tertiary butyl alcohol as solvent. The process has weight ratio between cyclopentene and solvent of 1 to (6-8), modular ratio between cyclopentene and hydrogen peroxide of 1 to (4-5), reaction temperature of 35-40 deg.c, reaction period of 4-8 hr. The catalyst has carrier of mesoporous Ti-HMS molecular sieve with Si/Ti molar ratio in 10-50, specific surface area 500-800 sq m/g and average pore diameter 5-10 nm, and active component of supported tungsten oxide in the content of 5-50wt%, and the weight ratio between the catalyst and cyclopentene is 1 to (2-6). The key to the present invention is proper catalyst carrier resulting in ideal reaction activity and high selectivity.
Description
Technical field
The present invention relates to a kind of method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene, be oxygenant with the hydrogen peroxide particularly, in the presence of the loaded catalyst of tungstenic by the method for oxidizing-synthesizing glutaric dialdehyde with cyclopentene.
Background technology
Glutaraldehyde is a kind of important chemical product, is widely used in fields such as oil production, health care, protein chemistry, foods and cosmetics manufacturing.At present, the method for suitability for industrialized production glutaraldehyde mainly is two step of a propenal synthesis method, and the shortcoming of this method is raw materials used costing an arm and a leg, and facility investment is big, and is seriously polluted, and the raw material boiling point is low, transportation inconvenience.Various countries competitively research and develop the novel process by oxidizing-synthesizing glutaric dialdehyde with cyclopentene in recent years, wherein are that oxygenant is the most competitive with the hydrogen peroxide.Because of a large amount of cyclopentenes of petrochemical complex by-product, and hydrogen peroxide is cheap and easy to get, and this greatly reduces the glutaraldehyde production cost, and the reaction conditions gentleness that should react, and is pollution-free substantially, so cyclopentenes oxidation preparing glutaric dialdehyde route has prospects for commercial application.
Cyclopentenes oxidation preparing glutaric dialdehyde early adopts the homogeneous catalysis oxidizing reaction, and its shortcoming is that catalyzer and product separation are relatively more difficult.Existing research emphasis progressively turns to and adopts aqueous hydrogen peroxide and be the heterogeneous catalytic oxidation of representative with the loading type tungsten-containing catalyst.As the disclosed technology of CN1425498 is to adopt homogeneous phase alcohol-hydrothermal method, makes a kind of TiO through airtight crystallization
2Microballoon prepares tungsten-containing catalyst as carrier.The transformation efficiency that adopts this catalyst rings amylene oxidizing reaction is 95.2%, and the glutaraldehyde yield is 69.4%.The disclosed technology of CN1446631 is that original position is introduced the catalyzer that the Tungsten oxide 99.999 component makes oxidizing reaction in the process of synthetic SBA-15 type total silicon mesoporous molecular sieve, and adopting this catalyzer glutaraldehyde yield is 78.9%.The disclosed technology of CN1380138 is that original position is introduced the catalyzer that the tungsten component makes oxidizing reaction in the process of synthetic MCM-41 type total silicon mesoporous molecular sieve, and the transformation efficiency that adopts this catalyst rings amylene oxidizing reaction is 100%, and the glutaraldehyde yield is 72%.These existing catalyzer all can be obtained more satisfactory reaction effect, and the transformation efficiency of cyclopentenes substantially all is 100%, and the glutaraldehyde yield generally can both reach about 70%.But from the experimental data of introducing, these activity of such catalysts are generally not high, and this time that is reflected in oxidizing reaction is all longer, is generally 12～60 hours.And the preparing carriers of these catalyzer is all more loaded down with trivial details, need heating in confined conditions to carry out long-time crystallization or aging mostly, so the Preparation of Catalyst cycle is long, the manufacturing cost height.
Summary of the invention
The invention provides a kind of is the method for oxygenant by oxidizing-synthesizing glutaric dialdehyde with cyclopentene with the hydrogen peroxide, and the technical problem that it will solve is further to shorten the yield of reaction times and raising glutaraldehyde by the improvement of catalyzer.
Below be the technical scheme that the present invention solves the problems of the technologies described above:
A kind of method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene, it is oxygenant that this method adopts hydrogen peroxide, the existence that is reflected at catalyzer is down and carry out in solvent tertiary butanol.The consumption of solvent is counted cyclopentenes with weight ratio: solvent=1: (6～8), the molar ratio of cyclopentenes and hydrogen peroxide are 1: (4～5).Temperature of reaction is 35～40 ℃, and the reaction times is 4～8 hours.Catalyzer is a carrier with the Ti-HMS mesoporous molecular sieve, and wherein the mol ratio of silicon and titanium is 10～50, specific surface area 500～800m
2/ g, mean pore size is 5～10nm, and the active ingredient of load is a Tungsten oxide 99.999 in the catalyzer, and its content is 5～50wt%, and catalyst consumption is counted catalyzer with weight ratio: cyclopentenes=1: (2～6).
The mol ratio of silicon and titanium is preferably 20～40 in the carrier of above-mentioned catalyzer; The content of active ingredient Tungsten oxide 99.999 is preferably 10～40wt% in the catalyzer; The granularity of catalyzer is preferably 100～120 orders; Catalyst consumption is preferably catalyzer in weight ratio: cyclopentenes=1: (2～5); The consumption of solvent is preferably cyclopentenes in weight ratio: solvent=1: (6.5～7.5).
The solid support material Ti-HMS mesoporous molecular sieve of above-mentioned catalyzer is ℃ following synthesizing in normal temperature～50, concrete steps are: template is dissolved in the aqueous hydrochloric acid, stir, the mixing solutions that dropping is made into by tetraethyl orthosilicate, Virahol, tetrabutyl titanate and ethanol, make it become white gels, through aging, filtration.Successively with ethanol and water washing, under 80～120 ℃ of temperature dry 2～5 hours, 300～800 ℃ of roasting temperatures 2～6 hours, promptly obtain Ti-HMS mesoporous molecular sieve carrier again.
In the above-mentioned preparing carriers process, template can be amino dodecane or tetradecy lamine, is preferably amino dodecane, and its consumption is 10～50% of a tetraethyl orthosilicate weight, is preferably 20～40%.The consumption of hydrochloric acid is 1～20% of a tetraethyl orthosilicate weight, is preferably 5～15%.Water consumption is 1～5 times of tetraethyl orthosilicate weight in the aqueous hydrochloric acid, is preferably 2～4 times.The consumption of Virahol is 5～50% of a tetraethyl orthosilicate weight, is preferably 10～40%.Consumption of ethanol is 1～8 times of tetraethyl orthosilicate weight, is preferably 1～5 times.The consumption of tetrabutyl titanate decides according to the mol ratio of silicon and titanium in the desired molecular sieve.
Activity of such catalysts component Tungsten oxide 99.999 can adopt pickling process to load to carrier to get on, concrete steps are: the initial compounds and the solubility promoter of tungsten are added in the hot water, stir to clarify, add the Ti-HMS molecular sieve carrier of preparation as stated above again, through aging, drying and roasting.After promptly get catalyst prod after grinding the granularity that reaches required.
In the active ingredient Tungsten oxide 99.999 loaded to process on the carrier, the initial compounds of tungsten can be soluble tungstate salt such as ammonium tungstate, sodium wolframate, preferably ammonium tungstate.Solvent temperature is 50～100 ℃, and solvent temperature is 70～90 ℃ preferably.Solubility promoter can be oxalic acid, ammoniacal liquor, preferably oxalic acid.The solubility promoter add-on is 0.5～5 times of initial compounds of tungsten.Digestion time is 2～24 hours, is preferably 2～16 hours.Drying temperature is 70～150 ℃, is preferably 90～120 ℃.Maturing temperature is 200～600 ℃, is preferably 300～500 ℃.
Compared with prior art, key of the present invention is that the catalyzer that reaction is adopted has used a kind of more suitable carriers, and this is a kind of novel mesoporous molecular sieve that embeds transition metal Ti.The contriver found through experiments, and this catalyzer has the very selectivity of ideal reactive behavior and Geng Gao in the reaction that is used for oxidizing-synthesizing glutaric dialdehyde with cyclopentene.Reaction times only needs 4～8 hours, and the transformation efficiency of cyclopentenes reaches 100%, and the yield of glutaraldehyde reaches about 80%.And used carrier and the catalyst preparation process of catalyzer is easy, and raw material is easy to get, and preparation cycle is short, unlike need carry out long-time crystallization in the prior art under air-tight state.Therefore the catalyzer low cost of manufacture helps large-scale industrial production.
Below will the invention will be further described by specific embodiment, because key of the present invention is the improvement of catalyzer, and other condition and the prior art of reaction are basic identical, so will pay attention to the description to catalyzer among the embodiment.
In an embodiment, cyclopentenes transformation efficiency and glutaraldehyde yield are defined as:
Embodiment
[embodiment 1]
The preparation of support of the catalyst:
At room temperature, the adding of 5g amino dodecane is contained in the 70mL aqueous solution of 1.5g hydrochloric acid, mechanical stirring drips the mixing solutions that is made into by 21g tetraethyl orthosilicate, 3.4g Virahol, 30g ethanol and 1.7g tetrabutyl titanate, stirs 2 hours.Aging 12 hours then, filter the back successively with ethanol and water washing.Under 80～120 ℃ of temperature dry 2～5 hours, again 400～800 ℃ of roasting temperatures 2～6 hours.Getting 100～120 order powder after the grinding, to obtain white Ti-HMS mesoporous molecular sieve be support of the catalyst.
Preparation of Catalyst:
In 70～90 ℃ oil bath, the 1.6g ammonium tungstate is dissolved in the 15ml deionized water, stir adding 0.9g oxalic acid down, continue to stir 20 minutes, treat solution clarification back adding 3g said catalyst carrier.Room temperature left standstill 12 hours, in 90～120 ℃ of dryings 3 hours, promptly got catalyst prod after 2～4 hours in 200～600 ℃ of roastings.
[embodiment 2～10]
Change the consumption of each support of the catalyst starting material and Tungsten oxide 99.999 starting material ammonium tungstate, all the other are with embodiment 1.
Measure the physical index of the catalyzer that each embodiment makes, data see Table 1.
Table 1.
| Specific surface area (m 2/g) | Mean pore size (nm) | Silicon/titanium in the carrier (mol ratio) | Tungsten oxide content (wt%) | |
| Embodiment 1 | 705.9 | 5.8 | 30 | 30 |
| Embodiment 2 | 769.2 | 6.3 | 30 | 30 |
| Embodiment 3 | 781.6 | 5.3 | 10 | 30 |
| Embodiment 4 | 765.7 | 5.4 | 40 | 20 |
| Embodiment 5 | 723.4 | 7.2 | 30 | 30 |
| Embodiment 6 | 680.4 | 7.8 | 20 | 20 |
| Embodiment 7 | 674.9 | 8.3 | 40 | 20 |
| Embodiment 8 | 678.3 | 7.3 | 40 | 40 |
| Embodiment 9 | 616.7 | 9.5 | 30 | 40 |
| Embodiment 10 | 653.5 | 9.4 | 40 | 40 |
The catalyzer number consecutively that each embodiment obtains is #1～#10.
[embodiment 11～20]
The reaction of cyclopentene heterogeneous catalytic oxidation synthesis of glutaraldehyde:
Be reflected in three mouthfuls of round-bottomed flasks and carry out, adopt induction stirring.Be heated to required reaction conditions, the concentration that adds aequum in the 60mL trimethyl carbinol is 50% hydrogen peroxide, adds the catalyzer of aequum and the cyclopentenes of aequum then.React while stirring, reaction finishes the back and adopts gas-chromatography marker method analytical reaction liquid to form, thus ring amylene transformation efficiency and glutaraldehyde yield.
Embodiment 11～20 uses the catalyzer that is numbered #1～#10 successively, and the concrete reaction conditions of each embodiment sees Table 2, and activity rating of catalyst the results are shown in Table 3.
Table 2.
| Temperature of reaction (℃) | Cyclopentenes/hydrogen peroxide (mol ratio) | Catalyzer/cyclopentenes (weight ratio) | Cyclopentenes/trimethyl carbinol (weight ratio) | |
| Embodiment 11 | 35 | 1/4 | 1/2 | 1/6.5 |
| Embodiment 12 | 38 | 1/4 | 1/2 | 1/6.0 |
| Embodiment 13 | 35 | 1/5 | 1/3 | 1/7.5 |
| Embodiment 14 | 38 | 1/5 | 1/3 | 1/7.5 |
| Embodiment 15 | 35 | 1/4 | 1/2 | 1/6.5 |
| Embodiment 16 | 35 | 1/5 | 1/6 | 1/7.5 |
| Embodiment 17 | 35 | 1/4 | 1/2 | 1/6.5 |
| Embodiment 18 | 40 | 1/4 | 1/2 | 1/6.0 |
| Embodiment 19 | 38 | 1/4 | 1/5 | 1/7.5 |
| Embodiment 20 | 35 | 1/4 | 1/3 | 1/8.0 |
Table 3.
| Reaction times (hr) | Cyclopentenes transformation efficiency (%) | Glutaraldehyde yield (%) | |
| Embodiment 11 | 4 | 99.3 | 74.3 |
| Embodiment 12 | 6 | 100 | 77.0 |
| Embodiment 13 | 6 | 100 | 71.8 |
| Embodiment 14 | 6 | 100 | 81.7 |
| Embodiment 15 | 8 | 100 | 78.8 |
| Embodiment 16 | 7 | 100 | 82.6 |
| Embodiment 17 | 8 | 100 | 80.7 |
| Embodiment 18 | 7 | 100 | 81.6 |
| Embodiment 19 | 6 | 100 | 78.3 |
| Embodiment 20 | 8 | 100 | 81.2 |
Claims (6)
1, a kind of method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene, it is oxygenant that this method adopts hydrogen peroxide, the existence that is reflected at catalyzer down and carry out in solvent tertiary butanol, the consumption of solvent is counted cyclopentenes with weight ratio: solvent=1: (6～8), the molar ratio of cyclopentenes and hydrogen peroxide is 1: (4～5), temperature of reaction is 35～40 ℃, reaction times is 4～8 hours, it is characterized in that catalyzer is a carrier with the Ti-HMS mesoporous molecular sieve, wherein the mol ratio of silicon and titanium is 10～50, specific surface area 500～800m
2/ g, mean pore size is 5～10nm, and the active ingredient of load is a Tungsten oxide 99.999 in the catalyzer, and its content is 5～50wt%, and catalyst consumption is counted catalyzer with weight ratio: cyclopentenes=1: (2～6).
2, the method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene according to claim 1 is characterized in that the mol ratio of silicon and titanium is 20～40 in the described support of the catalyst.
3, the method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene according to claim 1, the content that it is characterized in that active ingredient Tungsten oxide 99.999 in the described catalyzer is 10～40wt%.
4, the method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene according to claim 1, the granularity that it is characterized in that described catalyzer is 100～120 orders.
5, the method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene according to claim 1 is characterized in that described catalyst consumption counts catalyzer with weight ratio: cyclopentenes=1: (2～5).
6, the method by oxidizing-synthesizing glutaric dialdehyde with cyclopentene according to claim 1 is characterized in that the consumption of described solvent is counted cyclopentenes with weight ratio: solvent=1: (6.5～7.5).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383965B (en) * | 2014-11-19 | 2016-05-25 | 河南工业大学 | The immobilized tungsten oxide catalyst of a kind of metal-organic framework for the synthesis of glutaraldehyde and production method thereof |
| CN110372483B (en) * | 2019-07-17 | 2022-11-15 | 上海应用技术大学 | Process method for preparing glutaraldehyde by catalytic oxidation of cyclopentene |
| CN111138256B (en) * | 2019-12-16 | 2021-07-13 | 中国科学院大连化学物理研究所 | A kind of preparation method of adipaldehyde |
| CN114426468B (en) * | 2020-10-16 | 2024-05-28 | 中国石油化工股份有限公司 | Method for preparing glutaraldehyde by taking cyclopentene as raw material |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425498A (en) * | 2003-01-03 | 2003-06-25 | 复旦大学 | Supported tungstic acid catalyst for synthesizing glutaraldehyde and its producing method |
| CN1446631A (en) * | 2003-01-30 | 2003-10-08 | 复旦大学 | Molecular sieve catalyst containing pores in tungsten media utilized for synthesizing glutaraldehyde and its preparation method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425498A (en) * | 2003-01-03 | 2003-06-25 | 复旦大学 | Supported tungstic acid catalyst for synthesizing glutaraldehyde and its producing method |
| CN1446631A (en) * | 2003-01-30 | 2003-10-08 | 复旦大学 | Molecular sieve catalyst containing pores in tungsten media utilized for synthesizing glutaraldehyde and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| Ti_HMS的合成及其催化氧化性能. 刘卅等.石油学报，第21卷第3期. 2005 |
| Ti_HMS的合成及其催化氧化性能. 刘卅等.石油学报，第21卷第3期. 2005 * |
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