[go: up one dir, main page]

CL2022001675A1 - Derivados de benzimidazol - Google Patents

Derivados de benzimidazol

Info

Publication number
CL2022001675A1
CL2022001675A1 CL2022001675A CL2022001675A CL2022001675A1 CL 2022001675 A1 CL2022001675 A1 CL 2022001675A1 CL 2022001675 A CL2022001675 A CL 2022001675A CL 2022001675 A CL2022001675 A CL 2022001675A CL 2022001675 A1 CL2022001675 A1 CL 2022001675A1
Authority
CL
Chile
Prior art keywords
benzimidazole derivatives
benzimidazoles
processes
formula
medicine
Prior art date
Application number
CL2022001675A
Other languages
English (en)
Inventor
William Bagley Scott
Casimiro-Garcia Agustin
Cheng Xiayun
Elizabeth Davoren Jennifer
Aldrin Denny Rajiah
Stephen Gerstenberger Brian
Eldridge Lovering Frank
Dineshkumar Parikh Mihir
Walter Strohbach Joseph
Isidro Trujillo John
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CL2022001675A1 publication Critical patent/CL2022001675A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a bencimidazoles de la Fórmula (I) y sales de estos aceptables desde el punto de vista farmacéutico, en donde R1 a R6 son como se definen en la descripción; a su uso en la medicina; a composiciones que los contienen; a procesos para su preparación; y a intermediarios usados en dichos procesos. Los bencimidazoles de la Fórmula (I) son inhibidores de ITK y, por lo tanto, son potencialmente útiles en el tratamiento de diversos trastornos, que incluyen dermatitis atópica.
CL2022001675A 2019-12-20 2022-06-17 Derivados de benzimidazol CL2022001675A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962951030P 2019-12-20 2019-12-20
US202063108602P 2020-11-02 2020-11-02

Publications (1)

Publication Number Publication Date
CL2022001675A1 true CL2022001675A1 (es) 2023-03-17

Family

ID=73856233

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022001675A CL2022001675A1 (es) 2019-12-20 2022-06-17 Derivados de benzimidazol

Country Status (19)

Country Link
US (1) US11661419B2 (es)
EP (1) EP4077316A1 (es)
JP (1) JP2023507138A (es)
KR (1) KR20220118525A (es)
CN (1) CN115087655A (es)
AU (1) AU2020405536B2 (es)
BR (1) BR112022011838A2 (es)
CA (1) CA3103120A1 (es)
CL (1) CL2022001675A1 (es)
CO (1) CO2022008313A2 (es)
CR (1) CR20220299A (es)
DO (1) DOP2022000130A (es)
EC (1) ECSP22049160A (es)
IL (1) IL293831B2 (es)
MX (1) MX2022007518A (es)
PE (1) PE20221916A1 (es)
TW (1) TWI766484B (es)
UY (1) UY38998A (es)
WO (1) WO2021124155A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023552863A (ja) * 2020-12-15 2023-12-19 ファイザー・インク ベンゾイミダゾール誘導体および皮膚疾患の処置のためのｉｔｋの阻害剤としてのそれらの使用
CN114624358A (zh) * 2022-03-11 2022-06-14 哈尔滨圣泰生物制药有限公司 一种地氯雷他定口服液的质量检测方法
US20240423959A1 (en) * 2022-06-21 2024-12-26 Jjr&D, Llc Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT901786E (pt) 1997-08-11 2007-08-07 Pfizer Prod Inc Disperções farmacêuticas sólidas com biodisponibilidade melhorada
GB9911053D0 (en) 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
BR0213562A (pt) * 2001-10-26 2004-08-31 Aventis Pharma Inc Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna
JP2003231687A (ja) 2002-02-04 2003-08-19 Japan Tobacco Inc ピラゾリル縮合環化合物及びその医薬用途
EP1763524A1 (en) 2004-04-23 2007-03-21 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
EP1885725B1 (en) 2005-04-14 2008-09-24 F.Hoffmann-La Roche Ag Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents
GB0602178D0 (en) 2006-02-03 2006-03-15 Merck Sharp & Dohme Therapeutic treatment
WO2008024981A1 (en) 2006-08-24 2008-02-28 Serenex, Inc. Piperazine-substituted benzothiophenes for treatment of mental disorders
ATE519763T1 (de) 2008-02-25 2011-08-15 Hoffmann La Roche Pyrrolopyrazin-kinasehemmer
CN101952294B (zh) 2008-02-25 2014-11-26 霍夫曼-拉罗奇有限公司 吡咯并吡嗪激酶抑制剂
WO2009106445A1 (en) 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
JP5368484B2 (ja) 2008-02-25 2013-12-18 エフ．ホフマン−ラ ロシュ アーゲー ピロロピラジンキナーゼ阻害剤
WO2009106442A1 (en) 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
EP2196458A1 (en) 2008-12-10 2010-06-16 Laboratorios Del. Dr. Esteve, S.A. Process for obtaining enantiomerically enriched pyrazole derivatives
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
EP2292237A1 (en) 2009-08-14 2011-03-09 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention or treatment of pain induced by chemotherapy
US8299070B2 (en) 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
EP2366702A1 (en) 2010-03-18 2011-09-21 Almirall, S.A. New oxadiazole derivatives
US8481541B2 (en) 2010-03-22 2013-07-09 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
JP2013526558A (ja) 2010-05-20 2013-06-24 エフ．ホフマン−ラ ロシュ アーゲー Ｓｙｋ及びｊａｋ阻害剤としてのピロロピラジン誘導体
NZ605988A (en) * 2010-06-23 2014-11-28 Hanmi Science Co Ltd Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
EP2455080A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
EP2455081A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of crohn's disease
BR112013020041B1 (pt) 2011-02-07 2021-11-23 Plexxikon, Inc Compostos e composições para a modulação de quinases e uso dos mesmos
KR20140047160A (ko) 2011-08-12 2014-04-21 에프. 호프만-라 로슈 아게 인다졸 화합물, 조성물 및 사용 방법
EP2763990B1 (en) 2011-09-01 2017-02-22 F. Hoffmann-La Roche AG Pyrrolopyrazine kinase inhibitors
CN104781238A (zh) 2012-08-10 2015-07-15 弗·哈夫曼-拉罗切有限公司 吡唑甲酰胺化合物、组合物及使用方法
WO2014041518A1 (en) 2012-09-14 2014-03-20 Glenmark Pharmaceuticals S.A. Thienopyrrole derivatives as itk inhibitors
CN104640858B (zh) 2012-09-26 2018-11-06 霍夫曼-拉罗奇有限公司 环醚吡唑-4-基-杂环基-甲酰胺化合物及使用方法
CN103804364A (zh) 2012-11-06 2014-05-21 韩冰 一类治疗缺血性脑损伤的化合物及其用途
CN103804361A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103804291A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103800328A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103800337A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103800327A (zh) 2012-11-09 2014-05-21 韩冰 一类治疗青光眼的化合物及其用途
CN103800340A (zh) 2012-11-09 2014-05-21 韩冰 一类治疗青光眼的化合物及其用途
CN103804302A (zh) 2012-11-14 2014-05-21 杨育新 一类治疗创伤性脑损伤疾病的化合物及其用途
CN103804272A (zh) 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
CN103804351A (zh) 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
CN103804363A (zh) 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
CN104628657A (zh) 2013-11-06 2015-05-20 韩冰 一类治疗缺血性脑损伤的化合物及其用途
WO2016001341A1 (en) 2014-07-03 2016-01-07 F. Hoffmann-La Roche Ag Sulfonylaminopyridine compounds, compositions and methods of use
CN110845482B (zh) 2014-07-04 2024-01-19 日本烟草产业株式会社 制备吲哚化合物的方法
WO2016010108A1 (ja) 2014-07-18 2016-01-21 塩野義製薬株式会社 含窒素複素環誘導体およびそれらを含有する医薬組成物
CN105524067A (zh) 2014-09-28 2016-04-27 江苏柯菲平医药股份有限公司 4-取代吡咯并[2,3-d]嘧啶化合物及其用途
WO2016091916A1 (en) 2014-12-10 2016-06-16 F. Hoffmann-La Roche Ag Pyrazolylaminopurines as itk inhibitors
WO2016115455A2 (en) 2015-01-15 2016-07-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 6-aryl-7-substituted-3-(1h-pyrazol-5-yl)-7h-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the stat3 pathway with anti-proliferative activity
CN112979660A (zh) 2015-07-02 2021-06-18 豪夫迈·罗氏有限公司 二环内酰胺和其应用方法
SMT202400314T1 (it) 2018-05-25 2024-09-16 Japan Tobacco Inc Composto di indolo per trattare cistite interstiziale
JP7407705B2 (ja) 2018-05-25 2024-01-04 日本たばこ産業株式会社 インドール化合物を含む多発性硬化症の治療又は予防剤
EP3804727B1 (en) 2018-05-25 2023-10-11 Japan Tobacco Inc. Indol-containing compound for use in the treatment of the nephrotic syndrome
JP2023552863A (ja) * 2020-12-15 2023-12-19 ファイザー・インク ベンゾイミダゾール誘導体および皮膚疾患の処置のためのｉｔｋの阻害剤としてのそれらの使用

Also Published As

Publication number Publication date
ECSP22049160A (es) 2022-07-29
US11661419B2 (en) 2023-05-30
TW202130634A (zh) 2021-08-16
IL293831A (en) 2022-08-01
AU2020405536B2 (en) 2023-09-07
BR112022011838A2 (pt) 2022-08-30
MX2022007518A (es) 2022-09-19
TWI766484B (zh) 2022-06-01
US20210188829A1 (en) 2021-06-24
CA3103120A1 (en) 2021-06-20
CN115087655A (zh) 2022-09-20
PE20221916A1 (es) 2022-12-23
JP2023507138A (ja) 2023-02-21
CR20220299A (es) 2022-08-05
UY38998A (es) 2021-07-30
KR20220118525A (ko) 2022-08-25
IL293831B1 (en) 2023-10-01
WO2021124155A1 (en) 2021-06-24
AU2020405536A1 (en) 2022-07-14
DOP2022000130A (es) 2022-07-31
EP4077316A1 (en) 2022-10-26
IL293831B2 (en) 2024-02-01
CO2022008313A2 (es) 2022-07-08

Similar Documents

Publication Publication Date Title
CL2022001675A1 (es) Derivados de benzimidazol
CL2019001077A1 (es) Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer.
ECSP20070854A (es) Compuestos heteroaril tetracíclicos
UY38001A (es) Compuestos que inhiben las proteínas ras mutantes g12c
MX2018009257A (es) Derivados de benzimidazol como moduladores de ror-gamma.
CO2017009891A2 (es) Inhibidores de inhibidores del factor beta de crecimiento de transformación (tgf-beta)
SV2016005171A (es) Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih
CU20170154A7 (es) Derivados de pirazol-3-il-amina sustituidos como inhibidores cdk
CL2011002180A1 (es) Compuestos derivados de benzimidazol, inhibidores de mpges-1; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades inflamatorias y dolor.
NI201500048A (es) Derivados de 5-fenoxi-3h-pirimidin-4-ona y su uso como inhibidores de la transcriptasa inversa del vih
CL2019001495A1 (es) Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih.
ECSP17007208A (es) Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble
UY35535A (es) ?Derivados de fenil sulfonamidas?.
CL2019001991A1 (es) Moduladores del receptor de estrógeno.
CO2020004977A2 (es) Compuestos bicíclicos para su uso como inhibidores de la ripi quinasa
CR20160084A (es) Derivados de amida como agonistas del receptor del ácido lisofosfatídico
CR20180091A (es) 5-(n-bencil-tetrahidroisoquinolin-6-il)-piridin-3-il acético como inhibidores de la replicación del vih
ECSP21037191A (es) Pirazoles como moduladores de la hemoglobina
UY35536A (es) ?derivados de sulfonamida?.
BR112017013998A2 (pt) novos derivados de benzimidazol como agentes anti-histamínicos
DOP2022000203A (es) 3-fenoxiazetidin-1-il-pirazinas sustituidas con actividad antagonista gpr52
CO2021001925A2 (es) Piridopirimidinas como inhibidores del receptor de histamina h4
ECSP18056196A (es) Derivados de indano
ECSP099644A (es) Derivados de quinolina, composiciones farmacéuticas que los comprenden y el uso de tales en el tratamiento de enfermedades del sistema nervioso central y periférico