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CL2016001840A1 - Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cancer. - Google Patents

Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cancer.

Info

Publication number
CL2016001840A1
CL2016001840A1 CL2016001840A CL2016001840A CL2016001840A1 CL 2016001840 A1 CL2016001840 A1 CL 2016001840A1 CL 2016001840 A CL2016001840 A CL 2016001840A CL 2016001840 A CL2016001840 A CL 2016001840A CL 2016001840 A1 CL2016001840 A1 CL 2016001840A1
Authority
CL
Chile
Prior art keywords
inhibitors
complex
pharmaceutical composition
cancer treatment
compounds derived
Prior art date
Application number
CL2016001840A
Other languages
English (en)
Inventor
Han-Jie Zhou
David Wustrow
Original Assignee
Cleave Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52478057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016001840(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cleave Biosciences Inc filed Critical Cleave Biosciences Inc
Publication of CL2016001840A1 publication Critical patent/CL2016001840A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

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  • Health & Medical Sciences (AREA)
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  • Cardiology (AREA)
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  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Dermatology (AREA)
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Abstract

Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cáncer.
CL2016001840A 2014-01-20 2016-07-20 Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cancer. CL2016001840A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461929382P 2014-01-20 2014-01-20

Publications (1)

Publication Number Publication Date
CL2016001840A1 true CL2016001840A1 (es) 2017-04-17

Family

ID=52478057

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001840A CL2016001840A1 (es) 2014-01-20 2016-07-20 Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cancer.

Country Status (19)

Country Link
US (2) US9828363B2 (es)
EP (1) EP3097092B1 (es)
JP (1) JP6387111B2 (es)
KR (1) KR101922317B1 (es)
CN (1) CN106458996B (es)
AR (1) AR099138A1 (es)
AU (1) AU2015206292B2 (es)
BR (1) BR112016016421B1 (es)
CA (1) CA2936559C (es)
CL (1) CL2016001840A1 (es)
EA (1) EA031317B1 (es)
ES (1) ES2819867T3 (es)
IL (1) IL246692B (es)
MX (1) MX374379B (es)
NZ (1) NZ722624A (es)
SG (1) SG11201605699QA (es)
TW (1) TWI640516B (es)
WO (1) WO2015109285A1 (es)
ZA (1) ZA201605107B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3080101A1 (en) 2013-12-10 2016-10-19 Cleave Biosciences, Inc. Monocyclic pyrimidine/pyridine compounds as inhibitors of p97 complex
EA031317B1 (ru) 2014-01-20 2018-12-28 Клив Байосайенсиз, Инк. КОНДЕНСИРОВАННЫЕ ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ КОМПЛЕКСА p97
ES2894255T3 (es) * 2016-12-22 2022-02-14 Amgen Inc Derivados de benzoisotiazol, isotiazolo[3,4-b]piridina, quinazolina, ftalazina, pirido[2,3-d]piridazina y derivados de pirido[2,3-d]pirimidina como inhibidores de KRAS G12C para tratar el cáncer de pulmón, pancreático o colorrectal
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
EP4141005B1 (en) 2017-09-08 2024-04-03 Amgen Inc. Inhibitors of kras g12c and methods of using the same
JP7369719B2 (ja) 2018-06-12 2023-10-26 アムジエン・インコーポレーテツド ＫＲａｓ Ｇ１２Ｃ阻害剤及びそれを使用する方法
WO2020047192A1 (en) * 2018-08-31 2020-03-05 Mirati Therapeutics, Inc. Kras g12c inhibitors
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
CN118834208A (zh) 2019-05-21 2024-10-25 美国安进公司 固态形式
CN110078749B (zh) * 2019-06-04 2021-01-01 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 3a，3a′-双呋喃[2,3-b]吲哚啉类化合物、制备方法、药物组合物及应用
CN110872291B (zh) * 2019-11-26 2021-06-25 五邑大学 一种四氢吡啶并嘧啶类化合物及其制备方法和应用
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