CH668705A5 - Revetement pour formes pharmaceutiques a liberation prolongee. - Google Patents
Revetement pour formes pharmaceutiques a liberation prolongee. Download PDFInfo
- Publication number
- CH668705A5 CH668705A5 CH339/86A CH33986A CH668705A5 CH 668705 A5 CH668705 A5 CH 668705A5 CH 339/86 A CH339/86 A CH 339/86A CH 33986 A CH33986 A CH 33986A CH 668705 A5 CH668705 A5 CH 668705A5
- Authority
- CH
- Switzerland
- Prior art keywords
- coating
- water
- kaolin
- coating composition
- pharmaceutical forms
- Prior art date
Links
- 238000000576 coating method Methods 0.000 title description 44
- 239000011248 coating agent Substances 0.000 title description 33
- 238000013265 extended release Methods 0.000 title 1
- 239000000945 filler Substances 0.000 claims description 25
- 229920000642 polymer Polymers 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000005995 Aluminium silicate Substances 0.000 claims description 16
- 235000012211 aluminium silicate Nutrition 0.000 claims description 16
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 16
- 239000008199 coating composition Substances 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 5
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 239000000454 talc Substances 0.000 claims description 4
- 229910052623 talc Inorganic materials 0.000 claims description 4
- 230000035699 permeability Effects 0.000 claims description 3
- 125000000524 functional group Chemical group 0.000 claims description 2
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 17
- 239000003814 drug Substances 0.000 description 17
- 239000008188 pellet Substances 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 6
- 229960000520 diphenhydramine Drugs 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 6
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 5
- 229960003908 pseudoephedrine Drugs 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
- 230000001766 physiological effect Effects 0.000 description 4
- 229920003148 Eudragit® E polymer Polymers 0.000 description 3
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000012738 dissolution medium Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 229960000278 theophylline Drugs 0.000 description 3
- 239000004925 Acrylic resin Substances 0.000 description 2
- 229920000178 Acrylic resin Polymers 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- 229940123150 Chelating agent Drugs 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000464 adrenergic agent Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 229940033495 antimalarials Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000002327 cardiovascular agent Substances 0.000 description 1
- 229940125692 cardiovascular agent Drugs 0.000 description 1
- 239000003874 central nervous system depressant Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 239000002475 cognitive enhancer Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000002788 histamine agent Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 239000012764 mineral filler Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000008016 pharmaceutical coating Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69694585A | 1985-01-30 | 1985-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH668705A5 true CH668705A5 (fr) | 1989-01-31 |
Family
ID=24799149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH339/86A CH668705A5 (fr) | 1985-01-30 | 1986-01-29 | Revetement pour formes pharmaceutiques a liberation prolongee. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS61176536A (it) |
| AU (1) | AU5261886A (it) |
| BE (1) | BE904137A (it) |
| CH (1) | CH668705A5 (it) |
| DE (1) | DE3601002A1 (it) |
| DK (1) | DK44086A (it) |
| ES (1) | ES8802396A1 (it) |
| FR (1) | FR2576514A1 (it) |
| GB (1) | GB2170210A (it) |
| IT (1) | IT1190461B (it) |
| LU (1) | LU86273A1 (it) |
| NL (1) | NL8600210A (it) |
| SE (1) | SE8600377L (it) |
| ZA (1) | ZA86252B (it) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4971791A (en) * | 1985-08-26 | 1990-11-20 | The Procter & Gamble Company | Taste masking compositions |
| US4780315A (en) * | 1985-11-25 | 1988-10-25 | Eastman Kodak Company | Rumen-stable pellets |
| HU202120B (en) * | 1988-06-29 | 1991-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for film coating of medical compositions with polymer dispersions |
| NZ242065A (en) * | 1991-03-26 | 1996-06-25 | Csl Ltd | Delayed release implant having a degradable or rupturable polymeric coating |
| PT888111E (pt) * | 1996-03-08 | 2003-09-30 | Nycomed Danmark As | Composicao de multiplas unidades de dosagem de libertacao modificada. |
| US6420473B1 (en) * | 2000-02-10 | 2002-07-16 | Bpsi Holdings, Inc. | Acrylic enteric coating compositions |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2583274A (en) * | 1947-04-30 | 1952-01-22 | Monsanto Chemicals | Process for producing mineralcoated paper |
| GB751729A (en) * | 1952-06-25 | 1956-07-04 | John Charles Rice | Method of producing a high finish on paper products |
| GB749719A (en) * | 1953-10-21 | 1956-05-30 | Ici Ltd | Coating compositions |
| NL254259A (it) * | 1960-04-23 | |||
| GB945711A (en) * | 1960-09-01 | 1964-01-08 | British Oxygen Co Ltd | Emulsion paint |
| GB916134A (en) * | 1961-06-29 | 1963-01-23 | Nat Starch Chem Corp | Improvements in or relating to water-base vinyl acetate-methyl methacrylate gloss paints |
| FR1409758A (fr) * | 1964-05-13 | 1965-09-03 | Nobel Bozel | Compositions améliorant la résistance à la friction humide des papiers couchés et papiers obtenus |
| FR1583877A (it) * | 1967-05-25 | 1969-12-05 | ||
| US3935326A (en) * | 1967-06-28 | 1976-01-27 | Boehringer Mannheim G.M.B.H. | Process for coating tablets with aqueous resin dispersions |
| DE1617351A1 (it) * | 1967-06-28 | 1972-01-05 | ||
| DE1814669C3 (de) * | 1968-12-14 | 1974-10-03 | Roehm Gmbh, 6100 Darmstadt | Überzugsmittel für Arzneiformen |
| AT321182B (de) * | 1970-03-16 | 1975-03-25 | Pennwalt Corp | Überzugsmischung und Beschichten der Oberflächen von Steinen |
| GB1294173A (en) * | 1970-06-02 | 1972-10-25 | Ici Ltd | Coating compositions |
| DE2225317C3 (de) * | 1972-05-25 | 1978-06-01 | Basf Ag, 6700 Ludwigshafen | Papierstreichmassen |
| DE2522483C2 (de) * | 1975-05-21 | 1984-06-28 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von lackierten Tabletten |
| EP0052075A1 (de) * | 1980-11-12 | 1982-05-19 | Ciba-Geigy Ag | Körnige Arzneimittel-Retardform |
| JPS58109413A (ja) * | 1981-12-23 | 1983-06-29 | Eisai Co Ltd | 耐衝撃性腸溶錠 |
| IT1153487B (it) * | 1982-04-15 | 1987-01-14 | Prophin Lab Spa | Prodotti farmaceutici in forma-ritardo e procedimento per ottenerli |
-
1986
- 1986-01-13 ZA ZA86252A patent/ZA86252B/xx unknown
- 1986-01-15 DE DE19863601002 patent/DE3601002A1/de not_active Withdrawn
- 1986-01-21 GB GB08601390A patent/GB2170210A/en not_active Withdrawn
- 1986-01-22 AU AU52618/86A patent/AU5261886A/en not_active Abandoned
- 1986-01-23 FR FR8600926A patent/FR2576514A1/fr not_active Withdrawn
- 1986-01-28 LU LU86273A patent/LU86273A1/fr unknown
- 1986-01-29 BE BE6/48186A patent/BE904137A/fr unknown
- 1986-01-29 JP JP61016005A patent/JPS61176536A/ja active Pending
- 1986-01-29 CH CH339/86A patent/CH668705A5/fr not_active IP Right Cessation
- 1986-01-29 IT IT47594/86A patent/IT1190461B/it active
- 1986-01-29 DK DK44086A patent/DK44086A/da not_active Application Discontinuation
- 1986-01-29 NL NL8600210A patent/NL8600210A/nl not_active Application Discontinuation
- 1986-01-29 SE SE8600377A patent/SE8600377L/ not_active Application Discontinuation
- 1986-01-30 ES ES551440A patent/ES8802396A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE8600377D0 (sv) | 1986-01-29 |
| DK44086A (da) | 1986-07-31 |
| ES8802396A1 (es) | 1988-05-16 |
| IT8647594A0 (it) | 1986-01-29 |
| SE8600377L (sv) | 1986-07-31 |
| JPS61176536A (ja) | 1986-08-08 |
| AU5261886A (en) | 1986-08-07 |
| LU86273A1 (fr) | 1986-06-09 |
| NL8600210A (nl) | 1986-08-18 |
| DE3601002A1 (de) | 1986-07-31 |
| DK44086D0 (da) | 1986-01-29 |
| GB8601390D0 (en) | 1986-02-26 |
| FR2576514A1 (fr) | 1986-08-01 |
| GB2170210A (en) | 1986-07-30 |
| IT1190461B (it) | 1988-02-16 |
| ZA86252B (en) | 1986-09-24 |
| ES551440A0 (es) | 1988-05-16 |
| BE904137A (fr) | 1986-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |