CH653890A5 - Composizioni farmaceutiche ad attivita antineoplastica. - Google Patents
Composizioni farmaceutiche ad attivita antineoplastica. Download PDFInfo
- Publication number
- CH653890A5 CH653890A5 CH2772/83A CH277283A CH653890A5 CH 653890 A5 CH653890 A5 CH 653890A5 CH 2772/83 A CH2772/83 A CH 2772/83A CH 277283 A CH277283 A CH 277283A CH 653890 A5 CH653890 A5 CH 653890A5
- Authority
- CH
- Switzerland
- Prior art keywords
- pharmaceutical compositions
- compositions according
- formula
- cholesterol
- parts
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 15
- 230000000118 anti-neoplastic effect Effects 0.000 title claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 22
- 235000012000 cholesterol Nutrition 0.000 claims description 11
- KUGBQWBWWNPMIT-UHFFFAOYSA-N 1,1,2,2,3,3,4,4-octafluoropentan-1-ol Chemical compound CC(F)(F)C(F)(F)C(F)(F)C(O)(F)F KUGBQWBWWNPMIT-UHFFFAOYSA-N 0.000 claims description 8
- GUAMVMSOIYAUSK-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-hexadecafluorononan-1-ol Chemical compound CC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(O)(F)F GUAMVMSOIYAUSK-UHFFFAOYSA-N 0.000 claims description 7
- 239000008159 sesame oil Substances 0.000 claims description 6
- 235000011803 sesame oil Nutrition 0.000 claims description 6
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 230000001925 catabolic effect Effects 0.000 description 4
- 241000700159 Rattus Species 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 231100000403 acute toxicity Toxicity 0.000 description 2
- 230000007665 chronic toxicity Effects 0.000 description 2
- 231100000160 chronic toxicity Toxicity 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000009543 pathological alteration Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 231100000456 subacute toxicity Toxicity 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- BYKNGMLDSIEFFG-UHFFFAOYSA-N 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol Chemical compound OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)F BYKNGMLDSIEFFG-UHFFFAOYSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/34—Halogenated alcohols
- C07C31/38—Halogenated alcohols containing only fluorine as halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8221553A IT8221553A0 (it) | 1982-05-28 | 1982-05-28 | Composizioni farmaceutiche adattivita' antineoplastica. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH653890A5 true CH653890A5 (it) | 1986-01-31 |
Family
ID=11183507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH2772/83A CH653890A5 (it) | 1982-05-28 | 1983-05-20 | Composizioni farmaceutiche ad attivita antineoplastica. |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS591414A (nl) |
| AU (2) | AU552557B2 (nl) |
| BE (1) | BE896838A (nl) |
| CH (1) | CH653890A5 (nl) |
| DE (1) | DE3319304A1 (nl) |
| FR (1) | FR2527439A1 (nl) |
| GB (1) | GB2121280B (nl) |
| IE (1) | IE55137B1 (nl) |
| IL (1) | IL68796A0 (nl) |
| IN (1) | IN157042B (nl) |
| IT (1) | IT8221553A0 (nl) |
| LU (1) | LU84827A1 (nl) |
| NL (1) | NL8301899A (nl) |
| NZ (1) | NZ204393A (nl) |
| SE (1) | SE8302976L (nl) |
| ZA (1) | ZA833871B (nl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3836971C1 (nl) * | 1988-10-31 | 1990-05-17 | Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3219004C1 (de) * | 1982-05-19 | 1984-03-01 | Philippine Dr. 8000 München Hartmann | Arzneimittel zur Behandlung von Tumoren |
-
1982
- 1982-05-28 IT IT8221553A patent/IT8221553A0/it unknown
-
1983
- 1983-05-20 CH CH2772/83A patent/CH653890A5/it not_active IP Right Cessation
- 1983-05-26 BE BE2/60100A patent/BE896838A/nl not_active IP Right Cessation
- 1983-05-26 SE SE8302976A patent/SE8302976L/ not_active Application Discontinuation
- 1983-05-26 AU AU15000/83A patent/AU552557B2/en not_active Expired - Fee Related
- 1983-05-26 GB GB08314540A patent/GB2121280B/en not_active Expired
- 1983-05-26 IL IL68796A patent/IL68796A0/xx unknown
- 1983-05-26 JP JP58093889A patent/JPS591414A/ja active Pending
- 1983-05-27 ZA ZA833871A patent/ZA833871B/xx unknown
- 1983-05-27 DE DE19833319304 patent/DE3319304A1/de not_active Ceased
- 1983-05-27 LU LU84827A patent/LU84827A1/fr unknown
- 1983-05-27 NL NL8301899A patent/NL8301899A/nl not_active Application Discontinuation
- 1983-05-27 IN IN673/CAL/83A patent/IN157042B/en unknown
- 1983-05-27 IE IE1259/83A patent/IE55137B1/en unknown
- 1983-05-27 NZ NZ204393A patent/NZ204393A/en unknown
- 1983-05-27 FR FR8308776A patent/FR2527439A1/fr not_active Withdrawn
-
1988
- 1988-05-04 AU AU15570/88A patent/AU1557088A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB8314540D0 (en) | 1983-06-29 |
| JPS591414A (ja) | 1984-01-06 |
| FR2527439A1 (fr) | 1983-12-02 |
| AU1557088A (en) | 1988-11-10 |
| SE8302976D0 (sv) | 1983-05-26 |
| AU1500083A (en) | 1983-12-01 |
| NL8301899A (nl) | 1983-12-16 |
| GB2121280A (en) | 1983-12-21 |
| IL68796A0 (en) | 1983-09-30 |
| IE831259L (en) | 1983-11-28 |
| IE55137B1 (en) | 1990-06-06 |
| ZA833871B (en) | 1984-07-25 |
| NZ204393A (en) | 1986-03-14 |
| LU84827A1 (fr) | 1983-11-17 |
| BE896838A (nl) | 1983-09-16 |
| GB2121280B (en) | 1985-08-29 |
| AU552557B2 (en) | 1986-06-05 |
| DE3319304A1 (de) | 1983-12-01 |
| SE8302976L (sv) | 1983-11-29 |
| IN157042B (nl) | 1986-01-04 |
| IT8221553A0 (it) | 1982-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |