CH647787A5 - Procede d'obtention d'extraits de lierre grimpant, extraits obtenus et compositions pharmaceutiques. - Google Patents

Procede d'obtention d'extraits de lierre grimpant, extraits obtenus et compositions pharmaceutiques. Download PDF

Info

Publication number: CH647787A5
Authority: CH; Switzerland
Prior art keywords: extract; active; ivy; antiparasitic; titrating
Prior art date: 1979-07-05

Application number

CH5153/80A

Other languages

English (en)

French (fr)

Inventor

Pierre Bernard

Guy Balansard

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-05

Filing date

1980-07-04

Publication date

1985-02-15

1980-07-04 Application filed by Synthelabo filed Critical Synthelabo

1985-02-15 Publication of CH647787A5 publication Critical patent/CH647787A5/fr

Links

239000000284 extract Substances 0.000 title claims description 55
238000000034 method Methods 0.000 title claims description 16
230000009194 climbing Effects 0.000 title claims description 12
239000008194 pharmaceutical composition Substances 0.000 title claims 5
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 45
RYHDIBJJJRNDSX-MCGLQMIESA-N Hederacoside C Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)[C@H](OC(=O)[C@@]34[C@@H](CC(C)(C)CC3)C=3[C@@]([C@]5(C)CC[C@H]6[C@](C)(CO)[C@@H](O[C@H]7[C@@H]([C@@H](O)[C@@H](O)CO7)O[C@H]7[C@@H]([C@H](O)[C@@H](O)[C@H](C)O7)O)CC[C@]6(C)[C@H]5CC=3)(C)CC4)O2)O)[C@H](O)[C@H]1O RYHDIBJJJRNDSX-MCGLQMIESA-N 0.000 claims description 15
MLWBUURUTWPMOO-UHFFFAOYSA-N Hederasaponin C Natural products CC1OC(OC2C(O)COC(OC3CCC4(C)C(CCC5(C)C4CC=C6C7CC(C)(C)CCC7(CCC56C)C(=O)OC8OC(COC9OC(CO)C(OC%10OC(C)C(O)C(O)C%10O)C(O)C9O)C(O)C(O)C8O)C3(C)CO)C2O)C(O)C(O)C1O MLWBUURUTWPMOO-UHFFFAOYSA-N 0.000 claims description 15
RYHDIBJJJRNDSX-UHFFFAOYSA-N kalopanax-saponin B Natural products OC1C(O)C(O)C(C)OC1OC1C(CO)OC(OCC2C(C(O)C(O)C(OC(=O)C34C(CC(C)(C)CC3)C=3C(C5(C)CCC6C(C)(CO)C(OC7C(C(O)C(O)CO7)OC7C(C(O)C(O)C(C)O7)O)CCC6(C)C5CC=3)(C)CC4)O2)O)C(O)C1O RYHDIBJJJRNDSX-UHFFFAOYSA-N 0.000 claims description 15
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
239000000203 mixture Substances 0.000 claims description 12
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
229930182490 saponin Natural products 0.000 claims description 10
150000007949 saponins Chemical class 0.000 claims description 10
235000017709 saponins Nutrition 0.000 claims description 10
230000002141 anti-parasite Effects 0.000 claims description 9
229940121375 antifungal agent Drugs 0.000 claims description 8
239000003096 antiparasitic agent Substances 0.000 claims description 8
239000000706 filtrate Substances 0.000 claims description 7
230000002829 reductive effect Effects 0.000 claims description 7
239000002904 solvent Substances 0.000 claims description 7
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
239000002775 capsule Substances 0.000 claims description 5
239000000843 powder Substances 0.000 claims description 5
239000000243 solution Substances 0.000 claims description 5
MQFLXLMNOHHPTC-UHFFFAOYSA-N 1-isothiocyanato-9-(methylsulfinyl)nonane Chemical compound CS(=O)CCCCCCCCCN=C=S MQFLXLMNOHHPTC-UHFFFAOYSA-N 0.000 claims description 4
159000000011 group IA salts Chemical class 0.000 claims description 4
230000007935 neutral effect Effects 0.000 claims description 4
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 3
238000002386 leaching Methods 0.000 claims description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 2
238000007911 parenteral administration Methods 0.000 claims description 2
239000001397 quillaja saponaria molina bark Substances 0.000 claims description 2
241000208341 Hedera Species 0.000 claims 11
239000003429 antifungal agent Substances 0.000 claims 6
229940125687 antiparasitic agent Drugs 0.000 claims 6
240000008669 Hedera helix Species 0.000 claims 1
239000004480 active ingredient Substances 0.000 claims 1
238000000605 extraction Methods 0.000 claims 1
239000003889 eye drop Substances 0.000 claims 1
229940012356 eye drops Drugs 0.000 claims 1
239000002674 ointment Substances 0.000 claims 1
238000011200 topical administration Methods 0.000 claims 1
239000000047 product Substances 0.000 description 20
238000000338 in vitro Methods 0.000 description 15
239000000126 substance Substances 0.000 description 15
238000001727 in vivo Methods 0.000 description 14
230000000694 effects Effects 0.000 description 13
PXOYOCNNSUAQNS-AGNJHWRGSA-N alantolactone Chemical compound C1[C@H]2OC(=O)C(=C)[C@H]2C=C2[C@@H](C)CCC[C@@]21C PXOYOCNNSUAQNS-AGNJHWRGSA-N 0.000 description 10
230000000843 anti-fungal effect Effects 0.000 description 7
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
241000699666 Mus <mouse, genus> Species 0.000 description 6
206010000269 abscess Diseases 0.000 description 6
235000013601 eggs Nutrition 0.000 description 6
239000013558 reference substance Substances 0.000 description 6
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 5
241001465754 Metazoa Species 0.000 description 5
241001494479 Pecora Species 0.000 description 5
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 5
229960003942 amphotericin b Drugs 0.000 description 5
238000010790 dilution Methods 0.000 description 5
239000012895 dilution Substances 0.000 description 5
230000008034 disappearance Effects 0.000 description 5
239000002244 precipitate Substances 0.000 description 5
241000699670 Mus sp. Species 0.000 description 4
210000003608 fece Anatomy 0.000 description 4
239000002609 medium Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
241001480043 Arthrodermataceae Species 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
241000222122 Candida albicans Species 0.000 description 3
241000577452 Dicrocoelium Species 0.000 description 3
240000004808 Saccharomyces cerevisiae Species 0.000 description 3
229940095731 candida albicans Drugs 0.000 description 3
230000037304 dermatophytes Effects 0.000 description 3
238000002224 dissection Methods 0.000 description 3
230000035876 healing Effects 0.000 description 3
238000011534 incubation Methods 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
231100000636 lethal dose Toxicity 0.000 description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
241000242711 Fasciola hepatica Species 0.000 description 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
206010042343 Subcutaneous abscess Diseases 0.000 description 2
241000869417 Trematodes Species 0.000 description 2
241000224526 Trichomonas Species 0.000 description 2
TUFPZQHDPZYIEX-UHFFFAOYSA-N alpha-Santonin Natural products C1CC2(C)C=CC(=O)C=C2C2C1C(C)C(=O)O2 TUFPZQHDPZYIEX-UHFFFAOYSA-N 0.000 description 2
XJHDMGJURBVLLE-BOCCBSBMSA-N alpha-santonin Chemical compound C([C@]1(C)CC2)=CC(=O)C(C)=C1[C@@H]1[C@@H]2[C@H](C)C(=O)O1 XJHDMGJURBVLLE-BOCCBSBMSA-N 0.000 description 2
230000000507 anthelmentic effect Effects 0.000 description 2
238000011888 autopsy Methods 0.000 description 2
210000000013 bile duct Anatomy 0.000 description 2
239000002054 inoculum Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
229960000901 mepacrine Drugs 0.000 description 2
229960000282 metronidazole Drugs 0.000 description 2
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
GPKJTRJOBQGKQK-UHFFFAOYSA-N quinacrine Chemical compound C1=C(OC)C=C2C(NC(C)CCCN(CC)CC)=C(C=CC(Cl)=C3)C3=NC2=C1 GPKJTRJOBQGKQK-UHFFFAOYSA-N 0.000 description 2
229940074353 santonin Drugs 0.000 description 2
SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 description 1
SWDXALWLRYIJHK-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;piperazine Chemical compound C1CNCCN1.OC(=O)CC(O)(C(O)=O)CC(O)=O SWDXALWLRYIJHK-UHFFFAOYSA-N 0.000 description 1
241000224489 Amoeba Species 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
241000282465 Canis Species 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
241000224421 Heterolobosea Species 0.000 description 1
241000404582 Hymenolepis <angiosperm> Species 0.000 description 1
241001464384 Hymenolepis nana Species 0.000 description 1
206010061217 Infestation Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
208000030852 Parasitic disease Diseases 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
241000975692 Syphacia obvelata Species 0.000 description 1
241000242541 Trematoda Species 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
210000003001 amoeba Anatomy 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
238000000889 atomisation Methods 0.000 description 1
RIOXQFHNBCKOKP-UHFFFAOYSA-N benomyl Chemical compound C1=CC=C2N(C(=O)NCCCC)C(NC(=O)OC)=NC2=C1 RIOXQFHNBCKOKP-UHFFFAOYSA-N 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
210000003459 common hepatic duct Anatomy 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000035617 depilation Effects 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000037406 food intake Effects 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
230000002440 hepatic effect Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000008176 lyophilized powder Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
230000001069 nematicidal effect Effects 0.000 description 1
230000003071 parasitic effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229960005141 piperazine Drugs 0.000 description 1
229960000718 piperazine citrate Drugs 0.000 description 1
229940072033 potash Drugs 0.000 description 1
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
235000015320 potassium carbonate Nutrition 0.000 description 1
239000000523 sample Substances 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
238000003307 slaughter Methods 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
238000009331 sowing Methods 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
235000012141 vanillin Nutrition 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Botany (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Alternative & Traditional Medicine (AREA)
Biochemistry (AREA)
Medical Informatics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CH5153/80A 1979-07-05 1980-07-04 Procede d'obtention d'extraits de lierre grimpant, extraits obtenus et compositions pharmaceutiques. CH647787A5 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7917451A FR2460136B1 (fr)	1979-07-05	1979-07-05	Compositions pharmaceutiques contenant des extraits de lierre grimpant

Publications (1)

Publication Number	Publication Date
CH647787A5 true CH647787A5 (fr)	1985-02-15

Family

ID=9227547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH5153/80A CH647787A5 (fr)	1979-07-05	1980-07-04	Procede d'obtention d'extraits de lierre grimpant, extraits obtenus et compositions pharmaceutiques.

Country Status (13)

Country	Link
AT (1)	AT369264B (de)
BE (1)	BE884190A (de)
CH (1)	CH647787A5 (de)
DE (1)	DE3025223A1 (de)
ES (1)	ES8103974A1 (de)
FR (1)	FR2460136B1 (de)
GB (1)	GB2051575B (de)
GR (1)	GR69637B (de)
IE (1)	IE50062B1 (de)
IT (1)	IT1132510B (de)
LU (1)	LU82583A1 (de)
NL (1)	NL8003871A (de)
PT (1)	PT71495A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1195849B (it) *	1986-07-01	1988-10-27	Sigma Tau Ind Farmaceuti	Saponine triterpeniche ad attivita' antiinfiammatoria,mucolitica ed antiedemigena,procedimento per il loro ottenimento e composizioni farmaceutiche che li comprendono
DE4010042A1 (de) *	1990-03-29	1991-10-24	Cassella Ag	Verwendung von efeu zur topischen behandlung vermehrter schuppenbildung der behaarten und unbehaarten haut sowie der psoriasis
US20050014730A1 (en) *	2003-04-02	2005-01-20	Carlson Robert M.	Anti-fungal formulation of triterpene and essential oil
DE10335173A1 (de) *	2003-07-30	2005-03-03	Mirjana Kiener	Mittel zur Vergrösserung der weiblichen Brust
DE10345342A1 (de) *	2003-09-19	2005-04-28	Engelhard Arzneimittel Gmbh	Verfahren zur Herstellung eines lagerstabilen Extraktes aus Efeublättern, sowie ein nach diesem Verfahren hergestellter Extrakt
DE10345343A1 (de) *	2003-09-19	2005-04-14	Engelhard Arzneimittel Gmbh & Co. Kg	Verfahren zur Herstellung eines Extrakts aus Efeublättern und nach diesem Verfahren hergestellter Extrakt
GB0724967D0 (en) *	2007-12-21	2008-01-30	Univ Bangor	Composition and method
GB201404505D0 (en) *	2013-09-06	2014-04-30	Mars Inc	Oral anti-parasitic composition
EP3939596A1 (de)	2020-07-14	2022-01-19	Bimeda Animal Health Limited	Zusammensetzung zur behandlung von helminthbefall bei einem säugetier
CN114805466B (zh) *	2022-04-15	2023-06-20	湖南朗林生物资源股份有限公司	一种常春藤提取物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR6330E (fr) *	1905-06-14	1906-10-13	Petrus Johannes Portman	Dispositif automatique avec appareil de controle pour la sécurité de la circulation des chemins de fer
BE670523A (de) *	1964-10-09
FR6218M (de) *	1967-05-24	1968-07-29
FR2233071A1 (en) *	1973-06-14	1975-01-10	Prod Hyg Laboratoires	Flavones and saponins extracted from ivy - by solid-liquid extraction of undesirables followed by alcohol extraction

1979
- 1979-07-05 FR FR7917451A patent/FR2460136B1/fr not_active Expired
1980
- 1980-07-03 DE DE19803025223 patent/DE3025223A1/de not_active Withdrawn
- 1980-07-04 BE BE0/201310A patent/BE884190A/fr not_active IP Right Cessation
- 1980-07-04 PT PT71495A patent/PT71495A/pt unknown
- 1980-07-04 CH CH5153/80A patent/CH647787A5/fr not_active IP Right Cessation
- 1980-07-04 IE IE1393/80A patent/IE50062B1/en unknown
- 1980-07-04 NL NL8003871A patent/NL8003871A/nl not_active Application Discontinuation
- 1980-07-04 LU LU82583A patent/LU82583A1/fr unknown
- 1980-07-04 AT AT0350580A patent/AT369264B/de not_active IP Right Cessation
- 1980-07-04 GB GB8021943A patent/GB2051575B/en not_active Expired
- 1980-07-04 IT IT23262/80A patent/IT1132510B/it active
- 1980-07-04 ES ES493118A patent/ES8103974A1/es not_active Expired
- 1980-07-04 GR GR62377A patent/GR69637B/el unknown

Also Published As

Publication number	Publication date
NL8003871A (nl)	1981-01-07
IE50062B1 (en)	1986-02-05
ES493118A0 (es)	1981-04-01
IT8023262A0 (it)	1980-07-04
IE801393L (en)	1981-01-05
PT71495A (fr)	1980-08-01
ES8103974A1 (es)	1981-04-01
BE884190A (fr)	1981-01-05
GR69637B (de)	1982-07-06
AT369264B (de)	1982-12-27
DE3025223A1 (de)	1981-01-08
FR2460136B1 (fr)	1986-01-10
ATA350580A (de)	1982-05-15
IT1132510B (it)	1986-07-02
FR2460136A1 (fr)	1981-01-23
LU82583A1 (fr)	1980-10-08
GB2051575B (en)	1984-01-18
GB2051575A (en)	1981-01-21

Publication	Publication Date	Title
LU82026A1 (fr)	1980-07-21	Preparation pharmaceutique comprenant un glycoside cardiaque ayant un revetement de polymere
CH647787A5 (fr)	1985-02-15	Procede d'obtention d'extraits de lierre grimpant, extraits obtenus et compositions pharmaceutiques.
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