[go: up one dir, main page]

CH624011A5 - - Google Patents

Download PDF

Info

Publication number
CH624011A5
CH624011A5 CH961677A CH961677A CH624011A5 CH 624011 A5 CH624011 A5 CH 624011A5 CH 961677 A CH961677 A CH 961677A CH 961677 A CH961677 A CH 961677A CH 624011 A5 CH624011 A5 CH 624011A5
Authority
CH
Switzerland
Prior art keywords
solution
liposomes
encapsulated
liquid
aqueous
Prior art date
Application number
CH961677A
Other languages
English (en)
French (fr)
Inventor
Michel Schneider
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Priority to CH961677A priority Critical patent/CH624011A5/fr
Priority to IL55154A priority patent/IL55154A/xx
Priority to HU78BA3681A priority patent/HU179672B/hu
Priority to GB7832003A priority patent/GB2001929B/en
Priority to IE1574/78A priority patent/IE47067B1/en
Priority to JP9372978A priority patent/JPS5441279A/ja
Priority to NL787808167A priority patent/NL7808167A/xx
Priority to LU80071A priority patent/LU80071A1/xx
Priority to DE19782834307 priority patent/DE2834307A1/de
Priority to IT26441/78A priority patent/IT1097928B/it
Priority to ES472326A priority patent/ES472326A1/es
Priority to SE7808356A priority patent/SE433169B/sv
Priority to FR7822985A priority patent/FR2399242A1/fr
Priority to ZA00784407A priority patent/ZA784407B/xx
Priority to BE78189678A priority patent/BE869490A/xx
Priority to DK344478A priority patent/DK155036C/da
Priority to CA308,715A priority patent/CA1098410A/en
Priority to AU38666/78A priority patent/AU520916B2/en
Priority to SU782649649A priority patent/SU1158031A3/ru
Priority to US05/931,242 priority patent/US4224179A/en
Publication of CH624011A5 publication Critical patent/CH624011A5/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277Preparation processes; Proliposomes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/929Specified combination of agitation steps, e.g. mixing to make subcombination composition followed by homogenization

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
CH961677A 1977-08-05 1977-08-05 CH624011A5 (pt)

Priority Applications (20)

Application Number Priority Date Filing Date Title
CH961677A CH624011A5 (pt) 1977-08-05 1977-08-05
IL55154A IL55154A (en) 1977-08-05 1978-07-17 Process for the preparation of liposomes in aqueous solution
HU78BA3681A HU179672B (en) 1977-08-05 1978-08-02 Process for producing aequous solution of liposomes
GB7832003A GB2001929B (en) 1977-08-05 1978-08-02 Process for the preparation of liposomes in aqueous solution
IE1574/78A IE47067B1 (en) 1977-08-05 1978-08-02 Process for the preparation of liposomes in aqueous solution
JP9372978A JPS5441279A (en) 1977-08-05 1978-08-02 Manufacture of liposome solution or suspension in aqueous medium
NL787808167A NL7808167A (nl) 1977-08-05 1978-08-03 Werkwijze voor het bereiden van oplossingen of suspen- sies van liposomen in waterige media.
LU80071A LU80071A1 (fr) 1977-08-05 1978-08-03 Procede de preparation de liposomes en solution aqueuse
DE19782834307 DE2834307A1 (de) 1977-08-05 1978-08-03 Verfahren zur herstellung von liposomen in waessriger loesung
IT26441/78A IT1097928B (it) 1977-08-05 1978-08-03 Procedimento di preparazione di liposomi in soluzione acquosa
ES472326A ES472326A1 (es) 1977-08-05 1978-08-03 Procedimiento para la preparacion de liposomas en solucion o suspension acuosa
SE7808356A SE433169B (sv) 1977-08-05 1978-08-03 Forfarande for framstellning av vattenlosningar eller suspensioner av liposomer
FR7822985A FR2399242A1 (fr) 1977-08-05 1978-08-03 Procede de preparation de liposomes en solution aqueuse
ZA00784407A ZA784407B (en) 1977-08-05 1978-08-03 Process for the preparation of liposomes in aqueous solution
BE78189678A BE869490A (fr) 1977-08-05 1978-08-03 Procede de preparation de liposomes en solution aqueuse
DK344478A DK155036C (da) 1977-08-05 1978-08-03 Fremgangsmaade til fremstilling af oploesninger eller suspensioner af liposomer i vandige medier.
CA308,715A CA1098410A (en) 1977-08-05 1978-08-03 Process for the preparation of liposomes in aqueous solution
AU38666/78A AU520916B2 (en) 1977-08-05 1978-08-04 Preparing liposomes
SU782649649A SU1158031A3 (ru) 1977-08-05 1978-08-04 Способ получени липосом
US05/931,242 US4224179A (en) 1977-08-05 1978-08-04 Process for the preparation of liposomes in aqueous solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH961677A CH624011A5 (pt) 1977-08-05 1977-08-05

Publications (1)

Publication Number Publication Date
CH624011A5 true CH624011A5 (pt) 1981-07-15

Family

ID=4353843

Family Applications (1)

Application Number Title Priority Date Filing Date
CH961677A CH624011A5 (pt) 1977-08-05 1977-08-05

Country Status (20)

Country Link
US (1) US4224179A (pt)
JP (1) JPS5441279A (pt)
AU (1) AU520916B2 (pt)
BE (1) BE869490A (pt)
CA (1) CA1098410A (pt)
CH (1) CH624011A5 (pt)
DE (1) DE2834307A1 (pt)
DK (1) DK155036C (pt)
ES (1) ES472326A1 (pt)
FR (1) FR2399242A1 (pt)
GB (1) GB2001929B (pt)
HU (1) HU179672B (pt)
IE (1) IE47067B1 (pt)
IL (1) IL55154A (pt)
IT (1) IT1097928B (pt)
LU (1) LU80071A1 (pt)
NL (1) NL7808167A (pt)
SE (1) SE433169B (pt)
SU (1) SU1158031A3 (pt)
ZA (1) ZA784407B (pt)

Families Citing this family (306)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356167A (en) * 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
IT1111367B (it) * 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
ATE8584T1 (de) 1980-01-16 1984-08-15 Hans Georg Prof. Dr. Weder Verfahren und dialysiereinrichtung zur herstellung von bilayer-vesikeln und verwendung der bilayer-vesikel.
US4302459A (en) * 1980-03-19 1981-11-24 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives
DE3161962D1 (en) * 1980-07-01 1984-02-23 Oreal Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions
DE3173713D1 (en) * 1980-09-05 1986-03-20 Frappier Armand Inst Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane
GR77320B (pt) * 1980-12-22 1984-09-11 Procter & Gamble
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
GB2103485B (en) * 1981-08-10 1986-04-03 Wellcone Foundation Limited Th Liposomes containing antimonyanti-leishmanaisis drugs
NL193099C (nl) * 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4416872A (en) * 1982-03-17 1983-11-22 The United States Of America As Represented By The Secretary Of The Army Treatment of malaria with liposomes containing 8-aminoquinoline derivatives and glycoconjugates
WO1983003383A1 (en) * 1982-03-29 1983-10-13 Liposome Co Inc Stable plurilamellar vesicles
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US5435989A (en) * 1982-03-30 1995-07-25 Vestar, Inc. Method of targeting a specific location in a body
US5441745A (en) * 1982-03-30 1995-08-15 Vestar, Inc. Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body
US4425334A (en) 1982-04-02 1984-01-10 The Regents Of The University Of California Functional oxygen transport system
US4612370A (en) * 1982-04-02 1986-09-16 The Regents Of The University Of California Lipid-saccharide reaction products
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP0100964A3 (de) * 1982-07-31 1984-06-13 Reifenrath, Rainer, Dr. Pharmazeutisches Erzeugnis zur Behandlung und Prophylaxe von Infektionen sowie von Husten und obstruktiven Atemwegserkrankungen sowie Verfahren zu seiner Herstellung
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4501728A (en) * 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
FR2540381B1 (fr) * 1983-02-08 1986-05-30 Dior Sa Parfums Christian Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede
US5387410A (en) * 1983-03-18 1995-02-07 Mallinckrodt, Inc. Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US5186941A (en) * 1983-05-06 1993-02-16 Vestar, Inc. Vesicle formulation for the controlled release of therapeutic agents
FR2561101B1 (fr) * 1984-03-13 1986-10-31 Paris Sud Universite Procede de preparation de liposomes et liposomes ainsi obtenus
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US5231112A (en) 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4707453A (en) * 1985-04-05 1987-11-17 Becton Dickinson And Company Vesicle including a metal marker for use in an assay
US4698263A (en) * 1985-05-23 1987-10-06 Becton Dickinson And Company Sac having a marker linked thereto
US5409704A (en) * 1985-06-26 1995-04-25 The Liposome Company, Inc. Liposomes comprising aminoglycoside phosphates and methods of production and use
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
FR2591105B1 (fr) 1985-12-11 1989-03-24 Moet Hennessy Rech Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
JPH0751496B2 (ja) * 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
FR2597345B1 (fr) * 1986-04-22 1990-08-03 Oreal Composition cosmetique ou pharmaceutique a base d'une dispersion aqueuse de spherules lipidiques.
US6759057B1 (en) 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
DE3776763D1 (pt) * 1986-06-16 1992-03-26 The Liposome Co.,Inc., Princeton, N.J., Us
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
WO1988003797A1 (en) * 1986-11-28 1988-06-02 The Liposome Company, Inc. Phospholipid composition
US4783220A (en) * 1986-12-18 1988-11-08 Xerox Corporation Vesicle ink compositions
WO1988004573A1 (en) * 1986-12-23 1988-06-30 The Liposome Company, Inc. Liposome preparation and antibiotic
US5723147A (en) * 1987-02-23 1998-03-03 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
GB8704171D0 (en) * 1987-02-23 1987-04-01 Clayton Found Res Multivesicular liposomes
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
US5925375A (en) * 1987-05-22 1999-07-20 The Liposome Company, Inc. Therapeutic use of multilamellar liposomal prostaglandin formulations
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US5017501A (en) * 1987-11-25 1991-05-21 Abbott Laboratories Preparation of uniformly sized liposomes encapsulating an aqueous liquid
US4873035A (en) * 1987-11-25 1989-10-10 Abbott Laboratories Preparation of sized populations of liposomes
KR900000848B1 (ko) * 1987-12-30 1990-02-17 태평양화학 주식회사 리포좀을 함유한 화장료의 제조방법
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5043165A (en) * 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
US5116615A (en) * 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
DK0456724T3 (da) 1989-01-27 1995-10-02 Immunolytics Inc Præparat og fremgangsmåde til behandling af benign prostatisk hypertrofi
US5078986A (en) * 1989-02-15 1992-01-07 Mallinckrodt Medical, Inc. Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
IE904098A1 (en) * 1989-11-13 1991-05-22 Nova Pharm Corp Lipospheres for controlled delivery of substances
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5221535A (en) * 1989-11-13 1993-06-22 Nova Pharmaceutical Corporation Sustained release formulations of insect repellent
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
ZA911974B (en) * 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (pt) * 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
ATE138803T1 (de) * 1990-07-31 1996-06-15 Liposome Co Inc Anhäufung von aminosäuren und peptiden in liposomen
DK0550463T3 (da) * 1990-09-06 1996-11-04 Johnson & Son Inc S C Fremgangsmåde til stabilisering af liposomer samt sammensætninger indeholdende dem
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5567432A (en) * 1991-08-02 1996-10-22 Lau; John R. Masking of liposomes from RES recognition
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5455044A (en) * 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
DE69429511T2 (de) * 1993-05-21 2002-05-16 The Liposome Co., Inc. Reduzierung von durch liposome induzierte physiologischen gegenreaktionen
JP3002702B2 (ja) * 1993-11-16 2000-01-24 スカイファーム インコーポレーテッド 活性物質の制御放出を有する小胞
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
ES2192572T3 (es) * 1993-12-15 2003-10-16 Bracco Research Sa Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo.
ATE241340T1 (de) * 1994-02-17 2003-06-15 New York Blood Ct Inc Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US7091008B1 (en) * 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6008203A (en) * 1995-07-14 1999-12-28 Glycotech Corp. Methods for treatment of EGF receptor associated cancers
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
US6022500A (en) * 1995-09-27 2000-02-08 The United States Of America As Represented By The Secretary Of The Army Polymer encapsulation and polymer microsphere composites
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
US6143287A (en) * 1996-02-27 2000-11-07 New York Blood Center, Inc. Method and composition for hair removal
ATE345682T1 (de) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
PT977597E (pt) * 1996-09-11 2003-06-30 Imarx Pharmaceutical Corp Metodos melhorados para imagiologia de diagnosticoutilizando um agente de contraste e um vasodil atador
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US5997899A (en) 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
US5891467A (en) 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) * 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
EP2113247A3 (en) 1997-05-14 2010-05-05 The University Of British Columbia High efficiency encapsulation of nucleic acids in lipid vesicles
WO1998051278A2 (en) * 1997-05-14 1998-11-19 Inex Pharmaceuticals Corporation High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6123956A (en) * 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
EP2308470A1 (en) 1997-09-18 2011-04-13 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
DK1025211T3 (da) * 1997-10-31 2005-04-04 Univ Oklahoma Hyaluronansyntasegen og anvendelser deraf
ATE554748T1 (de) * 1997-11-14 2012-05-15 Pacira Pharmaceuticals Inc Herstellung von multivesikulären liposomen
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6727079B1 (en) 1998-02-25 2004-04-27 The United States Of America As Represented By The Department Of Health And Human Services cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product
US6987023B2 (en) * 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US7169410B1 (en) * 1998-05-19 2007-01-30 Sdg, Inc. Targeted liposomal drug delivery system
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
ES2275675T3 (es) * 2000-03-23 2007-06-16 Elan Pharmaceuticals, Inc. Compuestos y metodos para tratar la enfermedad de alzheimer.
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US20050287638A1 (en) * 2000-04-25 2005-12-29 Weigel Paul H Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
BR0111980A (pt) * 2000-06-30 2003-05-06 Elan Pharm Inc Amina substituìda, composto protegido, métodos para tratar um paciente que tenha ou para prevenir que um paciente contraia uma doença ou condição, para inibir a atividade da beta-secretase, para inibir a clivagem da proteìna precursora de amilóide (app), para inibir a produção do peptìdeo beta amilóide (a beta) em uma célula, para inibir a produção de placa beta0amilóide em um animal, e para tratar ou prevenir uma doença compreendendo depósitos de beta-amilóide no cérebro, composição método para produzir um complexo de beta-secretase, conjunto, e, uso de amina substituìda
AU2002246510B2 (en) * 2000-11-09 2007-09-20 Neopharm, Inc. SN-38 lipid complexes and methods of use
US20110301569A1 (en) 2001-01-20 2011-12-08 Gordon Wayne Dyer Methods and apparatus for the CVCS
US20020150566A1 (en) * 2001-03-23 2002-10-17 Kun-Liang Guan Method of inhibiting cancerous cell proliferation using Ras mutants of GDP-bound conformation
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
JP2005500319A (ja) * 2001-06-27 2005-01-06 イーラン ファーマスーティカルズ、インコーポレイテッド アルツハイマー病の治療に有用なβ−ヒドロキシアミン誘導体
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
JP2005516897A (ja) * 2001-11-07 2005-06-09 イネックス ファーマシューティカルズ コーポレイション 改善された粘膜のワクチン及びその使用方法
US7476400B2 (en) * 2001-11-13 2009-01-13 Ferndale Ip, Inc. High-concentration lidocaine compositions and methods for their preparation
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
WO2003059280A2 (en) * 2002-01-09 2003-07-24 Elan Pharmaceuticals, Inc. Efficient liposomal encapsulation
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
US20040009943A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Pathogen vaccines and methods for using the same
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
WO2004035032A2 (en) * 2002-08-20 2004-04-29 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
ES2831305T3 (es) 2002-10-29 2021-06-08 Insmed Inc Liposomas que comprenden un aminoglucósido para el tratamiento de infecciones pulmonares
JP4874548B2 (ja) * 2002-11-26 2012-02-15 ギリアード サイエンシーズ, インコーポレイテッド 勾配によるリポソームへの薬物充填方法
US6866856B2 (en) * 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
US20070248541A1 (en) * 2003-12-01 2007-10-25 Mitsubishi Pharma Corporation Liposome
US7504385B2 (en) * 2003-12-17 2009-03-17 Avon Products, Inc. si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
CA2564542C (en) 2004-04-22 2012-11-27 Celator Pharmaceuticals, Inc. Combination formulations of anthracycline agents and cytidine analogs
JP2008506780A (ja) 2004-07-19 2008-03-06 セレーター ファーマスーティカルズ、インク. 活性剤放出のための粒子状構築物
EP1807051A2 (en) 2004-11-05 2007-07-18 Inex Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
US9944713B2 (en) 2004-11-24 2018-04-17 Medicinal Bioconvergence Research Center Antibody specific to the AIMP2-DX2
US7459529B2 (en) 2004-11-24 2008-12-02 Seoul National University Industry Foundation AIMP2-DX2 and its uses
AU2005318928B2 (en) * 2004-12-20 2010-06-03 Australian Nuclear Science & Technology Organisation Controlled release of biological entities
US8992986B2 (en) * 2004-12-20 2015-03-31 Australian Nuclear Science & Technology Organisation Controlled release of biological entities
MX2007016021A (es) 2005-06-17 2008-04-16 Australian Nuclear Science Tec Particulas que tienen material hidrofobico en estas.
US8815291B2 (en) * 2005-06-17 2014-08-26 Austrailian Nuclear Science & Technology Organisation Particles comprising a releasable dopant therein
AU2006257726B2 (en) * 2005-06-17 2010-09-09 Australian Nuclear Science And Technology Organisation Particles having hydrophobic material therein
AU2006257727B2 (en) * 2005-06-17 2010-09-09 Encap Hive Pty Ltd Particles comprising a releasable dopant therein
WO2007032225A1 (ja) * 2005-09-15 2007-03-22 Kyoto University リポソーム、リポソームの製造方法及び微小反応空間内での反応制御方法
EP2395012B8 (en) 2005-11-02 2018-06-06 Arbutus Biopharma Corporation Modified siRNA molecules and uses thereof
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
WO2007070705A2 (en) * 2005-12-15 2007-06-21 The Trustees Of The University Of Pennsylvania Cationic lipid-mediated vectors
US20080094573A1 (en) * 2006-04-04 2008-04-24 Vermette Patrick Surface-modified materials, such as contact lenses, methods and kits for their preparation, and uses thereof
EP2064234B1 (en) * 2006-09-18 2011-11-02 Compugen Ltd. Bioactive peptides and method of using same
CA2701601C (en) 2006-10-03 2020-06-30 The Board Of Regents Of The University Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
EP2155165A1 (en) * 2007-04-20 2010-02-24 BioCure, Inc. Drug delivery vehicle containing vesicles in a hydrogel base
AU2008273813B2 (en) 2007-07-12 2013-06-13 Compugen Ltd. Bioactive peptides and method of using same
ITRM20070394A1 (it) * 2007-07-16 2009-01-17 Uni Cattolica Del Sacro Cuo Re Liposomi asimmetrici e loro usi in campo medico.
ES2550759T3 (es) 2007-08-17 2015-11-12 Celator Pharmaceuticals, Inc. Formulaciones farmacológicas de platino mejoradas
US20090247608A1 (en) 2007-12-04 2009-10-01 Alnylam Pharmaceuticals, Inc. Targeting Lipids
ES2916498T3 (es) 2007-12-06 2022-07-01 Genalyte Inc Método para identificar una secuencia de nucleótidos en una especie desconocida de ácido nucleico; y dispositivo para llevar a cabo el método
EP2231190B1 (en) * 2007-12-06 2012-09-26 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Particulate drug carriers as desensitizing agents
ES2535419T3 (es) 2007-12-27 2015-05-11 Protiva Biotherapeutics Inc. Silenciamiento de expresión de quinasa tipo polo usando ARN interferente
CA3044134A1 (en) 2008-01-02 2009-07-09 Arbutus Biopharma Corporation Improved compositions and methods for the delivery of nucleic acids
PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
CA2721380A1 (en) 2008-04-15 2009-10-22 Protiva Biotherapeutics, Inc. Silencing of csn5 gene expression using interfering rna
AU2009290396B2 (en) * 2008-09-11 2014-11-06 I.B.R. Israeli Biotechnology Research Ltd. Leucojum bulb extracts and use thereof
CA2984026C (en) 2008-10-09 2020-02-11 Arbutus Biopharma Corporation Improved amino lipids and methods for the delivery of nucleic acids
JP5656853B2 (ja) 2008-10-27 2015-01-21 ジェナリーテ, インコーポレイテッド 光学的な探査及び検知に基づくバイオセンサ
JP5774486B2 (ja) 2008-11-10 2015-09-09 テクミラ ファーマシューティカルズ コーポレイションTekmira Pharmaceuticals Corporation 治療薬を送達するための新規な脂質及び組成物
US20120101148A1 (en) 2009-01-29 2012-04-26 Alnylam Pharmaceuticals, Inc. lipid formulation
WO2010092597A2 (en) 2009-02-11 2010-08-19 Lyka Labs Limited Liposomal citicoline injection
EP2406376A1 (en) 2009-03-12 2012-01-18 Alnylam Pharmaceuticals, Inc. LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
JP5487666B2 (ja) * 2009-03-23 2014-05-07 コニカミノルタ株式会社 内水相を固定化することを特徴とするリポソームの製造方法
AU2010245933B2 (en) 2009-05-05 2016-06-16 Arbutus Biopharma Corporation Methods of delivering oligonucleotides to immune cells
KR20240015723A (ko) 2009-05-05 2024-02-05 알닐람 파마슈티칼스 인코포레이티드 지질 조성물
CN102625696B (zh) 2009-06-10 2015-06-03 阿尔尼拉姆医药品有限公司 改进的脂质制剂
US8283333B2 (en) 2009-07-01 2012-10-09 Protiva Biotherapeutics, Inc. Lipid formulations for nucleic acid delivery
FR2948035B1 (fr) * 2009-07-20 2015-04-24 Centre Nat Rech Scient Procede de fabrication de capsules, capsules ainsi obtenues et utilisation desdites capsules
WO2011011447A1 (en) 2009-07-20 2011-01-27 Protiva Biotherapeutics, Inc. Compositions and methods for silencing ebola virus gene expression
EP2464336A4 (en) 2009-08-14 2013-11-20 Alnylam Pharmaceuticals Inc COMPOSITIONS FORMULATED IN LIPIDS AND METHODS OF INHIBITING THE EXPRESSION OF EBOLA VIRUS GENE
EP2480668A2 (en) 2009-09-23 2012-08-01 Protiva Biotherapeutics Inc. Compositions and methods for silencing genes expressed in cancer
WO2011056682A1 (en) 2009-10-27 2011-05-12 The University Of British Columbia Reverse head group lipids, lipid particle compositions comprising reverse headgroup lipids, and methods for the delivery of nucleic acids
AU2010328336B2 (en) 2009-12-07 2017-03-02 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
US20130017223A1 (en) 2009-12-18 2013-01-17 The University Of British Columbia Methods and compositions for delivery of nucleic acids
CA2799091A1 (en) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc. Cationic lipids and methods of use thereof
US10077232B2 (en) 2010-05-12 2018-09-18 Arbutus Biopharma Corporation Cyclic cationic lipids and methods of use
EP4481047A2 (en) 2010-06-03 2024-12-25 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
WO2012016184A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
US20130202652A1 (en) 2010-07-30 2013-08-08 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
CA3060724A1 (en) 2010-11-05 2012-05-10 Genalyte, Inc. Optical analyte detection systems and methods of use
KR20130139254A (ko) 2010-11-09 2013-12-20 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 피부 침투 및 세포 진입(space) 펩타이드 및 그의 사용방법
EP2663548B1 (en) 2011-01-11 2017-04-05 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
WO2012109387A1 (en) 2011-02-08 2012-08-16 Halozyme, Inc. Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
EP2729127B1 (en) 2011-07-04 2018-05-02 Statens Serum Institut Methods for producing liposomes
EP3456317A1 (en) 2011-09-27 2019-03-20 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted pegylated lipids
US20150240238A1 (en) 2011-11-17 2015-08-27 The Regents Of The University Of California Therapeutic rna switches compositions and methods of use
EP2606897A1 (en) 2011-12-22 2013-06-26 Laboratorios Del. Dr. Esteve, S.A. Methods and compositions for the treatment of diseases caused by enveloped viruses
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
ES2898912T3 (es) 2012-02-24 2022-03-09 Arbutus Biopharma Corp Lípidos catiónicos de trialquilo y métodos para su uso
EP3907506A1 (en) 2012-03-12 2021-11-10 The Board of Trustees of the University of Illinois Optical analyte detection systems with magnetic enhancement and methods of their use
EP2666456A1 (en) 2012-05-21 2013-11-27 Natura Bisse International, S.A. Cometic compositions comprising magnetosomes and uses thereof
ES2848025T3 (es) 2012-09-04 2021-08-05 Eleison Pharmaceuticals LLC Prevención de la recidiva pulmonar del cáncer con cisplatino complejado con lípidos
JP6620093B2 (ja) 2013-07-23 2019-12-11 アービュートゥス バイオファーマ コーポレイションArbutus Biopharma Corporation メッセンジャーrnaを送達するための組成物及び方法
LT3033102T (lt) * 2013-08-13 2020-03-10 Northwestern University Dalelės, konjuguotos su peptidu
KR101465365B1 (ko) * 2013-10-15 2014-11-25 성균관대학교산학협력단 리포좀 내 고분자 충진된 다중 기능 복합 입자체 및 이의 제조방법
KR101638156B1 (ko) 2013-10-29 2016-07-08 가톨릭대학교 산학협력단 C형 간염 바이러스 감염 질환의 예방 또는 치료용 약학 조성물
WO2016033555A1 (en) 2014-08-28 2016-03-03 Halozyme, Inc. Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
WO2016054421A1 (en) 2014-10-02 2016-04-07 Protiva Biotherapeutics, Inc Compositions and methods for silencing hepatitis b virus gene expression
US20170369872A1 (en) 2014-12-18 2017-12-28 Alnylam Pharmaceuticals, Inc. Reversir tm compounds
JP6316182B2 (ja) 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
WO2016109400A2 (en) 2014-12-31 2016-07-07 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
EP3302435B1 (en) 2015-05-26 2023-03-08 Plumb Pharmaceuticals, Inc. Liposome loading
WO2016197132A1 (en) 2015-06-04 2016-12-08 Protiva Biotherapeutics Inc. Treating hepatitis b virus infection using crispr
EP3329003A2 (en) 2015-07-29 2018-06-06 Arbutus Biopharma Corporation Compositions and methods for silencing hepatitis b virus gene expression
EP3335028A1 (en) 2015-08-11 2018-06-20 Scintillon Institute for Biomedical and Bioenergy Research Optical analyses of particles and vesicles
US10363226B2 (en) 2015-08-12 2019-07-30 North Carolina State University Platelet membrane-coated drug delivery system
CA3010711A1 (en) 2016-01-08 2017-07-13 The Regents Of The University Of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
US10188749B2 (en) 2016-04-14 2019-01-29 Fred Hutchinson Cancer Research Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
EP3442585B1 (en) 2016-04-14 2022-11-09 Fred Hutchinson Cancer Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
KR20180133527A (ko) 2016-05-04 2018-12-14 랜티우스 메디컬 이메징, 인크. 초음파 조영제의 제조 방법 및 장치
EP3478838A1 (en) 2016-06-30 2019-05-08 Arbutus Biopharma Corporation Compositions and methods for delivering messenger rna
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US20190336532A1 (en) 2016-12-21 2019-11-07 Fred Hutchinson Cancer Research Center Scaffolds to treat solid tumor cells and escape variants
WO2018129270A1 (en) 2017-01-05 2018-07-12 Fred Hutchinson Cancer Research Center Systems and methods to improve vaccine efficacy
WO2019118806A1 (en) 2017-12-14 2019-06-20 Solid Biosciences Inc. Non-viral production and delivery of genes
WO2019133884A1 (en) 2018-01-01 2019-07-04 The Regents Of The University Of California Scale up synthesis of silicasome nanocarriers
TW202114732A (zh) 2019-06-20 2021-04-16 愛爾蘭商健生科學愛爾蘭無限公司 遞送b型肝炎病毒(hbv)疫苗之脂質奈米顆粒或脂質體
US20210023023A1 (en) * 2019-07-25 2021-01-28 Vasayo, Llc Liposomal nutraceutical compositions and methods of making the same
EP4121018A4 (en) 2020-03-17 2024-07-03 Genevant Sciences Gmbh CATIONIC LIPIDS FOR LIPID DNANOPARTICLE DELIVERY OF THERAPEUTICS TO HEPATIC STELLA CELLS
WO2022133230A1 (en) 2020-12-18 2022-06-23 Janssen Pharmaceuticals, Inc. Combination therapy for treating hepatitis b virus infection
AU2021403156A1 (en) 2020-12-18 2023-07-13 Genevant Sciences Gmbh Peg lipids and lipid nanoparticles
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
EP4312536A1 (en) 2021-04-01 2024-02-07 Vestaron Corporation Liposome formulations for pesticide delivery and methods for producing and using the same
EP4384508A2 (en) 2021-08-12 2024-06-19 Life Technologies Corporation Lipids for nucleic acid delivery
CN118922401A (zh) 2022-01-31 2024-11-08 盖纳万科学有限公司 用于脂质纳米颗粒的可电离阳离子脂质
AU2023211981A1 (en) 2022-01-31 2024-08-15 Genevant Sciences Gmbh Poly(alkyloxazoline)-lipid conjugates and lipid particles containing same
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
NL2035417B9 (en) 2022-07-19 2024-10-09 Coty Inc Cosmetic composition
WO2024031051A1 (en) 2022-08-05 2024-02-08 Life Technologies Corporation Lipids for nucleic acid delivery
TW202449152A (zh) 2023-02-09 2024-12-16 美商艾拉倫製藥股份有限公司 Reversir分子及其使用方法
WO2024209267A2 (en) 2023-04-03 2024-10-10 Jazz Pharmaceuticals Ireland Limited Modulators of nanoparticle uptake
WO2024233405A1 (en) 2023-05-05 2024-11-14 Coty Inc. Compositions and methods comprising a lotus flower extract blend and/or constituents thereof for treating skin
NL2035921B1 (en) 2023-05-05 2025-01-27 Coty Inc Cosmetic composition
WO2025052278A1 (en) 2023-09-05 2025-03-13 Genevant Sciences Gmbh Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells
US12251468B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12246092B1 (en) 2024-05-20 2025-03-11 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361680A (en) * 1963-05-13 1968-01-02 Sun Oil Co Use of ultrasonic vibrations to disperse a liquid in another liquid
BE744162A (fr) * 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
DE2249552A1 (de) * 1971-10-12 1973-05-30 Inchema S A Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen
US3932657A (en) * 1973-11-12 1976-01-13 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome encapsulation of chelating agents
GB1502774A (en) * 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
CH588887A5 (pt) * 1974-07-19 1977-06-15 Battelle Memorial Institute
JPS5126213A (ja) * 1974-08-21 1976-03-04 Tanabe Seiyaku Co Johoseibiryushiseizaino seiho
FR2315991A1 (fr) * 1975-06-30 1977-01-28 Oreal Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes
IL51791A0 (en) * 1976-04-14 1977-05-31 Exxon Research Engineering Co New injectable medicinal compositions
JPS5323872A (en) * 1976-08-17 1978-03-04 Takeda Chem Ind Ltd Preparation of microcapsule
US4107106A (en) * 1976-11-22 1978-08-15 Union Carbide Corporation Phenol-aldehyde-amine resin/glycol curatives for energy absorbing polyurethanes
JP2758985B2 (ja) * 1989-09-05 1998-05-28 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 親油性薬剤の非侵襲性用量対効果式投与のための方法及び組成物

Also Published As

Publication number Publication date
AU3866678A (en) 1980-02-07
AU520916B2 (en) 1982-03-04
FR2399242A1 (fr) 1979-03-02
DK155036B (da) 1989-01-30
ZA784407B (en) 1979-07-25
ES472326A1 (es) 1979-02-16
US4224179A (en) 1980-09-23
GB2001929B (en) 1982-07-28
DK155036C (da) 1989-06-26
LU80071A1 (fr) 1979-05-15
IL55154A (en) 1981-09-13
IT7826441A0 (it) 1978-08-03
SE7808356L (sv) 1979-02-06
HU179672B (en) 1982-11-29
SE433169B (sv) 1984-05-14
BE869490A (fr) 1979-02-05
FR2399242B1 (pt) 1983-01-07
IE47067B1 (en) 1983-12-14
DK344478A (da) 1979-02-06
IT1097928B (it) 1985-08-31
CA1098410A (en) 1981-03-31
IL55154A0 (en) 1978-09-29
SU1158031A3 (ru) 1985-05-23
GB2001929A (en) 1979-02-14
NL7808167A (nl) 1979-02-07
JPS6355978B2 (pt) 1988-11-07
JPS5441279A (en) 1979-04-02
IE781574L (en) 1979-02-05
DE2834307A1 (de) 1979-02-15

Similar Documents

Publication Publication Date Title
CH624011A5 (pt)
CA2066617C (en) Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants
EP0344040B1 (fr) Vecteur particulaire utile notamment pour le transport de molécules à activité biologique et procédé pour sa préparation
EP0004223B1 (fr) Procédé de fabrication de capsules lipidiques renfermant un matériau biologiquement actif, produits obtenus par ce procédé ainsi que leur utilisation
CA1267842A (en) Unilamellar lipid vesicles and method for their formation
US4485054A (en) Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
KR950002146B1 (ko) 단일 이중층 리포좀의 제조방법
EP0349429B1 (fr) Procédé de préparation de systèmes colloidaux dispersibles de lipides amphiphiles sous forme de liposomes submicroniques
US8501204B2 (en) Method for producing vesicle, vesicle obtained by the production method, and W/O/W emulsion for producing vesicle
EP0491921B1 (fr) Procede de preparation d'une lipoproteine modifiee par incorporation d'une substance active lipophile
EP0422978B1 (fr) Procédé de fabrication d'une dispersion aqueuse de vésicules lipidiques et composition à base de la dispersion ainsi obtenue
EP0365868B1 (fr) Procédé de séparation des glycolipides d'un mélange lipidique et utilisation des fractions obtenues
EP0393049B1 (fr) Liposomes, leur procede et application comme vecteur de produits
KR800001169B1 (ko) 수용액 중에서의 리포좀의 제조 방법
KR800001360B1 (ko) 리포솜의 제조법
FR2561101A1 (fr) Procede de preparation de liposomes et liposomes ainsi obtenus
WO1995001163A1 (fr) Nouvelles preparations pharmaceutiques a base de peptides pour la voie generale
JPH08311086A (ja) リン脂質混合物の製造方法
EP0658102A1 (fr) Nouvelles preparations pharmaceutiques a base de peptides pour la voie generale
JP2001139460A (ja) リポソームの調製方法
WO2004061457A1 (fr) Materiau hybride organique-inorganique, procede pour sa preparation

Legal Events

Date Code Title Description
PL Patent ceased
PL Patent ceased