CA3066077A1 - Inhibiteur d'agregation de tau - Google Patents
Inhibiteur d'agregation de tau Download PDFInfo
- Publication number
- CA3066077A1 CA3066077A1 CA3066077A CA3066077A CA3066077A1 CA 3066077 A1 CA3066077 A1 CA 3066077A1 CA 3066077 A CA3066077 A CA 3066077A CA 3066077 A CA3066077 A CA 3066077A CA 3066077 A1 CA3066077 A1 CA 3066077A1
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- peptide
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- WCNMEQDMUYVWMJ-JPZHCBQBSA-N wybutoxosine Chemical compound C1=NC=2C(=O)N3C(CC([C@H](NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WCNMEQDMUYVWMJ-JPZHCBQBSA-N 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical class OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne le domaine des inhibiteurs d'agrégation de tau. Plus particulièrement, l'invention concerne des agents thérapeutiques anti-amyloïdes. Plus précisément, l'invention concerne des compositions pharmaceutiques et des procédés de traitement d'états pathologiques ou maladies associés à une agrégation en utilisant certains peptides.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762516393P | 2017-06-07 | 2017-06-07 | |
| US62/516,393 | 2017-06-07 | ||
| PCT/US2018/036507 WO2018226992A1 (fr) | 2017-06-07 | 2018-06-07 | Inhibiteur d'agrégation de tau |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3066077A1 true CA3066077A1 (fr) | 2018-12-13 |
Family
ID=62817070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3066077A Abandoned CA3066077A1 (fr) | 2017-06-07 | 2018-06-07 | Inhibiteur d'agregation de tau |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230137562A1 (fr) |
| EP (1) | EP3634978A1 (fr) |
| JP (1) | JP2020523035A (fr) |
| CN (1) | CN110997693A (fr) |
| CA (1) | CA3066077A1 (fr) |
| WO (1) | WO2018226992A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106800590B (zh) * | 2015-11-25 | 2021-04-09 | 杭州智鹤丹谷生物医药有限公司 | 一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用 |
| CA3100072A1 (fr) * | 2018-05-15 | 2019-11-21 | Interk Peptide Therapeutics Limited | Agents d'activation |
| GB201820616D0 (en) * | 2018-12-18 | 2019-01-30 | Univ Of Lancaster | Compositions for binding to tau proteins |
| EP3771719A1 (fr) * | 2019-08-02 | 2021-02-03 | Hochschule für angewandte Wissenschaften Fachhochschule Coburg | Peptide se liant à la protéine tau |
| CN114057858B (zh) * | 2020-08-10 | 2023-03-21 | 上海瑞吉康生物医药有限公司 | 对引起神经变性和神经退行性疾病的蛋白聚集具有解聚作用的多肽 |
| DE102020128632A1 (de) | 2020-10-30 | 2022-05-05 | Hochschule Für Angewandte Wissenschaften Coburg | Tau-Protein-bindendes Peptid zur Therapie der Alzheimer-Demenz |
| KR102775835B1 (ko) * | 2021-10-25 | 2025-03-06 | 한국과학기술연구원 | 알츠하이머병 모델 동물의 제조방법 및 그에 의해 제조된 알츠하이머병 모델 동물 |
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| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| ES2334315B1 (es) | 2008-07-29 | 2011-02-28 | Universitat Pompeu Fabra | Peptidos con capacidad de penetracion celular y sus usos. |
| AU2009314049B2 (en) | 2008-11-13 | 2015-03-05 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| SG10201502270TA (en) | 2010-03-29 | 2015-05-28 | Univ Pennsylvania | Pharmacologically induced transgene ablation system |
| CA2833908C (fr) | 2010-04-23 | 2021-02-09 | University Of Massachusetts | Vecteurs aav ciblant le systeme nerveux central et leurs procedes d'utilisation |
| MX336623B (es) | 2010-06-14 | 2016-01-26 | Hoffmann La Roche | Peptidos penetradores de las celulas y usos de los mismos. |
| WO2011160126A2 (fr) * | 2010-06-18 | 2011-12-22 | Regents Of The University Of Colorado, A Body Corporate | Riborégulateurs s-adénosyl-(l)-homocystéine (sah) et compositions et utilisations correspondantes |
| WO2012057363A1 (fr) | 2010-10-27 | 2012-05-03 | 学校法人自治医科大学 | Virions de virus adéno-associé pour le transfert de gènes dans des cellules neuronales |
| WO2012090150A2 (fr) | 2010-12-27 | 2012-07-05 | Compugen Ltd | Nouveaux peptides pénétrant dans les cellules et leurs utilisations |
| WO2012115980A1 (fr) | 2011-02-22 | 2012-08-30 | California Institute Of Technology | Fourniture de protéines au moyen de vecteurs de virus adéno-associés (aav) |
| US20130028956A1 (en) * | 2011-07-29 | 2013-01-31 | Andre Fischer | Method for preventing or treating memory impairment and pharmaceutical compositions useful therefore |
| CN104271147B (zh) | 2011-12-27 | 2018-01-12 | 巴黎第六大学 | 细胞穿膜肽 |
| MX2014014464A (es) | 2012-06-26 | 2015-02-12 | Hoffmann La Roche | Peptidos penetrantes de celulas y metodos para identificar peptidos penetrantes de celulas. |
| JP2015523373A (ja) | 2012-07-09 | 2015-08-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ｅＩＦ４Ｅを標的化するための細胞浸透性ペプチド |
| AU2013316679B2 (en) | 2012-09-13 | 2017-12-14 | Les Hopitaux Universitaires De Geneve | Cell penetrating peptides |
| WO2014053882A1 (fr) * | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Peptides pénétrant dans les cellules pour l'administration intracellulaire de molécules |
| DE102012019882A1 (de) * | 2012-10-05 | 2014-04-10 | Forschungszentrum Jülich GmbH | Peptide zur Behandlung und Frühdiagnose von Morbus Alzheimer und anderer Tauopathien |
| HK1211602A1 (en) | 2012-10-08 | 2016-05-27 | F. Hoffmann-La Roche Ag | Cell penetrating peptides which bind irf5 |
| EP2961757B1 (fr) | 2013-02-28 | 2017-06-14 | Oligomer Sciences AB | Oligonucléotides pénétrant les cellules |
| WO2014147193A1 (fr) | 2013-03-20 | 2014-09-25 | Centre National De La Recherche Scientifique (Cnrs) | Nouveaux motifs peptidiques pénétrant dans les cellules |
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| CA2922516A1 (fr) * | 2013-08-27 | 2015-03-19 | The University Of British Columbia | Peptides idr et anti-biofilm cationiques de petite taille |
| EP3044318B1 (fr) | 2013-09-13 | 2019-05-01 | California Institute of Technology | Récupération sélective |
| WO2015075747A1 (fr) | 2013-11-19 | 2015-05-28 | Council Of Scientific And Industrial Research | Peptide pénétrant les cellules pour la délivrance de molécules biologiques |
| HRP20211024T4 (hr) | 2014-05-02 | 2025-06-20 | Genzyme Corporation | Aav vektori za gensku terapiju mrežnice i cns-a |
| JP6401871B2 (ja) | 2014-11-05 | 2018-10-10 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | パーキンソン病の治療のためのａａｄｃポリヌクレオチド |
| GB201421379D0 (en) | 2014-12-02 | 2015-01-14 | Isis Innovation Ltd And Medical Res Council | Molecule |
| EP3237434A1 (fr) | 2014-12-22 | 2017-11-01 | F. Hoffmann-La Roche AG | Peptides de pénétration cellulaire |
| MA41451A (fr) | 2015-02-04 | 2017-12-12 | Univ Washington | Constructions anti-tau |
-
2018
- 2018-06-07 US US16/615,026 patent/US20230137562A1/en not_active Abandoned
- 2018-06-07 EP EP18737454.1A patent/EP3634978A1/fr not_active Withdrawn
- 2018-06-07 CA CA3066077A patent/CA3066077A1/fr not_active Abandoned
- 2018-06-07 JP JP2020517766A patent/JP2020523035A/ja active Pending
- 2018-06-07 CN CN201880051326.3A patent/CN110997693A/zh active Pending
- 2018-06-07 WO PCT/US2018/036507 patent/WO2018226992A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3634978A1 (fr) | 2020-04-15 |
| US20230137562A1 (en) | 2023-05-04 |
| WO2018226992A1 (fr) | 2018-12-13 |
| WO2018226992A8 (fr) | 2019-12-12 |
| CN110997693A (zh) | 2020-04-10 |
| JP2020523035A (ja) | 2020-08-06 |
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