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CA2514303C - Polypeptides synthetiques a domaine unique imitant l'apolipoproteine e et methodes d'utilisation - Google Patents

Polypeptides synthetiques a domaine unique imitant l'apolipoproteine e et methodes d'utilisation Download PDF

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Publication number
CA2514303C
CA2514303C CA2514303A CA2514303A CA2514303C CA 2514303 C CA2514303 C CA 2514303C CA 2514303 A CA2514303 A CA 2514303A CA 2514303 A CA2514303 A CA 2514303A CA 2514303 C CA2514303 C CA 2514303C
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CA
Canada
Prior art keywords
arg
polypeptide
gly
ile
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2514303A
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English (en)
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CA2514303A1 (fr
Inventor
Gattadahalli M. Anantharamiah
David W. Garber
Geeta Datta
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UAB Research Foundation
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UAB Research Foundation
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Publication date
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Publication of CA2514303A1 publication Critical patent/CA2514303A1/fr
Application granted granted Critical
Publication of CA2514303C publication Critical patent/CA2514303C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne un polypeptide synthétique imitant une apolipoprotéine E présentant un domaine unique. L'invention concerne également un acide nucléique codant pour le polypeptide, des vecteurs comprenant l'acide nucléique, des anticorps spécifiques du polypeptide, des compositions renfermant ceux-ci et des méthodes d'utilisation correspondantes.
CA2514303A 2002-11-13 2003-11-13 Polypeptides synthetiques a domaine unique imitant l'apolipoproteine e et methodes d'utilisation Expired - Fee Related CA2514303C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42582102P 2002-11-13 2002-11-13
US60/425,821 2002-11-13
PCT/US2003/036268 WO2004043403A2 (fr) 2002-11-13 2003-11-13 Polypeptides synthetiques a domaine unique imitant l'apolipoproteine e et methodes d'utilisation

Publications (2)

Publication Number Publication Date
CA2514303A1 CA2514303A1 (fr) 2004-05-27
CA2514303C true CA2514303C (fr) 2012-09-18

Family

ID=32313056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2514303A Expired - Fee Related CA2514303C (fr) 2002-11-13 2003-11-13 Polypeptides synthetiques a domaine unique imitant l'apolipoproteine e et methodes d'utilisation

Country Status (7)

Country Link
US (2) US7563771B2 (fr)
EP (2) EP1599173B1 (fr)
AU (1) AU2003290825C1 (fr)
CA (1) CA2514303C (fr)
DK (1) DK1599173T3 (fr)
NZ (1) NZ541504A (fr)
WO (1) WO2004043403A2 (fr)

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Publication number Priority date Publication date Assignee Title
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
CA2514303C (fr) * 2002-11-13 2012-09-18 The Uab Research Foundation Polypeptides synthetiques a domaine unique imitant l'apolipoproteine e et methodes d'utilisation
CA2525517C (fr) 2003-06-19 2016-05-31 Applied Research Systems Ars Holding N.V. Utilisation d'agents modulateurs de la conversion de prions
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
US9814672B2 (en) * 2007-03-09 2017-11-14 Susan T. Laing Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
KR20100040951A (ko) 2007-08-09 2010-04-21 신토닉스 파마수티칼스, 인코포레이티드 면역조절성 펩티드
CA2704729C (fr) 2007-08-28 2020-06-23 Uab Research Foundation Polypeptides de synthese imitant l'apolipoproteine e et leurs procedes d'utilisation
JP2010537638A (ja) 2007-08-28 2010-12-09 ユーエービー リサーチ ファウンデーション 合成アポリポ蛋白質ｅ模倣ポリペプチドおよび使用方法
US8907061B2 (en) 2008-01-11 2014-12-09 Lawrence Livermore National Security, Llc. Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
US9539300B2 (en) 2012-03-31 2017-01-10 The Regents Of The University Of California Modulating disease through genetic engineering of plants
BR112017001860A2 (pt) 2014-07-31 2018-02-27 Uab Research Foundation peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal
WO2016049061A1 (fr) 2014-09-22 2016-03-31 Lawrence Livermore National Security, Llc Cuve électrochimique à circulation pour la production d'hydrogène et la réduction de cible dépendante de cofacteurs nicotinamides, procédés et systèmes s'y rapportant
US12226529B2 (en) 2015-08-25 2025-02-18 Lawrence Livermore National Security, Llc Stable nanolipoprotein particles and related compositions methods and systems
WO2017044899A1 (fr) * 2015-09-11 2017-03-16 Lawrence Livermore National Security, Llc Apolipoprotéines synthétique, et compositions, procédés et systèmes associés pour la formation de particules de nanolipoprotéine
US12083223B2 (en) 2017-05-02 2024-09-10 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions methods and systems for loading RNA
WO2018204421A2 (fr) 2017-05-02 2018-11-08 Lawrence Livermore National Security, Llc Télonanoparticules momp et compositions, procédés et systèmes s'y rapportant
CN119233984A (zh) * 2022-05-05 2024-12-31 美国政府(由卫生和人类服务部的部长所代表) 短载脂蛋白e模拟肽及其使用方法

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GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5843708A (en) 1988-01-05 1998-12-01 Ciba-Geigy Corporation Chimeric antibodies
US5473039A (en) * 1989-08-18 1995-12-05 The Scripps Research Institute Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs
US5331573A (en) 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
US6042828A (en) 1992-09-07 2000-03-28 Kyowa Hakko Kogyo Co., Ltd. Humanized antibodies to ganglioside GM2
US6107457A (en) * 1995-02-16 2000-08-22 Board Of Regents, The University Of Texas System Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth
US5631280A (en) 1995-03-29 1997-05-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6113898A (en) 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
CA2249459A1 (fr) * 1996-03-29 1997-10-09 Dario Boffelli Molecules amphipathiques agissant comme inhibiteurs de l'absorption du cholesterol et d'autres lipides
US5877153A (en) * 1996-06-11 1999-03-02 Commonwealth Biotechnologies Inc. Heparin-binding peptides
ZA975891B (en) 1996-07-05 1998-07-23 Combimatrix Corp Electrochemical solid phase synthesis of polymers
DE19736591A1 (de) 1997-08-22 1999-02-25 Peter Prof Dr Hegemann Verfahren zum Herstellen von Nukleinsäurepolymeren
US6201165B1 (en) 1997-10-16 2001-03-13 Board Of Regents, University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof
US6506880B2 (en) * 1998-03-17 2003-01-14 The Uab Research Foundation Synthetic peptides that enhance atherogenic lipoprotein uptake and lower plasma cholesterol
US6514523B1 (en) * 2000-02-14 2003-02-04 Ottawa Heart Institute Research Corporation Carrier particles for drug delivery and process for preparation
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US7166578B2 (en) * 2000-08-24 2007-01-23 The Regents Of The University Of California Orally administered peptides synergize statin activity
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US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
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NZ555826A (en) * 2004-12-06 2009-11-27 Univ California Methods for improving the structure and function of arterioles

Also Published As

Publication number Publication date
NZ541504A (en) 2009-04-30
EP1599173A2 (fr) 2005-11-30
AU2003290825C1 (en) 2009-12-10
WO2004043403A3 (fr) 2005-12-15
US7563771B2 (en) 2009-07-21
CA2514303A1 (fr) 2004-05-27
US20070101448A1 (en) 2007-05-03
EP1599173B1 (fr) 2017-02-22
EP1599173A4 (fr) 2011-12-28
WO2004043403A2 (fr) 2004-05-27
AU2003290825B2 (en) 2008-10-23
US8084423B2 (en) 2011-12-27
US20040186057A1 (en) 2004-09-23
DK1599173T3 (en) 2017-06-06
EP3254673A1 (fr) 2017-12-13
AU2003290825A1 (en) 2004-06-03

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Effective date: 20211115