[go: up one dir, main page]

CA2469833A1 - Domaines variable d'immunoglobuline canine, anticorps caninises, et procede de production et d'utilisation associes - Google Patents

Domaines variable d'immunoglobuline canine, anticorps caninises, et procede de production et d'utilisation associes Download PDF

Info

Publication number
CA2469833A1
CA2469833A1 CA002469833A CA2469833A CA2469833A1 CA 2469833 A1 CA2469833 A1 CA 2469833A1 CA 002469833 A CA002469833 A CA 002469833A CA 2469833 A CA2469833 A CA 2469833A CA 2469833 A1 CA2469833 A1 CA 2469833A1
Authority
CA
Canada
Prior art keywords
canine
caninized antibodies
making
antibodies
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002469833A
Other languages
English (en)
Other versions
CA2469833C (fr
Inventor
Eugene Regis Krah Iii
Hongliang Guo
Ashok Aiyappa
Robert Lawton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Idexx Laboratories Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2469833A1 publication Critical patent/CA2469833A1/fr
Application granted granted Critical
Publication of CA2469833C publication Critical patent/CA2469833C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002469833A 2001-12-21 2002-12-20 Domaines variable d'immunoglobuline canine, anticorps caninises, et procede de production et d'utilisation associes Expired - Fee Related CA2469833C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34487401P 2001-12-21 2001-12-21
US60/344,874 2001-12-21
PCT/US2002/041362 WO2003060080A2 (fr) 2001-12-21 2002-12-20 Domaines variable d'immunoglobuline canine, anticorps caninises, et procede de production et d'utilisation associes

Publications (2)

Publication Number Publication Date
CA2469833A1 true CA2469833A1 (fr) 2003-07-24
CA2469833C CA2469833C (fr) 2008-05-20

Family

ID=23352425

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002469833A Expired - Fee Related CA2469833C (fr) 2001-12-21 2002-12-20 Domaines variable d'immunoglobuline canine, anticorps caninises, et procede de production et d'utilisation associes

Country Status (6)

Country Link
US (1) US7261890B2 (fr)
EP (1) EP1485126A4 (fr)
JP (1) JP2005514063A (fr)
AU (1) AU2002359851A1 (fr)
CA (1) CA2469833C (fr)
WO (1) WO2003060080A2 (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521541B2 (en) * 2004-09-23 2009-04-21 Genetech Inc. Cysteine engineered antibodies and conjugates
EP1981912A2 (fr) * 2006-01-13 2008-10-22 Irm, Llc Anticorps diriges contre le recepteur de la lymphopoietine thymique pour le traitement des maladies allergiques
AU2008312457B2 (en) 2007-10-19 2014-04-17 Genentech, Inc. Cysteine engineered anti-TENB2 antibodies and antibody drug conjugates
MX2011000117A (es) 2008-07-10 2011-02-25 Toray Industries Composicion farmaceutica para tratamiento y prevencion de cancer.
RU2519675C2 (ru) * 2008-07-10 2014-06-20 Торэй Индастриз, Инк. Средство для индукции иммунитета и способ выявления злокачественной опухоли
WO2010027488A2 (fr) 2008-09-04 2010-03-11 Vet Therapeutics, Inc. Anticorps monoclonaux
AU2014200771B2 (en) * 2008-09-04 2016-05-26 Vet Therapeutics, Inc. Monoclonal antibodies
US8569460B2 (en) 2009-03-25 2013-10-29 Vet Therapeutics, Inc. Antibody constant domain regions and uses thereof
WO2010117448A2 (fr) * 2009-04-05 2010-10-14 Provenance Biopharmaceuticals Corp. Immunocytokines chimériques et leurs procédés d'utilisation
WO2010128372A1 (fr) 2009-05-08 2010-11-11 Allergosystem S.R.L. Dispositif de protection d'animaux de compagnie d'une allergie
CA2791560A1 (fr) * 2010-03-04 2011-09-09 Vet Therapeutics Inc. Anticorps monoclonaux diriges contre cd20
US9616120B2 (en) 2010-03-04 2017-04-11 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD20
CA2791866A1 (fr) * 2010-03-04 2011-09-09 Vet Therapeutics, Inc. Anticorps monoclonaux diriges contre le cd52
MA34062B1 (fr) 2010-03-04 2013-03-05 Macrogenics Inc Anticorps réagissant avec b7-h3, fragments immunologiquement actifs associés et utilisations associées
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
CN103068406B (zh) 2010-06-08 2017-06-30 基因泰克公司 半胱氨酸改造的抗体和偶联物
ES2910305T3 (es) 2010-08-19 2022-05-12 Zoetis Belgium S A Anticuerpos anti-NGF y su uso
US9580496B2 (en) 2011-05-06 2017-02-28 Nexvet Australia Pty Ltd Therapeutic canine immunoglobulins and methods of using same
GB2504889C (en) * 2011-05-06 2015-08-26 Nvip Pty Ltd Therapeutic canine immunoglobulins and methods of using the same
KR101783929B1 (ko) * 2011-05-06 2017-10-11 넥스베트 오스트레일리아 피티와이 리미티드 항신경성 성장 인자 항체 및 그의 제조방법과 이용방법
PT3498732T (pt) * 2011-05-06 2022-02-02 Zoetis Services Llc Anticorpos anti-fator de crescimento do nervo e método para preparação e utilização dos mesmos
GB201114858D0 (en) * 2011-08-29 2011-10-12 Nvip Pty Ltd Anti-nerve growth factor antibodies and methods of using the same
CA2835094C (fr) * 2011-05-06 2020-12-22 David Gearing Anticorps contre le facteur de croissance neuronale et leurs procedes de preparation et d'utilisation
WO2012178137A1 (fr) 2011-06-24 2012-12-27 Gillies Stephen D Protéines hybrides d'immunoglobuline à chaîne légère et leurs procédés d'utilisation
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
CA2851758A1 (fr) * 2011-10-13 2013-04-18 Nvip Pty Ltd Epitope de liaison cd20 felin/canin et compositions se liant a celui-ci
WO2013119419A1 (fr) 2012-02-08 2013-08-15 North Carolina State University Traitement de maladies allergiques avec des anticorps recombinants
ES2894852T3 (es) 2012-06-06 2022-02-16 Zoetis Services Llc Anticuerpos anti-NGF caninizados y métodos de los mismos
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
ES2969350T3 (es) 2013-12-20 2024-05-17 Intervet Int Bv Anticuerpos murinos caninizados anti-PD-1 canino
MX2017003123A (es) 2014-09-12 2017-05-12 Genentech Inc Anticuerpos y conjugados modificados geneticamente con cisteina.
US9758575B2 (en) 2015-04-06 2017-09-12 Yung Shin Pharmaceutical Industrial Co. Ltd. Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof
WO2017011316A1 (fr) 2015-07-10 2017-01-19 The Trustees Of The University Of Pennsylvania Traitement d'une maladie ou d'une affection canine positive aux cd20 à l'aide d'un récepteur d'antigène chimérique canin spécifique des cd20
WO2017102920A1 (fr) * 2015-12-18 2017-06-22 Intervet International B.V. Anticorps humains caninisés dirigés contre l'il-4r alpha humaine et canine
US11091556B2 (en) 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
PE20190353A1 (es) 2016-04-15 2019-03-07 Macrogenics Inc Moleculas de union b7-h3 novedosas, conjugados anticuerpo-farmaco de los mismos y metodos de uso de los mismos
EP3538558A4 (fr) 2016-11-09 2020-07-15 North Carolina State University Traitement de maladies allergiques au moyen d'une protéine chimérique
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use
GB2561352B (en) * 2017-04-10 2023-01-18 Genome Res Ltd Animal models and therapeutic molecules
MX2020009526A (es) 2018-03-12 2020-10-28 Zoetis Services Llc Anticuerpos anti-ngf y metodos de estos.
CA3093709C (fr) 2018-03-16 2024-03-26 Zoetis Services Llc Vaccins peptidiques contre l'interleukine-31
KR102587633B1 (ko) 2018-03-16 2023-10-10 조에티스 서비시즈 엘엘씨 수의학적 용도를 위한 인터류킨-31 단클론성 항체
WO2019183437A1 (fr) 2018-03-23 2019-09-26 North Carolina State University Procédés et compositions pour un anticorps dirigé contre un récepteur ige de haute affinité
GB2578867A (en) * 2018-10-09 2020-06-03 Genome Res Ltd Animal models and therapeutic molecules
KR20220089688A (ko) 2018-11-19 2022-06-28 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 항-pd-1 항체 및 이의 용도
WO2020176871A1 (fr) * 2019-02-28 2020-09-03 Ann And Robert H. Lurie Children's Hospital Of Chicago Anticorps contre la maladie de kawasaki identifiant des peptides d'hépacivirus
BR112022000721A2 (pt) * 2019-07-15 2022-03-08 Intervet Int Bv Anticorpos caninizados contra ctla-4 canina
CN119307505A (zh) * 2019-07-15 2025-01-14 英特维特国际股份有限公司 针对人和犬ctla-4的犬源化抗体
WO2021041972A1 (fr) * 2019-08-29 2021-03-04 Kindred Biosciences, Inc. Anticorps anti-il31 à usage vétérinaire
US20220119513A1 (en) 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
AU2021358987A1 (en) 2020-10-07 2023-05-11 Zoetis Services Llc Anti-ngf antibodies and methods of use thereof
CA3216131A1 (fr) * 2021-04-21 2022-10-27 Nicola J. MASON Anticorps monoclonaux canins contre la proteine 4 associee aux lymphocytes t cytotoxiques (ctla-4) canine
US20230192834A1 (en) * 2021-09-27 2023-06-22 Zoetis Services Llc Anti- tgfb1,2,3 antibodies and therapeutic uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2811096B2 (ja) 1989-09-30 1998-10-15 財団法人化学及血清療法研究所 イヌ免疫グロブリンκ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体
JP2837240B2 (ja) 1990-06-07 1998-12-14 財団法人化学及血清療法研究所 イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体
JP2811089B2 (ja) 1989-08-25 1998-10-15 財団法人化学及血清療法研究所 イヌ×マウスヘテロハイブリドーマおよびイヌ免疫グロブリンλ鎖の定常領域をコードする遺伝子断片
AU640397B2 (en) * 1989-08-25 1993-08-26 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulin
US5330883A (en) * 1992-06-29 1994-07-19 Lsi Logic Corporation Techniques for uniformizing photoresist thickness and critical dimension of underlying features
US5622842A (en) * 1994-11-09 1997-04-22 Merck & Co., Inc. DNA encoding canine immunoglobulin A
WO1997020859A1 (fr) * 1995-12-08 1997-06-12 Idexx Laboratories, Inc. Procedes et compositions relatifs a l'allergie chez les chiens
JPH09169795A (ja) 1995-12-22 1997-06-30 Hitachi Chem Co Ltd イヌ免疫グロブリンｅペプチド断片、それをコードするｄｎａ、そのｄｎａを含む組換えベクター、その組換えベクターを含む形質転換体及び抗イヌ免疫グロブリンｅ抗体の製造法
US6504013B1 (en) * 2000-02-01 2003-01-07 Idexx Laboratories, Inc. Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
DE69922873T2 (de) * 1998-04-09 2005-12-29 Idexx Laboratories, Inc. Spezifische Bindungsproteine zur Behandlung von Allergien beim Hund
AU2001253282A1 (en) * 2000-04-07 2001-10-23 Heska Corporation Compositions and methods related to canine igg and canine il-13 receptors

Also Published As

Publication number Publication date
AU2002359851A1 (en) 2003-07-30
EP1485126A4 (fr) 2007-03-21
US7261890B2 (en) 2007-08-28
CA2469833C (fr) 2008-05-20
WO2003060080A3 (fr) 2004-02-12
WO2003060080A2 (fr) 2003-07-24
AU2002359851A8 (en) 2003-07-30
US20040181039A1 (en) 2004-09-16
JP2005514063A (ja) 2005-05-19
EP1485126A2 (fr) 2004-12-15

Similar Documents

Publication Publication Date Title
CA2469833A1 (fr) Domaines variable d'immunoglobuline canine, anticorps caninises, et procede de production et d'utilisation associes
WO2006113643A3 (fr) Anticorps monoclonaux entierement humains a affinite elevee d'interleukine-8 et epitopes destines a ces anticorps
RS80704A (en) ANTI- av?6.ANTIBODIES
CY1111542T1 (el) Αντισωματα εξουδετερωσης του rsv υπερυψηλης συγγενειας
RS51829B (sr) Ljudska antitela specifična za interleukin 15 (il-15)
EP1578799A4 (fr) Anticorps agissant sur le facteur de necrose des tumeurs (tnf) et leurs utilisation
EA200100698A1 (ru) Моноклональные антитела человека к ctla-4
JP2004527212A5 (fr)
ATE384792T1 (de) Antikörpervarianten mit höheren bindungsaffinitäten im vergleich zu parentalen antikörpern
WO2006055638A3 (fr) Anticorps monoclonaux entierement humains diriges contre l'il-13
RS52889B (sr) Terapijsko humano anti-il-1r1 monoklonsko antitelo
WO1998050433A3 (fr) Anticorps monoclonaux humains contre le recepteur du facteur de croissance epidermique
IL173323A0 (en) Antibodies directed to parathyroid hormone (pth) and uses thereof
WO2003078600A3 (fr) Anticorps monoclonaux humains diriges contre la proteine m2 du virus de la grippe et methodes de production et d'utilisation de ceux-ci
WO2003057857A3 (fr) Anticorps diriges contre les pdgfd et utilisations
SG155883A1 (en) Anti-cd3 antibodies and methods of use thereof
ATE531812T1 (de) Humanisierung von nager-antikörpern
NZ594466A (en) Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
GEP20074222B (en) Antibodies to cd40
NZ547157A (en) Interferon Alpha Antibodies and their uses
DE60130538D1 (de) Humanisierte antikörper gegen ccr2 und verfahren zur deren verwendung
WO2006061723A3 (fr) Anticorps monoclonaux humains diriges contre la proteine m2 de la grippe, et methodes de production et d'utilisation desdits anticorps
ATE366746T1 (de) Gegen das semp1-protein gerichtete antikörper, verfahren zu deren herstellung, und deren anwendungen
WO2003016501A3 (fr) Anticorps de recombinaison, compositions et techniques de fabrication et d'utilisation de ces anticorps
ATE206621T1 (de) Il-8 antagonisten zur behandlung von asthma

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed