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CA2450289A1 - Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique - Google Patents

Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique Download PDF

Info

Publication number
CA2450289A1
CA2450289A1 CA002450289A CA2450289A CA2450289A1 CA 2450289 A1 CA2450289 A1 CA 2450289A1 CA 002450289 A CA002450289 A CA 002450289A CA 2450289 A CA2450289 A CA 2450289A CA 2450289 A1 CA2450289 A1 CA 2450289A1
Authority
CA
Canada
Prior art keywords
antibody
medium
inoculum
egfr
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002450289A
Other languages
English (en)
Inventor
Joseph Tarnowski
Daniel Velez
Joel Goldstein
Michael Barry
Diane Blumenthal
Girish Pendse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImClone LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002450289A priority Critical patent/CA2450289A1/fr
Priority to PCT/US2004/008802 priority patent/WO2004085474A2/fr
Publication of CA2450289A1 publication Critical patent/CA2450289A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA002450289A 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique Abandoned CA2450289A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002450289A CA2450289A1 (fr) 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique
PCT/US2004/008802 WO2004085474A2 (fr) 2003-03-20 2004-03-22 Procede de production d'un anticorps contre le recepteur du facteur de croissance epidermique

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45632403P 2003-03-20 2003-03-20
US52383603P 2003-11-19 2003-11-19
CA002450289A CA2450289A1 (fr) 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique

Publications (1)

Publication Number Publication Date
CA2450289A1 true CA2450289A1 (fr) 2005-05-19

Family

ID=34753238

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002450289A Abandoned CA2450289A1 (fr) 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique

Country Status (2)

Country Link
CA (1) CA2450289A1 (fr)
WO (1) WO2004085474A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1392359T4 (da) 2001-05-11 2013-06-10 Ludwig Inst For Cancer Res Ltd Specifikke bindingsproteiner og deres anvendelser.
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
BRPI0507608A (pt) * 2004-02-12 2007-07-03 Merck Patent Gmbh formulações de anticorpos anti-egfr lìquidas altamente concentradas
DE102007001370A1 (de) * 2007-01-09 2008-07-10 Curevac Gmbh RNA-kodierte Antikörper
EP2126127B1 (fr) 2007-01-25 2016-09-28 Dana-Farber Cancer Institute, Inc. Utilisation d'anticorps anti-egfr dans le traitement de maladie mediee par des mutants de recepteur du facteur de croissance epidermique (egfr)
CN104151430A (zh) 2007-03-01 2014-11-19 西福根有限公司 重组抗表皮生长因子受体抗体组合物
AU2008227123B2 (en) 2007-03-15 2014-03-27 Ludwig Institute For Cancer Research Ltd. Treatment method using EGFR antibodies and src inhibitors and related formulations
WO2008135259A2 (fr) * 2007-05-04 2008-11-13 Glycotope Gmbh Composition de molécules d'anticorps
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
WO2010022736A2 (fr) 2008-08-29 2010-03-04 Symphogen A/S Compositions de l'anticorps de recombinaison anti-récepteur du facteur de croissance anti-épidermique egfr
WO2010129276A2 (fr) * 2009-04-27 2010-11-11 Case Western Reserve University Agents de ciblage pyro-glutamate aβ
CA2807552A1 (fr) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Acides nucleiques modifies et leurs procedes d'utilisation
PT3590949T (pt) 2010-10-01 2022-08-02 Modernatx Inc Ácidos ribonucleicos contendo n1-metilpseudouracilos e suas utilizações
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
KR20190099538A (ko) 2011-10-03 2019-08-27 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도
SG11201402666WA (en) 2011-12-16 2014-10-30 Moderna Therapeutics Inc Modified nucleoside, nucleotide, and nucleic acid compositions
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2847329A4 (fr) 2012-04-02 2016-08-10 Moderna Therapeutics Inc Polynucléotides modifiés pour la production de protéines cytoplasmiques et cytosquelettiques
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
RS63237B1 (sr) 2012-11-26 2022-06-30 Modernatx Inc Terminalno modifikovana rnk
WO2014125382A2 (fr) * 2013-02-13 2014-08-21 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Cétuximab avec glycosylation modifiée et utilisations associées
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EA201591807A1 (ru) * 2013-03-15 2016-02-29 Янссен Байотек, Инк. Способы изготовления образцов для контроля содержания с-концевого лизина, галактозы и сиаловой кислоты в рекомбинантных белках
BR112016005526A2 (pt) 2013-09-12 2017-09-12 Halozyme Inc anticorpos receptores de fator de crescimento anti-epidérmido modificado e métodos de uso dos mesmos
EP3052106A4 (fr) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucléotides codant des polypeptides de modulation immunitaire
US10323076B2 (en) 2013-10-03 2019-06-18 Modernatx, Inc. Polynucleotides encoding low density lipoprotein receptor
CN105820248A (zh) * 2015-01-07 2016-08-03 上海张江生物技术有限公司 一种新型抗egfr单克隆抗体的制备方法及应用
WO2017161206A1 (fr) 2016-03-16 2017-09-21 Halozyme, Inc. Conjugués contenant des anticorps à activité conditionnelle ou des fragments de liaison à un antigène associés, et procédés d'utilisation
WO2017205465A2 (fr) 2016-05-24 2017-11-30 Griswold Karl Edwin Anticorps et leurs procédés de production

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ200438A3 (cs) * 2001-06-13 2004-06-16 Genmab A/S Název neuveden

Also Published As

Publication number Publication date
WO2004085474A3 (fr) 2004-12-23
WO2004085474A2 (fr) 2004-10-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued