CA2292899A1 - Element ntn-2 de la famille des ligands du tnf - Google Patents
Element ntn-2 de la famille des ligands du tnf Download PDFInfo
- Publication number
- CA2292899A1 CA2292899A1 CA002292899A CA2292899A CA2292899A1 CA 2292899 A1 CA2292899 A1 CA 2292899A1 CA 002292899 A CA002292899 A CA 002292899A CA 2292899 A CA2292899 A CA 2292899A CA 2292899 A1 CA2292899 A1 CA 2292899A1
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- CA
- Canada
- Prior art keywords
- human ntn
- human
- ntn
- polypeptide
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000010354 integration Effects 0.000 description 1
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- 239000002502 liposome Substances 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
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- 229930014626 natural product Natural products 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
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- 229940111202 pepsin Drugs 0.000 description 1
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- 238000011170 pharmaceutical development Methods 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Cette invention se rapporte aux polypeptides dits "NTN-2 HUMAIN" et à leurs acides nucléiques associés. Elle se rapporte aux polypeptides NTN-2 HUMAINS comportant un domaine NTN-2 HUMAIN possédant une activité spécifique de NTN-2 HUMAIN. Il est possible de produire ces polypeptides par recombinaison à partir de cellules hôtes transformées en utilisant les acides nucléiques de la présente invention. Cette invention se rapporte également à des agents de liaison spécifiques et à des procédés de fabrication et d'utilisation de compositions contenant ces polypeptides.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4877697P | 1997-06-06 | 1997-06-06 | |
| US6638797P | 1997-11-21 | 1997-11-21 | |
| US60/066,387 | 1997-11-21 | ||
| US60/048,776 | 1997-11-21 | ||
| PCT/US1998/011153 WO1998055620A1 (fr) | 1997-06-06 | 1998-06-03 | Element ntn-2 de la famille des ligands du tnf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2292899A1 true CA2292899A1 (fr) | 1998-12-10 |
Family
ID=26726521
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002292835A Abandoned CA2292835A1 (fr) | 1997-06-06 | 1998-06-03 | Membre ntn-2 de la famille des ligands du facteur de necrose tumorale (tnf) |
| CA002292899A Abandoned CA2292899A1 (fr) | 1997-06-06 | 1998-06-03 | Element ntn-2 de la famille des ligands du tnf |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002292835A Abandoned CA2292835A1 (fr) | 1997-06-06 | 1998-06-03 | Membre ntn-2 de la famille des ligands du facteur de necrose tumorale (tnf) |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0991759A1 (fr) |
| JP (1) | JP2002517977A (fr) |
| AU (1) | AU7608898A (fr) |
| CA (2) | CA2292835A1 (fr) |
| IL (1) | IL133316A0 (fr) |
| WO (1) | WO1998055621A1 (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689579B1 (en) | 1996-10-25 | 2004-02-10 | Human Genome Sciences, Inc. | Polynucleotides encoding neutrokine-α |
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| WO1999011791A2 (fr) * | 1997-09-05 | 1999-03-11 | University Of Washington | Recepteurs et ligands de la famille du facteur de necrose tumorale, acides nucleiques codants et agents de liaison associes |
| JP2002503444A (ja) * | 1997-11-26 | 2002-02-05 | イーライ・リリー・アンド・カンパニー | リガンドファミリー遺伝子 |
| US6297367B1 (en) | 1997-12-30 | 2001-10-02 | Chiron Corporation | Polynucleotide encoding TNFL1 |
| AU2093499A (en) * | 1997-12-30 | 1999-07-19 | Chiron Corporation | Members of tnf and tnfr families |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| WO2000026244A2 (fr) * | 1998-11-04 | 2000-05-11 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nouveau membre de la famille des facteurs de necrose des tumeurs, ligand du recepteur de la mort cellulaire (drl) et compositions et procedes correspondants |
| GB9828628D0 (en) * | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
| CA2358520C (fr) * | 1999-01-07 | 2011-12-13 | Zymogenetics, Inc. | Recepteurs solubles br43x2 et procedes d'utilisation |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| DK1415659T3 (da) | 1999-01-25 | 2011-10-03 | Biogen Idec Inc | BAFF, inhibitorer og anvendelse deraf i modulering af B-cellerespons |
| US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| US6475986B1 (en) * | 1999-02-02 | 2002-11-05 | Research Development Foundation | Uses of THANK, a TNF homologue that activates apoptosis |
| AU2880400A (en) * | 1999-02-12 | 2000-08-29 | Amgen, Inc. | Tnf-related proteins |
| US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
| EP1210425B2 (fr) | 1999-08-17 | 2015-06-17 | Biogen MA Inc. | Recepteur de baff (bcma) et agent immunoregulateur |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| ATE361318T1 (de) | 2000-05-12 | 2007-05-15 | Amgen Inc | Polypeptiden, die die april-vermittelte aktivierung von t-und b-zellen hemmen |
| MXPA02012434A (es) | 2000-06-16 | 2004-09-06 | Cambridge Antibody Tech | Anticuerpos que se unen inmunoespecificamente a estimulador de linfocitos ii. |
| US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
| WO2002016411A2 (fr) | 2000-08-18 | 2002-02-28 | Human Genome Sciences, Inc. | Polypeptides de fixation et procedes associes |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| EA010435B1 (ru) | 2001-05-11 | 2008-08-29 | Амген, Инк. | Связывающиеся с tall-1 молекулы и их применение |
| CN1612750B (zh) | 2001-05-24 | 2012-10-31 | 津莫吉尼蒂克斯公司 | Taci-免疫球蛋白融合蛋白质 |
| AU2004233164B2 (en) | 2003-03-28 | 2009-10-08 | Biogen Ma Inc. | Truncated BAFF receptors |
| WO2005051994A2 (fr) * | 2003-11-21 | 2005-06-09 | Zymogenetics, Inc. | Facteur de necrose tumorale ztnf11 |
| EP2332563A3 (fr) * | 2004-10-13 | 2013-03-13 | The Washington University | Utilisation de BAFF pour traiter la sepsie |
| JP2009507777A (ja) | 2005-08-09 | 2009-02-26 | ザイモジェネティクス，インコーポレイティド | ＴＡＣＩ−Ｉｇ融合分子を用いたＢ細胞性腫瘍の処置方法 |
| AU2006278227B2 (en) | 2005-08-09 | 2011-10-20 | Ares Trading S.A. | Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules |
| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック， インコーポレイテッド | Ｂ細胞アッセイに関する組成物及び方法。 |
| US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
| EP2035028A2 (fr) | 2006-05-15 | 2009-03-18 | Ares Trading S.A. | Procédés de traitement des maladies auto-immunes à l'aide d'une molécule de fusion taci-ig |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| CN106367714A (zh) | 2015-07-24 | 2017-02-01 | 先健科技(深圳)有限公司 | 铁基可吸收植入医疗器械与预制管及其制备方法 |
| WO2018115879A1 (fr) | 2016-12-21 | 2018-06-28 | Mereo Biopharma 3 Limited | Utilisation d'anticorps anti-sclérostine dans le traitement de l'ostéogenèse imparfaite |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2266439C (fr) * | 1996-10-25 | 2009-06-16 | Human Genome Sciences, Inc. | Neutrokine .alpha. |
| WO1998027114A2 (fr) * | 1996-12-17 | 1998-06-25 | Schering Corporation | Antigenes de surface mammaliens et reactifs associes |
-
1998
- 1998-06-03 CA CA002292835A patent/CA2292835A1/fr not_active Abandoned
- 1998-06-03 EP EP98923907A patent/EP0991759A1/fr not_active Withdrawn
- 1998-06-03 AU AU76088/98A patent/AU7608898A/en not_active Abandoned
- 1998-06-03 IL IL13331698A patent/IL133316A0/xx unknown
- 1998-06-03 CA CA002292899A patent/CA2292899A1/fr not_active Abandoned
- 1998-06-03 WO PCT/US1998/011294 patent/WO1998055621A1/fr not_active Application Discontinuation
- 1998-06-03 JP JP50275099A patent/JP2002517977A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2292835A1 (fr) | 1998-12-10 |
| AU7608898A (en) | 1998-12-21 |
| EP0991759A1 (fr) | 2000-04-12 |
| IL133316A0 (en) | 2001-04-30 |
| WO1998055621A1 (fr) | 1998-12-10 |
| JP2002517977A (ja) | 2002-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20040603 |