CA1147736A - 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine-maleate - Google Patents

2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine-maleate

Info

Publication number: CA1147736A
Authority: CA; Canada
Prior art keywords: amino; maleate; pyridine; fluoro; carbethoxyamino
Prior art date: 1980-09-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000385703A

Other languages

English (en)

French (fr)

Inventor

Walter Von Bebenburg, (Deceased)

Siegfried Pauluhn

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Evonik Operations GmbH

Original Assignee

Degussa GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-13

Filing date

1981-09-11

Publication date

1983-06-07

1981-09-11 Application filed by Degussa GmbH filed Critical Degussa GmbH

1983-06-07 Application granted granted Critical

1983-06-07 Publication of CA1147736A publication Critical patent/CA1147736A/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA000385703A 1980-09-13 1981-09-11 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine-maleate Expired CA1147736A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3034638		1980-09-13
DEP3034638.4		1980-09-13

Publications (1)

Publication Number	Publication Date
CA1147736A true CA1147736A (en)	1983-06-07

Family

ID=6111900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000385703A Expired CA1147736A (en)	1980-09-13	1981-09-11	2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine-maleate

Country Status (31)

Country	Link
US (1)	US4481205A (no)
JP (1)	JPS5781465A (no)
KR (1)	KR860000585B1 (no)
AR (1)	AR229101A1 (no)
AT (1)	AT375924B (no)
AU (1)	AU541020B2 (no)
BE (1)	BE890331A (no)
CA (1)	CA1147736A (no)
CH (1)	CH646952A5 (no)
CS (1)	CS226037B2 (no)
DD (1)	DD201786A5 (no)
DK (1)	DK159878C (no)
EG (1)	EG15446A (no)
ES (1)	ES505423A0 (no)
FI (1)	FI79531C (no)
FR (1)	FR2490225B1 (no)
GB (1)	GB2084138B (no)
GR (1)	GR75777B (no)
HU (1)	HU182720B (no)
IE (1)	IE51547B1 (no)
IL (1)	IL63801A (no)
IN (1)	IN155674B (no)
IT (1)	IT1171520B (no)
LU (1)	LU83633A1 (no)
NL (1)	NL189856C (no)
NO (1)	NO160919C (no)
PL (1)	PL130030B1 (no)
SE (1)	SE454693B (no)
SU (1)	SU1091855A3 (no)
YU (1)	YU43037B (no)
ZA (1)	ZA816336B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3416609A1 (de) *	1984-05-05	1985-11-07	Degussa Ag, 6000 Frankfurt	2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)- pyridin-gluconat und pharmazeutische zubereitungen, die diese substanz enthalten
NO860825L (no) *	1985-03-23	1986-09-24	Degussa	Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
JPH0568848U (ja) *	1991-11-18	1993-09-17	京都機械工具株式会社	チューブ絞り器
DE4327516A1 (de) *	1993-08-17	1995-02-23	Asta Medica Ag	Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
DE19625582A1 (de) *	1996-06-27	1998-01-02	Asta Medica Ag	Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen
DE19716984A1 (de) *	1997-04-23	1998-10-29	Asta Medica Ag	Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A
US6187324B1 (en) *	1998-08-11	2001-02-13	Kabushiki Kaisha Ogi Kogei	Cosmetic composition comprising at least one of Kumazasa extract and medicinal carbon
US6821995B1 (en)	1999-12-01	2004-11-23	Duke University	Method of treating batten disease
DE10327674A1 (de) *	2003-06-20	2005-01-05	Awd.Pharma Gmbh & Co. Kg	Injizierbare Darreichungsform von Flupirtin
US7741358B2 (en) *	2005-04-14	2010-06-22	N.V. Organon	Crystal form of asenapine maleate
US20080279930A1 (en) *	2007-05-07	2008-11-13	Bernd Terhaag	Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
US8501778B2 (en)	2008-06-20	2013-08-06	Nhwa Pharma. Corporation	Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent
CA2738866A1 (en) *	2008-08-06	2010-02-11	Bionevia Pharmaceuticals, Inc.	Flupirtine hydrochloride maleic acid cocrystal
DE102009023162B4 (de) *	2009-05-29	2011-07-07	Corden PharmaChem GmbH, 68305	Verfahren zur Herstellung von Flupirtin
CN102140077A (zh) *	2010-01-28	2011-08-03	范扶民	氟吡汀a晶型及其制备方法
WO2012004391A1 (en)	2010-07-09	2012-01-12	K.H.S. Pharma Holding Gmbh	Process for the preparation of flupirtine maleate
CN102241626B (zh) *	2011-05-03	2013-07-03	北京华睿鼎信科技有限公司	一种马来酸氟吡汀的合成工艺
WO2013080215A1 (en)	2011-11-30	2013-06-06	Arch Pharmalabs Limited	An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof
CN103086963A (zh) *	2013-01-29	2013-05-08	吉林修正药业新药开发有限公司	一种马来酸氟吡汀a晶型化合物及中间体的合成方法
CN104086481B (zh) *	2014-07-18	2016-05-11	四川新斯顿制药股份有限公司	一种马来酸氟吡汀的合成方法
CN111100010A (zh) *	2019-12-30	2020-05-05	山东省越兴化工有限公司	一种对氟苄胺的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1795858C2 (de) *	1968-07-19	1979-01-11	Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt	Benzylaminopyridine
US3969361A (en) *	1972-05-10	1976-07-13	Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler	2-Benzoyl-3-amino-pyridines

1981
- 1981-09-02 US US06/298,886 patent/US4481205A/en not_active Expired - Lifetime
- 1981-09-04 GB GB8126788A patent/GB2084138B/en not_active Expired
- 1981-09-04 IE IE2055/81A patent/IE51547B1/en not_active IP Right Cessation
- 1981-09-08 AR AR286685A patent/AR229101A1/es active
- 1981-09-09 YU YU2157/81A patent/YU43037B/xx unknown
- 1981-09-10 NO NO813082A patent/NO160919C/no unknown
- 1981-09-10 SU SU813332400A patent/SU1091855A3/ru active
- 1981-09-10 IN IN1018/CAL/81A patent/IN155674B/en unknown
- 1981-09-11 GR GR66021A patent/GR75777B/el unknown
- 1981-09-11 ES ES505423A patent/ES505423A0/es active Granted
- 1981-09-11 IL IL63801A patent/IL63801A/xx unknown
- 1981-09-11 ZA ZA816336A patent/ZA816336B/xx unknown
- 1981-09-11 JP JP56143721A patent/JPS5781465A/ja active Granted
- 1981-09-11 CH CH591081A patent/CH646952A5/de not_active IP Right Cessation
- 1981-09-11 BE BE6/47521A patent/BE890331A/fr not_active IP Right Cessation
- 1981-09-11 AU AU75163/81A patent/AU541020B2/en not_active Expired
- 1981-09-11 CA CA000385703A patent/CA1147736A/en not_active Expired
- 1981-09-11 PL PL1981232999A patent/PL130030B1/pl unknown
- 1981-09-11 CS CS816725A patent/CS226037B2/cs unknown
- 1981-09-11 AT AT0393481A patent/AT375924B/de not_active IP Right Cessation
- 1981-09-11 SE SE8105425A patent/SE454693B/sv not_active IP Right Cessation
- 1981-09-11 HU HU812635A patent/HU182720B/hu not_active IP Right Cessation
- 1981-09-11 LU LU83633A patent/LU83633A1/de unknown
- 1981-09-11 IT IT49272/81A patent/IT1171520B/it active
- 1981-09-11 FI FI812836A patent/FI79531C/fi not_active IP Right Cessation
- 1981-09-11 NL NLAANVRAGE8104211,A patent/NL189856C/xx not_active IP Right Cessation
- 1981-09-11 DK DK404681A patent/DK159878C/da active
- 1981-09-11 DD DD81233226A patent/DD201786A5/de unknown
- 1981-09-11 KR KR1019810003406A patent/KR860000585B1/ko active
- 1981-09-13 EG EG81515A patent/EG15446A/xx active
- 1981-09-14 FR FR8117328A patent/FR2490225B1/fr not_active Expired

Also Published As

Publication number	Publication date
DD201786A5 (de)	1983-08-10
CH646952A5 (de)	1984-12-28
ATA393481A (de)	1984-02-15
NL189856B (nl)	1993-03-16
EG15446A (en)	1986-06-30
GB2084138A (en)	1982-04-07
GR75777B (no)	1984-08-02
IT1171520B (it)	1987-06-10
DK159878B (da)	1990-12-24
BE890331A (fr)	1982-03-11
NO160919C (no)	1989-06-14
JPS5781465A (en)	1982-05-21
IE51547B1 (en)	1987-01-07
FR2490225A1 (fr)	1982-03-19
ES8206481A1 (es)	1982-08-16
CS226037B2 (en)	1984-03-19
FI79531C (fi)	1990-01-10
ZA816336B (en)	1982-09-29
DK404681A (da)	1982-03-14
AR229101A1 (es)	1983-06-15
ES505423A0 (es)	1982-08-16
IN155674B (no)	1985-02-23
HU182720B (en)	1984-03-28
US4481205A (en)	1984-11-06
AU7516381A (en)	1982-03-25
YU43037B (en)	1989-02-28
YU215781A (en)	1984-02-29
NL8104211A (nl)	1982-04-01
FI812836L (fi)	1982-03-14
SE8105425L (sv)	1982-03-14
KR830007556A (ko)	1983-10-21
PL130030B1 (en)	1984-07-31
SU1091855A3 (ru)	1984-05-07
FR2490225B1 (fr)	1985-09-06
NO813082L (no)	1982-03-15
IL63801A (en)	1984-10-31
FI79531B (fi)	1989-09-29
IT8149272A0 (it)	1981-09-11
SE454693B (sv)	1988-05-24
AT375924B (de)	1984-09-25
IE812055L (en)	1982-03-13
JPH0259149B2 (no)	1990-12-11
PL232999A1 (no)	1982-08-16
LU83633A1 (de)	1982-01-21
NO160919B (no)	1989-03-06
AU541020B2 (en)	1984-12-13
IL63801A0 (en)	1981-12-31
KR860000585B1 (ko)	1986-05-17
DK159878C (da)	1991-05-13
NL189856C (nl)	1993-08-16
GB2084138B (en)	1984-07-25

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Legal Events

Date	Code	Title	Description
2000-06-07	MKEX	Expiry