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ATA393481A - Verfahren zur herstellung des neuen 2-amino-3carbethoxyamino-6-(p-fluor-benzylamino)-pyridin maleats - Google Patents

Verfahren zur herstellung des neuen 2-amino-3carbethoxyamino-6-(p-fluor-benzylamino)-pyridin maleats

Info

Publication number
ATA393481A
ATA393481A AT0393481A AT393481A ATA393481A AT A393481 A ATA393481 A AT A393481A AT 0393481 A AT0393481 A AT 0393481A AT 393481 A AT393481 A AT 393481A AT A393481 A ATA393481 A AT A393481A
Authority
AT
Austria
Prior art keywords
tractors
tracking
type trailer
trailer
type
Prior art date
Application number
AT0393481A
Other languages
English (en)
Other versions
AT375924B (de
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of ATA393481A publication Critical patent/ATA393481A/de
Application granted granted Critical
Publication of AT375924B publication Critical patent/AT375924B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/76Nitrogen atoms to which a second hetero atom is attached
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT0393481A 1980-09-13 1981-09-11 Verfahren zur herstellung des neuen 2-amino-3carbethoxyamino-6-(p-fluor-benzylamino)-pyridin maleats AT375924B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3034638 1980-09-13

Publications (2)

Publication Number Publication Date
ATA393481A true ATA393481A (de) 1984-02-15
AT375924B AT375924B (de) 1984-09-25

Family

ID=6111900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0393481A AT375924B (de) 1980-09-13 1981-09-11 Verfahren zur herstellung des neuen 2-amino-3carbethoxyamino-6-(p-fluor-benzylamino)-pyridin maleats

Country Status (31)

Country Link
US (1) US4481205A (de)
JP (1) JPS5781465A (de)
KR (1) KR860000585B1 (de)
AR (1) AR229101A1 (de)
AT (1) AT375924B (de)
AU (1) AU541020B2 (de)
BE (1) BE890331A (de)
CA (1) CA1147736A (de)
CH (1) CH646952A5 (de)
CS (1) CS226037B2 (de)
DD (1) DD201786A5 (de)
DK (1) DK159878C (de)
EG (1) EG15446A (de)
ES (1) ES505423A0 (de)
FI (1) FI79531C (de)
FR (1) FR2490225B1 (de)
GB (1) GB2084138B (de)
GR (1) GR75777B (de)
HU (1) HU182720B (de)
IE (1) IE51547B1 (de)
IL (1) IL63801A (de)
IN (1) IN155674B (de)
IT (1) IT1171520B (de)
LU (1) LU83633A1 (de)
NL (1) NL189856C (de)
NO (1) NO160919C (de)
PL (1) PL130030B1 (de)
SE (1) SE454693B (de)
SU (1) SU1091855A3 (de)
YU (1) YU43037B (de)
ZA (1) ZA816336B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3416609A1 (de) * 1984-05-05 1985-11-07 Degussa Ag, 6000 Frankfurt 2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)- pyridin-gluconat und pharmazeutische zubereitungen, die diese substanz enthalten
NO860825L (no) * 1985-03-23 1986-09-24 Degussa Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
JPH0568848U (ja) * 1991-11-18 1993-09-17 京都機械工具株式会社 チューブ絞り器
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
DE19625582A1 (de) * 1996-06-27 1998-01-02 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen
DE19716984A1 (de) * 1997-04-23 1998-10-29 Asta Medica Ag Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A
US6187324B1 (en) * 1998-08-11 2001-02-13 Kabushiki Kaisha Ogi Kogei Cosmetic composition comprising at least one of Kumazasa extract and medicinal carbon
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
DE10327674A1 (de) * 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
US8501778B2 (en) 2008-06-20 2013-08-06 Nhwa Pharma. Corporation Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent
CA2738866A1 (en) * 2008-08-06 2010-02-11 Bionevia Pharmaceuticals, Inc. Flupirtine hydrochloride maleic acid cocrystal
DE102009023162B4 (de) * 2009-05-29 2011-07-07 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Flupirtin
CN102140077A (zh) * 2010-01-28 2011-08-03 范扶民 氟吡汀a晶型及其制备方法
WO2012004391A1 (en) 2010-07-09 2012-01-12 K.H.S. Pharma Holding Gmbh Process for the preparation of flupirtine maleate
CN102241626B (zh) * 2011-05-03 2013-07-03 北京华睿鼎信科技有限公司 一种马来酸氟吡汀的合成工艺
WO2013080215A1 (en) 2011-11-30 2013-06-06 Arch Pharmalabs Limited An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof
CN103086963A (zh) * 2013-01-29 2013-05-08 吉林修正药业新药开发有限公司 一种马来酸氟吡汀a晶型化合物及中间体的合成方法
CN104086481B (zh) * 2014-07-18 2016-05-11 四川新斯顿制药股份有限公司 一种马来酸氟吡汀的合成方法
CN111100010A (zh) * 2019-12-30 2020-05-05 山东省越兴化工有限公司 一种对氟苄胺的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795858C2 (de) * 1968-07-19 1979-01-11 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Benzylaminopyridine
US3969361A (en) * 1972-05-10 1976-07-13 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler 2-Benzoyl-3-amino-pyridines

Also Published As

Publication number Publication date
DD201786A5 (de) 1983-08-10
CH646952A5 (de) 1984-12-28
NL189856B (nl) 1993-03-16
EG15446A (en) 1986-06-30
GB2084138A (en) 1982-04-07
GR75777B (de) 1984-08-02
IT1171520B (it) 1987-06-10
DK159878B (da) 1990-12-24
BE890331A (fr) 1982-03-11
NO160919C (no) 1989-06-14
JPS5781465A (en) 1982-05-21
IE51547B1 (en) 1987-01-07
FR2490225A1 (fr) 1982-03-19
ES8206481A1 (es) 1982-08-16
CS226037B2 (en) 1984-03-19
FI79531C (fi) 1990-01-10
ZA816336B (en) 1982-09-29
DK404681A (da) 1982-03-14
AR229101A1 (es) 1983-06-15
ES505423A0 (es) 1982-08-16
IN155674B (de) 1985-02-23
HU182720B (en) 1984-03-28
CA1147736A (en) 1983-06-07
US4481205A (en) 1984-11-06
AU7516381A (en) 1982-03-25
YU43037B (en) 1989-02-28
YU215781A (en) 1984-02-29
NL8104211A (nl) 1982-04-01
FI812836L (fi) 1982-03-14
SE8105425L (sv) 1982-03-14
KR830007556A (ko) 1983-10-21
PL130030B1 (en) 1984-07-31
SU1091855A3 (ru) 1984-05-07
FR2490225B1 (fr) 1985-09-06
NO813082L (no) 1982-03-15
IL63801A (en) 1984-10-31
FI79531B (fi) 1989-09-29
IT8149272A0 (it) 1981-09-11
SE454693B (sv) 1988-05-24
AT375924B (de) 1984-09-25
IE812055L (en) 1982-03-13
JPH0259149B2 (de) 1990-12-11
PL232999A1 (de) 1982-08-16
LU83633A1 (de) 1982-01-21
NO160919B (no) 1989-03-06
AU541020B2 (en) 1984-12-13
IL63801A0 (en) 1981-12-31
KR860000585B1 (ko) 1986-05-17
DK159878C (da) 1991-05-13
NL189856C (nl) 1993-08-16
GB2084138B (en) 1984-07-25

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
EIH Change in the person of patent owner
ELA Expired due to lapse of time