CA1067407A - Pharmaceutical preparation in the form of a foil having an active substance incorporated therein - Google Patents

Pharmaceutical preparation in the form of a foil having an active substance incorporated therein

Info

Publication number: CA1067407A
Authority: CA; Canada
Prior art keywords: cellulose; foil; composition according; sheet; water
Prior art date: 1974-07-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA230,802A

Other languages

English (en)

French (fr)

Inventor

Peter Fuchs

Jurgen Hilmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-07-05

Filing date

1975-07-04

Publication date

1979-12-04

1974-07-05 Priority claimed from DE2432925A external-priority patent/DE2432925C3/de

1974-10-17 Priority claimed from DE19742449865 external-priority patent/DE2449865B2/de

1975-07-04 Application filed by Schering AG filed Critical Schering AG

1979-12-04 Application granted granted Critical

1979-12-04 Publication of CA1067407A publication Critical patent/CA1067407A/en

Status Expired legal-status Critical Current

Links

239000011888 foil Substances 0.000 title abstract description 98
239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
239000013543 active substance Substances 0.000 title description 41
239000000203 mixture Substances 0.000 claims abstract description 54
229920002678 cellulose Polymers 0.000 claims abstract description 42
239000001913 cellulose Substances 0.000 claims abstract description 42
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 29
239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 29
229940071676 hydroxypropylcellulose Drugs 0.000 claims abstract description 29
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
239000003795 chemical substances by application Substances 0.000 claims abstract description 9
239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 8
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 8
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 8
229940071826 hydroxyethyl cellulose Drugs 0.000 claims abstract description 8
239000000262 estrogen Substances 0.000 claims abstract description 6
239000000583 progesterone congener Substances 0.000 claims abstract description 5
229920000609 methyl cellulose Polymers 0.000 claims abstract description 4
239000001923 methylcellulose Substances 0.000 claims abstract description 4
235000010981 methylcellulose Nutrition 0.000 claims abstract description 4
229920000642 polymer Polymers 0.000 claims description 30
239000000725 suspension Substances 0.000 claims description 27
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 26
239000003814 drug Substances 0.000 claims description 11
239000000945 filler Substances 0.000 claims description 9
239000002904 solvent Substances 0.000 claims description 8
-1 hydroxyalkyl ether Chemical compound 0.000 claims description 7
238000001035 drying Methods 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
150000001875 compounds Chemical class 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
229920001451 polypropylene glycol Polymers 0.000 claims description 3
238000011200 topical administration Methods 0.000 claims description 3
229920002675 Polyoxyl Polymers 0.000 claims description 2
239000008194 pharmaceutical composition Substances 0.000 claims 3
239000002552 dosage form Substances 0.000 claims 2
229940011871 estrogen Drugs 0.000 claims 2
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
239000012456 homogeneous solution Substances 0.000 claims 1
230000006872 improvement Effects 0.000 claims 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
239000002798 polar solvent Substances 0.000 claims 1
239000000243 solution Substances 0.000 claims 1
239000000463 material Substances 0.000 abstract description 7
229960002900 methylcellulose Drugs 0.000 abstract description 3
239000003960 organic solvent Substances 0.000 abstract description 3
239000001856 Ethyl cellulose Substances 0.000 abstract description 2
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract description 2
206010061218 Inflammation Diseases 0.000 abstract description 2
HLKZFSVWBQSKKH-UHFFFAOYSA-N but-3-enoic acid;1-ethenylpyrrolidin-2-one Chemical compound OC(=O)CC=C.C=CN1CCCC1=O HLKZFSVWBQSKKH-UHFFFAOYSA-N 0.000 abstract description 2
235000019325 ethyl cellulose Nutrition 0.000 abstract description 2
229920001249 ethyl cellulose Polymers 0.000 abstract description 2
229960004667 ethyl cellulose Drugs 0.000 abstract description 2
230000004054 inflammatory process Effects 0.000 abstract description 2
239000003112 inhibitor Substances 0.000 abstract description 2
YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical group COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 abstract description 2
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 abstract description 2
239000004480 active ingredient Substances 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
239000002831 pharmacologic agent Substances 0.000 abstract 1
FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
229940124530 sulfonamide Drugs 0.000 abstract 1
239000003204 tranquilizing agent Substances 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 46
238000002360 preparation method Methods 0.000 description 35
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 25
229960002568 ethinylestradiol Drugs 0.000 description 25
235000019441 ethanol Nutrition 0.000 description 23
229960004400 levonorgestrel Drugs 0.000 description 18
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
239000000126 substance Substances 0.000 description 8
IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 6
229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 6
229960001652 norethindrone acetate Drugs 0.000 description 6
239000003921 oil Substances 0.000 description 6
229940099429 polyoxyl 40 stearate Drugs 0.000 description 6
229920002472 Starch Polymers 0.000 description 5
235000019698 starch Nutrition 0.000 description 5
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
239000006071 cream Substances 0.000 description 4
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 4
229940081974 saccharin Drugs 0.000 description 4
235000019204 saccharin Nutrition 0.000 description 4
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 4
239000008107 starch Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
244000299461 Theobroma cacao Species 0.000 description 3
235000009470 Theobroma cacao Nutrition 0.000 description 3
235000002864 food coloring agent Nutrition 0.000 description 3
239000008101 lactose Substances 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
235000019759 Maize starch Nutrition 0.000 description 2
229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
235000010216 calcium carbonate Nutrition 0.000 description 2
XZBJVIQXJHGUBE-HZMVJJPJSA-N fluocortolone pivalate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)COC(=O)C(C)(C)C)[C@@]2(C)C[C@@H]1O XZBJVIQXJHGUBE-HZMVJJPJSA-N 0.000 description 2
ZKUDBRCEOBOWLF-UHFFFAOYSA-N glisoxepide Chemical compound O1C(C)=CC(C(=O)NCCC=2C=CC(=CC=2)S(=O)(=O)NC(=O)NN2CCCCCC2)=N1 ZKUDBRCEOBOWLF-UHFFFAOYSA-N 0.000 description 2
229960003236 glisoxepide Drugs 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
229940053934 norethindrone Drugs 0.000 description 2
VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 2
QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 2
239000008389 polyethoxylated castor oil Substances 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
229920002545 silicone oil Polymers 0.000 description 2
235000012756 tartrazine Nutrition 0.000 description 2
239000004149 tartrazine Substances 0.000 description 2
239000003232 water-soluble binding agent Substances 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
KLCDQSGLLRINHY-UHFFFAOYSA-N 1-phenyldiazenylnaphthalen-2-amine Chemical compound NC1=CC=C2C=CC=CC2=C1N=NC1=CC=CC=C1 KLCDQSGLLRINHY-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
229920003043 Cellulose fiber Polymers 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000011797 cavity material Substances 0.000 description 1
230000001427 coherent effect Effects 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
230000002254 contraceptive effect Effects 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
239000008298 dragée Substances 0.000 description 1
210000005069 ears Anatomy 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
235000013305 food Nutrition 0.000 description 1
UCNNJGDEJXIUCC-UHFFFAOYSA-L hydroxy(oxo)iron;iron Chemical compound [Fe].O[Fe]=O.O[Fe]=O UCNNJGDEJXIUCC-UHFFFAOYSA-L 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229960004719 nandrolone Drugs 0.000 description 1
210000001331 nose Anatomy 0.000 description 1
239000002674 ointment Substances 0.000 description 1
238000012856 packing Methods 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000000344 soap Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000003892 spreading Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000003860 storage Methods 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
239000004173 sunset yellow FCF Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
229960000943 tartrazine Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA230,802A 1974-07-05 1975-07-04 Pharmaceutical preparation in the form of a foil having an active substance incorporated therein Expired CA1067407A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2432925A DE2432925C3 (de)	1974-07-05	1974-07-05	Folienförmige Arzneimittel
DE19742449865 DE2449865B2 (de)	1974-10-17	1974-10-17	Folienförmiges Arzneimittel

Publications (1)

Publication Number	Publication Date
CA1067407A true CA1067407A (en)	1979-12-04

Family

ID=25767384

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA230,802A Expired CA1067407A (en)	1974-07-05	1975-07-04	Pharmaceutical preparation in the form of a foil having an active substance incorporated therein

Country Status (17)

Country	Link
JP (1)	JPS6028810B2 (xx)
CA (1)	CA1067407A (xx)
CH (1)	CH625704A5 (xx)
DD (1)	DD122196A5 (xx)
DK (1)	DK143221C (xx)
EG (1)	EG11756A (xx)
FI (1)	FI60354C (xx)
FR (1)	FR2276811A1 (xx)
GB (1)	GB1510999A (xx)
IE (1)	IE42604B1 (xx)
IL (1)	IL47573A (xx)
IN (1)	IN142428B (xx)
NL (1)	NL186294C (xx)
NO (1)	NO752416L (xx)
PH (1)	PH18973A (xx)
RO (1)	RO68836A (xx)
SE (1)	SE413285B (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9289386B2 (en)	2009-01-29	2016-03-22	Nitto Denko Corporation	Oral film-form base and oral film-form preparation
US9724309B2 (en)	2010-03-30	2017-08-08	Nitto Denko Corporation	Film-form preparation and method for producing the same
US10092505B2 (en)	2012-01-11	2018-10-09	Nitto Denko Corporation	Oral film-form base and preparation

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4332789A (en)	1975-12-15	1982-06-01	Hoffmann-La Roche Inc.	Pharmaceutical unit dosage forms
AU514195B2 (en)	1975-12-15	1981-01-29	F. Hoffmann-La Roche & Co.	Dosage form
GB1601923A (en) *	1977-06-09	1981-11-04	Beecham Group Ltd	Sustained release compositions
IL59063A (en) *	1979-01-11	1983-12-30	Key Pharma	Polymeric diffusion matrix for release of pharmaceutical dosage
EP0063657A1 (en) *	1981-04-29	1982-11-03	Merck & Co. Inc.	Topical application of interferon inducers
JPS59222406A (ja) *	1983-06-01	1984-12-14	Teijin Ltd	歯周疾患治療用製剤及びその製造法
JPS6086576U (ja) *	1983-11-15	1985-06-14	株式会社豊田自動織機製作所	流体噴射式織機の緯糸貯留装置における緯糸案内装置
JPS61280423A (ja) *	1985-06-05	1986-12-11	Kiyuukiyuu Yakuhin Kogyo Kk	口腔内粘膜貼付剤
DE3601923A1 (de) *	1986-01-23	1987-07-30	Behringwerke Ag	Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung
SE8602666D0 (sv) *	1986-06-16	1986-06-16	Leo Ab	Intravaginal devices
DE3630603A1 (de) *	1986-09-09	1988-03-10	Desitin Arzneimittel Gmbh	Darreichungs- und dosierungsform fuer arzneimittelwirkstoffe, reagentien oder dergleichen sowie verfahren zu deren herstellung
DE4018247A1 (de) *	1990-06-07	1991-12-12	Lohmann Therapie Syst Lts	Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen
DE19508029C2 (de) *	1995-03-07	1997-10-09	Richard Prof Dr Sueverkruep	Darreichungsform zur äußerlichen Applikation von ophthalmischen Arzneistoffen und Verfahren zur Herstellung derselben
DE19646392A1 (de) *	1996-11-11	1998-05-14	Lohmann Therapie Syst Lts	Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
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ATE553746T1 (de) *	2003-01-30	2012-05-15	Monosolrx Llc	Verfahren zur herstellung eines dünnen films, thermolabile wirkstoffe enthaltend
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1975
- 1975-05-19 IN IN993/CAL/1975A patent/IN142428B/en unknown
- 1975-06-17 FI FI751801A patent/FI60354C/fi not_active IP Right Cessation
- 1975-06-24 JP JP50078601A patent/JPS6028810B2/ja not_active Expired
- 1975-06-26 IL IL47573A patent/IL47573A/xx unknown
- 1975-06-30 NL NLAANVRAGE7507785,A patent/NL186294C/xx not_active IP Right Cessation
- 1975-06-30 DK DK295075A patent/DK143221C/da not_active IP Right Cessation
- 1975-06-30 RO RO7582701A patent/RO68836A/ro unknown
- 1975-07-02 EG EG382A patent/EG11756A/xx active
- 1975-07-02 PH PH17340A patent/PH18973A/en unknown
- 1975-07-03 SE SE7507659-6A patent/SE413285B/xx not_active IP Right Cessation
- 1975-07-03 CH CH870075A patent/CH625704A5/de not_active IP Right Cessation
- 1975-07-03 DD DD187079A patent/DD122196A5/xx unknown
- 1975-07-03 IE IE1474/75A patent/IE42604B1/en unknown
- 1975-07-03 NO NO752416A patent/NO752416L/no unknown
- 1975-07-04 FR FR7521022A patent/FR2276811A1/fr active Granted
- 1975-07-04 CA CA230,802A patent/CA1067407A/en not_active Expired
- 1975-07-04 GB GB28252/75A patent/GB1510999A/en not_active Expired

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9289386B2 (en)	2009-01-29	2016-03-22	Nitto Denko Corporation	Oral film-form base and oral film-form preparation
US9724309B2 (en)	2010-03-30	2017-08-08	Nitto Denko Corporation	Film-form preparation and method for producing the same
US10092505B2 (en)	2012-01-11	2018-10-09	Nitto Denko Corporation	Oral film-form base and preparation

Also Published As

Publication number	Publication date
IN142428B (xx)	1977-07-09
DK143221C (da)	1981-11-30
SE7507659L (sv)	1976-01-07
FI751801A (xx)	1976-01-06
SE413285B (sv)	1980-05-19
RO68836A (ro)	1980-07-15
IE42604B1 (en)	1980-09-10
FR2276811B1 (xx)	1980-04-11
NO752416L (xx)	1976-01-06
EG11756A (en)	1977-11-30
IL47573A0 (en)	1975-08-31
FI60354C (fi)	1982-01-11
GB1510999A (en)	1978-05-17
AU8252775A (en)	1977-01-06
JPS5129218A (en)	1976-03-12
CH625704A5 (en)	1981-10-15
FI60354B (fi)	1981-09-30
NL186294C (nl)	1990-11-01
FR2276811A1 (fr)	1976-01-30
JPS6028810B2 (ja)	1985-07-06
NL186294B (nl)	1990-06-01
IE42604L (en)	1976-01-05
DK143221B (da)	1981-07-27
IL47573A (en)	1978-10-31
DK295075A (da)	1976-01-06
DD122196A5 (xx)	1976-09-20
PH18973A (en)	1985-11-26
NL7507785A (nl)	1976-01-07

Publication	Publication Date	Title
CA1067407A (en)	1979-12-04	Pharmaceutical preparation in the form of a foil having an active substance incorporated therein
US4136162A (en)	1979-01-23	Medicament carriers in the form of film having active substance incorporated therein
US4136145A (en)	1979-01-23	Medicament carriers in the form of film having active substance incorporated therein
DE2432925C3 (de)	1985-11-21	Folienförmige Arzneimittel
US4138013A (en)	1979-02-06	Enteric capsules
US4317447A (en)	1982-03-02	Drug delivery system
US6372246B1 (en)	2002-04-16	Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
AU2001283909B2 (en)	2006-12-21	Solution-, Dispersion-or emulsion-producing film dermatics
AP679A (en)	1998-09-28	Oral 2-methyl-thieno-benzodiazepine formulation.
US3803300A (en)	1974-04-09	Ointment foil and method of preparing the same
CA2329556A1 (en)	2001-06-23	Method of preparing a watersoluble film
JPH03503636A (ja)	1991-08-15	生理学的活性物質の投与のための吸蔵体
CN100421652C (zh)	2008-10-01	共轭雌激素药物组合物及其应用方法
DE3873410T2 (de)	1993-01-21	Formulierung zur oralen arzneistoffabgabe, sowie verfahren zu deren herstellung.
US4344968A (en)	1982-08-17	Pharmaceutical vehicle
KR0124791B1 (ko)	1997-11-25	필름 피복 정제
DE2449865B2 (de)	1981-06-19	Folienförmiges Arzneimittel
NZ192532A (en)	1984-10-19	Polymeric diffusion matrix and a transdermal drug delivery device
PL190376B1 (pl)	2005-12-30	Preparat do stosowania w jamie ustnej
CZ321594A3 (en)	1995-09-13	Pharmaceutical preparation for inhibiting changes of skin and vagina
US3197369A (en)	1965-07-27	Coated gelatin capsules
US4421738A (en)	1983-12-20	Sugar-coated tablet containing fat-soluble pharmaceutical material
CN103340822B (zh)	2014-11-26	益康唑或其盐阴道膨胀栓及其制备方法和检测方法
US3325472A (en)	1967-06-13	Polycyclohexose-polyoxyethyleneglycol suppository bases
JPH04505328A (ja)	1992-09-17	浸透圧剤形

CA1067407A - Pharmaceutical preparation in the form of a foil having an active substance incorporated therein - Google Patents

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ID=25767384

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Cited By (3)

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Cited By (3)

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