[go: up one dir, main page]

BRPI1011710A8 - lágrimas artificiais e usos trapêuticos - Google Patents

lágrimas artificiais e usos trapêuticos Download PDF

Info

Publication number
BRPI1011710A8
BRPI1011710A8 BRPI1011710A BRPI1011710A BRPI1011710A8 BR PI1011710 A8 BRPI1011710 A8 BR PI1011710A8 BR PI1011710 A BRPI1011710 A BR PI1011710A BR PI1011710 A BRPI1011710 A BR PI1011710A BR PI1011710 A8 BRPI1011710 A8 BR PI1011710A8
Authority
BR
Brazil
Prior art keywords
oil
artificial tears
traumatic
syndrome
dog
Prior art date
Application number
BRPI1011710A
Other languages
English (en)
Inventor
V Gore Anuradha
Pujara Chetan
Krock Kevin
S Jordan Robert
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42312750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1011710(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI1011710A2 publication Critical patent/BRPI1011710A2/pt
Publication of BRPI1011710A8 publication Critical patent/BRPI1011710A8/pt
Publication of BRPI1011710B1 publication Critical patent/BRPI1011710B1/pt
Publication of BRPI1011710B8 publication Critical patent/BRPI1011710B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/55Linaceae (Flax family), e.g. Linum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"lágrimas artificiais e usos trapêuticos". a presente invenção refere-se a composições oftálmicas, por exemplo lágrimas artificiais, apropriadas para o tratamento da síndrome do olho seco em um ser humano ou outro mamífero sofrendo de tal síndrome, por exemplo, um cachorro ou gato, que compreende uma mistura de óleo de mamona com outro óleo, por exemplo, um óleo alimentício, por exemplo azeite de oliva, óleo de gergelim, óleo de milho e etc.
BRPI1011710A 2009-06-05 2010-06-03 composição para ser usada como uma lágrima artificial BRPI1011710B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18433909P 2009-06-05 2009-06-05
US61/184,339 2009-06-05
PCT/US2010/037153 WO2010141648A2 (en) 2009-06-05 2010-06-03 Artificial tears and therapeutic uses

Publications (4)

Publication Number Publication Date
BRPI1011710A2 BRPI1011710A2 (pt) 2016-03-22
BRPI1011710A8 true BRPI1011710A8 (pt) 2019-11-05
BRPI1011710B1 BRPI1011710B1 (pt) 2021-01-26
BRPI1011710B8 BRPI1011710B8 (pt) 2021-05-25

Family

ID=42312750

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1011710A BRPI1011710B8 (pt) 2009-06-05 2010-06-03 composição para ser usada como uma lágrima artificial

Country Status (24)

Country Link
US (7) US8496976B2 (pt)
EP (1) EP2437762B1 (pt)
KR (1) KR101778316B1 (pt)
CN (2) CN104906170A (pt)
AU (1) AU2010256652B2 (pt)
BR (1) BRPI1011710B8 (pt)
CA (1) CA2764802A1 (pt)
DK (1) DK2437762T3 (pt)
ES (1) ES2646338T3 (pt)
HK (1) HK1214943A1 (pt)
HR (1) HRP20171691T1 (pt)
HU (1) HUE034213T2 (pt)
IL (1) IL216800A (pt)
LT (1) LT2437762T (pt)
MX (2) MX2011013007A (pt)
MY (1) MY172185A (pt)
NO (1) NO2437762T3 (pt)
NZ (1) NZ596932A (pt)
PL (1) PL2437762T3 (pt)
PT (1) PT2437762T (pt)
RU (1) RU2589837C2 (pt)
SI (1) SI2437762T1 (pt)
WO (1) WO2010141648A2 (pt)
ZA (1) ZA201108979B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8569367B2 (en) 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
ES2646338T3 (es) 2009-06-05 2017-12-13 Allergan, Inc. Lágrimas artificiales y usos terapéuticos
US8957048B2 (en) * 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
DK2787968T3 (da) * 2011-12-07 2020-06-02 Allergan Inc Effektiv lipidlevering til menneskelig tårefilm under anvendelse af et saltsensitivt emulsionssystem
US9278132B2 (en) * 2012-02-13 2016-03-08 Bausch & Lomb Incorporated Ophthalmic pharmaceutical compositions and methods of making and using same
US10085960B2 (en) 2012-03-30 2018-10-02 Brien Holden Vision Institute Methods and compositions for reducing ocular discomfort
US9289494B2 (en) 2013-11-20 2016-03-22 RestorTears, LLC Method of treating ocular disorders with compounds found in Harderian gland secretions
WO2016029034A1 (en) 2014-08-20 2016-02-25 Silk Technologies, Ltd. Fibroin-derived protein composition
MX372988B (es) * 2014-11-25 2020-04-06 Allergan Inc Composiciones oftalmicas estabilizadas de omega 3.
WO2017066429A1 (en) 2015-10-14 2017-04-20 Paul Gavaris Ophthalmic treatment composition and vehicle for delivery of pharmaceutical substances or therapeutic agents
JP2019519596A (ja) 2016-04-08 2019-07-11 コーネル・ユニバーシティーCornell University シルク由来タンパク質を使用して創傷治癒を増進する方法
WO2019005139A1 (en) * 2017-06-30 2019-01-03 Jenivision Inc. FORMULATIONS FOR HAIR GROWTH
JOP20170147B1 (ar) * 2016-07-07 2021-08-17 Salvat Lab Sa تركيبة عينية تشتمل على زيت الخروع ودهون ثلاثية متوسطة السلسلة
MX2019001633A (es) 2016-08-12 2019-09-18 Silk Tech Ltd Proteina derivada de la seda para el tratamiento de la inflamacion.
CA3032695C (en) * 2016-08-19 2021-11-23 Akrivista, LLC Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye
GB201618175D0 (en) * 2016-10-27 2016-12-14 Warneford Healthcare Ltd Pharmaceutical compositions
JP7311160B2 (ja) 2017-08-18 2023-07-19 アクリビスタ エルエルシー ドライアイ症候群を診断及び処置する方法及びヒトの眼を処置するための組成物
WO2020021481A1 (en) 2018-07-27 2020-01-30 Johnson & Johnson Vision Care, Inc. Compositions and methods for treating the eye
BR112021000634A2 (pt) 2018-07-27 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Composições e métodos para tratar os olhos
WO2020021480A2 (en) 2018-07-27 2020-01-30 Johnson & Johnson Vision Care, Inc. Compositions and methods for treating the eye
CN112739337B (zh) 2018-07-27 2024-05-24 强生外科视力公司 用于治疗眼睛的组合物和方法
US10966948B2 (en) 2019-07-23 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US11166997B2 (en) 2018-07-27 2021-11-09 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US11197841B2 (en) 2019-07-23 2021-12-14 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US11110051B2 (en) 2018-08-30 2021-09-07 Johnson & Johnson Consumer Inc. Topical compositions comprising Pichia anomala and n-acetyl glucosamine
US11045416B2 (en) 2018-08-30 2021-06-29 Johnson & Johnson Consumer Inc. Topical compositions comprising Pichia anomala and retinol
KR20210009947A (ko) 2019-07-18 2021-01-27 윤영선 산소가 도입된 점안제, 및 그 제조방법
EP3824877A1 (en) 2019-11-19 2021-05-26 Johnson & Johnson Consumer Inc. Compositions and methods for treating the eye
US11969454B2 (en) 2019-11-19 2024-04-30 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US11969451B2 (en) 2019-11-19 2024-04-30 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
CN112823789B (zh) 2019-11-19 2024-05-10 强生外科视力公司 用于治疗眼睛的组合物和方法
EP4059508A1 (en) 2021-03-19 2022-09-21 Johnson & Johnson Consumer Inc. Methods of using compositions comprising an iceland moss extract

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56104814A (en) * 1980-01-25 1981-08-20 Kunihiro Okanoe Preparation of eye drop
US4649047A (en) 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
ATE109970T1 (de) 1987-09-03 1994-09-15 Univ Georgia Res Found Cyclosporin-augenmittel.
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
BE1003578A4 (fr) * 1988-10-26 1992-04-28 Sandoz Sa Nouvelles compositions ophtalmiques a base d'une cyclosporine.
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
WO1997024129A1 (en) 1995-12-27 1997-07-10 Rohto Pharmaceutical Co., Ltd. Pharmaceutical composition containing trehalose
US5981607A (en) 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
GB0012597D0 (en) 2000-05-25 2000-07-12 Astrazeneca Ab Formulation
US7027446B2 (en) 2001-07-18 2006-04-11 P-Cube Ltd. Method and apparatus for set intersection rule matching
JP4284491B2 (ja) 2002-07-16 2009-06-24 豊和工業株式会社 ピストン外形の加工データ生成装置
UY28126A1 (es) * 2002-12-24 2004-06-30 Alcon Inc Uso de glucocorticoides selectivos para la superficie ocular en el tratamiento de la sequedad ocular
US8992974B2 (en) * 2003-02-24 2015-03-31 Pharmaceuticals Productions, Inc. Transmucosal drug delivery system
US20040185068A1 (en) 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
US20060251685A1 (en) 2003-03-18 2006-11-09 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye
US20060009522A1 (en) 2004-07-01 2006-01-12 Reza Dana Compositions and methods for treating eye disorders and conditions
US20070265353A1 (en) * 2004-08-27 2007-11-15 Senju Pharmaceutical Co., Ltd. Eye Drops for the Treatment of Dry Eye
US8569367B2 (en) * 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
CN100562340C (zh) * 2005-06-17 2009-11-25 中国科学院上海药物研究所 一种微乳型人工泪液
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
WO2008035246A2 (en) 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
WO2008027341A2 (en) * 2006-08-30 2008-03-06 Merck & Co., Inc. Topical ophthalmic formulations
CN101668511A (zh) * 2007-02-28 2010-03-10 阿西克斯医疗公司 正常化睑板腺分泌的方法和化合物
CN101554369B (zh) * 2008-05-12 2012-07-25 陈亚玲 一种外用复合油纳米乳喷雾剂和滴眼剂及其制备方法
UA36915U (uk) * 2008-05-28 2008-11-10 Львівський Національний Медичний Університет Ім. Данила Галицького Очні краплі для лікування запальних захворювань судинної оболонки та сухого кератокон'юнктивіту, які викликані аутоімунними процесами
IT1393419B1 (it) 2009-03-19 2012-04-20 Medivis S R L Composizioni oftalmiche a base di acidi grassi polinsaturi omega-3 e omega-6.
US9480645B2 (en) 2009-06-02 2016-11-01 Abbott Medical Optics Inc. Omega-3 oil containing ophthalmic emulsions
ES2646338T3 (es) 2009-06-05 2017-12-13 Allergan, Inc. Lágrimas artificiales y usos terapéuticos

Also Published As

Publication number Publication date
BRPI1011710A2 (pt) 2016-03-22
CA2764802A1 (en) 2010-12-09
EP2437762B1 (en) 2017-08-09
US11045515B2 (en) 2021-06-29
PL2437762T3 (pl) 2018-01-31
KR20120046151A (ko) 2012-05-09
US20240108677A1 (en) 2024-04-04
CN102458430A (zh) 2012-05-16
US20250082709A1 (en) 2025-03-13
RU2011151468A (ru) 2013-07-20
WO2010141648A3 (en) 2011-03-10
AU2010256652A1 (en) 2012-01-12
DK2437762T3 (da) 2017-11-20
US8496976B2 (en) 2013-07-30
CN104906170A (zh) 2015-09-16
HK1214943A1 (zh) 2016-08-12
IL216800A (en) 2017-03-30
US20120201910A1 (en) 2012-08-09
AU2010256652B2 (en) 2015-11-26
NO2437762T3 (pt) 2018-01-06
US20140141106A1 (en) 2014-05-22
US9821020B2 (en) 2017-11-21
NZ596932A (en) 2014-04-30
RU2589837C2 (ru) 2016-07-10
HRP20171691T1 (hr) 2017-12-15
MX2011013007A (es) 2012-02-28
BRPI1011710B1 (pt) 2021-01-26
SI2437762T1 (en) 2018-02-28
US20220008496A1 (en) 2022-01-13
IL216800A0 (en) 2012-02-29
EP2437762A2 (en) 2012-04-11
US20180264063A1 (en) 2018-09-20
MX358504B (es) 2018-08-21
BRPI1011710B8 (pt) 2021-05-25
LT2437762T (lt) 2017-11-27
HUE034213T2 (en) 2018-01-29
PT2437762T (pt) 2017-11-14
MY172185A (en) 2019-11-15
US20130295206A1 (en) 2013-11-07
KR101778316B1 (ko) 2017-09-13
ES2646338T3 (es) 2017-12-13
ZA201108979B (en) 2012-08-29
WO2010141648A2 (en) 2010-12-09
US8679554B2 (en) 2014-03-25

Similar Documents

Publication Publication Date Title
BRPI1011710A8 (pt) lágrimas artificiais e usos trapêuticos
BR112012006692A2 (pt) composição farmacêutica compreendendo ácido graxo de omega-3 e um derivado de hidróxi de uma estatina e métodos de uso das mesmas
ECSP12012211A (es) Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf)
BR112013007314A2 (pt) anticorpos anti-cd48 e seus usos
EA202091999A3 (ru) Применение ингибиторов dpp iv
BR112014033102A2 (pt) produto para uso no tratamento profilático ou terapêutico de uma emoção negativa ou comportamento introvertido
BRPI0918139A2 (pt) composição, alimento medicinal ou funcional, suplemento alimentar ou dietético para tratamento de distúrbios de desenvolvimento pervasivos com terapêuticos redox-ativos e uso
ATE551063T1 (de) Verwendung von bifidobacterium longum zur prophylaxe und behandlung von entzündungen
UA109271C2 (uk) Комбінація фітоканабіноїдів та темозоламіду для лікування гліоми
CO6571886A2 (es) Antagonistas de pcsk9
BRPI0808775A2 (pt) compostos e composições como moduladores de atividade de gpr119
MX358617B (es) Formulaciones de inhibidores de dpp iv.
IL186741A0 (en) Optical probe for delivery of light
BR112012005835A2 (pt) alteração da temperatura em um corpo de mamífero
ATE456369T1 (de) Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen
GT200600254A (es) Moduladores de aminoquinolina y aminoquinazolina quinasa
MX2009012645A (es) Formulaciones y metodos para tratar el ojo seco.
IN2012DN03178A (pt)
BRPI0919013A2 (pt) Dispositivo e sistema de implante pélvico
BR112012005044A2 (pt) composições que compreendem tramadol e celecoxib no tratamento de dor.
BR112014011481A2 (pt) hidrolisado de colágeno e seu uso
BR112014000634A2 (pt) métodos para tratamento de incontinência associada com atividade sexual
BR112013004562A2 (pt) 2-óxi-quinolina-3-carboxamidas substituídas como moduladores kcnq2/3
BR112012015386B8 (pt) composição oftálmica tópica
CY1116158T1 (el) Υποκατεστημενα 2-οξο- και 2-θειοξο-διυδροκινολινο-3-καρβοξαμιδια σαν διαμορφωτες kcnq2/3

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/01/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/06/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF