BRPI0819328A2 - Inibidores de replicação de vírus da imunodeficiência humana - Google Patents

Inibidores de replicação de vírus da imunodeficiência humana

Info

Publication number: BRPI0819328A2
Authority: BR; Brazil
Prior art keywords: immunodeficiency virus; human immunodeficiency; virus replication; replication inhibitors; inhibitors
Prior art date: 2007-11-15

Application number

Other languages

English (en)

Inventor

Rebekah J Carson

Lee Fader

Stephen Kawai

Serge Landry

Youla S Tsantrizos

Christian Brochu

Sebastien Morin

Mathieu Parisien

Bruno Simoneau

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-15

Filing date

2008-11-03

Publication date

2015-05-12

2008-11-03 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2015-05-12 Publication of BRPI0819328A2 publication Critical patent/BRPI0819328A2/pt

2016-02-10 Publication of BRPI0819328A8 publication Critical patent/BRPI0819328A8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0819328A 2007-11-15 2008-11-03 Compostos inibidores de replicação de vírus da imunodeficiência humana, composição farmacêutica e uso dos ditos compostos BRPI0819328A8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98834207P	2007-11-15	2007-11-15
PCT/CA2008/001935 WO2009062288A1 (en)	2007-11-15	2008-11-03	Inhibitors of human immunodeficiency virus replication

Publications (2)

Publication Number	Publication Date
BRPI0819328A2 true BRPI0819328A2 (pt)	2015-05-12
BRPI0819328A8 BRPI0819328A8 (pt)	2016-02-10

Family

ID=40638277

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0819328A BRPI0819328A8 (pt)	2007-11-15	2008-11-03	Compostos inibidores de replicação de vírus da imunodeficiência humana, composição farmacêutica e uso dos ditos compostos

Country Status (18)

Country	Link
US (1)	US7956068B2 (pt)
EP (2)	EP2574610A1 (pt)
JP (1)	JP5269085B2 (pt)
KR (1)	KR20100108337A (pt)
CN (1)	CN102124011A (pt)
AR (1)	AR069334A1 (pt)
AU (1)	AU2008323561B2 (pt)
BR (1)	BRPI0819328A8 (pt)
CA (1)	CA2705312C (pt)
CL (1)	CL2008003405A1 (pt)
ES (1)	ES2402322T3 (pt)
IL (1)	IL205746A0 (pt)
MX (1)	MX2010005292A (pt)
NZ (1)	NZ585297A (pt)
RU (1)	RU2503679C2 (pt)
TW (1)	TW200920363A (pt)
WO (1)	WO2009062288A1 (pt)
ZA (1)	ZA201003305B (pt)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2588220A1 (en) *	2004-12-23	2006-06-29	Pfizer Products Inc.	Heteroaromatic derivatives useful as anticancer agents
US8338441B2 (en)	2009-05-15	2012-12-25	Gilead Sciences, Inc.	Inhibitors of human immunodeficiency virus replication
GB0908394D0 (en)	2009-05-15	2009-06-24	Univ Leuven Kath	Novel viral replication inhibitors
GB0913636D0 (en)	2009-08-05	2009-09-16	Univ Leuven Kath	Novel viral replication inhibitors
CA2802492C (en)	2010-07-02	2018-10-16	Gilead Sciences, Inc.	2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
PT2588450T (pt)	2010-07-02	2017-08-03	Gilead Sciences Inc	Derivados do ácido naft-2-ilacético para tratamento da sida
US8633200B2 (en)	2010-09-08	2014-01-21	Bristol-Myers Squibb Company	Inhibitors of human immunodeficiency virus replication
BR112013011991A2 (pt) *	2010-11-15	2016-08-30	Viiv Healthcare Uk Ltd	composto, composição farmacêutica, uso de um composto, método de tratamento, produto, e kit.
RU2013121785A (ru)	2010-11-15	2014-12-27	Католике Универзитайт Лойфен	Новые противовирусные соединения
EP2694479A1 (en) *	2011-04-04	2014-02-12	Gilead Sciences, Inc.	Process for the preparation of an hiv integrase inhibitor
EP2508511A1 (en)	2011-04-07	2012-10-10	Laboratoire Biodim	Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2511273B8 (en) *	2011-04-15	2019-06-26	Hivih	Inhibitors of viral replication, their process of preparation and their therapeutical uses
KR20140027295A (ko) *	2011-04-21	2014-03-06	길리애드 사이언시즈, 인코포레이티드	벤조티아졸 화합물 및 이들의 약학적 용도
WO2013012649A1 (en) *	2011-07-15	2013-01-24	Glaxosmithkline Llc	Azaindole compounds and methods for treating hiv
US8791108B2 (en)	2011-08-18	2014-07-29	Bristol-Myers Squibb Company	Inhibitors of human immunodeficiency virus replication
EP2772480B2 (en)	2011-10-25	2020-12-09	Shionogi & Co., Ltd.	Hiv replication inhibitor
PT2781519T (pt) *	2011-11-15	2019-12-17	St Pharm Co Ltd	Novo derivado de pirrolopiridina antiviral e um método de produção do mesmo
WO2013103738A1 (en)	2012-01-04	2013-07-11	Gilead Sciences, Inc.	Napthalene acetic acid derivatives against hiv infection
WO2013103724A1 (en)	2012-01-04	2013-07-11	Gilead Sciences, Inc.	2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
US8629276B2 (en)	2012-02-15	2014-01-14	Bristol-Myers Squibb Company	Inhibitors of human immunodeficiency virus replication
US9034882B2 (en) *	2012-03-05	2015-05-19	Bristol-Myers Squibb Company	Inhibitors of human immunodeficiency virus replication
US9006235B2 (en)	2012-03-06	2015-04-14	Bristol-Myers Squibb Company	Inhibitors of human immunodeficiency virus replication
UY34750A (es) *	2012-04-20	2013-11-29	Gilead Sciences Inc	?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?.
CA2876370A1 (en) *	2012-07-12	2014-01-16	Viiv Healthcare Uk Limited	Compounds and methods for treating hiv
US8906929B2 (en)	2012-08-16	2014-12-09	Bristol-Myers Squibb Company	Inhibitors of human immunodeficiency virus replication
EP2716639A1 (en)	2012-10-05	2014-04-09	Laboratoire Biodim	Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2716632A1 (en)	2012-10-05	2014-04-09	Laboratoire Biodim	Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2719685A1 (en)	2012-10-11	2014-04-16	Laboratoire Biodim	Inhibitors of viral replication, their process of preparation and their therapeutical uses
TW201441197A (zh)	2013-01-31	2014-11-01	Shionogi & Co	Ｈｉｖ複製抑制劑
US9655889B2 (en)	2013-03-13	2017-05-23	VIIV Healthcare UK (No.5) Limited	Inhibitors of human immunodeficiency virus replication
CN105189510B (zh)	2013-03-13	2017-05-17	百时美施贵宝公司	人免疫缺陷病毒复制的抑制剂
CN105189511B (zh)	2013-03-13	2017-05-24	百时美施贵宝公司	人免疫缺陷病毒复制的抑制剂
WO2014159076A1 (en)	2013-03-14	2014-10-02	Bristol-Myers Squibb Company	Inhibitors of human immunodeficiency virus replication
ES2623904T3 (es)	2013-03-14	2017-07-12	VIIV Healthcare UK (No.5) Limited	Inhibidores de la replicación del virus de la inmunodeficiencia humana
EA201690089A1 (ru)	2013-06-11	2017-04-28	Латвийский Институт Органического Синтеза	ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ
EP2821104A1 (en)	2013-07-05	2015-01-07	Laboratoire Biodim	Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2821082A1 (en)	2013-07-05	2015-01-07	Laboratoire Biodim	Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use
US9944656B2 (en)	2014-02-12	2018-04-17	VIIV Healthcare UK (No.5) Limited	Benzothiazole macrocycles as inhibitors of human immunodeficiency virus replication
WO2015126758A1 (en)	2014-02-18	2015-08-27	Bristol-Myers Squibb Company	Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9409922B2 (en)	2014-02-18	2016-08-09	Bristol-Myers Squibb Company	Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
EP3152215A1 (en)	2014-02-18	2017-04-12	ViiV Healthcare UK (No.5) Limited	Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9938271B2 (en)	2014-02-19	2018-04-10	VIIV Healthcare UK (No.5) Limited	Inhibitors of human immunodeficiency virus replication
US9273067B2 (en)	2014-02-19	2016-03-01	Bristol-Myers Squibb Company	Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9637501B2 (en)	2014-02-20	2017-05-02	Viiv Healthcare Uk (No. 5) Limited	Pyridin-3-yl acetic acid macrocycles as inhibitors of human immunodeficiency virus replication
US9193720B2 (en)	2014-02-20	2015-11-24	Bristol-Myers Squibb Company	Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
US9975906B2 (en)	2014-05-16	2018-05-22	Shionogi & Co., Ltd.	Tricyclic heterocycle derivatives having HIV replication inhibitory effect
KR20180011267A (ko)	2015-05-29	2018-01-31	시오노기 앤드 컴파니, 리미티드	Hiv 복제 저해 작용을 갖는 함질소 3환성 유도체
BR112018000177A2 (pt)	2015-07-06	2018-09-04	Viiv Healthcare Uk No 5 Ltd	composto, composição, e, método para tratar a infecção pelo hiv.
CA2991268A1 (en)	2015-07-08	2017-01-12	VIIV Healthcare UK (No.5) Limited	Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
KR20180025914A (ko)	2015-07-09	2018-03-09	비브 헬스케어 유케이 (넘버5) 리미티드	인간 면역결핍 바이러스 복제의 억제제로서의 피리딘-3-일 아세트산 유도체
BR112018000253A2 (pt)	2015-07-09	2018-09-04	Viiv Healthcare Uk No 5 Ltd	composto, composição, e, método para tratar a infecção pelo hiv.
JP2018522052A (ja)	2015-08-07	2018-08-09	ヴィーブヘルスケアユーケー（ナンバー５）リミテッド	ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体
KR20180035908A (ko)	2015-08-10	2018-04-06	비브 헬스케어 유케이 (넘버5) 리미티드	인간 면역결핍 바이러스 복제의 억제제로서의 이미다조피리딘 매크로사이클
AR105653A1 (es)	2015-08-11	2017-10-25	VIIV HEALTHCARE UK (Nº 5) LTD	Derivados del ácido 5-(n-bencil-tetrahidroisoquinolin-6-il)-piridin-3-il acético como inhibidores de la replicación del virus de la inmunodeficiencia humana
KR20180035916A (ko) *	2015-08-12	2018-04-06	비브 헬스케어 유케이 (넘버5) 리미티드	인간 면역결핍 바이러스 복제의 억제제로서 5-(n-융합된 트리사이클릭 아릴 테트라하이드로이소퀴놀린-6-일) 피리딘-3-일 아세트산 유도체
TW201718537A (zh)	2015-08-12	2017-06-01	Ｖｉｉｖ醫療保健英國（Ｎｏ．５）有限公司	做為人類免疫缺陷病毒複製抑制劑之吡啶－３－基乙酸衍生物
US10577353B2 (en)	2015-08-12	2020-03-03	VIIV Healthcare UK (No.5) Limited	5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
JP2018523695A (ja)	2015-08-20	2018-08-23	ヴィーブヘルスケアユーケー（ナンバー５）リミテッド	ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体
JP2019515003A (ja)	2016-05-11	2019-06-06	ヴィーブヘルスケアユーケー（ナンバー５）リミテッド	ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体
WO2017195111A1 (en)	2016-05-11	2017-11-16	VIIV Healthcare UK (No.5) Limited	Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
JP2019515000A (ja)	2016-05-11	2019-06-06	ヴィーブヘルスケアユーケー（ナンバー５）リミテッド	ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体
JP2020503348A (ja)	2017-01-03	2020-01-30	ヴィーブヘルスケアユーケー（ナンバー５）リミテッド	ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体
EP3565810A1 (en)	2017-01-03	2019-11-13	ViiV Healthcare UK (No.5) Limited	Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2019244066A2 (en)	2018-06-19	2019-12-26	VIIV Healthcare UK (No.5) Limited	Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2020003093A1 (en)	2018-06-25	2020-01-02	VIIV Healthcare UK (No.5) Limited	Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2020014068A1 (en)	2018-07-09	2020-01-16	Boehringer Ingelheim Animal Health USA Inc.	Anthelminthic heterocyclic compounds
CN113195469B (zh) *	2019-02-19	2024-05-24	四川科伦博泰生物医药股份有限公司	含氮并环化合物、其制备方法及用途
WO2020191091A1 (en)	2019-03-19	2020-09-24	Boehringer Ingelheim Animal Health USA Inc.	Anthelmintic aza-benzothiophene and aza-benzofuran compounds
IL298596A (en)	2020-05-29	2023-01-01	Boehringer Ingelheim Animal Health Usa Inc	Anthelmintic heterocyclic compounds
US11999742B2 (en)	2021-11-01	2024-06-04	Boehringer Ingelheim Vetmedica Gmbh	Substituted pyrrolo[1,2-b]pyridazines as anthelmintics
CN114436879A (zh) *	2022-01-14	2022-05-06	海南三帝制药有限公司	一种盐酸三甲卡因的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8804448D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
WO1993004047A1 (en) *	1991-08-16	1993-03-04	Merck & Co., Inc.	Quinazoline derivatives as inhibitors of hiv reverse transcriptase
US5747486A (en) *	1994-11-08	1998-05-05	Takeda Chemical Industries	Thienopyridine or thienopyrimidine derivatives and their use
US5620997A (en) *	1995-05-31	1997-04-15	Warner-Lambert Company	Isothiazolones
FR2761687B1 (fr) *	1997-04-08	2000-09-15	Centre Nat Rech Scient	Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques
SK6652000A3 (en) *	1997-11-11	2002-05-09	Pfizer Prod Inc	Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
FR2819507B1 (fr) *	2001-01-17	2007-09-28	Inst Rech Developpement Ird	Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus
EP2335700A1 (en) *	2001-07-25	2011-06-22	Boehringer Ingelheim (Canada) Ltd.	Hepatitis C virus polymerase inhibitors with a heterobicylic structure
FR2839646B1 (fr) *	2002-05-17	2008-04-11	Bioalliance Pharma	Utilisation de derives de quinoleine a effet anti-integrase et ses applications
EP2045242A1 (en) *	2002-08-13	2009-04-08	Shionogi&Co., Ltd.	Heterocyclic compounds having inhibitory activity against HIV integrase
US20060094755A1 (en) *	2004-10-28	2006-05-04	Bioflexis, Llc	Novel quinoline-based metal chelators as antiviral agents
JP5116660B2 (ja) *	2005-03-31	2013-01-09	イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ	Ｈｉｖインテグラーゼ阻害剤
ES2892304T3 (es) *	2005-04-28	2022-02-03	Viiv Healthcare Co	Derivado de carbamoilpiridona policíclico que tiene actividad inhibidora de la integrasa del VIH
US7939537B2 (en) *	2005-10-04	2011-05-10	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.	HIV integrase inhibitors
KR20080064182A (ko) *	2005-10-27	2008-07-08	시오노기세야쿠 가부시키가이샤	Ｈｉｖ 인테그라아제 억제활성을 가지는 다환성카르바모일피리돈 유도체
US7939545B2 (en) *	2006-05-16	2011-05-10	Boehringer Ingelheim International Gmbh	Inhibitors of human immunodeficiency virus replication

2008
- 2008-11-03 US US12/743,143 patent/US7956068B2/en active Active
- 2008-11-03 AU AU2008323561A patent/AU2008323561B2/en not_active Ceased
- 2008-11-03 EP EP12199561A patent/EP2574610A1/en not_active Withdrawn
- 2008-11-03 KR KR1020107013084A patent/KR20100108337A/ko not_active Ceased
- 2008-11-03 ES ES08850892T patent/ES2402322T3/es active Active
- 2008-11-03 BR BRPI0819328A patent/BRPI0819328A8/pt not_active IP Right Cessation
- 2008-11-03 CA CA2705312A patent/CA2705312C/en not_active Expired - Fee Related
- 2008-11-03 EP EP08850892A patent/EP2220095B1/en active Active
- 2008-11-03 RU RU2010123989/04A patent/RU2503679C2/ru not_active IP Right Cessation
- 2008-11-03 MX MX2010005292A patent/MX2010005292A/es active IP Right Grant
- 2008-11-03 NZ NZ585297A patent/NZ585297A/en not_active IP Right Cessation
- 2008-11-03 CN CN2008801247470A patent/CN102124011A/zh active Pending
- 2008-11-03 WO PCT/CA2008/001935 patent/WO2009062288A1/en active Application Filing
- 2008-11-03 JP JP2010533394A patent/JP5269085B2/ja active Active
- 2008-11-14 CL CL2008003405A patent/CL2008003405A1/es unknown
- 2008-11-14 TW TW097144270A patent/TW200920363A/zh unknown
- 2008-11-14 AR ARP080104989A patent/AR069334A1/es not_active Application Discontinuation
2010
- 2010-05-11 ZA ZA2010/03305A patent/ZA201003305B/en unknown
- 2010-05-13 IL IL205746A patent/IL205746A0/en unknown

Also Published As

Publication number	Publication date
MX2010005292A (es)	2010-07-05
NZ585297A (en)	2012-06-29
JP2011503117A (ja)	2011-01-27
CL2008003405A1 (es)	2010-02-12
EP2220095A4 (en)	2011-01-26
ZA201003305B (en)	2011-03-30
RU2010123989A (ru)	2011-12-20
JP5269085B2 (ja)	2013-08-21
BRPI0819328A8 (pt)	2016-02-10
TW200920363A (en)	2009-05-16
CN102124011A (zh)	2011-07-13
RU2503679C2 (ru)	2014-01-10
AU2008323561A1 (en)	2009-05-22
CA2705312C (en)	2013-06-25
EP2220095A1 (en)	2010-08-25
KR20100108337A (ko)	2010-10-06
EP2574610A1 (en)	2013-04-03
IL205746A0 (en)	2010-11-30
US20100305115A1 (en)	2010-12-02
EP2220095B1 (en)	2013-01-02
AU2008323561B2 (en)	2013-07-18
AR069334A1 (es)	2010-01-13
US7956068B2 (en)	2011-06-07
ES2402322T3 (es)	2013-04-30
WO2009062288A1 (en)	2009-05-22
CA2705312A1 (en)	2009-05-22

Publication	Publication Date	Title
BRPI0819328A2 (pt)	2015-05-12	Inibidores de replicação de vírus da imunodeficiência humana
BRPI0820307A2 (pt)	2019-09-24	inibidores de replicação do vírus da imunodeficiência humana
BRPI1010644A2 (pt)	2016-03-15	inibidores da replicação do vírus da imunodeficiência humana
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