PT2781519T - Novo derivado de pirrolopiridina antiviral e um método de produção do mesmo - Google Patents
Novo derivado de pirrolopiridina antiviral e um método de produção do mesmoInfo
- Publication number
- PT2781519T PT2781519T PT128491404T PT12849140T PT2781519T PT 2781519 T PT2781519 T PT 2781519T PT 128491404 T PT128491404 T PT 128491404T PT 12849140 T PT12849140 T PT 12849140T PT 2781519 T PT2781519 T PT 2781519T
- Authority
- PT
- Portugal
- Prior art keywords
- same
- production method
- novel antiviral
- pyrrolopyridine derivative
- pyrrolopyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20110119102 | 2011-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2781519T true PT2781519T (pt) | 2019-12-17 |
Family
ID=48429876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT128491404T PT2781519T (pt) | 2011-11-15 | 2012-11-15 | Novo derivado de pirrolopiridina antiviral e um método de produção do mesmo |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9499537B2 (pt) |
| EP (1) | EP2781519B1 (pt) |
| JP (1) | JP5893156B2 (pt) |
| KR (1) | KR101467477B1 (pt) |
| CN (1) | CN104066732B (pt) |
| DK (1) | DK2781519T3 (pt) |
| ES (1) | ES2760981T3 (pt) |
| HU (1) | HUE046795T2 (pt) |
| PL (1) | PL2781519T3 (pt) |
| PT (1) | PT2781519T (pt) |
| WO (1) | WO2013073875A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013288369B2 (en) * | 2012-07-12 | 2018-03-29 | Viiv Healthcare Uk Limited | Compounds and methods for treating HIV |
| TW201441197A (zh) | 2013-01-31 | 2014-11-01 | Shionogi & Co | Ｈｉｖ複製抑制劑 |
| EP2821082A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use |
| ES2654242T3 (es) | 2014-02-12 | 2018-02-12 | Viiv Healthcare (No.5) Limited | Macrociclos de benzotiazol como inhibidores de la réplica del virus de la inmunodeficiencia humana |
| WO2015126758A1 (en) | 2014-02-18 | 2015-08-27 | Bristol-Myers Squibb Company | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9834566B2 (en) | 2014-02-18 | 2017-12-05 | VIIV Healthcare UK (No.5) Limited | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9409922B2 (en) | 2014-02-18 | 2016-08-09 | Bristol-Myers Squibb Company | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9273067B2 (en) | 2014-02-19 | 2016-03-01 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| JP6579549B2 (ja) | 2014-05-16 | 2019-09-25 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害作用を有する３環性複素環誘導体 |
| KR101592370B1 (ko) * | 2014-06-09 | 2016-02-11 | 한국화학연구원 | 신규한 피롤로피리딘 유도체 및 이의 hiv 저해제로서의 용도 |
| CN104478911A (zh) * | 2014-12-19 | 2015-04-01 | 成都安斯利生物医药有限公司 | 一种制备3-三氟甲基吡咯硼酸的方法 |
| US10494380B2 (en) | 2015-05-29 | 2019-12-03 | Shionogi & Co., Ltd. | Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity |
| KR102148294B1 (ko) * | 2017-03-24 | 2020-08-26 | 에스티팜 주식회사 | 신규한 피롤로피리딘 유도체, 이의 제조방법 및 용도 |
| EP3601291A1 (en) | 2017-03-29 | 2020-02-05 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
| JP7096686B2 (ja) * | 2017-03-30 | 2022-07-06 | 住友化学株式会社 | アミノ基を有する有機リチウム化合物およびその中間体の製造方法、並びに有機リチウム化合物を用いた共役ジエン系重合体の製造方法 |
| EP4089094A4 (en) | 2020-01-10 | 2023-08-02 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | TRICYCLIC TETRAHYDROISOQUINOLINE DERIVATIVE, METHOD FOR PREPARING IT AND ITS APPLICATION IN MEDICINE |
| KR20220023187A (ko) * | 2020-08-20 | 2022-03-02 | 에스티팜 주식회사 | 피롤로피리딘 유도체 및 이들의 용도 |
| KR20230123996A (ko) | 2021-01-11 | 2023-08-24 | 에스티팜 주식회사 | 피롤로피리딘 유도체의 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0510319A (pt) * | 2004-04-26 | 2007-10-16 | Pfizer | inibidores da enzima integrase de hiv |
| DE102004060659A1 (de) * | 2004-12-15 | 2006-07-06 | Lanxess Deutschland Gmbh | Neue substituierte 1H-Pyrrolo[2,3-b]pyridine und deren Herstellung |
| US7939545B2 (en) * | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| GB0710528D0 (en) * | 2007-06-01 | 2007-07-11 | Glaxo Group Ltd | Novel compounds |
| CA2705312C (en) * | 2007-11-15 | 2013-06-25 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| JP5269087B2 (ja) * | 2007-11-16 | 2013-08-21 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルス複製のインヒビター |
| AU2008323558C1 (en) * | 2007-11-16 | 2014-05-01 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| GB0908394D0 (en) * | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| WO2012102985A1 (en) * | 2011-01-24 | 2012-08-02 | Glaxosmithkline Llc | Isoquinoline compounds and methods for treating hiv |
| EP2731436B1 (en) * | 2011-07-15 | 2017-03-08 | VIIV Healthcare UK Limited | 2-(pyrrolo[2,3-b]pyridine-5-yl)-2-(t-butoxy)-acetic acid derivatives as hiv replication inhibitors for the treatment of aids |
-
2012
- 2012-11-15 PT PT128491404T patent/PT2781519T/pt unknown
- 2012-11-15 JP JP2014542241A patent/JP5893156B2/ja active Active
- 2012-11-15 KR KR1020120129805A patent/KR101467477B1/ko active IP Right Grant
- 2012-11-15 ES ES12849140T patent/ES2760981T3/es active Active
- 2012-11-15 HU HUE12849140A patent/HUE046795T2/hu unknown
- 2012-11-15 DK DK12849140.4T patent/DK2781519T3/da active
- 2012-11-15 CN CN201280066270.1A patent/CN104066732B/zh active Active
- 2012-11-15 WO PCT/KR2012/009689 patent/WO2013073875A1/ko active Application Filing
- 2012-11-15 EP EP12849140.4A patent/EP2781519B1/en active Active
- 2012-11-15 PL PL12849140T patent/PL2781519T3/pl unknown
-
2014
- 2014-05-15 US US14/278,955 patent/US9499537B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5893156B2 (ja) | 2016-03-23 |
| HUE046795T2 (hu) | 2020-03-30 |
| PL2781519T3 (pl) | 2020-06-29 |
| ES2760981T3 (es) | 2020-05-18 |
| US20140249162A1 (en) | 2014-09-04 |
| WO2013073875A1 (ko) | 2013-05-23 |
| JP2014533298A (ja) | 2014-12-11 |
| US9499537B2 (en) | 2016-11-22 |
| EP2781519B1 (en) | 2019-10-30 |
| CN104066732B (zh) | 2016-04-13 |
| DK2781519T3 (da) | 2019-12-16 |
| CN104066732A (zh) | 2014-09-24 |
| EP2781519A1 (en) | 2014-09-24 |
| KR101467477B1 (ko) | 2014-12-02 |
| EP2781519A4 (en) | 2015-06-24 |
| KR20130054211A (ko) | 2013-05-24 |
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