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BRPI0720588B8 - derivados de pirazol-quinazolina substituídos, processo para sua preparação e seu uso como inibidores da quinase - Google Patents

derivados de pirazol-quinazolina substituídos, processo para sua preparação e seu uso como inibidores da quinase

Info

Publication number
BRPI0720588B8
BRPI0720588B8 BRPI0720588A BRPI0720588A BRPI0720588B8 BR PI0720588 B8 BRPI0720588 B8 BR PI0720588B8 BR PI0720588 A BRPI0720588 A BR PI0720588A BR PI0720588 A BRPI0720588 A BR PI0720588A BR PI0720588 B8 BRPI0720588 B8 BR PI0720588B8
Authority
BR
Brazil
Prior art keywords
preparation
quinazoline derivatives
kinase inhibitors
substituted pyrazol
pyrazol
Prior art date
Application number
BRPI0720588A
Other languages
English (en)
Inventor
Valsasina Barbara
Posteri Helena
Beria Italo
Gabriella Brasca Maria
Caruso Michele
Ferguson Ronald
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39304592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0720588(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of BRPI0720588A2 publication Critical patent/BRPI0720588A2/pt
Publication of BRPI0720588B1 publication Critical patent/BRPI0720588B1/pt
Publication of BRPI0720588B8 publication Critical patent/BRPI0720588B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support

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  • Health & Medical Sciences (AREA)
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Abstract

derivados de pirazol-quinazolina substituídos, processo para sua preparação e seu uso como inibidores da quinase a presente invenção se refere aos derivados de pirazol-quinazolina de fórmula (i), como definido no relatório descritivo e sais farmaceuticamente aceitáveis destes, processos para a sua preparação e composições farmacêuticas compreendendo-os conforme, além do processo para a sua preparação e as composições farmacêuticas que os compre-endem. os compostos da invenção podem ser úteis nas terapias para tratamento de doenças associadas à atividade desordenada da proteína quinase, tal como o câncer.
BRPI0720588A 2006-12-21 2007-12-17 derivados de pirazol-quinazolina substituídos, processo para sua preparação e seu uso como inibidores da quinase BRPI0720588B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP06126902.3 2006-12-21
IT06126902.3 2006-12-21
EP06126902 2006-12-21
EP07118039.2 2007-10-08
IT07118039.2 2007-10-08
EP07118039 2007-10-08
PCT/EP2007/064096 WO2008074788A1 (en) 2006-12-21 2007-12-17 Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0720588A2 BRPI0720588A2 (pt) 2014-02-25
BRPI0720588B1 BRPI0720588B1 (pt) 2020-03-10
BRPI0720588B8 true BRPI0720588B8 (pt) 2021-05-25

Family

ID=39304592

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720588A BRPI0720588B8 (pt) 2006-12-21 2007-12-17 derivados de pirazol-quinazolina substituídos, processo para sua preparação e seu uso como inibidores da quinase

Country Status (23)

Country Link
US (1) US8614220B2 (pt)
EP (1) EP2125822B1 (pt)
JP (1) JP5498796B2 (pt)
KR (1) KR101512284B1 (pt)
AR (1) AR064608A1 (pt)
AU (1) AU2007336281B2 (pt)
BR (1) BRPI0720588B8 (pt)
CA (1) CA2673451C (pt)
CL (1) CL2007003756A1 (pt)
DK (1) DK2125822T3 (pt)
EA (1) EA017769B1 (pt)
ES (1) ES2527696T3 (pt)
HU (1) HUE024105T2 (pt)
IL (1) IL199323A (pt)
MX (1) MX2009006613A (pt)
NO (1) NO342675B1 (pt)
NZ (1) NZ578417A (pt)
PL (1) PL2125822T3 (pt)
PT (1) PT2125822E (pt)
SG (1) SG177911A1 (pt)
SI (1) SI2125822T1 (pt)
TW (1) TWI418560B (pt)
WO (1) WO2008074788A1 (pt)

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WO2009071480A2 (en) * 2007-12-04 2009-06-11 Nerviano Medical Sciences S.R.L. Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
EA020703B9 (ru) * 2008-06-26 2015-12-30 Ле Лаборатуар Сервье Пиразолохиназолины
CA2739148A1 (en) * 2008-10-17 2010-04-22 Boehringer Ingelheim International Gmbh Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (pi3-kinases) inhibitor
IT1395724B1 (it) * 2009-02-25 2012-10-19 Neuroscienze Pharmaness S C A R L Composti farmaceutici
AR076784A1 (es) * 2009-05-26 2011-07-06 Nerviano Medical Sciences Srl Combinacion terapeutica que comprende un inhibidor de plk1 y un agente antineoplasico
WO2011012534A1 (en) 2009-07-29 2011-02-03 Nerviano Medical Sciences S.R.L. Plk inhibitor salts
JP5997143B2 (ja) * 2010-07-30 2016-09-28 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ タンパク質キナーゼ活性の調整剤としてのイソオキサゾロ−キナゾリン
PT2632467T (pt) * 2010-10-25 2016-08-29 G1 Therapeutics Inc Inibidores cdk
WO2012080990A1 (en) 2010-12-17 2012-06-21 Nerviano Medical Sciences S.R.L. Substituted pyrazolo-quinazoline derivatives as kinase inhibitors
ES2586588T3 (es) 2011-01-26 2016-10-17 Nerviano Medical Sciences S.R.L. Derivados tricíclicos, procedimiento para su preparación y su uso como inhibidores de quinasa
JP5925809B2 (ja) * 2011-01-26 2016-05-25 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 三環系ピロロ誘導体、その調製方法およびそのキナーゼ阻害剤としての使用
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
HRP20211864T1 (hr) 2015-07-06 2022-03-04 Alkermes, Inc. Inhibitori hetero-halo histonske deacetilaze
MX394242B (es) 2017-01-11 2025-03-24 Rodin Therapeutics Inc Inhibidores biciclicos de histona desacetilasa
SMT202200232T1 (it) 2017-08-07 2022-07-21 Alkermes Inc Inibitori biciclici di istone deacetilasi
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
CN113056267A (zh) 2018-08-26 2021-06-29 凯帝夫肿瘤科技有限公司 Plk1靶磷酸化状态以及用plk1抑制剂治疗癌症
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
JP7621280B2 (ja) * 2019-02-25 2025-01-24 カーディフ・オンコロジー・インコーポレイテッド 平滑筋の非アドレナリン作動性収縮及び前立腺細胞増殖を阻害するためのオンバンサーティブ
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
KR20220064369A (ko) 2019-08-14 2022-05-18 인사이트 코포레이션 Cdk2 저해제로서의 이미다졸릴 피리디미딘일아민 화합물
CR20220170A (es) 2019-10-11 2022-10-10 Incyte Corp Aminas bicíclicas como inhibidoras de la cdk2
WO2021194321A1 (en) * 2020-03-27 2021-09-30 Uppthera Benzimidazole thiophene derivative compounds inducing selective degradation of plk1
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