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BRPI0407306A - 1,2,4- triazinas de inibição de hiv - Google Patents

1,2,4- triazinas de inibição de hiv

Info

Publication number
BRPI0407306A
BRPI0407306A BRPI0407306-1A BRPI0407306A BRPI0407306A BR PI0407306 A BRPI0407306 A BR PI0407306A BR PI0407306 A BRPI0407306 A BR PI0407306A BR PI0407306 A BRPI0407306 A BR PI0407306A
Authority
BR
Brazil
Prior art keywords
hiv
triazines
inhibiting
triazins
remedy
Prior art date
Application number
BRPI0407306-1A
Other languages
English (en)
Inventor
Adriaan Jan Jans Paul
Paulus Joannes Lewi
Marc Rene De Jonge
Lucien Maria Henricus Koymans
Hendrik Maarten Vinkes
Frederik Frans Desire Daeyaert
Jan Heeres
Ruben Gerardus George Leenders
Georges Joseph Corne Hoornaert
Amuri Kilonda
Donald William Ludovich
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0407306A publication Critical patent/BRPI0407306A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furnace Details (AREA)

Abstract

"1,2,4-TRIAZINAS DE INIBIçãO DE HIV". A presente invenção refere-se a inibidores de replicação de HIV da fórmula (1) como definido no relatório descritivo, seu uso como um remédio, seus processos para a preparação e composições farmacêuticas compreendendo-os.
BRPI0407306-1A 2003-02-07 2004-02-05 1,2,4- triazinas de inibição de hiv BRPI0407306A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0301289 2003-02-07
PCT/EP2004/050084 WO2004074266A1 (en) 2003-02-07 2004-02-05 Hiv inhibiting 1,2,4-triazines

Publications (1)

Publication Number Publication Date
BRPI0407306A true BRPI0407306A (pt) 2006-02-21

Family

ID=32892827

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407306-1A BRPI0407306A (pt) 2003-02-07 2004-02-05 1,2,4- triazinas de inibição de hiv

Country Status (20)

Country Link
US (1) US7585861B2 (pt)
EP (1) EP1597242B1 (pt)
JP (1) JP4783725B2 (pt)
KR (1) KR20050105190A (pt)
CN (2) CN1747941A (pt)
AP (1) AP2005003365A0 (pt)
AT (1) ATE402152T1 (pt)
AU (1) AU2004213173B2 (pt)
BR (1) BRPI0407306A (pt)
CA (1) CA2513123C (pt)
DE (1) DE602004015254D1 (pt)
EA (1) EA010379B1 (pt)
ES (1) ES2311146T3 (pt)
HR (1) HRP20050690A2 (pt)
IL (1) IL170120A (pt)
MX (1) MXPA05008368A (pt)
NO (1) NO20054127L (pt)
PL (1) PL232814B1 (pt)
WO (1) WO2004074266A1 (pt)
ZA (1) ZA200506254B (pt)

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CA2567574C (en) 2004-04-08 2013-01-08 Targegen, Inc. Benzotriazine inhibitors of kinases
CA2575002C (en) * 2004-08-10 2015-01-20 Janssen Pharmaceutica N.V. Hiv inhibiting 1,2,4-triazin-6-one derivatives
PL382308A1 (pl) 2004-08-25 2007-08-20 Targegen, Inc. Związki heterocykliczne i sposoby stosowania
WO2006034440A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
CA2580762A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
WO2006034315A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
AU2005286731A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
WO2007130075A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
MX362412B (es) 2005-11-01 2019-01-15 Targegen Inc Inhibidores de biaril meta-pirimidina de cinasas.
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
AU2008210455A1 (en) * 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
KR101860057B1 (ko) 2008-05-21 2018-05-21 어리어드 파마슈티칼스, 인코포레이티드 키나아제 억제제로서 포스포러스 유도체
CN102131807B (zh) 2008-07-23 2013-11-20 沃泰克斯药物股份有限公司 吡唑并吡啶激酶抑制剂
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
MX2011000837A (es) 2008-07-23 2011-04-05 Vertex Pharma Inhibidores de pirazolpiridina cinasa triciclica.
AU2009279611A1 (en) 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
CA2760705A1 (en) 2009-05-06 2010-11-11 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
JP2013518113A (ja) 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピラジンキナーゼ阻害剤
EP2528917B1 (en) 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
EP2582702A1 (en) 2010-01-27 2013-04-24 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
AU2010363329A1 (en) 2010-11-07 2013-05-09 Targegen, Inc. Compositions and methods for treating myelofibrosis
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
MX388576B (es) 2016-06-07 2025-03-20 Jacobio Pharmaceuticals Co Ltd Derivados heterociclicos novedosos utiles como inhibidores de shp2.
AU2018239542C1 (en) 2017-03-23 2021-02-11 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as SHP2 inhibitors
CN112839935A (zh) 2018-09-26 2021-05-25 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
WO2021071984A1 (en) * 2019-10-08 2021-04-15 Skyhawk Therapeutics, Inc. Compounds for modulating splicing
CR20220325A (es) 2019-12-20 2022-08-19 Tenaya Therapeutics Inc Fluoroalquil-oxadiazoles y sus usos
CN111333543B (zh) * 2020-04-17 2022-09-16 武汉工程大学 一种利匹韦林中间体的合成方法
IL308152A (en) 2021-05-04 2024-01-01 Tenaya Therapeutics Inc 2-fluoroalkyl-4,3,1-oxadiazol-5-yl-thiazole, HDAC6 inhibitors for use in the treatment of metabolic disease and HFPEF
CN115745848A (zh) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 一种氨基胍的加工合成工艺
CN117658936A (zh) * 2023-11-30 2024-03-08 上海予君生物科技发展有限公司 一种3,5,6-三氯-[1,2,4]-噻嗪的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
IL123654A (en) 1995-11-23 2001-08-08 Janssen Pharmaceutica Nv Process for the preparation of solid mixtures of cyclodextrins and pharmaceutical preparations containing such solid mixtures
NO311614B1 (no) * 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
DE69905306T2 (de) 1998-03-27 2003-11-27 Janssen Pharmaceutica N.V., Beerse HIV hemmende Pyrimidin Derivate
EP0945447A1 (en) * 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
CN1295567A (zh) 1998-03-27 2001-05-16 株式会社Lg化学 作为新型抗氧剂的聚乙氧基化抗坏血酸衍生物及其制备方法
SK287269B6 (sk) * 1998-11-10 2010-05-07 Janssen Pharmaceutica N. V. Derivát pyrimidínu, jeho použitie, spôsob jeho prípravy a farmaceutická kompozícia, kombinácia a produkt s jeho obsahom
AP1636A (en) * 1998-11-10 2006-07-17 Janssen Pharmaceutica Nv 2.4-disubstituted triazine derivatives.
AU783981C (en) * 2000-05-08 2007-05-03 Janssen Pharmaceutica N.V. HIV replication inhibitors
ATE367814T1 (de) * 2001-03-15 2007-08-15 Janssen Pharmaceutica Nv Hiv hemmende pyrazinon-derivate
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز

Also Published As

Publication number Publication date
DE602004015254D1 (de) 2008-09-04
PL232814B1 (pl) 2019-07-31
CA2513123A1 (en) 2004-09-02
AP2005003365A0 (en) 2005-09-30
AU2004213173B2 (en) 2010-07-29
MXPA05008368A (es) 2005-11-04
JP4783725B2 (ja) 2011-09-28
US20070037811A1 (en) 2007-02-15
JP2006516983A (ja) 2006-07-13
AU2004213173A1 (en) 2004-09-02
KR20050105190A (ko) 2005-11-03
IL170120A (en) 2013-04-30
CA2513123C (en) 2013-04-23
WO2004074266A8 (en) 2004-11-11
HRP20050690A2 (en) 2006-08-31
WO2004074266A1 (en) 2004-09-02
EP1597242B1 (en) 2008-07-23
ATE402152T1 (de) 2008-08-15
NO20054127L (no) 2005-09-05
EA010379B1 (ru) 2008-08-29
EA200501268A1 (ru) 2006-02-24
CN102503903A (zh) 2012-06-20
US7585861B2 (en) 2009-09-08
ZA200506254B (en) 2008-02-27
PL378107A1 (pl) 2006-03-06
CN1747941A (zh) 2006-03-15
EP1597242A1 (en) 2005-11-23
ES2311146T3 (es) 2009-02-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.