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BR9813608A - Polipeptìdeo isolado, sequências de ácido nucleico isolado e mutante, construção de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, processos para produzir uma sequência de ácido nucleico mutante, para produzir um polipeptìdeo, para produzir um mutante de uma célula originária e para produzir uma proteìna, e, célula mutante - Google Patents

Polipeptìdeo isolado, sequências de ácido nucleico isolado e mutante, construção de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, processos para produzir uma sequência de ácido nucleico mutante, para produzir um polipeptìdeo, para produzir um mutante de uma célula originária e para produzir uma proteìna, e, célula mutante

Info

Publication number
BR9813608A
BR9813608A BR9813608-9A BR9813608A BR9813608A BR 9813608 A BR9813608 A BR 9813608A BR 9813608 A BR9813608 A BR 9813608A BR 9813608 A BR9813608 A BR 9813608A
Authority
BR
Brazil
Prior art keywords
nucleic acid
mutant
producing
isolated
cell
Prior art date
Application number
BR9813608-9A
Other languages
English (en)
Other versions
BR9813608B1 (pt
Inventor
Alexander Blinkovsky
Tony S Byun
Alan V Klotz
Alan Sloma
Kimberly Brown
Maria Tang
Miko Fujii
Chigusa Marumoto
Lene V Kofod
Original Assignee
Novo Nordisk A S Novo Nordisk
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A S Novo Nordisk, Japan Tobacco Inc filed Critical Novo Nordisk A S Novo Nordisk
Publication of BR9813608A publication Critical patent/BR9813608A/pt
Publication of BR9813608B1 publication Critical patent/BR9813608B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"POLIPEPTìDEO ISOLADO, SEQUêNCIAS DE áCIDO NUCLEICO ISOLADO E MUTANTE, CONSTRUçãO DE áCIDO NUCLEICO, VETOR DE EXPRESSãO RECOMBINANTE , CéLULA HOSPEDEIRA RECOMBINANTE, PROCESSOS PARA PRODUZIR UMA SEQUêNCIA DE áCIDO NUCLEICO MUTANTE, PARA PRODUZIR UM POLIPEPTìDEO, PARA PRODUZIR UM MUTANTE DE UMA CéLULA ORIGINáRIA E PARA PRODUZIR UMA PROTEìNA, E, CéLULA MUTANTE" A presente invenção refere-se a polipeptídeos isolados tendo atividade de aminopeptidase e sequências de ácido nucleico isolado codificando os polipeptídeos. A invenção também se refere a construções de ácido nucleico, vetores e células hospedeiras compreendendo as sequências de ácido nucleico assim como processos para produzir e usar os polipeptídeos.
BRPI9813608-9A 1997-12-16 1998-11-13 célula hospedeira de bacillus transgênica, e, processo para produzir um polipeptìdeo tendo atividade aminopeptidase. BR9813608B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6971997P 1997-12-16 1997-12-16
DK146597 1997-12-16
DK67098 1998-05-15
PCT/DK1998/000495 WO1999031226A1 (en) 1997-12-16 1998-11-13 Polypeptides having aminopeptidase activity and nucleic acids encoding same

Publications (2)

Publication Number Publication Date
BR9813608A true BR9813608A (pt) 2000-10-17
BR9813608B1 BR9813608B1 (pt) 2011-11-01

Family

ID=27220854

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9813608-9A BR9813608B1 (pt) 1997-12-16 1998-11-13 célula hospedeira de bacillus transgênica, e, processo para produzir um polipeptìdeo tendo atividade aminopeptidase.

Country Status (12)

Country Link
US (3) US6184020B1 (pt)
EP (1) EP1042457B1 (pt)
JP (1) JP3979622B2 (pt)
KR (2) KR100556071B1 (pt)
CN (1) CN1247777C (pt)
AT (1) ATE319818T1 (pt)
AU (1) AU755387B2 (pt)
BR (1) BR9813608B1 (pt)
CA (1) CA2315274C (pt)
DE (1) DE69833784T2 (pt)
NZ (1) NZ505066A (pt)
WO (1) WO1999031226A1 (pt)

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US6261794B1 (en) * 1999-10-14 2001-07-17 Saint Louis University Methods for identifying inhibitors of methionine aminopeptidases
US20020182701A1 (en) * 2001-08-30 2002-12-05 Saint Louis University Dominant negative variants of methionine aminopeptidase 2 (MetAP2) and clinical uses thereof
US6617209B1 (en) * 2002-02-22 2003-09-09 Intel Corporation Method for making a semiconductor device having a high-k gate dielectric
US20040242566A1 (en) * 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
US7638638B2 (en) 2003-05-14 2009-12-29 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
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US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP1699777B1 (en) * 2003-09-08 2012-12-12 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US20050065144A1 (en) * 2003-09-08 2005-03-24 Syrrx, Inc. Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
UA85871C2 (uk) * 2004-03-15 2009-03-10 Такеда Фармасьютікал Компані Лімітед Інгібітори дипептидилпептидази
JP2008501714A (ja) * 2004-06-04 2008-01-24 武田薬品工業株式会社 ジペプチジルペプチダーゼインヒビター
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7888011B2 (en) * 2004-10-18 2011-02-15 U.S. Genomics, Inc. Methods for isolation of nucleic acids from prokaryotic spores
JP2008524331A (ja) * 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
PE20070522A1 (es) * 2005-09-14 2007-07-11 Takeda Pharmaceutical 2-[6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo-3,4-dihidro-2h-pirimidin-1-ilmetil]-4-fluoro-benzonitrilo como inhibidor de dipeptidil peptidasa y composiciones farmaceuticas que lo contienen
AU2006290908C1 (en) * 2005-09-14 2014-04-03 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetes
US20070060529A1 (en) * 2005-09-14 2007-03-15 Christopher Ronald J Administration of dipeptidyl peptidase inhibitors
CA2622642C (en) * 2005-09-16 2013-12-31 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200745080A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2007112368A1 (en) * 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Preparation of (r)-3-aminopiperidine dihydrochloride
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
SI2073810T1 (sl) * 2006-09-13 2011-12-30 Takeda Pharmaceutical Uporaba 2-6(3-amino-piperidin-1-il)-3-metil-2,4-diokso-3,4-dihidro-2H-pirimidin -1-ilmetil-4-fluoro-benzonitrila za zdravljenje diabetesa, raka, avtoimunskih motenj in infekcije s HIV
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US20100144140A1 (en) * 2008-12-10 2010-06-10 Novellus Systems, Inc. Methods for depositing tungsten films having low resistivity for gapfill applications
CN102492645A (zh) * 2011-11-22 2012-06-13 江南大学 一种高产氨肽酶的重组枯草芽孢杆菌及其构建方法和应用
CN102492646A (zh) * 2011-11-22 2012-06-13 江南大学 一种高产氨肽酶的重组大肠杆菌及其构建方法
CN102876705B (zh) * 2012-10-29 2013-10-30 江南大学 一种原生质体转化选育高产亮氨酸氨肽酶菌株的方法
KR20250020836A (ko) * 2023-08-04 2025-02-11 소재우 스핑고모나스 야노이쿠야에를 이용한 미생물 균주 및 이를 포함하는 오폐수 정화제

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US6465209B1 (en) * 1997-05-16 2002-10-15 Novozymes Biotech, Inc. Methods of producing protein hydrolysates

Also Published As

Publication number Publication date
JP2003525573A (ja) 2003-09-02
KR20050046012A (ko) 2005-05-17
KR20010033182A (ko) 2001-04-25
NZ505066A (en) 2002-10-25
KR100556071B1 (ko) 2006-03-10
CN1247777C (zh) 2006-03-29
US6184020B1 (en) 2001-02-06
CA2315274C (en) 2009-01-27
DE69833784T2 (de) 2006-10-19
AU1332899A (en) 1999-07-05
JP3979622B2 (ja) 2007-09-19
US6673571B2 (en) 2004-01-06
WO1999031226A1 (en) 1999-06-24
US6303360B1 (en) 2001-10-16
CA2315274A1 (en) 1999-06-24
KR100511655B1 (ko) 2005-08-31
DE69833784D1 (de) 2006-05-04
AU755387B2 (en) 2002-12-12
US20020177210A1 (en) 2002-11-28
ATE319818T1 (de) 2006-03-15
EP1042457B1 (en) 2006-03-08
CN1282369A (zh) 2001-01-31
BR9813608B1 (pt) 2011-11-01
EP1042457A1 (en) 2000-10-11

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Legal Events

Date Code Title Description
TC Change of name
B25A Requested transfer of rights approved

Free format text: JAPAN TOBACCO, INC (JP), NOVOZYMES BIOTECH, INC. (US), NOVOZYMES A/S (DK)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 37, INDEFIRO DO PRESENTE PEDIDO, UMA VEZ QUE AS REIVINDICACOES ESTAO INDEFINIDAS E/OU NAO ESTAO FUNDAMENTADAS NO RELATORIO DESCRITIVO (ART. 25 DA LPI).

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/11/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)