ATE386126T1 - Verbesserte expressionsvektoren - Google Patents
Verbesserte expressionsvektorenInfo
- Publication number
- ATE386126T1 ATE386126T1 AT97947444T AT97947444T ATE386126T1 AT E386126 T1 ATE386126 T1 AT E386126T1 AT 97947444 T AT97947444 T AT 97947444T AT 97947444 T AT97947444 T AT 97947444T AT E386126 T1 ATE386126 T1 AT E386126T1
- Authority
- AT
- Austria
- Prior art keywords
- expression vectors
- improved expression
- nucleic acid
- constructs
- encodes
- Prior art date
Links
- 239000013604 expression vector Substances 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000009977 dual effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Image Generation (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2954596P | 1996-11-08 | 1996-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE386126T1 true ATE386126T1 (de) | 2008-03-15 |
Family
ID=21849585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97947444T ATE386126T1 (de) | 1996-11-08 | 1997-11-07 | Verbesserte expressionsvektoren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6117651A (de) |
| EP (1) | EP0946711B1 (de) |
| JP (1) | JP2001503274A (de) |
| KR (1) | KR20000068934A (de) |
| CN (1) | CN1244214A (de) |
| AT (1) | ATE386126T1 (de) |
| AU (1) | AU718382B2 (de) |
| CA (1) | CA2271230A1 (de) |
| DE (1) | DE69738514D1 (de) |
| HU (1) | HUP0001650A3 (de) |
| IL (1) | IL129843A0 (de) |
| NZ (1) | NZ335628A (de) |
| WO (1) | WO1998020111A1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2443266A1 (en) * | 2001-02-13 | 2002-08-22 | University Of Florida | A bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes |
| US7172865B2 (en) * | 2001-08-13 | 2007-02-06 | Saint Louis University | Rapid and sensitive assay for the detection and quantification of coregulators of nucleic acid binding factors |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| NZ534930A (en) * | 2002-01-31 | 2006-07-28 | Univ Saint Louis | Methods of detecting and quantifying nucleic acid binding factors and coregulators thereof based upon proximity-based luminescence transfer |
| MXPA04012496A (es) | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
| CN1678624B (zh) | 2002-07-03 | 2011-10-26 | 陶氏环球技术公司 | 苯甲酸盐-和邻氨基苯甲酸盐-诱导的启动子 |
| MXPA05000872A (es) | 2002-07-23 | 2005-04-28 | Neose Technologies Inc | Sintesis de glicoproteinas utilizando glicosiltransferasas bacterianas. |
| BRPI0408358A (pt) | 2003-03-14 | 2006-03-21 | Neose Technologies Inc | polìmeros hidrossolúveis ramificados e seus conjugados |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| US7932364B2 (en) | 2003-05-09 | 2011-04-26 | Novo Nordisk A/S | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| EP1656453A2 (de) * | 2003-08-22 | 2006-05-17 | Nucleonics, Inc. | Eukaryontische expressionssysteme zur expression inhibitorischer rna in mehreren intrazellulären kompartimenten |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| US20080015142A1 (en) * | 2003-12-03 | 2008-01-17 | Defrees Shawn | Glycopegylated Follicle Stimulating Hormone |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| WO2005070138A2 (en) | 2004-01-08 | 2005-08-04 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
| WO2005067601A2 (en) * | 2004-01-09 | 2005-07-28 | Neose Technologies, Inc. | Vectors for recombinant protein expression in e.coli |
| EP2484759B1 (de) | 2004-02-04 | 2014-06-25 | ratiopharm GmbH | Verfahren zur Neufaltung von Säuger-Glykosyltransferasen |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| EP1784492B1 (de) * | 2004-08-23 | 2010-10-06 | Alnylam Pharmaceuticals, Inc. | Expressionskonstrukte mit mehreren rna-polymerase-iii-promotoren |
| EP1799249A2 (de) | 2004-09-10 | 2007-06-27 | Neose Technologies, Inc. | Glycopegyliertes interferon alpha |
| CA2585758C (en) | 2004-10-29 | 2017-08-01 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| NZ556436A (en) | 2005-01-10 | 2010-11-26 | Biogenerix Ag | Glycopegylated granulocyte colony stimulating factor |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP1888098A2 (de) | 2005-05-25 | 2008-02-20 | Neose Technologies, Inc. | Glykopegylierte erythropoetin-formulierungen |
| US20080255026A1 (en) * | 2005-05-25 | 2008-10-16 | Glycopegylated Factor 1X | Glycopegylated Factor Ix |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| US8198045B2 (en) | 2006-04-19 | 2012-06-12 | Biogenerix Ag | Expression of O-glycosylated therapeutic proteins in prokaryotic microorganisms |
| CN101516388B (zh) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| NZ580030A (en) | 2007-04-03 | 2012-06-29 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
| MX2009011851A (es) | 2007-05-02 | 2010-03-04 | Merial Ltd | Plasmidos de dna que tienen expresion y estabilidad mejoradas. |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| EP2626079A3 (de) | 2008-02-27 | 2014-03-05 | Novo Nordisk A/S | Konjugierte Faktor-VIII-Moleküle |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2020185831A1 (en) | 2019-03-12 | 2020-09-17 | Varigen Biosciences Corporation | Expression vector |
| US20240018529A1 (en) * | 2022-04-19 | 2024-01-18 | Worcester Polytechnic Institute | Inducible promoters |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4565785A (en) * | 1978-06-08 | 1986-01-21 | The President And Fellows Of Harvard College | Recombinant DNA molecule |
| US4673641A (en) * | 1982-12-16 | 1987-06-16 | Molecular Genetics Research And Development Limited Partnership | Co-aggregate purification of proteins |
| US4710473A (en) * | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
| US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
| US4795706A (en) * | 1985-01-31 | 1989-01-03 | Eli Lilly And Company | Novel expression control sequences |
| US5304472A (en) * | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| US5342763A (en) * | 1992-11-23 | 1994-08-30 | Genentech, Inc. | Method for producing polypeptide via bacterial fermentation |
| US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
-
1997
- 1997-11-07 DE DE69738514T patent/DE69738514D1/de not_active Expired - Lifetime
- 1997-11-07 CN CN97180609A patent/CN1244214A/zh active Pending
- 1997-11-07 IL IL12984397A patent/IL129843A0/xx unknown
- 1997-11-07 KR KR1019997004107A patent/KR20000068934A/ko active IP Right Grant
- 1997-11-07 HU HU0001650A patent/HUP0001650A3/hu unknown
- 1997-11-07 JP JP52185798A patent/JP2001503274A/ja not_active Ceased
- 1997-11-07 AU AU52524/98A patent/AU718382B2/en not_active Ceased
- 1997-11-07 US US08/965,850 patent/US6117651A/en not_active Expired - Lifetime
- 1997-11-07 CA CA002271230A patent/CA2271230A1/en not_active Abandoned
- 1997-11-07 AT AT97947444T patent/ATE386126T1/de not_active IP Right Cessation
- 1997-11-07 EP EP97947444A patent/EP0946711B1/de not_active Expired - Lifetime
- 1997-11-07 NZ NZ335628A patent/NZ335628A/xx unknown
- 1997-11-07 WO PCT/US1997/020528 patent/WO1998020111A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2271230A1 (en) | 1998-05-14 |
| AU718382B2 (en) | 2000-04-13 |
| CN1244214A (zh) | 2000-02-09 |
| DE69738514D1 (de) | 2008-03-27 |
| IL129843A0 (en) | 2000-02-29 |
| WO1998020111A1 (en) | 1998-05-14 |
| AU5252498A (en) | 1998-05-29 |
| EP0946711A1 (de) | 1999-10-06 |
| EP0946711B1 (de) | 2008-02-13 |
| HUP0001650A2 (hu) | 2000-09-28 |
| JP2001503274A (ja) | 2001-03-13 |
| NZ335628A (en) | 2000-10-27 |
| EP0946711A4 (de) | 2004-10-27 |
| KR20000068934A (ko) | 2000-11-25 |
| HUP0001650A3 (en) | 2001-09-28 |
| US6117651A (en) | 2000-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |