BR9713507A - Aril carboxamidas bicìclicas e seu uso terapêutico - Google Patents
Aril carboxamidas bicìclicas e seu uso terapêuticoInfo
- Publication number
- BR9713507A BR9713507A BR9713507-0A BR9713507A BR9713507A BR 9713507 A BR9713507 A BR 9713507A BR 9713507 A BR9713507 A BR 9713507A BR 9713507 A BR9713507 A BR 9713507A
- Authority
- BR
- Brazil
- Prior art keywords
- halogen
- alkyl
- therapeutic use
- optionally substituted
- optionally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>"ARIL CARBOXAMIDAS BICìCLICAS E SEU USO TERAPêUTICO"<D>. Composto de fórmula geral (i) possuem utilidade terapêutica através da inibição de TNF ou fosfodiesterase, (i) em que (1) X é N e (a) Z é =CR~ 1~-CR^ 2^= e Y é N, (B) Z é =CR~ 1~ e Y é O, S ou NR~ 4~, ou (c) Z é =CR~ 1~-N= e Y é CR^ 2^, ou (2) X é NR~ 4~, Z é =CR~ 1~= e Y é N; Q é O ou S; R~ 1~ e R~ 2~ são iguais ou diferentes e são cada um COR~ 6~, C(=NOR~ 6~)R~ 13~, alquil-C(=NOR~ 6~)R~ 13~, NR~ 8~R~ 9~, CON(R~ 6~)~ 2~, halogênio, CF~ 3~, CN, CO~ 2~H, CO~ 2~R~ 10~, R~ 6~,CO-het onde het é um anel heterocíclico (tal como morfolina ou piperidina) ligado via um átomo de N no anel e, opcionalmente, substituído com um ou mais R~ 14~ ou o grupo cíclico (a) R~ 3~ é OH, tioalquila, ou C~ 1-6~ alcóxi ou cicloalcóxi cada um opcionalmente substituído com um ou mais halogênios; R~ 4~ é H ou alquila; R~ 5~ é arila ou heteroarila, cada um dos quais podendo ser opcionalmente substituído com um ou mais substituintes escolhidos dentre halogênio, opcionalmente alquila substituída por halogênio, hidróxi, opcionalmente alcóxi substituído por halogênio, CO~ 2~H, CO~ 2~R~ 10~, CONR~ 11~R~ 12~, COR~ 10~, SO~ 2~R~ 10~, SO~ 2~NR~ 11~R~ 12~, NR~ 8~R~ 9~ e CN.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623860.5A GB9623860D0 (en) | 1996-11-15 | 1996-11-15 | Novel compounds |
| GBGB9708062.6A GB9708062D0 (en) | 1997-04-22 | 1997-04-22 | Novel compounds |
| PCT/GB1997/003154 WO1998022460A1 (en) | 1996-11-15 | 1997-11-17 | Bicyclic aryl carboxamides and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9713507A true BR9713507A (pt) | 2000-02-29 |
Family
ID=26310411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9713507-0A BR9713507A (pt) | 1996-11-15 | 1997-11-17 | Aril carboxamidas bicìclicas e seu uso terapêutico |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6353010B1 (pt) |
| EP (1) | EP0944616B1 (pt) |
| JP (1) | JP2001504479A (pt) |
| KR (1) | KR20000053274A (pt) |
| CN (1) | CN1114604C (pt) |
| AT (1) | ATE242234T1 (pt) |
| AU (1) | AU726590B2 (pt) |
| BR (1) | BR9713507A (pt) |
| CA (1) | CA2268037A1 (pt) |
| CZ (1) | CZ158299A3 (pt) |
| DE (1) | DE69722656T2 (pt) |
| DK (1) | DK0944616T3 (pt) |
| ES (1) | ES2200163T3 (pt) |
| HU (1) | HUP0000189A3 (pt) |
| ID (1) | ID21698A (pt) |
| IL (1) | IL129337A0 (pt) |
| NO (1) | NO992337D0 (pt) |
| NZ (1) | NZ335197A (pt) |
| RU (1) | RU2176642C2 (pt) |
| SK (1) | SK283534B6 (pt) |
| TR (1) | TR199901730T2 (pt) |
| WO (1) | WO1998022460A1 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
| GB0003256D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| GB0003254D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| RU2285002C2 (ru) * | 2001-06-15 | 2006-10-10 | Астеллас Фарма Инк. | Производное пиридина и фармацевтическая композиция на его основе |
| SI1944322T1 (sl) * | 2002-07-19 | 2015-06-30 | Abbvie Biotechnology Ltd. | Zdravljenje s TNP alfa povezanih bolezni |
| CN1902193B (zh) | 2003-12-04 | 2011-07-13 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的喹喔啉 |
| WO2005087749A1 (ja) * | 2004-03-15 | 2005-09-22 | Kyowa Hakko Kogyo Co., Ltd. | ２−アミノキナゾリン誘導体 |
| MX2007010063A (es) * | 2005-02-17 | 2008-01-16 | Albany Molecular Res Inc | Benzoxazol-carboxamidas para el tratamiento de la naucea y el vomito inducidos por quimioterapia y sindrome del intestino irritable con diarrea predominante. |
| US7893267B2 (en) * | 2005-03-14 | 2011-02-22 | High Point Pharmaceuticals, Llc | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors |
| CN101500607B (zh) | 2005-05-16 | 2013-11-27 | 阿布维生物技术有限公司 | TNFα抑制剂治疗腐蚀性多关节炎的用途 |
| WO2007097197A1 (ja) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | アミド誘導体またはその塩 |
| US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| WO2008019363A2 (en) * | 2006-08-07 | 2008-02-14 | Albany Molecular Research, Inc. | 2-alkylbenzoxazole carboxamides as 5ht3 modulators |
| WO2008026687A1 (fr) | 2006-09-01 | 2008-03-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivé de pyrazolopyridine carboxamide et inhibiteur de phosphodiestérase (pde) comprenant le dérivé |
| RU2459821C2 (ru) * | 2006-09-07 | 2012-08-27 | Байоджен Айдек Ма Инк. | Модуляторы киназы, ассоциированной с рецептором интерлейкина-1 |
| WO2008154543A2 (en) | 2007-06-11 | 2008-12-18 | Abbott Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis |
| TWI444379B (zh) | 2007-06-29 | 2014-07-11 | Sunesis Pharmaceuticals Inc | 有用於作為Ｒａｆ激酶抑制劑之化合物 |
| MX2011008995A (es) | 2009-02-27 | 2011-09-15 | Ambit Biosciences Corp | Derivados de quinazolina de modulacion de cinasa jak y metodos para usar los mismos. |
| CA2810024A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Quinazoline compounds and methods of use thereof |
| EA028626B1 (ru) * | 2012-06-11 | 2017-12-29 | Юсб Байофарма Спрл | БЕНЗИМИДАЗОЛЫ, МОДУЛИРУЮЩИЕ TNF-α |
| CN104780764A (zh) * | 2012-09-05 | 2015-07-15 | 拜尔农作物科学股份公司 | 取代的2-酰氨基苯并咪唑、2-酰氨基苯并噁唑和2-酰氨基苯并噻唑或其盐作为活性物质对抗非生物植物胁迫的用途 |
| CN108440333A (zh) * | 2018-03-29 | 2018-08-24 | 江苏道博化工有限公司 | 分散染料中间体的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50140442A (pt) | 1974-04-16 | 1975-11-11 | ||
| AU2458684A (en) | 1983-02-14 | 1984-08-23 | Usv Pharmaceutical Corp. | Benzoheterocyclic carbamates |
| DE3835660A1 (de) * | 1988-03-25 | 1989-10-12 | Bayer Ag | 7-substituierte 2-carbonamido-benzthiazol-3-oxide |
| DE4014937A1 (de) | 1990-05-10 | 1991-11-14 | Bayer Ag | 2,3-disubstituierte chinoxaline als leistungsfoerderer fuer tiere |
| GB9219634D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| GB9219632D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| EP0664792B1 (en) | 1992-10-14 | 2000-01-05 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
| DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| GB9301660D0 (en) | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9306578D0 (en) | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| US6083961A (en) | 1994-08-03 | 2000-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole compounds as bradykinin antagonists |
| DE69531623T2 (de) * | 1994-10-12 | 2004-06-17 | Euroceltique S.A. | Neue benzoxazole |
| US5665737B1 (en) | 1994-10-12 | 1999-02-16 | Euro Celtique Sa | Substituted benzoxazoles |
-
1997
- 1997-11-17 DE DE69722656T patent/DE69722656T2/de not_active Expired - Fee Related
- 1997-11-17 AU AU49602/97A patent/AU726590B2/en not_active Ceased
- 1997-11-17 HU HU0000189A patent/HUP0000189A3/hu unknown
- 1997-11-17 CN CN97199650A patent/CN1114604C/zh not_active Expired - Fee Related
- 1997-11-17 EP EP97912370A patent/EP0944616B1/en not_active Expired - Lifetime
- 1997-11-17 TR TR1999/01730T patent/TR199901730T2/xx unknown
- 1997-11-17 DK DK97912370T patent/DK0944616T3/da active
- 1997-11-17 RU RU99112569/04A patent/RU2176642C2/ru not_active IP Right Cessation
- 1997-11-17 SK SK644-99A patent/SK283534B6/sk unknown
- 1997-11-17 CZ CZ991582A patent/CZ158299A3/cs unknown
- 1997-11-17 ID IDW990356A patent/ID21698A/id unknown
- 1997-11-17 AT AT97912370T patent/ATE242234T1/de not_active IP Right Cessation
- 1997-11-17 KR KR1019990704253A patent/KR20000053274A/ko not_active Application Discontinuation
- 1997-11-17 BR BR9713507-0A patent/BR9713507A/pt unknown
- 1997-11-17 WO PCT/GB1997/003154 patent/WO1998022460A1/en not_active Application Discontinuation
- 1997-11-17 IL IL12933797A patent/IL129337A0/xx not_active IP Right Cessation
- 1997-11-17 CA CA002268037A patent/CA2268037A1/en not_active Abandoned
- 1997-11-17 JP JP52334598A patent/JP2001504479A/ja not_active Ceased
- 1997-11-17 ES ES97912370T patent/ES2200163T3/es not_active Expired - Lifetime
- 1997-11-17 NZ NZ335197A patent/NZ335197A/xx unknown
-
1999
- 1999-05-14 NO NO992337A patent/NO992337D0/no not_active Application Discontinuation
- 1999-10-21 US US09/422,473 patent/US6353010B1/en not_active Expired - Fee Related
-
2002
- 2002-01-14 US US10/050,005 patent/US20020094987A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CZ158299A3 (cs) | 1999-09-15 |
| NO992337L (no) | 1999-05-14 |
| US6353010B1 (en) | 2002-03-05 |
| NO992337D0 (no) | 1999-05-14 |
| RU2176642C2 (ru) | 2001-12-10 |
| ID21698A (id) | 1999-07-15 |
| ES2200163T3 (es) | 2004-03-01 |
| ATE242234T1 (de) | 2003-06-15 |
| EP0944616A1 (en) | 1999-09-29 |
| EP0944616B1 (en) | 2003-06-04 |
| US20020094987A1 (en) | 2002-07-18 |
| JP2001504479A (ja) | 2001-04-03 |
| AU4960297A (en) | 1998-06-10 |
| KR20000053274A (ko) | 2000-08-25 |
| CA2268037A1 (en) | 1998-05-28 |
| CN1114604C (zh) | 2003-07-16 |
| CN1237168A (zh) | 1999-12-01 |
| DK0944616T3 (da) | 2003-09-29 |
| AU726590B2 (en) | 2000-11-09 |
| HUP0000189A2 (hu) | 2001-04-28 |
| WO1998022460A1 (en) | 1998-05-28 |
| SK64499A3 (en) | 2000-03-13 |
| HUP0000189A3 (en) | 2002-01-28 |
| TR199901730T2 (xx) | 1999-09-21 |
| DE69722656T2 (de) | 2004-05-13 |
| DE69722656D1 (de) | 2003-07-10 |
| IL129337A0 (en) | 2000-02-17 |
| SK283534B6 (sk) | 2003-09-11 |
| NZ335197A (en) | 2000-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |