BR9707636A - Composto composição farmacêutica uso de um composto e processos para preparar composto e para tratar um distúrbio ou doença de um organismo animal vivo - Google Patents
Composto composição farmacêutica uso de um composto e processos para preparar composto e para tratar um distúrbio ou doença de um organismo animal vivoInfo
- Publication number
- BR9707636A BR9707636A BR9707636A BR9707636A BR9707636A BR 9707636 A BR9707636 A BR 9707636A BR 9707636 A BR9707636 A BR 9707636A BR 9707636 A BR9707636 A BR 9707636A BR 9707636 A BR9707636 A BR 9707636A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- disease
- disorder
- disorders
- treat
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 150000003813 tropane derivatives Chemical class 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 201000001272 cocaine abuse Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK19496 | 1996-02-22 | ||
| PCT/EP1997/000850 WO1997030997A1 (en) | 1996-02-22 | 1997-02-21 | Tropane-derivatives, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9707636A true BR9707636A (pt) | 1999-07-27 |
Family
ID=8090830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9707636A BR9707636A (pt) | 1996-02-22 | 1997-02-21 | Composto composição farmacêutica uso de um composto e processos para preparar composto e para tratar um distúrbio ou doença de um organismo animal vivo |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US6288079B1 (cs) |
| EP (2) | EP1130020A1 (cs) |
| JP (1) | JP3238414B2 (cs) |
| KR (1) | KR100446571B1 (cs) |
| CN (1) | CN1077574C (cs) |
| AT (1) | ATE203023T1 (cs) |
| AU (1) | AU720358B2 (cs) |
| BG (1) | BG63945B1 (cs) |
| BR (1) | BR9707636A (cs) |
| CA (1) | CA2244773C (cs) |
| CZ (1) | CZ287007B6 (cs) |
| DE (1) | DE69705608T2 (cs) |
| DK (1) | DK0885220T3 (cs) |
| EE (1) | EE04751B1 (cs) |
| ES (1) | ES2159839T3 (cs) |
| GR (1) | GR3036829T3 (cs) |
| HU (1) | HU228356B1 (cs) |
| IL (1) | IL125146A (cs) |
| IS (1) | IS1824B (cs) |
| NO (1) | NO318731B1 (cs) |
| NZ (1) | NZ330886A (cs) |
| PL (1) | PL185132B1 (cs) |
| PT (1) | PT885220E (cs) |
| RU (1) | RU2167876C2 (cs) |
| SG (1) | SG99853A1 (cs) |
| SI (1) | SI0885220T1 (cs) |
| SK (1) | SK281813B6 (cs) |
| TR (1) | TR199801641T2 (cs) |
| UA (1) | UA49872C2 (cs) |
| WO (1) | WO1997030997A1 (cs) |
| ZA (1) | ZA971525B (cs) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69943110D1 (de) * | 1998-09-30 | 2011-02-17 | Nihon Mediphysics Co Ltd | Verfahren zur herstellung von optisch aktiven tropinon-monokarbonsäurederivaten |
| AUPP627498A0 (en) | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
| JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| DE20203103U1 (de) * | 2001-10-11 | 2002-07-11 | Organix, Inc., Woburn, Mass. | Serotonin-Wiederaufnahme-Inhibitoren |
| WO2003037313A2 (en) * | 2001-10-31 | 2003-05-08 | Recovery Pharmaceuticals, Inc. | Methods for the treatment of addiction |
| US7381733B2 (en) | 2001-11-30 | 2008-06-03 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
| CN1655787A (zh) * | 2002-05-30 | 2005-08-17 | 神经研究公司 | 治疗慢性疼痛的三单胺再摄取抑制剂 |
| AU2003277827A1 (en) | 2002-11-01 | 2004-05-25 | Neurosearch A/S | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2004050690A1 (en) | 2002-12-02 | 2004-06-17 | Xenome Ltd | NOVEL χ-CONOTOXIN PEPTIDES (-I) |
| US7507717B2 (en) | 2002-12-02 | 2009-03-24 | Xenome Ltd. | Type II chi-conotoxin peptides (noradrenaline transporter inhibitors) |
| WO2004072071A1 (en) | 2003-02-12 | 2004-08-26 | Neurosearch A/S | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN100551924C (zh) * | 2003-02-12 | 2009-10-21 | 神经研究公司 | 8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
| NZ541248A (en) | 2003-02-12 | 2008-04-30 | Neurosearch As | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN100372850C (zh) * | 2003-02-12 | 2008-03-05 | 神经研究公司 | 新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
| CN100368409C (zh) | 2003-06-24 | 2008-02-13 | 神经研究公司 | 8-氮杂双环[3.2.1]辛烷衍生物及其用于制备单胺神经递质再摄取抑制剂的用途 |
| AR045141A1 (es) * | 2003-07-31 | 2005-10-19 | Neurosearch As | Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas. |
| ATE380813T1 (de) | 2003-10-03 | 2007-12-15 | Pfizer | Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen |
| NZ547152A (en) * | 2003-10-16 | 2009-12-24 | Neurosearch As | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
| EP1686965A2 (de) * | 2003-11-18 | 2006-08-09 | Boehringer Ingelheim International GmbH | Feste pharmazeutische zubereitungsform |
| JP2007518754A (ja) * | 2004-01-22 | 2007-07-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | モノアミン神経伝達物質再取込みインヒビターとドーパミンアゴニストを含む医薬組成物 |
| JP2007519646A (ja) * | 2004-01-22 | 2007-07-19 | ノイロサーチ アクティーゼルスカブ | 体重の持続的低減のための化合物 |
| JP2007518755A (ja) * | 2004-01-22 | 2007-07-12 | ノイロサーチ アクティーゼルスカブ | モノアミン神経伝達物質再取り込み阻害剤及びｎ−メチル−ｄ−アスパラギン酸（ｎｍｄａ）受容体アンタゴニストを含む医薬組成物 |
| DE102004004965B4 (de) * | 2004-01-31 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates |
| EP1755602A1 (en) * | 2004-06-04 | 2007-02-28 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation |
| EP1761527A1 (en) * | 2004-06-18 | 2007-03-14 | Neurosearch A/S | Novel 9-aza-bicyclo¬3.3.1|nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2005123679A2 (en) | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US7524958B2 (en) | 2004-06-18 | 2009-04-28 | Neurosearch A/S | Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| AU2005288914B2 (en) * | 2004-09-30 | 2011-05-19 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| MX2007002384A (es) | 2004-09-30 | 2007-05-11 | Neurosearch As | Nuevos derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina. |
| DE602006007550D1 (de) | 2005-02-10 | 2009-08-13 | Neurosearch As | Alkylsubstituierte homopiperazinderivate und deren verwendung als monoamin neurotransmitter wiederaufnahmeinhibitoren |
| JP2008534650A (ja) * | 2005-04-04 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | 新規置換ジアザビシクロ誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 |
| US20090137625A1 (en) | 2005-04-08 | 2009-05-28 | Dan Peters | Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors |
| EP1899301B1 (en) * | 2005-06-28 | 2010-09-15 | NeuroSearch A/S | Novel 3-aza-spiro[5.5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2008546828A (ja) | 2005-06-28 | 2008-12-25 | ノイロサーチ アクティーゼルスカブ | 新規な３−アザ−スピロ［５．５］ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用 |
| ATE481386T1 (de) * | 2005-06-28 | 2010-10-15 | Neurosearch As | Neue 3-aza-spiroä5.5üundec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern |
| US7943630B2 (en) * | 2005-06-28 | 2011-05-17 | Neurosearch A/S | 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CA2614833A1 (en) * | 2005-07-12 | 2007-01-18 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising 2, 3-disubstituted tropanes for the treatment of disorders of sexual desire |
| KR101594898B1 (ko) | 2005-07-15 | 2016-02-18 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| US8383817B2 (en) * | 2005-08-24 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Benztropine compounds and uses thereof |
| WO2007028769A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for neuroprotection |
| WO2007028770A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease |
| EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| TW200804367A (en) | 2005-11-11 | 2008-01-16 | Neurosearch As | Novel compounds |
| US7700596B2 (en) | 2006-02-10 | 2010-04-20 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| TW200800980A (en) * | 2006-02-17 | 2008-01-01 | Neurosearch As | Novel compounds |
| EP2083921A2 (en) | 2006-09-04 | 2009-08-05 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| US20100035914A1 (en) * | 2006-09-11 | 2010-02-11 | Barbara Bertani | Azabicyclic compounds as inhibitors of monoamines reuptake |
| GB0703998D0 (en) * | 2007-03-01 | 2007-04-11 | Glaxo Group Ltd | Novel salt |
| TW200904815A (en) | 2007-05-09 | 2009-02-01 | Neurosearch As | Novel compounds |
| US20100286134A1 (en) * | 2007-09-10 | 2010-11-11 | Neurosearch A/S | Novel phenoxazin-3-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP2201004A1 (en) * | 2007-09-10 | 2010-06-30 | Neurosearch A/S | Novel benzooxazol- and benzooxathiol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP2222302A1 (en) * | 2007-11-20 | 2010-09-01 | NeuroSearch A/S | A method for treating over-eating disorders |
| US20100286194A1 (en) * | 2007-11-20 | 2010-11-11 | Neurosearch A/S | Method for treating addiction |
| NZ596104A (en) | 2009-05-12 | 2014-01-31 | Albany Molecular Res Inc | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
| US8815894B2 (en) | 2009-05-12 | 2014-08-26 | Bristol-Myers Squibb Company | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
| AU2010247514A1 (en) | 2009-05-15 | 2011-11-17 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2011032903A1 (en) | 2009-09-21 | 2011-03-24 | Neurosearch A/S | Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2011092061A1 (en) | 2010-01-29 | 2011-08-04 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2011117289A1 (en) | 2010-03-25 | 2011-09-29 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors |
| US8153653B2 (en) * | 2010-06-22 | 2012-04-10 | Hoffmann-La Roche Inc. | Amido-tropane derivatives |
| WO2012000881A1 (en) | 2010-07-02 | 2012-01-05 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2012024397A2 (en) | 2010-08-17 | 2012-02-23 | Albany Molecular Research, Inc. | 2,5-methano-and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| EP2625170A1 (en) | 2010-10-07 | 2013-08-14 | Takeda Pharmaceutical Company Limited | 1,4-oxazepane derivatives |
| CA2864264C (en) | 2012-02-16 | 2020-05-05 | Neurosearch A/S | Pharmaceutical compositions for combination therapy |
| MA41634B1 (fr) | 2015-03-03 | 2021-09-30 | Saniona As | Formulation à base de combinaison de tésofensine et de métoprolol |
| EA026727B1 (ru) * | 2015-09-10 | 2017-05-31 | Замертон Холдингс Лимитед | Соль (1r,2r,3s)-3-(3,4-дихлорфенил)-2-(этоксиметил)-8-метил-8-азабицикло[3.2.1]октана и фталевой кислоты, способ её получения, продукт способа, фармацевтические композиции для лечения и/или профилактики нарушений, связанных с ожирением, их применение и способы лечения и/или профилактики нарушений, связанных с ожирением |
| WO2017121432A1 (en) | 2016-01-15 | 2017-07-20 | Saniona A/S | Tesofensine and metoprolol for treatment of hypertension |
| EA028995B1 (ru) * | 2016-02-25 | 2018-01-31 | Замертон Холдингс Лимитед | Соль тезофензина и оптически активных ацетиламинокислот, их применение для лечения и/или профилактики нарушений, связанных с ожирением |
| CR20190142A (es) | 2016-09-07 | 2019-05-22 | Saniona As | Composiciones de tesofensina |
| DE102017210141A1 (de) | 2017-06-16 | 2018-12-20 | Henkel Ag & Co. Kgaa | Portion zur Bereitstellung tensidhaltiger Flotten |
| MX2021008208A (es) | 2019-01-07 | 2021-11-17 | Saniona As | Tesofensina para la reduccion del peso corporal para pacientes con sindrome de prader-willi. |
| MX2022013236A (es) | 2020-04-22 | 2023-01-24 | Saniona As | Tratamiento de la obesidad hipotalamica. |
| TWI772928B (zh) * | 2020-10-21 | 2022-08-01 | 行政院原子能委員會核能研究所 | 非放射性標準品β-CFT之製備方法 |
| WO2024008808A1 (en) | 2022-07-08 | 2024-01-11 | Initiator Pharma A/S | Compound for treatment of female sexual dysfunction |
| CN115572289A (zh) * | 2022-10-24 | 2023-01-06 | 龙曦宁（上海）医药科技有限公司 | 一种特索芬辛的合成方法 |
| IL319787A (en) | 2022-10-28 | 2025-05-01 | Initiator Pharma As | Compound for pain treatment |
| WO2024146892A1 (en) | 2023-01-03 | 2024-07-11 | Initiator Pharma A/S | Compound for treatment of erectile dysfunction |
| WO2025051846A1 (en) | 2023-09-05 | 2025-03-13 | Initiator Pharma A/S | Compound for treatment of female sexual dysfunction |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281130A (en) | 1979-05-24 | 1981-07-28 | Sterling Drug Inc. | Lower-alkyl 4,6,7,8,8a-9-hexahydro-6,9-ethanothieno[3,2-f]indolizine-10-carboxylate |
| US5128118A (en) | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
| US5380848A (en) * | 1990-08-09 | 1995-01-10 | Research Triangle Institute | Cocaine receptor binding ligands |
| US5496953A (en) | 1990-08-09 | 1996-03-05 | Research Triangle Institute | Cocaine receptor binding ligands |
| DK0644775T3 (da) | 1991-11-15 | 2000-03-06 | Nat Inst Health | Kokainreceptorbindende ligander |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
| GEP19991749B (en) | 1994-04-19 | 1999-09-10 | Neurosearch As | Propane-2-Aldoxine Derivatives as Neurotransmitter Reuptake Inhibitors |
| GB9626611D0 (en) * | 1996-12-20 | 1997-02-05 | Unilever Plc | Agglomerated silicas |
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1997
- 1997-02-21 PT PT97903355T patent/PT885220E/pt unknown
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- 1997-02-21 RU RU98117314/04A patent/RU2167876C2/ru active
- 1997-02-21 UA UA98073814A patent/UA49872C2/uk unknown
- 1997-02-21 NZ NZ330886A patent/NZ330886A/xx not_active IP Right Cessation
- 1997-02-21 SK SK929-98A patent/SK281813B6/sk not_active IP Right Cessation
- 1997-02-21 AU AU17940/97A patent/AU720358B2/en not_active Ceased
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- 1997-02-21 CA CA002244773A patent/CA2244773C/en not_active Expired - Lifetime
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- 1997-02-21 DK DK97903355T patent/DK0885220T3/da active
- 1997-02-21 KR KR10-1998-0706518A patent/KR100446571B1/ko not_active Expired - Fee Related
- 1997-02-21 ZA ZA9701525A patent/ZA971525B/xx unknown
- 1997-02-21 WO PCT/EP1997/000850 patent/WO1997030997A1/en active IP Right Grant
- 1997-02-21 EP EP01108256A patent/EP1130020A1/en not_active Withdrawn
- 1997-02-21 CZ CZ19982520A patent/CZ287007B6/cs not_active IP Right Cessation
- 1997-02-21 EE EE9800254A patent/EE04751B1/xx not_active IP Right Cessation
- 1997-02-21 US US09/101,524 patent/US6288079B1/en not_active Expired - Lifetime
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- 1997-02-21 CN CN97192505A patent/CN1077574C/zh not_active Expired - Fee Related
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- 1997-02-21 JP JP52981097A patent/JP3238414B2/ja not_active Expired - Fee Related
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1998
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- 1998-08-17 IS IS4825A patent/IS1824B/is unknown
- 1998-08-21 NO NO19983877A patent/NO318731B1/no not_active IP Right Cessation
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2001
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2002
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