[go: up one dir, main page]

BR112016017041A2 - Proteína isolada tendo atividade de fosfatase, polinucleotídeo, vetor, célula hospedeira, método para produzir uma proteína e composição - Google Patents

Proteína isolada tendo atividade de fosfatase, polinucleotídeo, vetor, célula hospedeira, método para produzir uma proteína e composição

Info

Publication number
BR112016017041A2
BR112016017041A2 BR112016017041A BR112016017041A BR112016017041A2 BR 112016017041 A2 BR112016017041 A2 BR 112016017041A2 BR 112016017041 A BR112016017041 A BR 112016017041A BR 112016017041 A BR112016017041 A BR 112016017041A BR 112016017041 A2 BR112016017041 A2 BR 112016017041A2
Authority
BR
Brazil
Prior art keywords
protein
polynucleotide
vector
producing
composition
Prior art date
Application number
BR112016017041A
Other languages
English (en)
Other versions
BR112016017041B1 (pt
Inventor
Raaben Willem
Johannes Cornelius Jonk Luigi
Jan VAN DEN BERG Erik
Van Elsas Andrea
Luis Millán Jose
Original Assignee
Am Pharma Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Am Pharma Bv filed Critical Am Pharma Bv
Publication of BR112016017041A2 publication Critical patent/BR112016017041A2/pt
Publication of BR112016017041B1 publication Critical patent/BR112016017041B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

PROTEÍNA ISOLADA TENDO ATIVIDADE DE FOSFATASE, POLINUCLEOTÍDEO, VETOR, CÉLULA HOSPEDEIRA, MÉTODO PARA PRODUZIR UMA PROTEÍNA E COMPOSIÇÃO. A invenção refere-se às fosfatases alcalinas melhoradas, composições farmacêuticas compreendendo fosfatases alcalinas melhoradas e o uso de fosfatases alcalinas melhoradas para impedir, tratar ou curar doenças.
BR112016017041-5A 2014-01-24 2015-01-26 Proteína quimérica isolada, vetor, método para produzir a proteína quimérica isolada e composição BR112016017041B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14152526.1 2014-01-24
EP14152526 2014-01-24
EP14188158 2014-10-08
EP14188158.1 2014-10-08
PCT/NL2015/050048 WO2015112017A1 (en) 2014-01-24 2015-01-26 Chimeric alkaline phosphatase-like proteins

Publications (2)

Publication Number Publication Date
BR112016017041A2 true BR112016017041A2 (pt) 2017-10-03
BR112016017041B1 BR112016017041B1 (pt) 2023-09-26

Family

ID=52464544

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016017041-5A BR112016017041B1 (pt) 2014-01-24 2015-01-26 Proteína quimérica isolada, vetor, método para produzir a proteína quimérica isolada e composição

Country Status (22)

Country Link
US (4) US9926544B2 (pt)
EP (2) EP3425048A1 (pt)
JP (3) JP6940949B2 (pt)
KR (1) KR102166110B1 (pt)
CN (2) CN106164262B (pt)
AU (1) AU2015209783B2 (pt)
BR (1) BR112016017041B1 (pt)
CA (1) CA2937328C (pt)
DK (1) DK3097189T3 (pt)
ES (1) ES2684639T3 (pt)
HU (1) HUE039784T2 (pt)
IL (1) IL246898B (pt)
MX (1) MX369041B (pt)
PE (1) PE20161442A1 (pt)
PH (1) PH12016501441B1 (pt)
PL (1) PL3097189T3 (pt)
RU (1) RU2683635C2 (pt)
SA (1) SA516371532B1 (pt)
SG (1) SG11201606060WA (pt)
SI (1) SI3097189T1 (pt)
WO (1) WO2015112017A1 (pt)
ZA (1) ZA201605028B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3425048A1 (en) 2014-01-24 2019-01-09 AM-Pharma B.V. Chimeric alkaline phosphatase-like proteins
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
WO2016090251A1 (en) 2014-12-05 2016-06-09 Alexion Pharmaceuticals, Inc. Treating seizure with recombinant alkaline phosphatase
JP6868561B2 (ja) 2015-01-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼ欠損を有する被験者を治療する方法
RU2745528C2 (ru) * 2015-08-17 2021-03-26 Алексион Фармасьютикалз, Инк. Производство щелочных фосфатаз
EP3368062A4 (en) 2015-10-30 2019-07-03 Alexion Pharmaceuticals, Inc. METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
US11186832B2 (en) 2016-04-01 2021-11-30 Alexion Pharmaceuticals, Inc. Treating muscle weakness with alkaline phosphatases
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
EP3345614A1 (en) * 2017-01-05 2018-07-11 Amrif B.V. Composition comprising alkaline phosphatase for use in the treatment of arthritides
AU2018243320B2 (en) * 2017-03-31 2025-03-27 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia (HPP) in adults and adolescents
US11338020B2 (en) 2018-01-09 2022-05-24 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
RU2020129445A (ru) 2018-03-08 2022-04-08 Ам-Фарма Б.В. Рекомбинантная щелочная фосфатаза для применения при лечении связанного с сепсисом острого повреждения почек
US11654184B2 (en) 2018-03-20 2023-05-23 Theriva Biologics, Inc. Alkaline phosphatase agents for treatment of radiation disorders
CA3094173A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Intestinal alkaline phosphatase formulations
JP2021519590A (ja) 2018-03-30 2021-08-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド 糖タンパク質の製造
CN110499283A (zh) * 2018-05-17 2019-11-26 西安组织工程与再生医学研究所 Wnt信号通路激活剂在制备改善低碱性磷酸酯酶症干细胞成骨分化能力异常产品中的应用
WO2020033867A2 (en) 2018-08-10 2020-02-13 Alexion Pharmaceuticals, Inc. Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
CN113993541A (zh) 2019-05-06 2022-01-28 合成生物制品有限公司 基于碱性磷酸酶的肿瘤学治疗
CN111110835A (zh) * 2020-01-22 2020-05-08 李鑫荣 一种肠碱性磷酸酶的新应用及其制剂的细胞活性检测方法
US20240009280A1 (en) 2020-09-09 2024-01-11 Am-Pharma B.V. Recombinant alkaline phosphatase for use in treating acute respiratory distress syndrome
AU2022218782A1 (en) 2021-02-12 2023-08-17 Alexion Pharmaceuticals, Inc. Alkaline phosphatase polypeptides and methods of use thereof
CN118580341B (zh) * 2024-06-24 2025-03-18 浙江大学 一种寄生线虫spi-i8蛋白及其在防治炎症疾病中的应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
EP0441252B1 (en) 1990-02-07 1997-09-03 Abbott Laboratories Alkaline phosphatase enzymes having improved specific activity for use in indicator reagents
DK0584343T3 (da) 1992-03-10 1999-09-13 Jolla Cancer Res Found Rekombinant alkalisk phosphatase fra kalvetarme
JPH06284885A (ja) * 1993-04-02 1994-10-11 Tosoh Corp 組換えヒト小腸アルカリフォスファタ−ゼ
EP0701441A1 (en) 1993-06-01 1996-03-20 Cortex Pharmaceuticals, Inc. Alkaline and acid phosphatase inhibitors in treatment of neurological disorders
AU4835693A (en) 1993-08-13 1995-03-14 Rijksuniversiteit Te Groningen Pharmaceutical composition comprising phosphatase or a derivative thereof
EP0732933B1 (en) 1993-11-15 2002-10-09 Celtrix Pharmaceuticals, Inc. Use of igf-1 and igfbp-3 in the manufacture of a medicament for treating a renal disorder
WO1996039203A1 (en) 1995-06-06 1996-12-12 Gensci Regeneration Laboratories, Inc. Modified osteogenic materials
FR2736065B1 (fr) 1995-06-29 1997-09-19 Commissariat Energie Atomique Phosphatases alcalines bacteriennes modifiees et leurs applications.
JP3488327B2 (ja) 1995-12-21 2004-01-19 よつ葉乳業株式会社 牛乳脂肪球膜含有画分の製造法
US20020114802A1 (en) 1998-02-10 2002-08-22 Tjellstrom Bo Arthur Einar Oral immunoglobulin treatment for inflammatory bowel disease
DE19819962A1 (de) 1998-05-05 1999-11-11 Roche Diagnostics Gmbh Hochaktive alkalische Phosphatase
EP1141717A1 (en) 1998-12-21 2001-10-10 Stichting voor de Technische Wetenschappen Diagnosis of sepsis using the lps-binding moiety of alkaline phosphatase
JP2000350596A (ja) 1999-06-11 2000-12-19 Toyobo Co Ltd 分泌性アルカリフォスファターゼの選択的活性測定方法
EP1132086B1 (en) 2000-01-31 2006-05-31 Pfizer Products Inc. Use of prostaglandin (PGE2) receptor 4 (EP4) selective agonists for the treatment of acute and chronic renal failure
AU2001272761A1 (en) 2000-07-19 2002-01-30 Mitsubishi Pharma Corporation Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
EP1191097A1 (en) 2000-09-21 2002-03-27 Leids Universitair Medisch Centrum Induction of exon skipping in eukaryotic cells
DE10101793A1 (de) 2001-01-17 2002-08-01 Manfred Nilius Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen
CA2434362A1 (en) 2001-01-20 2002-07-25 Cardion Ag Pluripotent adult stem cells derived from regenerative tissue
JP4238726B2 (ja) 2001-06-01 2009-03-18 味の素株式会社 腸疾患用の薬剤
US7157260B2 (en) 2001-07-26 2007-01-02 Japan Science & Technology Agency Nicotianamine synthase and gene encoding the same
JP4169966B2 (ja) 2001-11-14 2008-10-22 株式会社ヤクルト本社 炎症性腸疾患予防治療剤
CN1425766A (zh) 2001-12-19 2003-06-25 复旦大学 一种多肽——人含碱性磷酸酶活性位点的蛋白－9.24和编码这种多肽的多核苷酸
CA2503621A1 (en) * 2002-11-13 2004-05-27 Genentech, Inc. Methods and compositions for diagnosing dysplasia
US7048914B2 (en) 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
AU2003295264A1 (en) * 2002-12-23 2004-07-14 Rijksuniversiteit Groningen Modulation of the thioredoxin pathway
CA2524255C (en) 2003-03-21 2014-02-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
JP4305071B2 (ja) 2003-06-30 2009-07-29 株式会社ニコン 信号補正方法
JP2005065564A (ja) 2003-08-22 2005-03-17 Hiroshi Ueda センサー蛋白質
US7157261B2 (en) 2003-10-27 2007-01-02 Canji, Inc. Rat secreted embryonic alkaline phosphatase
US20110142817A1 (en) 2004-02-04 2011-06-16 Pharmaaware Sepsis B.V. Means and method for treating and/or preventing necrotizing enterocolitis
ES2624905T3 (es) 2004-02-04 2017-07-18 Am-Pharma B.V. Uso de fosfatasa alcalina para la desintoxicación de LPS
AU2006220772A1 (en) 2005-03-04 2006-09-14 Verenium Corporation Nucleic acids and proteins and methods for making and using them
US20070059300A1 (en) 2005-09-12 2007-03-15 Zoltan Laboratories Llc Compounds and compositions to control abnormal cell growth
EP1965830B1 (en) 2005-12-28 2014-05-14 Zoltan Laboratories Llc Use of alkaline phosphatase to maintain healthy tissue mass in mammals
RU2006103770A (ru) * 2006-02-08 2007-08-20 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) (Ru) Высокоактивная бактериальная щелочная фосфатаза и фрагмент днк, кодирующий щелочную фосфатазу
US20070280922A1 (en) 2006-06-06 2007-12-06 Zoltan Kiss Consulting Combinations of human proteins to enhance viability of stem cells and progenitor cells
US7718170B2 (en) 2006-08-21 2010-05-18 Essential Skincare, Llc Alkaline phosphatase compositions to reduce skin cancer
EP1952823A1 (en) 2007-01-30 2008-08-06 AM-Pharma B.V. The use of alkaline phosphatase in the treatment of reduced renal function
WO2008104199A1 (en) 2007-03-01 2008-09-04 Gelato Corporation N.V. Use of ecto-phosphatases for the treatment of (acute) myocardial infarction
EP1985697A1 (en) 2007-04-27 2008-10-29 AM-Pharma B.V. Modified phosphatases
DK2158319T3 (da) * 2007-05-11 2012-03-19 Enobia Pharma Inc Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf
EP2030980A1 (en) 2007-08-28 2009-03-04 AM-Pharma B.V. Mutants of lactoferrin
CA2716400C (en) 2008-02-29 2017-05-09 Alloksys Life Sciences B.V. Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases
JP2011521916A (ja) 2008-05-19 2011-07-28 バーナム インスティテュート フォー メディカル リサーチ 腸アルカリホスファターゼモジュレーターおよびそれの使用
WO2010025267A2 (en) 2008-08-29 2010-03-04 The General Hospital Corporation Methods of modulating gastrointestinal tract flora levels with alkaline phosphatase
KR20130118203A (ko) * 2010-04-30 2013-10-29 알렉시온 파마 인터내셔널 에스에이알엘 매트릭스 무기물화 장애의 처리방법, 조성물 및 키트
US20140219984A1 (en) 2011-06-08 2014-08-07 Am-Pharma B.V. The Use of Alkaline Phosphatase for Preserving Renal Function
EP3425048A1 (en) 2014-01-24 2019-01-09 AM-Pharma B.V. Chimeric alkaline phosphatase-like proteins
PT3461891T (pt) 2014-01-24 2020-07-30 Am Pharma Bv Processamento a jusante de uma fosfatase alcalina

Also Published As

Publication number Publication date
JP2020058375A (ja) 2020-04-16
KR20160117487A (ko) 2016-10-10
HUE039784T2 (hu) 2019-02-28
DK3097189T3 (en) 2018-09-03
MX369041B (es) 2019-10-25
ES2684639T3 (es) 2018-10-03
KR102166110B1 (ko) 2020-10-16
EP3425048A1 (en) 2019-01-09
RU2683635C2 (ru) 2019-03-29
US20240174994A1 (en) 2024-05-30
US9926544B2 (en) 2018-03-27
RU2016131879A (ru) 2018-03-01
US20190024062A1 (en) 2019-01-24
NZ722253A (en) 2021-11-26
US20170009216A1 (en) 2017-01-12
JP2022160503A (ja) 2022-10-19
JP7408734B2 (ja) 2024-01-05
CN106164262A (zh) 2016-11-23
ZA201605028B (en) 2020-02-26
BR112016017041B1 (pt) 2023-09-26
EP3097189A1 (en) 2016-11-30
CA2937328C (en) 2022-09-27
CN106164262B (zh) 2020-08-07
CA2937328A1 (en) 2015-07-30
US10822597B2 (en) 2020-11-03
IL246898B (en) 2019-09-26
MX2016009625A (es) 2017-05-01
JP2017505128A (ja) 2017-02-16
SG11201606060WA (en) 2016-08-30
PE20161442A1 (es) 2017-01-12
IL246898A0 (en) 2016-09-29
WO2015112017A1 (en) 2015-07-30
RU2016131879A3 (pt) 2018-08-16
EP3097189B1 (en) 2018-07-11
SI3097189T1 (sl) 2018-10-30
JP6940949B2 (ja) 2021-09-29
US11746340B2 (en) 2023-09-05
AU2015209783B2 (en) 2020-10-01
PL3097189T3 (pl) 2018-11-30
AU2015209783A1 (en) 2016-08-04
PH12016501441A1 (en) 2016-08-22
SA516371532B1 (ar) 2019-02-11
CN111778228A (zh) 2020-10-16
PH12016501441B1 (en) 2023-02-22
US20210163905A1 (en) 2021-06-03

Similar Documents

Publication Publication Date Title
BR112016017041A2 (pt) Proteína isolada tendo atividade de fosfatase, polinucleotídeo, vetor, célula hospedeira, método para produzir uma proteína e composição
MX2022009148A (es) Composiciones y metodos para el tratamiento de hemoglobinopatias.
CL2020002043A1 (es) Métodos y composiciones para la entrega de proteínas terapeuticas.
BR112017020895A2 (pt) inibidores de indolamina-2,3-dioxigenase para o tratamento de câncer
BR112019001607A2 (pt) inibidores macrocíclicos de quinases
BR112017023161A2 (pt) composições de ácido obeticólico e métodos de uso
CL2017001204A1 (es) Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa
PH12016501966B1 (en) Compounds and compositions as toll-like receptor 7 agonists
EA201791867A1 (ru) Бициклические гетероциклы как ингибиторы fgfr4
MX382033B (es) Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
EA201890725A1 (ru) Агонисты фарнезоидного х-рецептора и их применение
BR112017010088A2 (pt) polinucleotídeo modulatório, pré-micro-rna artificial, vírus recombinante de aav, composição compreendendo o plasmídeo ou vetor, kit compreendendo o referido plasmídeo ou vetor e uso do mesmo
BR112016029662A2 (pt) compostos de heteroaril para inibição de quinase
BR112016022855A2 (pt) composições e métodos para modular a expressão de pkk
BR112016030690A2 (pt) moduladores do receptor de arila e métodos de fabricar e usar os mesmos
EA201692201A1 (ru) Соединения и композиции в качестве агонистов toll-подобного рецептора 7
MX2017011997A (es) Carbamatos de piperacina y metodos de preparacion y uso.
BR112017007414A2 (pt) combinações compreendendo siponimod e laquinimod para o tratamento de esclerose múltipla
GT201800102A (es) Polipéptidos que inhiben cd4ol
MX387235B (es) Derivados de pirazolopiridina y su uso en terapia
AR112069A1 (es) Inmunoglobulinas que fijan aggrecan
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
BR112017012504A2 (pt) derivados de piperidina como inibidores de hdac1/2
MX395032B (es) Ciertos inhibidores de la proteína quinasa.
BR112018014540A2 (pt) formulações/composições compreendendo inibidor de btk

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B25G Requested change of headquarter approved

Owner name: AM-PHARMA B.V. (NL)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/01/2015, OBSERVADAS AS CONDICOES LEGAIS