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BR112013022917A2 - derivados 3,4-dihidro-pirrolo[1,2-a]pirazino-1-ilamina úteis como inibidores de beta-secretase (bace) - Google Patents

derivados 3,4-dihidro-pirrolo[1,2-a]pirazino-1-ilamina úteis como inibidores de beta-secretase (bace)

Info

Publication number
BR112013022917A2
BR112013022917A2 BR112013022917A BR112013022917A BR112013022917A2 BR 112013022917 A2 BR112013022917 A2 BR 112013022917A2 BR 112013022917 A BR112013022917 A BR 112013022917A BR 112013022917 A BR112013022917 A BR 112013022917A BR 112013022917 A2 BR112013022917 A2 BR 112013022917A2
Authority
BR
Brazil
Prior art keywords
bace
secretase
pyrrolo
pyrazine
dihydro
Prior art date
Application number
BR112013022917A
Other languages
English (en)
Inventor
Andrés Avelino Trabanco-Suarez
Francisca Delgado-Jiménez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112013022917A2 publication Critical patent/BR112013022917A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR112013022917A 2011-03-09 2012-03-07 derivados 3,4-dihidro-pirrolo[1,2-a]pirazino-1-ilamina úteis como inibidores de beta-secretase (bace) BR112013022917A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11157418 2011-03-09
PCT/EP2012/053863 WO2012120023A1 (en) 2011-03-09 2012-03-07 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

Publications (1)

Publication Number Publication Date
BR112013022917A2 true BR112013022917A2 (pt) 2016-12-06

Family

ID=43833325

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013022917A BR112013022917A2 (pt) 2011-03-09 2012-03-07 derivados 3,4-dihidro-pirrolo[1,2-a]pirazino-1-ilamina úteis como inibidores de beta-secretase (bace)

Country Status (20)

Country Link
US (1) US9845326B2 (pt)
EP (1) EP2683721B1 (pt)
JP (1) JP5853035B2 (pt)
KR (1) KR102012675B1 (pt)
CN (1) CN103415521B (pt)
AU (1) AU2012224632B2 (pt)
BR (1) BR112013022917A2 (pt)
CA (1) CA2825620C (pt)
CL (1) CL2013002511A1 (pt)
CO (1) CO6751283A2 (pt)
EA (1) EA023824B1 (pt)
ES (1) ES2534973T3 (pt)
IL (1) IL228239A (pt)
MX (1) MX340031B (pt)
MY (1) MY163346A (pt)
PH (1) PH12013501805A1 (pt)
SG (1) SG193342A1 (pt)
UA (1) UA109687C2 (pt)
WO (1) WO2012120023A1 (pt)
ZA (1) ZA201306719B (pt)

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KR20170095881A (ko) 2014-12-18 2017-08-23 얀센 파마슈티카 엔.브이. 베타―세크레타제의 ２,３,４,５―테트라히드로피리딘―６―아민 및 ３,４―디히드로―２ｈ―피롤―５―아민 화합물 억제제
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JP2022543106A (ja) 2019-07-30 2022-10-07 エイコニゾ セラピューティクス，インコーポレーテッド Ｈｄａｃ６インヒビターおよびそれらの使用
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KR20170095881A (ko) 2014-12-18 2017-08-23 얀센 파마슈티카 엔.브이. 베타―세크레타제의 ２,３,４,５―테트라히드로피리딘―６―아민 및 ３,４―디히드로―２ｈ―피롤―５―아민 화합물 억제제

Also Published As

Publication number Publication date
EP2683721B1 (en) 2015-01-28
US9845326B2 (en) 2017-12-19
UA109687C2 (xx) 2015-09-25
CO6751283A2 (es) 2013-09-16
JP5853035B2 (ja) 2016-02-09
NZ615720A (en) 2014-08-29
AU2012224632B2 (en) 2016-06-16
MX340031B (es) 2016-06-21
CA2825620A1 (en) 2012-09-13
SG193342A1 (en) 2013-10-30
CL2013002511A1 (es) 2014-01-24
CA2825620C (en) 2019-04-23
CN103415521A (zh) 2013-11-27
ES2534973T3 (es) 2015-04-30
PH12013501805A1 (en) 2013-11-18
US20130345228A1 (en) 2013-12-26
IL228239A0 (en) 2013-11-25
CN103415521B (zh) 2016-01-06
AU2012224632A1 (en) 2013-08-01
EP2683721A1 (en) 2014-01-15
ZA201306719B (en) 2015-04-29
MY163346A (en) 2017-09-15
IL228239A (en) 2016-06-30
JP2014507455A (ja) 2014-03-27
KR20140019332A (ko) 2014-02-14
MX2013010280A (es) 2013-10-01
KR102012675B1 (ko) 2019-08-21
EA023824B1 (ru) 2016-07-29
HK1189223A1 (zh) 2014-05-30
WO2012120023A1 (en) 2012-09-13
EA201391296A1 (ru) 2014-01-30

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