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BR112013018046A2 - peptídeos isolados ou purificados, composição farmacêutica, métodos para bloquear a sinalização por um ou mais membros da família citocina-yc, para inibir a ligação de citocinas-yc a subunidade-yc e para utilizar peptídeos ou derivados dos mesmos ou composição farmacêutica, usos de peptídeos isolados ou purificados ou derivados dos mesmos ou composição farmacêutica - Google Patents

peptídeos isolados ou purificados, composição farmacêutica, métodos para bloquear a sinalização por um ou mais membros da família citocina-yc, para inibir a ligação de citocinas-yc a subunidade-yc e para utilizar peptídeos ou derivados dos mesmos ou composição farmacêutica, usos de peptídeos isolados ou purificados ou derivados dos mesmos ou composição farmacêutica Download PDF

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Publication number
BR112013018046A2
BR112013018046A2 BR112013018046A BR112013018046A BR112013018046A2 BR 112013018046 A2 BR112013018046 A2 BR 112013018046A2 BR 112013018046 A BR112013018046 A BR 112013018046A BR 112013018046 A BR112013018046 A BR 112013018046A BR 112013018046 A2 BR112013018046 A2 BR 112013018046A2
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BR
Brazil
Prior art keywords
cytokine
pharmaceutical composition
interleukin
family
derivatives
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Application number
BR112013018046A
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English (en)
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BR112013018046B1 (pt
Inventor
Azimi Nazli
Tagaya Yutaka
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Bioniz Llc
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Application filed by Bioniz Llc filed Critical Bioniz Llc
Publication of BR112013018046A2 publication Critical patent/BR112013018046A2/pt
Publication of BR112013018046B1 publication Critical patent/BR112013018046B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids

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Abstract

peptídeos isolados ou purificados, composição farmacêutica, métodos para bloquear a sinalização por um ou mais membros da família citocina-yc, para inibir a ligação de citocinas-yc a subunidade-yc e para utilizar peptídeos ou derivados dos mesmos ou composição farmacêutica, usos de peptídeos isolados ou purificados ou derivados dos mesmos ou composição farmacêutica as várias modalidades referem-se a antagonistas peptídicos de citocinas da família-yc, interleucina-2 (il-2), interleucina-4 (il-4), interleucina-7 (il-7), interleucina-9 (il-9), interleucina-15 (il-15), e interleucina-21 (il-21). as citocinas-yc estão associadas a doenças humanas importantes, tais como a leucemia, doenças autoimunes, doenças de colágeno, diabetes mellitus, doenças de pele, doenças neuronais degenerativas e doenca de enxerto-versus-hospedeiro (gvhd). assim, os inibidores da atividade de citocina-yc são agentes terapêuticos e cosméticos valiosos, bem como ferramentas de pesquisa. as abordagens tradicionais para inibir a atividade de citocina-yc envolvem criar anticorpos neutralizantes contra cada membro da família de citocina-yc individual/subunidade de receptor. no entanto, o sucesso tem sido limitado e, muitas vezes, multiplos membros da família citocina-yc cooperam para causar o estado da doença. utilização combinatória de anticorpos neutralizantes criados contra cada fator é impraticável e apresenta um risco aumentado de reações imunes adversas. as presentes modalidades superam estas desvantagens através da utilização de antagonistas de peptídeo com base no sítio de consenso da ligação da subunidade-yc para inibir a actividade da citocina-yc.
BR112013018046-3A 2011-01-18 2012-01-17 Conjugado peptídico, composição farmacêutica, métodos in vitro para bloquear sinalização por um ou mais membros de família citocina-yc e para inibir ligação de citocina-yc a subunidade-yc e uso de conjugado peptídico ou de composição farmacêutica BR112013018046B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161433890P 2011-01-18 2011-01-18
US61/433,890 2011-01-18
US201161527049P 2011-08-24 2011-08-24
US61/527,049 2011-08-24
PCT/US2012/021566 WO2012099886A1 (en) 2011-01-18 2012-01-17 Compositions and mehthods for modulating gamma-c-cytokine activity

Publications (2)

Publication Number Publication Date
BR112013018046A2 true BR112013018046A2 (pt) 2020-01-21
BR112013018046B1 BR112013018046B1 (pt) 2023-01-31

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BR112013018046-3A BR112013018046B1 (pt) 2011-01-18 2012-01-17 Conjugado peptídico, composição farmacêutica, métodos in vitro para bloquear sinalização por um ou mais membros de família citocina-yc e para inibir ligação de citocina-yc a subunidade-yc e uso de conjugado peptídico ou de composição farmacêutica

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US (10) US9133244B2 (pt)
EP (3) EP3636274B1 (pt)
JP (4) JP6395379B2 (pt)
CN (2) CN109021069A (pt)
AU (3) AU2012207456C1 (pt)
BR (1) BR112013018046B1 (pt)
CA (1) CA2824515C (pt)
CY (1) CY1122846T1 (pt)
DK (2) DK2665486T3 (pt)
ES (2) ES2989085T3 (pt)
FI (1) FI3636274T3 (pt)
HR (1) HRP20200470T1 (pt)
LT (1) LT2665486T (pt)
PL (2) PL3636274T3 (pt)
PT (2) PT3636274T (pt)
RS (1) RS60050B1 (pt)
SI (1) SI2665486T1 (pt)
SM (1) SMT202000142T1 (pt)
WO (1) WO2012099886A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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WO2015089217A2 (en) * 2013-12-10 2015-06-18 Bionz, Llc Methods of developing selective peptide antagonists
ES2989085T3 (es) 2011-01-18 2024-11-25 Bioniz Therapeutics Inc Composiciones para modular la actividad de citoquinas gamma-c
CN104789527B (zh) * 2015-05-15 2018-05-29 江苏杰晟生物科技有限公司 一种自体自然杀伤细胞鸡尾酒式培养的制备方法及其试剂盒产品
ES2884357T3 (es) 2015-10-09 2021-12-10 Bioniz Llc Modulación de la actividad de las citocinas gamma-c
EP3453401A4 (en) * 2016-05-06 2020-01-29 Wang, Mulin INTERLEUKIN COMBINATION AND THEIR USE
JP2020513020A (ja) * 2017-04-07 2020-04-30 バイオニズ リミテッド ライアビリティー カンパニー γｃサイトカイン活性の安定な調節剤
CN116850291A (zh) * 2018-07-19 2023-10-10 国立大学法人东京大学 Htlv-1相关性脊髓病（ham）治疗或预防剂、及ham的治疗方法
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