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BR112012026112A2 - método de tratar obesidade usando moduladores de inflamação antioxidantes - Google Patents

método de tratar obesidade usando moduladores de inflamação antioxidantes

Info

Publication number
BR112012026112A2
BR112012026112A2 BR112012026112A BR112012026112A BR112012026112A2 BR 112012026112 A2 BR112012026112 A2 BR 112012026112A2 BR 112012026112 A BR112012026112 A BR 112012026112A BR 112012026112 A BR112012026112 A BR 112012026112A BR 112012026112 A2 BR112012026112 A2 BR 112012026112A2
Authority
BR
Brazil
Prior art keywords
antioxidant inflammation
inflammation modulators
treating obesity
treating
antioxidant
Prior art date
Application number
BR112012026112A
Other languages
English (en)
Other versions
BR112012026112B1 (pt
Inventor
Colin J Meyer
Warren Huff
Original Assignee
Reata Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44259866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012026112(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc
Publication of BR112012026112A2 publication Critical patent/BR112012026112A2/pt
Publication of BR112012026112B1 publication Critical patent/BR112012026112B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

método de tratar obesidade usando moduladores de inflamação antioxidantes. a presente invenção refere-se a métodos de tratar e/ou previnir obesidade compreendendo a administração de moduladores de inflamação antioxidantes descritos aqui, incluindo, por exemplo, bardoxolona metila.
BR112012026112-6A 2010-04-12 2011-04-12 Uso de compostos moduladores de inflamação antioxidantes e composição farmacêutica BR112012026112B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32327610P 2010-04-12 2010-04-12
US61/323,276 2010-04-12
US38909010P 2010-10-01 2010-10-01
US61/389,090 2010-10-01
PCT/US2011/032156 WO2011130302A2 (en) 2010-04-12 2011-04-12 Method of treating obesity using antioxidant inflammation modulators

Publications (2)

Publication Number Publication Date
BR112012026112A2 true BR112012026112A2 (pt) 2016-06-28
BR112012026112B1 BR112012026112B1 (pt) 2020-03-17

Family

ID=44259866

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012026112-6A BR112012026112B1 (pt) 2010-04-12 2011-04-12 Uso de compostos moduladores de inflamação antioxidantes e composição farmacêutica

Country Status (31)

Country Link
US (3) US10105372B2 (pt)
EP (1) EP2558105B1 (pt)
JP (1) JP5990160B2 (pt)
KR (1) KR101819699B1 (pt)
CN (1) CN102939089B (pt)
AU (1) AU2011240690C1 (pt)
BR (1) BR112012026112B1 (pt)
CA (1) CA2795320C (pt)
CL (1) CL2012002859A1 (pt)
CY (1) CY1122480T1 (pt)
DK (1) DK2558105T3 (pt)
EA (1) EA026567B1 (pt)
ES (1) ES2768204T3 (pt)
HR (1) HRP20192291T1 (pt)
HU (1) HUE047994T2 (pt)
IL (1) IL222273B (pt)
LT (1) LT2558105T (pt)
ME (1) ME03713B (pt)
MX (1) MX357596B (pt)
MY (1) MY163031A (pt)
NZ (1) NZ602826A (pt)
PH (1) PH12012502041B1 (pt)
PL (1) PL2558105T3 (pt)
PT (1) PT2558105T (pt)
RS (1) RS59850B1 (pt)
SG (2) SG10201808661XA (pt)
SI (1) SI2558105T1 (pt)
SM (1) SMT202000086T1 (pt)
TW (1) TWI558724B (pt)
WO (1) WO2011130302A2 (pt)
ZA (1) ZA201207518B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US8129429B2 (en) 2008-01-11 2012-03-06 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
NZ588708A (en) 2008-04-18 2012-09-28 Reata Pharmaceuticals Inc 2-cyano steroid derivatives including an anti-inflammatory pharmacore
EA022588B1 (ru) 2008-04-18 2016-01-29 Ритэ Фамэсутикл, Инк. Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце
CA2721838C (en) 2008-04-18 2017-05-23 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
CA2721666C (en) 2008-04-18 2017-05-23 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives
WO2010011782A1 (en) 2008-07-22 2010-01-28 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
LT2558105T (lt) 2010-04-12 2020-02-10 Reata Pharmaceuticals, Inc. Bardoksolono metilas, skirtas nutukimo gydymui
EP2651902B1 (en) 2010-12-17 2017-11-08 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
ES2729405T3 (es) 2011-03-11 2019-11-04 Reata Pharmaceuticals Inc Derivados triterpenoides de C4-monometilo y métodos de uso de los mismos
KR101174701B1 (ko) * 2011-12-29 2012-08-17 서울대학교산학협력단 진저레논 에이를 포함하는 비만 예방용 식품 조성물, 비만 치료용 약학조성물 및 비만 치료용 동물용 의약품
MX357060B (es) 2012-04-27 2018-06-25 Reata Pharmaceuticals Inc Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos.
WO2013188818A1 (en) 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US9593074B2 (en) 2012-09-10 2017-03-14 Reata Pharmaceuticals, Inc. C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
CA2884400A1 (en) * 2012-09-10 2014-03-13 Abbvie Inc. Glycyrrhetinic acid derivatives and methods of use thereof
EP4082541A1 (en) 2012-09-27 2022-11-02 The Children's Medical Center Corporation Compounds for the treatment of obesity and methods of use thereof
JP6328102B2 (ja) 2013-03-19 2018-05-23 第一三共株式会社 テルペノイド誘導体
UY35534A (es) 2013-04-24 2014-10-31 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
WO2015027206A1 (en) * 2013-08-23 2015-02-26 Reata Pharmaceuticals, Inc. Methods of treating and preventing endothelial dysfunction using bardoxololone methyl or analogs thereof
TWI670263B (zh) 2014-01-24 2019-09-01 美商瑞塔醫藥有限責任公司 作為抗氧化發炎調節劑之經芳基及芳基烷基取代之吡唑及嘧啶三環烯酮
US10155003B2 (en) 2014-05-05 2018-12-18 The Board Of Regents Of The University Of Texas System Methods and compositions comprising ursolic acid and/or resveratrol for treating diabetes, or cancer
WO2016039359A1 (ja) 2014-09-10 2016-03-17 第一三共株式会社 眼疾患治療用及び予防用徐放性医薬組成物
EA038328B1 (ru) 2015-02-12 2021-08-10 Рита Фармасьютикалз, Инк. Имидазолильные трициклические еноны как антиоксидантные модуляторы воспаления
CN105017374B (zh) * 2015-07-20 2017-03-01 山西大学 一种齐墩果酸内酯类衍生物及其制备方法和应用
US20170056373A1 (en) * 2015-09-01 2017-03-02 Syracuse University Ghrelin o-acyltransferase inhibitors
CN108290922B (zh) 2015-09-23 2021-12-07 里亚塔医药公司 用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物
KR20190050800A (ko) * 2016-09-08 2019-05-13 레제네라 파마 리미티드 트리테르페노이드를 포함하는 조성물 및 시신경병증을 치료하기 위한 이의 용도
BR112019009256A2 (pt) 2016-11-08 2019-07-16 Reata Pharmaceuticals Inc métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
US11993574B2 (en) 2018-06-15 2024-05-28 Reata Pharmaceuticals, Inc Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma
US12060340B2 (en) 2018-06-20 2024-08-13 Reata Pharmaceuticals, Inc Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith
WO2021016191A1 (en) 2019-07-19 2021-01-28 Reata Pharmaceuticals, Inc. C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof
KR20230017204A (ko) * 2020-04-29 2023-02-03 바이오에이지 랩스, 인코포레이티드 노화-관련 질환 치료용 저산소증-유도 인자 프롤릴 히드록실라제 억제제
WO2024145502A1 (en) * 2022-12-29 2024-07-04 The Board Of Regents Of The University Of Texas System Synthetic triterpenoids and compositions thereof in weight management, skeletal muscle function, and appetite suppression

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191586A (en) 1978-10-10 1981-10-19 Sterling Drug Inc Cyanoketones derived from glycyrrhetinic acid and pharmaceutical compositions
US4395423A (en) 1978-10-10 1983-07-26 Sterling Drug Inc. Polycyclic cyanoketones
US6025395A (en) 1994-04-15 2000-02-15 Duke University Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
DK1178952T5 (da) 1999-05-14 2008-03-17 Univ California Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer
US6890946B2 (en) 1999-12-23 2005-05-10 Indiana University Research And Technology Corporation Use of parthenolide to inhibit cancer
WO2002003996A1 (en) 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
EP1322661A1 (en) 2000-09-29 2003-07-02 Regents Of The University Of Minnesota Triterpenes having fungicidal activity against yeast
US6878751B1 (en) 2000-10-19 2005-04-12 Imperial College Of Science Technology And Medicine Administration of resveratrol to treat inflammatory respiratory disorders
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
CA2430454A1 (en) 2000-11-28 2002-06-20 Board Of Regents, The University Of Texas System Cddo-compounds and combination therapies thereof
JP4391087B2 (ja) * 2001-03-23 2009-12-24 シャイアー カナダ インコーポレイテッド 癌の処置のための薬学的組み合わせ
WO2002092768A2 (en) 2001-05-14 2002-11-21 University Of Maryland, Baltimore Novel alanine transaminase enzyme and methods of use
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
JP2006515859A (ja) 2002-05-13 2006-06-08 トラスティーズ オブ ダートマス カレッジ 阻害剤およびその使用法
EP1457206A1 (en) 2003-03-13 2004-09-15 Fournier Laboratories Ireland Limited Combined use of a fibrate and orlistat for the treatment of obesity
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
RU2005133970A (ru) * 2003-05-09 2007-06-20 Ново Нордиск А/С (DK) Пептиды, применяемые для лечения ожирения
EP1625158A2 (en) 2003-05-09 2006-02-15 Novo Nordisk A/S Peptides for use in treating obesity
EP1633208A1 (en) 2003-05-27 2006-03-15 DSM IP Assets B.V. Novel nutraceutical compositions and use thereof
WO2005042002A2 (en) 2003-10-30 2005-05-12 Entelos, Inc. Treatment of rhematoid arthritis with flip antagonists
WO2005046732A2 (en) 2003-11-04 2005-05-26 THE UNITED SATES OF AMERICA as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES, NIH Methods and compositions for the inhibition of hiv-1 replication
ES2282926T3 (es) 2003-12-22 2007-10-16 Alcon, Inc. Agentes para el tratamiento de la retinopatia glaucomatosa y de la neuropatia optica.
JP2005314381A (ja) 2004-03-30 2005-11-10 Anges Mg Inc 増殖性腎疾患の予防・治療・改善剤
WO2005113761A2 (en) 2004-04-19 2005-12-01 University Of Maryland, Baltimore Novel alanine transaminase enzymes and methods of use
US7772195B2 (en) 2004-07-29 2010-08-10 Board Of Trustees Of Michigan State University Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia
CA2579231C (en) 2004-09-07 2018-07-10 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups
WO2007005879A2 (en) 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
US20070249561A1 (en) 2006-04-25 2007-10-25 Taylor Bradley K Pharmacological method for treatment of neuropathic pain
US8389573B2 (en) 2006-06-27 2013-03-05 Wellington Laboratories Inc. Glycyrrhetinic acid derivatives
WO2008016095A1 (fr) 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE
JP2008110962A (ja) 2006-08-02 2008-05-15 Santen Pharmaceut Co Ltd Nrf2活性化物質を有効成分として含む角結膜障害の予防または治療剤
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP2094651A1 (en) 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
JP2008247898A (ja) 2007-03-08 2008-10-16 Santen Pharmaceut Co Ltd トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
WO2008136838A1 (en) 2007-05-04 2008-11-13 Trustees Of Dartmouth College Novel amide derivatives of cddo and methods of use thereof
US8088824B2 (en) 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
WO2009023845A2 (en) 2007-08-15 2009-02-19 The Board Of Regents Of The University Of Texas System Combination therapy with synthetic triterpenoids and gemcitabine
WO2009058849A1 (en) 2007-10-29 2009-05-07 University Of Rochester Use of electrophilic compounds for inducing platelet production or maintaining platelet function
US8129429B2 (en) * 2008-01-11 2012-03-06 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
EA022588B1 (ru) * 2008-04-18 2016-01-29 Ритэ Фамэсутикл, Инк. Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце
CA2721666C (en) 2008-04-18 2017-05-23 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives
CA2721838C (en) 2008-04-18 2017-05-23 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
NZ588708A (en) 2008-04-18 2012-09-28 Reata Pharmaceuticals Inc 2-cyano steroid derivatives including an anti-inflammatory pharmacore
US8071632B2 (en) * 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
WO2010011782A1 (en) 2008-07-22 2010-01-28 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
MY173715A (en) 2009-02-13 2020-02-18 Reata Pharmaceuticals Inc Delayed release, oral dosage compositions that contain amorphous cddo-me
LT2558105T (lt) * 2010-04-12 2020-02-10 Reata Pharmaceuticals, Inc. Bardoksolono metilas, skirtas nutukimo gydymui
US8618125B2 (en) 2011-01-14 2013-12-31 Heptiva LLC Composition comprising hepatic therapeutic active for treating liver diseases, certain cancers and liver health maintenance
CN102875634B (zh) 2012-10-24 2014-08-20 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯的几种晶型
CN102887936A (zh) 2012-10-24 2013-01-23 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯晶型

Also Published As

Publication number Publication date
KR101819699B1 (ko) 2018-01-17
AU2011240690B2 (en) 2014-06-19
SMT202000086T1 (it) 2020-03-13
LT2558105T (lt) 2020-02-10
AU2011240690C1 (en) 2014-11-06
HRP20192291T1 (hr) 2020-03-20
SG10201808661XA (en) 2018-11-29
US20110281955A1 (en) 2011-11-17
KR20130096635A (ko) 2013-08-30
EP2558105A2 (en) 2013-02-20
US11911395B2 (en) 2024-02-27
PT2558105T (pt) 2020-01-30
US20240335457A1 (en) 2024-10-10
CN102939089B (zh) 2018-04-10
MY163031A (en) 2017-07-31
CA2795320C (en) 2019-01-22
PH12012502041A1 (en) 2013-01-21
NZ602826A (en) 2014-11-28
JP5990160B2 (ja) 2016-09-07
PL2558105T3 (pl) 2020-04-30
SI2558105T1 (sl) 2020-02-28
EA201291031A1 (ru) 2013-04-30
MX357596B (es) 2018-07-16
CY1122480T1 (el) 2021-01-27
TWI558724B (zh) 2016-11-21
WO2011130302A3 (en) 2012-01-05
SG184830A1 (en) 2012-11-29
CL2012002859A1 (es) 2013-08-02
AU2011240690A1 (en) 2012-10-25
IL222273A0 (en) 2012-12-31
ZA201207518B (en) 2017-08-30
IL222273B (en) 2019-03-31
BR112012026112B1 (pt) 2020-03-17
CA2795320A1 (en) 2011-10-20
HUE047994T2 (hu) 2020-05-28
MX2012011892A (es) 2012-11-30
ES2768204T3 (es) 2020-06-22
WO2011130302A2 (en) 2011-10-20
PH12012502041B1 (en) 2020-02-26
EA026567B1 (ru) 2017-04-28
TW201139458A (en) 2011-11-16
CN102939089A (zh) 2013-02-20
US20190076443A1 (en) 2019-03-14
DK2558105T3 (da) 2020-01-27
RS59850B1 (sr) 2020-02-28
EP2558105B1 (en) 2019-11-20
ME03713B (me) 2021-01-20
US10105372B2 (en) 2018-10-23
JP2013523888A (ja) 2013-06-17

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