BR112012019286A2 - bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other uses - Google Patents
bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other usesInfo
- Publication number
- BR112012019286A2 BR112012019286A2 BR112012019286A BR112012019286A BR112012019286A2 BR 112012019286 A2 BR112012019286 A2 BR 112012019286A2 BR 112012019286 A BR112012019286 A BR 112012019286A BR 112012019286 A BR112012019286 A BR 112012019286A BR 112012019286 A2 BR112012019286 A2 BR 112012019286A2
- Authority
- BR
- Brazil
- Prior art keywords
- certain
- antiseptic
- compositions
- treatment
- bismuththiols
- Prior art date
Links
- 230000002421 anti-septic effect Effects 0.000 title abstract 3
- 230000001580 bacterial effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- BIGYLAKFCGVRAN-UHFFFAOYSA-N 1,3,4-thiadiazolidine-2,5-dithione Chemical compound S=C1NNC(=S)S1 BIGYLAKFCGVRAN-UHFFFAOYSA-N 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003214 anti-biofilm Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
bismuto-tióis como antisséptico para usos biomédicos, que incluem tratamento de biofilmes bacterianos e outros usos. trata-se de composições e métodos, que incluem novas suspensões de microparticulado homogêneas, para o tratamento de superfícies naturais que contêm biofilme bacteriano, que incluem efeitos inesperados de intensificação ou sinergia entre os compostos de bismuto-tiol (bt) e determinados antibióticos, para fornecer formulações que incluem formulações de antisséptico. as propriedades antibacterianas e as propriedades anti-biofilme anteriormente imprevistas dos compostos de bt e combinações de composto de bt-mais-antibiótico apresentadas também são descritas, que incluem eficácias preferenciais de determinadas tais composições para o tratamento de determinadas infecções bacterianas gram-positivas e diferentes eficácias preferenciais de determinadas tais composições para o tratamento de determinadas infecções bacterianas gram-negativas.bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other uses. These are compositions and methods, including novel homogeneous microparticulate suspensions, for treating natural surfaces containing bacterial biofilm, which include unexpected effects of intensification or synergy between bismuth-thiol (bt) compounds and certain antibiotics to provide formulations that include antiseptic formulations. The previously unanticipated antibacterial properties and anti-biofilm properties of the bt compounds and combinations of bt-plus-antibiotic compound presented are also described, which include preferential efficiencies of certain such compositions for the treatment of certain gram-positive and different bacterial infections. Preferred efficiencies of certain such compositions for the treatment of certain gram-negative bacterial infections.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/023108 WO2010091124A2 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
| US37318810P | 2010-08-12 | 2010-08-12 | |
| PCT/US2011/023549 WO2011097347A2 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012019286A2 true BR112012019286A2 (en) | 2018-06-26 |
Family
ID=44356067
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012019286A BR112012019286A2 (en) | 2010-02-03 | 2011-02-03 | bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other uses |
| BR112013003127A BR112013003127A2 (en) | 2010-08-12 | 2011-08-11 | bismuththiols as antiseptics for agricultural, industrial and other uses |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013003127A BR112013003127A2 (en) | 2010-08-12 | 2011-08-11 | bismuththiols as antiseptics for agricultural, industrial and other uses |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP2603083A4 (en) |
| JP (7) | JP2013535506A (en) |
| KR (6) | KR20200015814A (en) |
| CN (2) | CN103096720B (en) |
| AU (3) | AU2011289338B2 (en) |
| BR (2) | BR112012019286A2 (en) |
| CA (1) | CA2807993C (en) |
| CL (2) | CL2013000430A1 (en) |
| IL (3) | IL224684A (en) |
| MX (4) | MX371047B (en) |
| NZ (1) | NZ606634A (en) |
| PH (2) | PH12013500267A1 (en) |
| RU (2) | RU2018108411A (en) |
| SG (3) | SG187801A1 (en) |
| UA (1) | UA113616C2 (en) |
| WO (1) | WO2012021754A2 (en) |
| ZA (1) | ZA201301841B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2393491B1 (en) | 2009-02-03 | 2020-04-22 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
| US9028878B2 (en) | 2009-02-03 | 2015-05-12 | Microbion Corporation | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
| KR20200015814A (en) * | 2010-02-03 | 2020-02-12 | 마이크로비온 코포레이션 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
| CA2907173A1 (en) * | 2013-03-18 | 2014-09-25 | Theranovis Gmbh & Co. Kg | Composition for oral care |
| RU2525200C1 (en) * | 2013-04-09 | 2014-08-10 | Алексей Георгиевич Бородкин | Agent for protection and repair of wound of trees |
| KR101703732B1 (en) * | 2013-11-07 | 2017-02-07 | (주)아모레퍼시픽 | Anti-inflammatory composition containing enzymated camellia japonica seed oil |
| WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
| BR112020004156A2 (en) | 2017-08-30 | 2020-09-08 | Nobio Ltd. | antimicrobial particles and methods of applying them |
| CN107950536A (en) * | 2017-12-04 | 2018-04-24 | 刘志伟 | A kind of bactericidal composition containing Bravo |
| CN108839186B (en) * | 2018-05-15 | 2021-02-26 | 阜南县金威工艺品有限公司 | Mildew-proof treatment method for mulberry twig woven product |
| JP2021533194A (en) | 2018-07-31 | 2021-12-02 | マイクロビオン コーポレーション | Bismuth thiol composition and how to treat wounds |
| BR112021001731A2 (en) | 2018-07-31 | 2021-04-27 | Microbion Corporation | bismuth-thiol compositions and methods of use |
| KR101990253B1 (en) * | 2018-11-22 | 2019-06-17 | 하봉호 | Container type mushroom growing apparatus |
| CN109997856B (en) * | 2019-04-15 | 2020-11-03 | 广西大学 | Composition of small molecular compound and application thereof |
| KR102126721B1 (en) * | 2019-07-16 | 2020-06-25 | (주)인트론바이오테크놀로지 | Novel Enterobacter aerogenes bacteriophage Ent-AEP-1 and its use for preventing proliferation of Enterobacter aerogenes and Enterobacter cloacae |
| JP7458622B2 (en) * | 2019-09-18 | 2024-04-01 | 学校法人東京農業大学 | Substances that reduce the resistance of antibiotic-resistant microorganisms and methods for reducing the resistance of antibiotic-resistant microorganisms |
| CN110663672B (en) * | 2019-11-13 | 2024-04-26 | 南京林业大学 | Thread-driven root pesticide application head |
| US11479655B2 (en) * | 2020-01-15 | 2022-10-25 | The Boeing Company | Compositions for use with polysulfide sealants and related methods |
| KR102197719B1 (en) | 2020-05-07 | 2021-01-04 | 곽태진 | Cuttlefish breeding system |
| CN111856546B (en) * | 2020-06-23 | 2022-07-29 | 中国辐射防护研究院 | Sample preparation method for radiochemical analysis of Cs-137 in marine organism ash |
| CN113969300B (en) * | 2020-07-23 | 2024-08-23 | 禾美生物科技(浙江)有限公司 | Eucalyptus leaf composite active extract process and antibacterial application thereof |
| CN112640907B (en) * | 2021-01-19 | 2021-11-16 | 西南大学 | New application of lipoic acid for inhibiting plant fungal pathogens and method for preventing and controlling postharvest fungal diseases of citrus fruits |
| KR102431000B1 (en) * | 2021-07-22 | 2022-08-11 | 농업회사법인 주식회사 아그로비즈 | Composition for an autoimmune builder of plants containing aspirin and benzothiazole, and method of using the same |
| EP4310192A1 (en) * | 2022-07-21 | 2024-01-24 | C4Diagnostics | Method of determining the existence and/or degree of resistance of microorganisms to antimicrobial agents |
| CN115323778B (en) * | 2022-08-16 | 2023-07-18 | 汕头市润丰纺织科技实业有限公司 | Chitosan-I type collagen amino acid composite antibacterial finishing liquid, preparation method thereof and antibacterial fabric |
| TR2022012983A2 (en) * | 2022-08-17 | 2022-09-21 | Marmara Ueniv Strateji Gelis Dai Bsk Muhasebe Birimi | A BIOCOMPATIBLE PRODUCT WITH REPRESENTATIVE AND THERAPEUTIC PROPERTIES FOR BONE DISORDERS AND/OR FRACTURES AND A METHOD FOR OBTAINING THE SUBJECT PRODUCT |
| CN115532295B (en) * | 2022-09-27 | 2023-07-25 | 苏州大学 | Application of Nanomaterials Containing Zn-N-C Active Centers in Removal of Bacterial Biofilms |
| KR102644907B1 (en) * | 2023-12-01 | 2024-03-07 | (주)신용이엔씨 | Eco-friendly grouting composition for ground reinforcement and method of manufacturing the same |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2809971A (en) * | 1955-11-22 | 1957-10-15 | Olin Mathieson | Heavy-metal derivatives of 1-hydroxy-2-pyridinethiones and method of preparing same |
| JP3813644B2 (en) * | 1994-08-29 | 2006-08-23 | 英治 安里 | Bismuth complex and antibacterial agent containing the same |
| US5928671A (en) * | 1995-04-25 | 1999-07-27 | Winthrop University Hospital | Method and composition for inhibiting bacteria |
| US6086921A (en) * | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
| US6017936A (en) * | 1997-03-14 | 2000-01-25 | Arch Chemicals, Inc. | Method for producing particles of pyrithione salts and particles so produced |
| US5999828A (en) * | 1997-03-19 | 1999-12-07 | Qualcomm Incorporated | Multi-user wireless telephone having dual echo cancellers |
| AU2003204105B2 (en) * | 1997-10-28 | 2005-11-17 | Winthrop-University Hospital | Metal/Thiol Biocides |
| WO1999039707A1 (en) * | 1998-02-04 | 1999-08-12 | Winthrop-University Hospital | Metal-thiols as immunomodulating agents |
| US6465015B1 (en) * | 1998-02-24 | 2002-10-15 | Arch Chemicals, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
| TWI245763B (en) * | 1998-04-02 | 2005-12-21 | Janssen Pharmaceutica Nv | Biocidal benzylbiphenyl derivatives |
| US7108861B1 (en) * | 1998-09-23 | 2006-09-19 | Cernofina, Llc | Environmentally benign crop protection agents |
| US6682724B2 (en) * | 1999-02-23 | 2004-01-27 | Arch Chemcials, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
| US6630172B2 (en) * | 2001-01-22 | 2003-10-07 | Kareem I. Batarseh | Microbicidal composition containing potassium sodium tartrate |
| US6582719B2 (en) * | 2001-02-02 | 2003-06-24 | The Trustees Of Columbia University In The City Of New York | Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms |
| JP4357166B2 (en) * | 2002-10-21 | 2009-11-04 | 日揮触媒化成株式会社 | Antibacterial / antifungal / algae-proof composition |
| WO2008043175A1 (en) * | 2006-10-13 | 2008-04-17 | Kane Biotech Inc. | SOLUBLE β-N-ACETYLGLUCOSAMINIDASE BASED ANTIBIOFILM COMPOSITIONS AND USES THEREOF |
| US7381751B2 (en) * | 2003-08-26 | 2008-06-03 | Shantha Sarangapani | Antimicrobial composition for medical articles |
| KR101153785B1 (en) * | 2004-10-25 | 2012-07-09 | 셀로노바 바이오사이언시스 저머니 게엠베하 | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
| JP4568232B2 (en) * | 2006-01-06 | 2010-10-27 | 秀和 西松 | Artificial bone head holder |
| JP2007332040A (en) * | 2006-06-12 | 2007-12-27 | Shinshu Univ | Antibacterial agent containing carbon nanotube, and material and preparation using the same |
| AU2008207864B2 (en) * | 2007-01-24 | 2013-07-11 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
| US8343536B2 (en) * | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
| AU2008254484B2 (en) * | 2007-05-18 | 2013-11-28 | Sciessent, Llc | Bioactive agrichemical compositions and use thereof |
| JP5642540B2 (en) * | 2007-06-01 | 2014-12-17 | アロウ・インターナショナル・インコーポレイテッドＡｒｒｏｗ Ｉｎｔｅｒｎａｔｉｏｎａｌ， Ｉｎｃ． | Combined fibrinolytic and antimicrobial catheter and use thereof |
| EP2545906B1 (en) * | 2007-07-25 | 2017-04-19 | Boston Scientific Limited | Colour-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and colour-coded syringe comprising the same |
| EP2393491B1 (en) * | 2009-02-03 | 2020-04-22 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
| KR20200015814A (en) * | 2010-02-03 | 2020-02-12 | 마이크로비온 코포레이션 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
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