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BR0312358A - Derivados de pirimidina 2,5-substituìda como antagonistas ix de receptor de ccr-3 - Google Patents

Derivados de pirimidina 2,5-substituìda como antagonistas ix de receptor de ccr-3

Info

Publication number
BR0312358A
BR0312358A BR0312358-8A BR0312358A BR0312358A BR 0312358 A BR0312358 A BR 0312358A BR 0312358 A BR0312358 A BR 0312358A BR 0312358 A BR0312358 A BR 0312358A
Authority
BR
Brazil
Prior art keywords
ccr
receptor antagonists
pyrimidine derivatives
substituted pyrimidine
substituted
Prior art date
Application number
BR0312358-8A
Other languages
English (en)
Inventor
Daisy Joe Du Bois
Long Mao
Daniel Harry Rogers
John Patrick Williams
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0312358A publication Critical patent/BR0312358A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE PIRIMIDINA 2,5-SUBSTITUìDA COMO ANTAGONISTAS IX DE RECEPTOR DE CCR-3". A presente invenção refere-se a derivados de pirimidina de fórmula (I): em que Ar^ 1^, Ar^ 2^, R^ 1^-R^ 5^, X, Z e alk são como definidos no relatório. Os compostos são utilizáveis como antagonistas de receptor de CCR-3 e assim podem ser usados para o tratamento de doenças mediadas por CCR-3.
BR0312358-8A 2002-07-02 2003-06-25 Derivados de pirimidina 2,5-substituìda como antagonistas ix de receptor de ccr-3 BR0312358A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39352402P 2002-07-02 2002-07-02
PCT/EP2003/006698 WO2004004731A1 (en) 2002-07-02 2003-06-25 2, 5-substituted pyrimidine derivatives as ccr-3 receptor antagonists ix

Publications (1)

Publication Number Publication Date
BR0312358A true BR0312358A (pt) 2005-04-05

Family

ID=30115597

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312358-8A BR0312358A (pt) 2002-07-02 2003-06-25 Derivados de pirimidina 2,5-substituìda como antagonistas ix de receptor de ccr-3

Country Status (11)

Country Link
US (1) US6984643B2 (pt)
EP (1) EP1521582A1 (pt)
JP (1) JP2006502107A (pt)
CN (1) CN1665506A (pt)
AU (1) AU2003246587A1 (pt)
BR (1) BR0312358A (pt)
CA (1) CA2490148A1 (pt)
MX (1) MXPA04012345A (pt)
PL (1) PL375263A1 (pt)
RU (1) RU2005102586A (pt)
WO (1) WO2004004731A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2396419T3 (es) * 2004-09-08 2013-02-21 Mitsubishi Tanabe Pharma Corporation Compuestos de morfolina para el tratamiento de inflamaciones
HUP0500879A2 (en) 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
TWI444379B (zh) * 2007-06-29 2014-07-11 Sunesis Pharmaceuticals Inc 有用於作為Ｒａｆ激酶抑制劑之化合物
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
CN102659796B (zh) * 2012-04-05 2014-10-08 北京师范大学 氟-18标记的螺环哌啶类sigma-1受体化合物及制备方法和应用
EP3050574B1 (en) 2015-01-28 2019-10-09 Universite De Bordeaux Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease
US12221463B2 (en) 2020-08-07 2025-02-11 The Board Of Regents Of The University Of Oklahoma Method of promoting wound healing by inhibiting CCR3
CN113683571B (zh) * 2021-08-30 2023-02-28 上海日异生物科技有限公司 一种2-甲基-5-溴嘧啶的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716166A (en) * 1986-10-21 1987-12-29 American Home Products Corporation Histamine H1 antagonists
DE69408750T2 (de) 1993-08-26 1998-07-23 Ono Pharmaceutical Co 4-Aminopyrimidin Derivate
CA2250231A1 (en) 1996-04-03 1997-10-09 Robert P. Gomez Inhibitors of farnesyl-protein transferase
AU706150B2 (en) 1996-04-03 1999-06-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2350903A1 (en) * 1998-11-20 2000-06-02 F. Hoffmann-La Roche Ag Pyrrolidine derivatives-ccr-3 receptor antagonists
JO2308B1 (en) 1999-05-31 2005-09-12 اف. هوفمان- لاروش أيه جي‏ Derivatives of phenylpyrmidine
SK285670B6 (sk) 1999-06-29 2007-06-07 Egis Gy�Gyszergy�R Rt. Deriváty piperazinylalkyltiopyrimidínu, spôsob ich prípravy, ich použitie a farmaceutické kompozície s ich obsahom
WO2001010439A1 (fr) * 1999-08-04 2001-02-15 Teijin Limited Antagonistes d'amine cyclique ccr3

Also Published As

Publication number Publication date
MXPA04012345A (es) 2005-02-25
PL375263A1 (en) 2005-11-28
US20040014775A1 (en) 2004-01-22
RU2005102586A (ru) 2005-09-20
AU2003246587A1 (en) 2004-01-23
CA2490148A1 (en) 2004-01-15
WO2004004731A1 (en) 2004-01-15
CN1665506A (zh) 2005-09-07
US6984643B2 (en) 2006-01-10
EP1521582A1 (en) 2005-04-13
JP2006502107A (ja) 2006-01-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010.