[go: up one dir, main page]

BRPI0407913A - antagonistas receptores de ccr-3 - Google Patents

antagonistas receptores de ccr-3

Info

Publication number
BRPI0407913A
BRPI0407913A BRPI0407913-2A BRPI0407913A BRPI0407913A BR PI0407913 A BRPI0407913 A BR PI0407913A BR PI0407913 A BRPI0407913 A BR PI0407913A BR PI0407913 A BRPI0407913 A BR PI0407913A
Authority
BR
Brazil
Prior art keywords
ccr
receptor antagonists
compounds
useful
formula
Prior art date
Application number
BRPI0407913-2A
Other languages
English (en)
Inventor
Leyi Gong
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0407913A publication Critical patent/BRPI0407913A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"ANTAGONISTAS RECEPTORES DE CCR-3". A presente invenção refere-se a compostos de Fórmula (I), em que Ar, Ar¬ 1¬, R¬ 3-R¬ 5¬, E, F, T, Q e m são como definidos no relatório descritivo. Os compostos são úteis como antagonistas receptores de CCR-3, e portanto, podem ser usados para o tratamento de doenças mediadas por CCR-3.
BRPI0407913-2A 2003-02-27 2004-02-19 antagonistas receptores de ccr-3 BRPI0407913A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45038003P 2003-02-27 2003-02-27
PCT/EP2004/001588 WO2004076448A1 (en) 2003-02-27 2004-02-19 Ccr-3 receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0407913A true BRPI0407913A (pt) 2006-03-01

Family

ID=32927646

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407913-2A BRPI0407913A (pt) 2003-02-27 2004-02-19 antagonistas receptores de ccr-3

Country Status (12)

Country Link
US (3) US7081531B2 (pt)
EP (1) EP1599472A1 (pt)
JP (1) JP2006515340A (pt)
KR (1) KR20050113202A (pt)
CN (1) CN1753891A (pt)
AU (1) AU2004215679A1 (pt)
BR (1) BRPI0407913A (pt)
CA (1) CA2516634A1 (pt)
MX (1) MXPA05009014A (pt)
PL (1) PL378753A1 (pt)
RU (1) RU2005129550A (pt)
WO (1) WO2004076448A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0501956D0 (en) * 2005-01-31 2005-03-09 Arrow Internat Nebulizer formulation
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
EP1931620A1 (en) * 2005-09-22 2008-06-18 Sanofi-Aventis Amino-alkyl-amide derivatives as ccr3 receptor liquids
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
RU2010137862A (ru) * 2008-02-13 2012-03-20 ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) Производное бициклоамина
HUP0800478A2 (en) * 2008-07-31 2010-03-01 Sanofi Aventis Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands
EP2393804B1 (en) 2009-02-06 2014-04-16 Janssen Pharmaceuticals, Inc. Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
ES2431619T3 (es) 2009-05-07 2013-11-27 Janssen Pharmaceuticals, Inc. Derivados de indazol y aza-indazol sustituidos como moduladores de gamma-secretasa
JP2012532912A (ja) 2009-07-15 2012-12-20 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド ガンマセクレターゼモジュレーターとしての置換されたトリアゾールおよびイミダゾール誘導体
AU2011206634B2 (en) 2010-01-15 2014-11-13 Cellzome Limited Novel substituted bicyclic triazole derivatives as gamma secretase modulators
WO2012126984A1 (en) 2011-03-24 2012-09-27 Janssen Pharmaceuticals, Inc. Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
KR101913135B1 (ko) 2011-07-15 2018-10-30 얀센 파마슈티칼즈, 인코포레이티드 감마 세크레타제 조절 인자로서의 신규의 치환 인돌 유도체
EP2850083B1 (en) 2012-05-16 2016-04-27 Janssen Pharmaceuticals, Inc. Substituted 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives useful for the treatment of (inter alia) alzheimer's disease
JP6275161B2 (ja) 2012-12-20 2018-02-07 ヤンセン ファーマシューティカ エヌ．ベー． γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
CN104936958B (zh) 2013-01-17 2019-07-26 詹森药业有限公司 作为γ分泌酶调节剂的新颖的经取代的吡啶并-哌嗪酮衍生物
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
DK3050574T3 (da) 2015-01-28 2020-01-20 Univ Bordeaux Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
US4366154A (en) * 1981-11-09 1982-12-28 Sandoz, Inc. Tropyl derivatives
WO1994022846A1 (en) 1993-03-30 1994-10-13 Pfizer Inc. Compounds enhancing antitumor activity of other cytotoxic agents
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
KR20010087395A (ko) * 1998-11-17 2001-09-15 프리돌린 클라우스너, 롤란드 비. 보레르 4-아로일-피페리딘-씨씨알-3 수용체 길항물질 3
TR200101397T2 (tr) * 1998-11-20 2001-11-21 F.Hoffmann-La Roche Ag Piperidin CCR-3 reseptörü antagonistleri
US6331541B1 (en) * 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1220840A2 (en) * 1999-10-15 2002-07-10 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
WO2002026708A1 (en) * 2000-09-27 2002-04-04 Toray Industries, Inc. Nitrogen-containing compounds and ccr3 inhibitors containing the same as the active ingredient

Also Published As

Publication number Publication date
US20060194790A1 (en) 2006-08-31
CA2516634A1 (en) 2004-09-10
PL378753A1 (pl) 2006-05-15
US20040176416A1 (en) 2004-09-09
KR20050113202A (ko) 2005-12-01
MXPA05009014A (es) 2005-10-18
US7081531B2 (en) 2006-07-25
WO2004076448A1 (en) 2004-09-10
RU2005129550A (ru) 2006-07-27
JP2006515340A (ja) 2006-05-25
US20060189596A1 (en) 2006-08-24
CN1753891A (zh) 2006-03-29
AU2004215679A1 (en) 2004-09-10
EP1599472A1 (en) 2005-11-30

Similar Documents

Publication Publication Date Title
BRPI0407913A (pt) antagonistas receptores de ccr-3
NL300933I2 (nl) Letermovir
BRPI0412347A (pt) 2-aminofenil-4-fenilpiridinas como inibidores de quinase
BR0307351A (pt) Composto, composição farmacêutica, método para tratar uma condição ou estado de doença mediados pela atividade de p38 quinase ou mediados por citocinas produzidas pela atividade de p38 quinase, uso de um composto, e, processo para preparar um composto
EA200802213A1 (ru) Способы лечения заболеваний крови
UY27872A1 (es) Inhibidores de caspasa y usos de los mismos.
UY29246A1 (es) Nuevos compuestos
ATE482213T1 (de) Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine
BRPI0514841A (pt) inibidores de piridila da sinalização de hedgehog, processo de preparação dos mesmos e composição compreendendo os referidos inibidores
BR0314379A (pt) Quinazolinonas espirocondensadas e a sua utilização como inibidores de fosfodiesterase
BRPI0410760A (pt) compostos, processo para fabricação dos mesmos, composições farmacêuticas e uso deste compostos
EA200802054A1 (ru) Ингибиторы фермента
SE0401762D0 (sv) Novel compounds
MX2007003108A (es) Compuestos imidazo-3-il-amina sustituidos y biciclicos.
IS8485A (is) Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki
UA99485C2 (ru) Хиназолиндионовые производные, их получение и их применение в терапии
UA83875C2 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
BRPI0409454A (pt) compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com o receptor de glucagon e sua utilização
BR0318278A (pt) compostos de éter aminocicloexìlico e usos dos mesmo
DK1789398T3 (da) 2-amino-quinazolin derivater anvendelige som inhibitorer af B-sekretase (BACE)
TW200740787A (en) (6-Fluoro-benzo[1,3]dioxolyl)-morpholin-4-yl-methanones
BRPI0409580A (pt) compostos de quinazolina
BRPI0315644B8 (pt) compostos de piperazinil e diazapanil benzamidas e benzotioamidas, suas composições e respectivos usos
BRPI0508051A (pt) derivados de heteroarilaminopirazol utilizáveis para o tratamento de diabetes
BR0316723A (pt) Derivados de anilinopirazol úteis para o tratamento de diabetes

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired