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BR0213172A - Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico - Google Patents

Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico

Info

Publication number
BR0213172A
BR0213172A BR0213172-2A BR0213172A BR0213172A BR 0213172 A BR0213172 A BR 0213172A BR 0213172 A BR0213172 A BR 0213172A BR 0213172 A BR0213172 A BR 0213172A
Authority
BR
Brazil
Prior art keywords
lower alkyl
pyridine
amino
carboxylic acid
acid amide
Prior art date
Application number
BR0213172-2A
Other languages
English (en)
Inventor
Matthias Heinrich Nettekoven
Sebastien Schmitt
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0213172A publication Critical patent/BR0213172A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"AMIDA DO áCIDO 8-AMINO-[1,2,4]TRIAZOLO[1,5-a] PIRIDINA-6-CARBOXìLICO". A invenção refere-se a compostos de fórmula (I), onde R^ 1^ é -NR<39>R" onde R<39>e R" são independentemente entre si, alquila inferior, -(CH~ 2~)~ n~C(O)NR^ a^R^ b^-(CH~ 2~)~ n~-heteroarila, (CH~ 2~)~ n~-arila, -(CH~ 2~)~ n~-CN, -(CH~ 2~)~ n~-O-alquila inferior ou -(CH~ 2~)~ n~-cicloalquila, ou R<39> e R" formam, juntamente com o átomo de nitrogênio, um anel não aromático de cinco ou seis membros que pode conter um heteroátomo O ou S adicional e cujos anéis podem ser não substituídos ou substituídos com um ou dois substituintes, selecionados dentre o grupo alquila inferior, -C(O)NR^ A^ R^ b^ ou -(CH~ 2~)~ n~-O-alquila inferior e R^ aR^ b^ são independentemente entre si, hidrogênio ou alquila inferior, R^ 2^ é arila ou heteroarila, substituída ou não substituída com alquila inferior ou halogênio. n é 0, 1, 2 ou 3, e a seus sais farmaceuticamente aceitáveis. Os compostos são de utilidade no tratamento de doenças associadas com o receptor A~ 2~ de adenosina.
BR0213172-2A 2001-10-08 2002-10-04 Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico BR0213172A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01123948 2001-10-08
PCT/EP2002/011152 WO2003030904A1 (en) 2001-10-08 2002-10-04 8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide

Publications (1)

Publication Number Publication Date
BR0213172A true BR0213172A (pt) 2004-09-14

Family

ID=8178876

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213172-2A BR0213172A (pt) 2001-10-08 2002-10-04 Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico

Country Status (13)

Country Link
US (1) US6689790B2 (pt)
EP (1) EP1435952A1 (pt)
JP (1) JP4101755B2 (pt)
KR (1) KR100614486B1 (pt)
CN (1) CN1564686A (pt)
AR (1) AR036734A1 (pt)
AU (1) AU2002347055B2 (pt)
BR (1) BR0213172A (pt)
CA (1) CA2462806A1 (pt)
MX (1) MXPA04003277A (pt)
PL (1) PL370067A1 (pt)
RU (1) RU2296763C2 (pt)
WO (1) WO2003030904A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009259867A1 (en) * 2008-06-20 2009-12-23 Genentech, Inc. Triazolopyridine JAK inhibitor compounds and methods
US20100048557A1 (en) * 2008-06-20 2010-02-25 Bing-Yan Zhu Triazolopyridine JAK Inhibitor Compounds and Methods
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
NZ598242A (en) * 2009-07-17 2013-09-27 Japan Tobacco Inc Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer
CA2858778A1 (en) * 2012-02-09 2013-08-15 F. Hoffmann-La Roche Ag Process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives
US9048427B2 (en) * 2013-03-06 2015-06-02 National Tsing Hua University Thin film fabrication of rubber material with piezoelectric characteristics
KR20160015211A (ko) * 2013-05-31 2016-02-12 닛산 가가쿠 고교 가부시키 가이샤 복소환 아미드 화합물
CN104370807B (zh) * 2014-11-13 2016-10-05 安徽星宇化工有限公司 一种6-羟基-5-硝基烟酸的合成方法及其分离提纯方法
US11472811B2 (en) 2018-04-08 2022-10-18 Beigene, Ltd. Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist
CN110742893B (zh) * 2018-07-23 2024-04-05 百济神州(北京)生物科技有限公司 A2a受体拮抗剂治疗癌症的方法
JP7399589B2 (ja) * 2018-09-12 2023-12-18 日本化薬株式会社 有害生物防除剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE287263C (pt) *
DE69820866T2 (de) * 1997-03-24 2004-12-30 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
US6506772B1 (en) * 2000-12-15 2003-01-14 Hoffmann-La Roche Inc. Substituted [1,2,4]triazolo[1,5a]pyridine derivatives with activity as adenosine receptor ligands

Also Published As

Publication number Publication date
CN1564686A (zh) 2005-01-12
CA2462806A1 (en) 2003-04-17
AU2002347055B2 (en) 2006-10-12
EP1435952A1 (en) 2004-07-14
RU2296763C2 (ru) 2007-04-10
WO2003030904A1 (en) 2003-04-17
KR20040048940A (ko) 2004-06-10
JP4101755B2 (ja) 2008-06-18
KR100614486B1 (ko) 2006-08-22
PL370067A1 (en) 2005-05-16
RU2004114278A (ru) 2005-10-27
JP2005508942A (ja) 2005-04-07
AR036734A1 (es) 2004-09-29
US20030207911A1 (en) 2003-11-06
US6689790B2 (en) 2004-02-10
MXPA04003277A (es) 2004-07-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE A 8.6, DA RPI 2108 DE 31/05/2011.