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BR0210216A - Holotoxina do cólera imunogênica, mutante (ct-crm), composição imunogênica, métodos para aumentar a resposta imune de um hospedeiro vertebrado a um antìgeno, e para produzir uma holotoxina do cólera imunogênica, mutante, sequência ou molécula de ácido nucleico isolado e purificado, célula hospedeira, e, uso de uma holotoxina do cólera mutante - Google Patents

Holotoxina do cólera imunogênica, mutante (ct-crm), composição imunogênica, métodos para aumentar a resposta imune de um hospedeiro vertebrado a um antìgeno, e para produzir uma holotoxina do cólera imunogênica, mutante, sequência ou molécula de ácido nucleico isolado e purificado, célula hospedeira, e, uso de uma holotoxina do cólera mutante

Info

Publication number
BR0210216A
BR0210216A BR0210216-1A BR0210216A BR0210216A BR 0210216 A BR0210216 A BR 0210216A BR 0210216 A BR0210216 A BR 0210216A BR 0210216 A BR0210216 A BR 0210216A
Authority
BR
Brazil
Prior art keywords
mutant
immunogenic
cholera holotoxin
holotoxin
immune response
Prior art date
Application number
BR0210216-1A
Other languages
English (en)
Inventor
Bruce A Green
Randall K Holmes
Michael G Jobling
Duzhang Zhu
Original Assignee
Wyeth Corp
Us Gov Univ Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Us Gov Univ Health Sciences filed Critical Wyeth Corp
Publication of BR0210216A publication Critical patent/BR0210216A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"HOLOTOXINA DO CóLERA IMUNOGêNICA, MUTANTE (CT-CRM), COMPOSIçãO IMUNOGêNICA, MéTODOS PARA AUMENTAR A RESPOSTA IMUNE DE UM HOSPEDEIRO VERTEBRADO A UM ANTìGENO, E PARA PRODUZIR UMA HOLOTOXINA DO CóLERA IMUNOGêNICA, MUTANTE, SEQuêNCIA OU MOLéCULA DE áCIDO NUCLEICO ISOLADO E PURIFICADO, CéLULA HOSPEDEIRA, E USO DE UMA HOLOTOXINA DO CóLERA MUTANTE". Holotoxinas do cólera mutantes tendo substituições ou inserções de aminoácido únicas ou duplas têm toxicidade reduzida comparadas com a holotoxina do cólera do tipo selvagem. As holotoxinas do cólera mutantes são úteis como adjuvantes em composições antigênicas para aumentar a resposta imune em um hospedeiro vertebrado a um antígeno selecionado de uma bactéria, vírus, fungo ou parasita patogênicos, uma célula cancerosa, uma célula de tumor, um alergênio ou uma auto-molécula.
BR0210216-1A 2001-06-07 2002-06-05 Holotoxina do cólera imunogênica, mutante (ct-crm), composição imunogênica, métodos para aumentar a resposta imune de um hospedeiro vertebrado a um antìgeno, e para produzir uma holotoxina do cólera imunogênica, mutante, sequência ou molécula de ácido nucleico isolado e purificado, célula hospedeira, e, uso de uma holotoxina do cólera mutante BR0210216A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29653101P 2001-06-07 2001-06-07
PCT/US2002/021008 WO2002098369A2 (en) 2001-06-07 2002-06-05 Mutant forms of cholera holotoxin as an adjuvant

Publications (1)

Publication Number Publication Date
BR0210216A true BR0210216A (pt) 2004-06-08

Family

ID=23142408

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210216-1A BR0210216A (pt) 2001-06-07 2002-06-05 Holotoxina do cólera imunogênica, mutante (ct-crm), composição imunogênica, métodos para aumentar a resposta imune de um hospedeiro vertebrado a um antìgeno, e para produzir uma holotoxina do cólera imunogênica, mutante, sequência ou molécula de ácido nucleico isolado e purificado, célula hospedeira, e, uso de uma holotoxina do cólera mutante

Country Status (11)

Country Link
US (3) US7332174B2 (pt)
EP (1) EP1404279A4 (pt)
JP (2) JP2005508143A (pt)
KR (2) KR20080078717A (pt)
CN (1) CN1541111A (pt)
AU (1) AU2002322380B2 (pt)
BR (1) BR0210216A (pt)
CA (1) CA2449670A1 (pt)
IL (2) IL159209A0 (pt)
MX (1) MXPA03011135A (pt)
WO (1) WO2002098369A2 (pt)

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Also Published As

Publication number Publication date
KR20080078717A (ko) 2008-08-27
JP2009112301A (ja) 2009-05-28
WO2002098369A2 (en) 2002-12-12
MXPA03011135A (es) 2004-09-08
US20080311144A1 (en) 2008-12-18
EP1404279A4 (en) 2007-08-08
JP2005508143A (ja) 2005-03-31
KR100877258B1 (ko) 2009-01-12
US7658931B2 (en) 2010-02-09
IL159209A0 (en) 2004-06-01
CA2449670A1 (en) 2002-12-12
IL159209A (en) 2010-04-29
US20040176571A1 (en) 2004-09-09
CN1541111A (zh) 2004-10-27
US20070122428A1 (en) 2007-05-31
AU2002322380B2 (en) 2006-11-02
US7332174B2 (en) 2008-02-19
KR20040044412A (ko) 2004-05-28
EP1404279A2 (en) 2004-04-07
WO2002098369A3 (en) 2003-02-20

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