BR0203518A - Proteìnas purificadas do envelope do vìrus de hepatite c para uso diagnóstico e terapêutico - Google Patents
Proteìnas purificadas do envelope do vìrus de hepatite c para uso diagnóstico e terapêuticoInfo
- Publication number
- BR0203518A BR0203518A BR0203518-9A BR0203518A BR0203518A BR 0203518 A BR0203518 A BR 0203518A BR 0203518 A BR0203518 A BR 0203518A BR 0203518 A BR0203518 A BR 0203518A
- Authority
- BR
- Brazil
- Prior art keywords
- diagnostic
- relates
- hcv
- present
- virus envelope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 241000711549 Hepacivirus C Species 0.000 title abstract 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 108700008783 Hepatitis C virus E1 Proteins 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PROTEìNAS PURIFICADAS DO ENVELOPE DO VìRUS DE HEPATITE C PARA USO DIAGNóSTICO E TERAPêUTICO". A presente invenção se refere a um processo para a purificação de proteínas do envoltório de HCV simples ou oligoméricas específicas recombinantes selecionadas do grupo que consistem em E1 e/ou E2 e/ou E1/E2, caracterizado pelo fato de que, depois de se submeter a lise as células hospedeiras transformadas para se isolar a proteína expressa de modo recombinante, é conduzida uma etapa de redução ou clivagem de ligação dissulfeto com um agente de clivagem de ligação dissulfeto. A presente invenção também se refere a uma composição isolada por tal processo. A presente invenção também se refere à aplicação para fins de diagnóstico e terapêuticos destas composições. Além disso a invenção se refere ao emprego da proteína E1 de HCV e de seus peptídeos para o prognóstico e a monitoração da eficácia clínica e/ou do resultado clínico de tratamento contra HCV.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26066901P | 2001-01-11 | 2001-01-11 | |
| US31576801P | 2001-08-30 | 2001-08-30 | |
| PCT/EP2002/000219 WO2002055548A2 (en) | 2001-01-11 | 2002-01-11 | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0203518A true BR0203518A (pt) | 2002-12-17 |
Family
ID=26948130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0203518-9A Withdrawn BR0203518A (pt) | 2001-01-11 | 2002-01-11 | Proteìnas purificadas do envelope do vìrus de hepatite c para uso diagnóstico e terapêutico |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1463753A2 (pt) |
| KR (1) | KR20020089371A (pt) |
| CN (1) | CN1547588A (pt) |
| AR (1) | AR032240A1 (pt) |
| AU (1) | AU2002238502B2 (pt) |
| BR (1) | BR0203518A (pt) |
| CA (1) | CA2400643A1 (pt) |
| CZ (1) | CZ20032164A3 (pt) |
| HU (1) | HUP0302416A2 (pt) |
| IL (1) | IL151033A0 (pt) |
| MX (1) | MXPA02008886A (pt) |
| NO (1) | NO20024325L (pt) |
| PL (1) | PL363175A1 (pt) |
| RU (1) | RU2313363C2 (pt) |
| TR (1) | TR200202169T1 (pt) |
| WO (1) | WO2002055548A2 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002086101A2 (en) | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Core-glycosylated hcv envelope proteins |
| AU2003283365A1 (en) * | 2002-11-08 | 2004-06-07 | Innogenetics N.V. | HCV vaccine compositions comprising E1 and NS3 peptides |
| EP1561470A1 (en) * | 2003-06-20 | 2005-08-10 | Innogenetics N.V. | HCV vaccines comprising the envelope-1 (E1) protein or the corresponding DNA and at least one antiviral agent |
| EP2267004A3 (en) * | 2003-09-22 | 2011-04-27 | Green Peptide Co., Ltd. | Peptide derived from hepatitis C virus |
| CN100365124C (zh) * | 2005-10-27 | 2008-01-30 | 云南大学 | 一段丙型肝炎病毒特异性cDNA序列的应用 |
| CN115980352A (zh) * | 2022-12-30 | 2023-04-18 | 宁波博肽生物技术有限公司 | 一种hcv抗原包被预处理剂、抗原包被方法及检测试剂盒 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG71728A1 (en) * | 1994-07-29 | 2000-04-18 | Innogenetics Nv | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
-
2002
- 2002-01-11 RU RU2002121632/15A patent/RU2313363C2/ru not_active IP Right Cessation
- 2002-01-11 CZ CZ20032164A patent/CZ20032164A3/cs unknown
- 2002-01-11 BR BR0203518-9A patent/BR0203518A/pt not_active Withdrawn
- 2002-01-11 MX MXPA02008886A patent/MXPA02008886A/es active IP Right Grant
- 2002-01-11 PL PL02363175A patent/PL363175A1/xx unknown
- 2002-01-11 IL IL15103302A patent/IL151033A0/xx unknown
- 2002-01-11 CN CNA028006097A patent/CN1547588A/zh active Pending
- 2002-01-11 EP EP02704649A patent/EP1463753A2/en not_active Withdrawn
- 2002-01-11 TR TR2002/02169T patent/TR200202169T1/xx unknown
- 2002-01-11 KR KR1020027011431A patent/KR20020089371A/ko active IP Right Grant
- 2002-01-11 HU HU0302416A patent/HUP0302416A2/hu unknown
- 2002-01-11 CA CA002400643A patent/CA2400643A1/en not_active Abandoned
- 2002-01-11 WO PCT/EP2002/000219 patent/WO2002055548A2/en active IP Right Grant
- 2002-01-11 AU AU2002238502A patent/AU2002238502B2/en not_active Ceased
- 2002-01-14 AR ARP020100104A patent/AR032240A1/es unknown
- 2002-09-10 NO NO20024325A patent/NO20024325L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2313363C2 (ru) | 2007-12-27 |
| MXPA02008886A (es) | 2003-04-25 |
| RU2002121632A (ru) | 2004-03-20 |
| IL151033A0 (en) | 2003-04-10 |
| WO2002055548A8 (en) | 2002-10-31 |
| CZ20032164A3 (cs) | 2003-10-15 |
| PL363175A1 (en) | 2004-11-15 |
| EP1463753A2 (en) | 2004-10-06 |
| CN1547588A (zh) | 2004-11-17 |
| NO20024325D0 (no) | 2002-09-10 |
| HUP0302416A2 (hu) | 2003-10-28 |
| AU2002238502B2 (en) | 2007-09-06 |
| WO2002055548A2 (en) | 2002-07-18 |
| KR20020089371A (ko) | 2002-11-29 |
| WO2002055548A3 (en) | 2004-08-05 |
| AU2002238502A1 (en) | 2002-07-24 |
| AU2002238502B9 (en) | 2002-07-24 |
| CA2400643A1 (en) | 2002-07-18 |
| TR200202169T1 (tr) | 2004-06-21 |
| AR032240A1 (es) | 2003-10-29 |
| NO20024325L (no) | 2002-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: PARA QUE A SOLICITACAO REQUERIDA NA PETICAO NO 061086/RJ DE 07/11/2002 SEJA ATENDIDA, O REQUERENTEDEVE APRESENTAR DOCUMENTO DE CESSAO, DECLARANDO A PARTICIPACAO DO REFERENTE INVENTOR. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A(S) 8A E 9A ANUIDADE(S) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |