BR0215081A - Proteìnas purificadas do envoltório do vìrus de hepatite c para uso diagnóstico e terapêutico - Google Patents
Proteìnas purificadas do envoltório do vìrus de hepatite c para uso diagnóstico e terapêuticoInfo
- Publication number
- BR0215081A BR0215081A BR0215081-6A BR0215081A BR0215081A BR 0215081 A BR0215081 A BR 0215081A BR 0215081 A BR0215081 A BR 0215081A BR 0215081 A BR0215081 A BR 0215081A
- Authority
- BR
- Brazil
- Prior art keywords
- relates
- proteins
- wrap
- diagnostic
- present
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PROTEìNAS PURIFICADAS DO ENVOLTóRIO DO VìRUS DE HEPATITE C PARA USO DIAGNóSTICO E TERAPêUTICO". A presente invenção se refere a um processo para a purificação de proteínas do envoltório de HCV simples ou oligoméricas específicas recombinantes selecionadas do grupo que consistem em E1 e/ou E2 e/ou E1/E2, caracterizado pelo fato de que, depois de se submeter a lise as células hospedeiras transformadas para se isolar a proteína expressa de modo recombinante, é conduzida uma etapa de redução ou clivagem de ligação dissulfeto com um agente de clivagem de ligação dissulfeto. A presente invenção também se refere a uma composição isolada por tal processo. A presente invenção também se refere à aplicação diagnóstica e terapêutica destas composições. Além disso, a invenção se, refere ao emprego da proteína E1 de HCV e de seus peptídeos para o prognóstico e a monitoração da eficácia clínica e/ou do resultado clínico de tratamento contra HCV.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2051001A | 2001-12-18 | 2001-12-18 | |
| US41835802P | 2002-10-16 | 2002-10-16 | |
| PCT/EP2002/014480 WO2003051912A2 (en) | 2001-12-18 | 2002-12-18 | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0215081A true BR0215081A (pt) | 2004-10-19 |
Family
ID=26693530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0215081-6A BR0215081A (pt) | 2001-12-18 | 2002-12-18 | Proteìnas purificadas do envoltório do vìrus de hepatite c para uso diagnóstico e terapêutico |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1461080A2 (pt) |
| JP (1) | JP2005516939A (pt) |
| KR (1) | KR20040076869A (pt) |
| CN (1) | CN1622828A (pt) |
| AU (1) | AU2002361160B2 (pt) |
| BR (1) | BR0215081A (pt) |
| CA (1) | CA2468690A1 (pt) |
| IL (1) | IL162236A0 (pt) |
| MX (1) | MXPA04005891A (pt) |
| NZ (1) | NZ533396A (pt) |
| RU (1) | RU2319505C2 (pt) |
| WO (1) | WO2003051912A2 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| WO2002086101A2 (en) | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Core-glycosylated hcv envelope proteins |
| FR2859221B1 (fr) * | 2003-08-28 | 2005-10-14 | Centre Nat Rech Scient | Vecteur de co-expression de domaines membranaires de proteines d'enveloppe d'un virus et utilisations |
| EP1574517A1 (en) | 2004-03-09 | 2005-09-14 | Innogenetics N.V. | HCV E1 comprising specific disulfide bridges |
| WO2006044923A2 (en) * | 2004-10-18 | 2006-04-27 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis c infection |
| CN100365124C (zh) * | 2005-10-27 | 2008-01-30 | 云南大学 | 一段丙型肝炎病毒特异性cDNA序列的应用 |
| WO2009030872A1 (en) * | 2007-09-07 | 2009-03-12 | Mats Axel Atterdag Persson | Materials and methods for the treatment of hepatitis c |
| CN102112155B (zh) | 2008-06-05 | 2016-08-10 | 埃博灵克斯股份有限公司 | 针对病毒包膜蛋白的氨基酸序列和用于治疗病毒疾病的包含其的多肽 |
| CN105061592A (zh) | 2009-06-05 | 2015-11-18 | 埃博灵克斯股份有限公司 | 用于预防和/或治疗呼吸道感染的单价、二价和三价抗人呼吸道合胞病毒(hrsv)纳米抗体构建体 |
| US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| CN103732250A (zh) * | 2011-06-14 | 2014-04-16 | 全球免疫股份有限公司 | 基于酵母的治疗或预防丁型肝炎病毒感染的组合物和方法 |
| RU2570553C2 (ru) * | 2013-11-20 | 2015-12-10 | Федеральное бюджетное учреждение "Всероссийский научно-исследовательский институт лесоводства и механизации лесного хозяйства (ФБУ ВНИИЛМ) | Способ очистки вирусных полиэдров |
| CN104327170A (zh) * | 2014-05-16 | 2015-02-04 | 中国疾病预防控制中心病毒病预防控制所 | 丙型肝炎病毒(hcv)细胞进入抑制肽zte1序列及应用 |
| CA2961568A1 (en) | 2014-09-17 | 2016-03-24 | The University Of Iowa Research Foundation | Viral rna segments as immunomodulatory agents and vaccine components |
| JP7068284B2 (ja) * | 2016-09-29 | 2022-05-16 | マクファーレン バーネット インスティテュート フォー メディカル リサーチ アンド パブリック ヘルス リミテッド | アセンブルした糖タンパク質 |
| US20220041650A1 (en) * | 2018-12-03 | 2022-02-10 | Duke University | Purification method for recombinant proteins and nanoparticles |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0992580B1 (en) * | 1993-11-04 | 2005-03-09 | Innogenetics N.V. | Immunodominant human T-cell epitopes of Hepatitis C virus |
| ATE286067T1 (de) * | 1998-06-24 | 2005-01-15 | Innogenetics Nv | Hcv hüllproteine partikel : verwendung für therapeutische impfung |
-
2002
- 2002-12-18 CN CNA028282027A patent/CN1622828A/zh active Pending
- 2002-12-18 WO PCT/EP2002/014480 patent/WO2003051912A2/en active IP Right Grant
- 2002-12-18 CA CA002468690A patent/CA2468690A1/en not_active Abandoned
- 2002-12-18 NZ NZ533396A patent/NZ533396A/en unknown
- 2002-12-18 RU RU2004116914/15A patent/RU2319505C2/ru not_active IP Right Cessation
- 2002-12-18 IL IL16223602A patent/IL162236A0/xx unknown
- 2002-12-18 BR BR0215081-6A patent/BR0215081A/pt not_active IP Right Cessation
- 2002-12-18 AU AU2002361160A patent/AU2002361160B2/en not_active Expired - Fee Related
- 2002-12-18 KR KR10-2004-7009720A patent/KR20040076869A/ko not_active Application Discontinuation
- 2002-12-18 EP EP02796675A patent/EP1461080A2/en not_active Withdrawn
- 2002-12-18 JP JP2003552792A patent/JP2005516939A/ja active Pending
-
2004
- 2004-06-16 MX MXPA04005891A patent/MXPA04005891A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003051912A2 (en) | 2003-06-26 |
| MXPA04005891A (es) | 2004-09-13 |
| RU2319505C2 (ru) | 2008-03-20 |
| EP1461080A2 (en) | 2004-09-29 |
| AU2002361160A1 (en) | 2003-06-30 |
| IL162236A0 (en) | 2005-11-20 |
| WO2003051912A3 (en) | 2004-03-04 |
| KR20040076869A (ko) | 2004-09-03 |
| WO2003051912A9 (en) | 2004-07-15 |
| NZ533396A (en) | 2005-04-29 |
| CA2468690A1 (en) | 2003-06-26 |
| JP2005516939A (ja) | 2005-06-09 |
| RU2004116914A (ru) | 2005-04-20 |
| AU2002361160B2 (en) | 2008-07-03 |
| CN1622828A (zh) | 2005-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A(S) 7A E 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |