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BR0016611A - Moduladores de neurotransmissão de dopamina - Google Patents

Moduladores de neurotransmissão de dopamina

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Publication number
BR0016611A
BR0016611A BR0016611-1A BR0016611A BR0016611A BR 0016611 A BR0016611 A BR 0016611A BR 0016611 A BR0016611 A BR 0016611A BR 0016611 A BR0016611 A BR 0016611A
Authority
BR
Brazil
Prior art keywords
alkyl
dopamine neurotransmission
oso
tetrahydrofuran
phenyl
Prior art date
Application number
BR0016611-1A
Other languages
English (en)
Other versions
BR0016611B1 (pt
Inventor
Andersson Bengt
Clas Sonesson
Susanna Waters
Nicholas Waters
Joakim Tedroff
Original Assignee
Carlsson A Research Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlsson A Research Ab filed Critical Carlsson A Research Ab
Publication of BR0016611A publication Critical patent/BR0016611A/pt
Publication of BR0016611B1 publication Critical patent/BR0016611B1/pt

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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  • Nutrition Science (AREA)

Abstract

"MODULADORES DE NEUROTRANSMISSãO DE DOPAMINA". Novos compostos de 4-(fenil-N-alquil)-piperazina 3-substituída ou e 4-(fenil-N-alquil)-piperidina 3-substituída da Fórmula (1), em que X é N, CH e C, contudo, X só pode ser C quando o composto compreende uma ligação dupla na linha pontilhada; R, é OSO~ 2~CF~ 3~, OSO~ 2~CH~ 3~, SOR~ 3~, SO~ 2~R~ 3~, COR~ 3~, NO~ 2~CONHR~ 3~e quando X é CH ou C, R~ 1~ também pode ser CF~ 3~, CN, F, CI, Br ou I; R~ 2~ é C~ 1~-C~ 4~ alquila, uma alila, CH~ 2~ SCH~ 3~, CH~ 2~CH~ 2~ OCH~ 3~, CH~ 2~CH~ 2~CH~ 2~F, CH~ 2~CF~ 3~, 3,3,3-trifluoropropila, 4,4,4-trifluorobutila ou -(CH2)-R~ 4~; R~ 3~ é C~ 1~-C~ 3~ alquila, CF~ 3~ ou N(R~ 2~)~ 2~; R~ 4~ é - C~ 3~-C~ 6~ Cicloalquila, 2-tetraidrofurano e 3-tetraidrofurano; bem como sais farmaceuticamente aceitáveis dos mesmos são divulgados. Também, composições farmacêuticas compreendendo os compostos acima e métodos, em que os compostos acima são usados para o tratamento de distúrbios no sistema nervoso central são divulgados.
BRPI0016611-1A 1999-12-22 2000-12-22 moduladores de neurotransmissão de dopamina, composição farmacêutica contendo os mesmos e seu uso. BR0016611B1 (pt)

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SE9904724-3 1999-12-22
SE9904724A SE9904724D0 (sv) 1999-12-22 1999-12-22 New modulators of dopamine neurotransmission I
PCT/SE2000/002674 WO2001046145A1 (en) 1999-12-22 2000-12-22 New modulators of dopamine neurotransmission

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