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BG63799B1 - Използване на заместени аденозин производни и негови аналози - Google Patents

Използване на заместени аденозин производни и негови аналози Download PDF

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Publication number
BG63799B1
BG63799B1 BG100963A BG10096396A BG63799B1 BG 63799 B1 BG63799 B1 BG 63799B1 BG 100963 A BG100963 A BG 100963A BG 10096396 A BG10096396 A BG 10096396A BG 63799 B1 BG63799 B1 BG 63799B1
Authority
BG
Bulgaria
Prior art keywords
alkyl
amino
thienyl
adenosine
ethyl
Prior art date
Application number
BG100963A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100963A (en
Inventor
Alfred Spada
Cynthia FINCK
Michael Myers
Original Assignee
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer Pharmaceuticals Inc. filed Critical Rhone-Poulenc Rorer Pharmaceuticals Inc.
Publication of BG100963A publication Critical patent/BG100963A/xx
Publication of BG63799B1 publication Critical patent/BG63799B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG100963A 1994-04-19 1996-11-06 Използване на заместени аденозин производни и негови аналози BG63799B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22988294A 1994-04-19 1994-04-19
US08/316,761 US5561134A (en) 1990-09-25 1994-10-03 Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
PCT/US1995/004800 WO1995028160A1 (en) 1994-04-19 1995-04-19 Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties

Publications (2)

Publication Number Publication Date
BG100963A BG100963A (en) 1997-08-29
BG63799B1 true BG63799B1 (bg) 2003-01-31

Family

ID=26923699

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100963A BG63799B1 (bg) 1994-04-19 1996-11-06 Използване на заместени аденозин производни и негови аналози

Country Status (28)

Country Link
US (2) US5561134A (hu)
EP (2) EP1006115A3 (hu)
JP (1) JPH09512020A (hu)
KR (1) KR970702045A (hu)
CN (1) CN1086704C (hu)
AP (1) AP699A (hu)
AT (1) ATE260106T1 (hu)
AU (1) AU684635B2 (hu)
BG (1) BG63799B1 (hu)
BR (1) BR9507327A (hu)
CA (1) CA2188147C (hu)
CZ (1) CZ289528B6 (hu)
DE (1) DE69532608T2 (hu)
DK (1) DK0758897T3 (hu)
EE (1) EE9600156A (hu)
ES (1) ES2217279T3 (hu)
FI (1) FI964218A7 (hu)
HU (1) HUT75331A (hu)
NO (1) NO317727B1 (hu)
NZ (1) NZ284357A (hu)
OA (1) OA10464A (hu)
PL (1) PL182942B1 (hu)
PT (1) PT758897E (hu)
RO (1) RO119225B1 (hu)
RU (1) RU2166319C2 (hu)
SI (1) SI9520055A (hu)
SK (1) SK284039B6 (hu)
WO (1) WO1995028160A1 (hu)

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EP0758897B1 (en) 2004-02-25
AU2294995A (en) 1995-11-10
MX9604999A (es) 1998-05-31
EE9600156A (et) 1997-06-16
RU2166319C2 (ru) 2001-05-10
FI964218A0 (fi) 1996-10-18
NO964438D0 (no) 1996-10-18
EP0758897A1 (en) 1997-02-26
DK0758897T3 (da) 2004-05-03
CN1148811A (zh) 1997-04-30
EP1006115A2 (en) 2000-06-07
FI964218L (fi) 1996-12-17
AU684635B2 (en) 1997-12-18
FI964218A7 (fi) 1996-12-17
US5561134A (en) 1996-10-01
NO317727B1 (no) 2004-12-13
AP699A (en) 1998-12-01
US5736554A (en) 1998-04-07
WO1995028160A1 (en) 1995-10-26
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BR9507327A (pt) 1997-10-07
NZ284357A (en) 2001-06-29
HK1011294A1 (en) 1999-07-09
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PL316961A1 (en) 1997-02-17
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CN1086704C (zh) 2002-06-26
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CA2188147A1 (en) 1995-10-26
ATE260106T1 (de) 2004-03-15
RO119225B1 (ro) 2004-06-30
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PL182942B1 (pl) 2002-05-31
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CZ289528B6 (cs) 2002-02-13
HU9602829D0 (en) 1996-12-30
DE69532608T2 (de) 2005-01-05
DE69532608D1 (de) 2004-04-01
JPH09512020A (ja) 1997-12-02
HUT75331A (en) 1997-05-28
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