BG100040A - Индолови производни като 5-нт1а и/или 5-нт2 лиганди - Google Patents

Индолови производни като 5-нт1а и/или 5-нт2 лиганди Download PDF

Info

Publication number: BG100040A
Authority: BG; Bulgaria
Prior art keywords: ylmethyl; indole; compound; methoxy; alkyl
Prior art date: 1993-04-08

Application number

BG100040A

Other languages

Bulgarian (bg)

English (en)

Inventor

Quintero Myrna Gil

Vincenzo Martino

Franco Borsini

Maria Pellegrini

Marco Turconi

Ettore Giraldo

Original Assignee

Boehringer Ingelheim Italia S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-08

Filing date

1995-10-02

Publication date

1996-03-29

1995-10-02 Application filed by Boehringer Ingelheim Italia S.P.A. filed Critical Boehringer Ingelheim Italia S.P.A.

1996-03-29 Publication of BG100040A publication Critical patent/BG100040A/bg

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Catalysts (AREA)

BG100040A 1993-04-08 1995-10-02 Индолови производни като 5-нт1а и/или 5-нт2 лиганди BG100040A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI930699A IT1271352B (it)	1993-04-08	1993-04-08	Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
PCT/EP1994/001016 WO1994024125A1 (en)	1993-04-08	1994-03-31	Indole derivatives as 5-ht1a and/or 5-ht2 ligands

Publications (1)

Publication Number	Publication Date
BG100040A true BG100040A (bg)	1996-03-29

Family

ID=11365694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG100040A BG100040A (bg)	1993-04-08	1995-10-02	Индолови производни като 5-нт1а и/или 5-нт2 лиганди

Country Status (20)

Country	Link
US (1)	US5834493A (fi)
EP (1)	EP0694033A1 (fi)
JP (1)	JPH08508738A (fi)
CN (1)	CN1124960A (fi)
AU (1)	AU684276B2 (fi)
BG (1)	BG100040A (fi)
BR (1)	BR9406206A (fi)
CA (1)	CA2160020A1 (fi)
CZ (1)	CZ283398B6 (fi)
FI (1)	FI954734A0 (fi)
HU (1)	HUT74090A (fi)
IL (1)	IL109234A (fi)
IT (1)	IT1271352B (fi)
NO (1)	NO953967L (fi)
NZ (1)	NZ265055A (fi)
PL (1)	PL310995A1 (fi)
SG (1)	SG50507A1 (fi)
SK (1)	SK119795A3 (fi)
WO (1)	WO1994024125A1 (fi)
ZA (1)	ZA942383B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9420521D0 (en) *	1994-10-12	1994-11-30	Smithkline Beecham Plc	Novel compounds
BR9808740A (pt) *	1997-05-09	2000-10-03	Lundbeck & Co As H	Método para fabricação de sertindol
US6673827B1 (en)	1999-06-29	2004-01-06	The Uab Research Foundation	Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
US6861448B2 (en) *	1998-01-14	2005-03-01	Virtual Drug Development, Inc.	NAD synthetase inhibitors and uses thereof
WO1999036422A1 (en)	1998-01-14	1999-07-22	The Uab Research Foundation	Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
US6133287A (en) *	1998-03-24	2000-10-17	Allelix Biopharmaceuticals Inc.	Piperidine-indole compounds having 5-HT6 affinity
ES2182509T3 (es) *	1998-04-08	2003-03-01	Wyeth Corp	Derivados de n-ariloxietilamina para el tratamiento de la depresion.
JP2002513018A (ja) *	1998-04-29	2002-05-08	アメリカン・ホーム・プロダクツ・コーポレイション	セロトニン作動薬
FR2799463B1 (fr) *	1999-10-12	2004-04-16	Adir	Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
DE19951360A1 (de) *	1999-10-26	2001-05-03	Aventis Pharma Gmbh	Substituierte Indole
US6503894B1 (en)	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
PL363238A1 (en)	2000-12-22	2004-11-15	Wyeth	Heterocyclylalkylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands
US7135479B2 (en)	2002-09-12	2006-11-14	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
CA2796756A1 (en) *	2010-04-22	2011-10-27	Intra-Cellular Therapies, Inc.	Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders
EP2836213B1 (en)	2012-04-14	2018-07-04	Intra-Cellular Therapies, Inc.	Fused gamma carbolines
DK2968320T3 (da)	2013-03-15	2021-02-01	Intra Cellular Therapies Inc	Organiske forbindelser
IL305990A (en)	2013-12-03	2023-11-01	Intra Cellular Therapies Inc	Compressed gamma-carboline heterocyclic compounds are modified for use in the treatment of type I and/or type II bipolar disorders
KR20170012209A (ko)	2014-04-04	2017-02-02	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
MX365969B (es)	2014-04-04	2019-06-21	Intra Cellular Therapies Inc	Gamma-carbolinas fusionadas con heterociclos sustituidas con deuterio.
WO2017023894A1 (en) *	2015-08-03	2017-02-09	Raze Therapeutics, Inc.	Mthfd2 inhibitors and uses thereof
DK3407888T3 (da)	2016-01-26	2021-04-06	Intra Cellular Therapies Inc	Pyridopyrroloquinoxalinforbindelser, deres sammensætninger og anvendelser
PL3407889T3 (pl)	2016-03-25	2021-11-22	Intra-Cellular Therapies, Inc.	Związki organiczne i ich zastosowanie w leczeniu lub zapobieganiu zaburzeniom ośrodkowego układu nerwowego
WO2017172795A1 (en)	2016-03-28	2017-10-05	Intra-Cellular Therapies, Inc.	Novel compositions and methods
WO2018071233A1 (en)	2016-10-12	2018-04-19	Intra-Cellular Therapies, Inc.	Amorphous solid dispersions
WO2018126140A1 (en)	2016-12-29	2018-07-05	Intra-Cellular Therapies, Inc.	Organic compounds
EP3562484B1 (en)	2016-12-29	2021-08-25	Intra-Cellular Therapies, Inc.	Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
US10716786B2 (en)	2017-03-24	2020-07-21	Intra-Cellular Therapies, Inc.	Transmucosal and subcutaneous compositions
WO2019023063A1 (en)	2017-07-26	2019-01-31	Intra-Cellular Therapies, Inc.	ORGANIC COMPOUNDS
EP3658145A4 (en)	2017-07-26	2021-04-21	Intra-Cellular Therapies, Inc.	ORGANIC COMPOUNDS
WO2019237037A1 (en)	2018-06-08	2019-12-12	Intra-Cellular Therapies, Inc.	Novel methods
WO2020047241A1 (en)	2018-08-29	2020-03-05	Intra-Cellular Therapies, Inc.	Novel compositions and methods
US10695345B2 (en)	2018-08-31	2020-06-30	Intra-Cellular Therapies, Inc.	Pharmaceutical capsule compositions comprising lumateperone mono-tosylate
CA3108553A1 (en)	2018-08-31	2020-03-05	Intra-Cellular Therapies, Inc.	Novel methods
CA3141223A1 (en)	2019-07-07	2021-01-14	Sharon Mates	Novel methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0429341A3 (en) *	1989-11-20	1991-11-13	Rhone-Poulenc Sante	Heterocyclic derivatives, their preparation and pharmaceuticals containing them
DK0592438T5 (da) *	1990-10-15	1999-12-06	Pfizer Inc.	Indolderivater
JP3140155B2 (ja) *	1992-03-09	2001-03-05	杏林製薬株式会社	Ｎ，ｎ’−ジ置換アミド誘導体
CA2092112A1 (en) *	1992-03-23	1993-09-24	Nobuyoshi Iwata	Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

1993
- 1993-04-08 IT ITMI930699A patent/IT1271352B/it active IP Right Grant
1994
- 1994-03-31 PL PL94310995A patent/PL310995A1/xx unknown
- 1994-03-31 CN CN94192345A patent/CN1124960A/zh active Pending
- 1994-03-31 JP JP6522684A patent/JPH08508738A/ja active Pending
- 1994-03-31 SG SG1996002949A patent/SG50507A1/en unknown
- 1994-03-31 BR BR9406206A patent/BR9406206A/pt not_active Application Discontinuation
- 1994-03-31 CZ CZ952602A patent/CZ283398B6/cs unknown
- 1994-03-31 SK SK1197-95A patent/SK119795A3/sk unknown
- 1994-03-31 US US08/530,354 patent/US5834493A/en not_active Expired - Fee Related
- 1994-03-31 NZ NZ265055A patent/NZ265055A/en unknown
- 1994-03-31 EP EP94913101A patent/EP0694033A1/en not_active Withdrawn
- 1994-03-31 AU AU65382/94A patent/AU684276B2/en not_active Ceased
- 1994-03-31 WO PCT/EP1994/001016 patent/WO1994024125A1/en not_active Application Discontinuation
- 1994-03-31 CA CA002160020A patent/CA2160020A1/en not_active Abandoned
- 1994-03-31 HU HU9502913A patent/HUT74090A/hu unknown
- 1994-04-06 IL IL109234A patent/IL109234A/en not_active IP Right Cessation
- 1994-04-07 ZA ZA942383A patent/ZA942383B/xx unknown
1995
- 1995-10-02 BG BG100040A patent/BG100040A/bg unknown
- 1995-10-05 NO NO953967A patent/NO953967L/no unknown
- 1995-10-05 FI FI954734A patent/FI954734A0/fi unknown

Also Published As

Publication number	Publication date
IT1271352B (it)	1997-05-27
FI954734A (fi)	1995-10-05
SG50507A1 (en)	1998-07-20
US5834493A (en)	1998-11-10
CN1124960A (zh)	1996-06-19
HUT74090A (en)	1996-11-28
JPH08508738A (ja)	1996-09-17
IL109234A0 (en)	1994-07-31
SK119795A3 (en)	1996-04-03
CZ260295A3 (en)	1996-01-17
NO953967L (no)	1995-12-05
WO1994024125A1 (en)	1994-10-27
EP0694033A1 (en)	1996-01-31
IL109234A (en)	1998-04-05
HU9502913D0 (en)	1995-11-28
ZA942383B (en)	1995-10-09
FI954734A0 (fi)	1995-10-05
ITMI930699A0 (it)	1993-04-08
NZ265055A (en)	1996-09-25
CA2160020A1 (en)	1994-10-27
AU684276B2 (en)	1997-12-11
AU6538294A (en)	1994-11-08
CZ283398B6 (cs)	1998-04-15
ITMI930699A1 (it)	1994-10-08
PL310995A1 (en)	1996-01-22
NO953967D0 (no)	1995-10-05
BR9406206A (pt)	1996-02-06

Publication	Publication Date	Title
BG100040A (bg)	1996-03-29	Индолови производни като 5-нт1а и/или 5-нт2 лиганди
RU2294932C2 (ru)	2007-03-10	Новые производные индола со сродством к рецептору 5-ht6
RU2134266C1 (ru)	1999-08-10	Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1)
US20040242589A1 (en)	2004-12-02	3-arylsulfonyl-7-piperzinyl-indoles-benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
EP0773942A1 (en)	1997-05-21	4-indole derivatives as serotonin agonists and antagonists
HUT70195A (en)	1995-09-28	Process for producing benzimidazolone derivatives and pharmaceutical preparations containing them
KR20020030126A (ko)	2002-04-22	５―ｈｔ１ｂ 길항제로서의 피페라진 유도체
CZ20032614A3 (en)	2004-03-17	N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor
US5393761A (en)	1995-02-28	3-arylindole compounds
JPH04253976A (ja)	1992-09-09	新規インドール誘導体
JPH06271571A (ja)	1994-09-27	インドール、インダゾール及びベンズイソオキサゾール化合物、それらの製法およびそれらを含有する製薬組成物
AU765317B2 (en)	2003-09-18	4,5,6 and 7-indole and indoline derivatives, their preparation and use
US5661169A (en)	1997-08-26	1-benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, their preparation and the pharmaceutical compositions containing them
US5576336A (en)	1996-11-19	Indole derivatives as dopamine D4 antagonists
JP4740116B2 (ja)	2011-08-03	精神疾患および神経障害の処置のための５−ｈｔ受容体アンタゴニスト
CA1337202C (en)	1995-10-03	Cyclic amides which are leukotriene antagonists
US5607957A (en)	1997-03-04	Imidazole, triazole and tetrazole derivatives
JPS6257606B2 (fi)	1987-12-02
KR101471987B1 (ko)	2014-12-12	일정한 ｃｎｓ-관련 질환을 치료하기 위한 2-알킬-인다졸 화합물
JP5536781B2 (ja)	2014-07-02	アリールスルホンアミドアミン化合物および５−ｈｔ６リガンドとしてのそれらの使用
RU2127732C1 (ru)	1999-03-20	Эфиры бис-фенилпиперазинникотиновой кислоты, способ их получения (варианты), фармацевтическая композиция и способ лечения расстройств центральной нервной системы
KR100363484B1 (ko)	2003-02-05	3-치환1-아릴인돌화합물
JPH0525140A (ja)	1993-02-02	ベンズイミダゾール誘導体
KR100837035B1 (ko)	2008-06-10	모노아민 재흡수 억제제로서의 3-아미노-1-아릴프로필 인돌
Mawer et al.	1996	Indole derivatives as dopamine D 4 antagonists