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AU8587598A - Trans-species nuclear transfer - Google Patents

Trans-species nuclear transfer

Info

Publication number
AU8587598A
AU8587598A AU85875/98A AU8587598A AU8587598A AU 8587598 A AU8587598 A AU 8587598A AU 85875/98 A AU85875/98 A AU 85875/98A AU 8587598 A AU8587598 A AU 8587598A AU 8587598 A AU8587598 A AU 8587598A
Authority
AU
Australia
Prior art keywords
trans
nuclear transfer
species nuclear
species
transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU85875/98A
Inventor
Tanja Dominko
Neal L. First
Maissam Mitalipoua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU8587598A publication Critical patent/AU8587598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU85875/98A 1997-07-26 1998-07-24 Trans-species nuclear transfer Abandoned AU8587598A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5310397P 1997-07-26 1997-07-26
US60053103 1997-07-26
PCT/US1998/015387 WO1999005266A2 (en) 1997-07-26 1998-07-24 Trans-species nuclear transfer

Publications (1)

Publication Number Publication Date
AU8587598A true AU8587598A (en) 1999-02-16

Family

ID=21981947

Family Applications (1)

Application Number Title Priority Date Filing Date
AU85875/98A Abandoned AU8587598A (en) 1997-07-26 1998-07-24 Trans-species nuclear transfer

Country Status (2)

Country Link
AU (1) AU8587598A (en)
WO (1) WO1999005266A2 (en)

Families Citing this family (61)

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GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
JP2001500725A (en) * 1996-08-19 2001-01-23 ユニヴァーシティー オヴ マサチューセッツ Embryonic or stem cell-like cell lines produced by interspecies nuclear transfer
US7696404B2 (en) 1996-08-19 2010-04-13 Advanced Cell Technology, Inc. Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
EP1060243A4 (en) * 1998-03-02 2005-03-09 Univ Massachusetts EMBRYONIC CELL LINES OR STEM CELL-SIMILAR CELL LINES PRODUCED BY CORE TRANSPLANT BETWEEN DIFFERENT SPECIES
JP2002511234A (en) * 1998-03-16 2002-04-16 リレグ ピーティーワイ リミテッド Swine nuclear transfer
IL147179A0 (en) * 1999-06-30 2002-08-14 Advanced Cell Tech Inc Cytoplasmic transfer to de-differentiate recipient cells
WO2001000794A1 (en) * 1999-06-30 2001-01-04 Hwang, Woo-Suk Method for producing cloned tigers by employing inter-species nuclear transplantation technique
JP2003503044A (en) * 1999-06-30 2003-01-28 ワン，ウー−サク Method for producing human cloned embryos using interspecies nuclear transfer technology
WO2001000795A1 (en) * 1999-06-30 2001-01-04 Hwang, Woo-Suk A method for producing cloned cows
US7621606B2 (en) 2001-08-27 2009-11-24 Advanced Cell Technology, Inc. Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
EP1214404A4 (en) * 1999-09-14 2003-09-03 Univ Massachusetts LINES OF EMBRYONIC OR STRAIN CELLS PRODUCED BY NUCLEAR TRANSPLANTATION OF CROSS SPECIES AND TECHNIQUE FOR ENHANCING EMBRYONIC DEVELOPMENT BY GENETIC MODIFICATION OF DONOR CELLS OR TISSUE CULTURE.
NZ519346A (en) * 1999-12-20 2004-02-27 Univ Massachusetts Embryonic or stem-like cells produced by cross species nuclear transplantation
US20100167404A1 (en) 2005-08-03 2010-07-01 Advanced Cell Technology, Inc. Methods of Reprogramming Animal Somatic Cells
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
HRP20181648T1 (en) 2013-04-16 2019-01-25 Regeneron Pharmaceuticals, Inc. TARGET GENOMIC TARGET MODIFICATION
RS58159B1 (en) 2013-12-11 2019-03-29 Regeneron Pharma Methods and compositions for the targeted modification of a genome
MX388127B (en) 2013-12-11 2025-03-19 Regeneron Pharma METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME.
CA2950173C (en) 2014-06-06 2023-10-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for modifying a targeted locus
KR102386101B1 (en) 2014-06-26 2022-04-14 리제너론 파마슈티칼스 인코포레이티드 Methods and compositions for targeted genetic modifications and methods of use
ES2731437T3 (en) 2014-11-21 2019-11-15 Regeneron Pharma Methods and compositions for directed genetic modification through the use of guide RNA pairs
CN107208113A (en) 2014-12-19 2017-09-26 瑞泽恩制药公司 Method and composition for carrying out targeting genetic modification by the multiple targeting of single step
KR102616160B1 (en) 2015-03-16 2023-12-22 리제너론 파마슈티칼스 인코포레이티드 Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception
CN107920498A (en) 2015-05-29 2018-04-17 瑞泽恩制药公司 The non-human animal destroyed with C9ORF72 locus
KR20180110107A (en) 2016-02-16 2018-10-08 리제너론 파마슈티칼스 인코포레이티드 Non-human animal with the mutated quinoleninase gene
CN113831407B (en) 2016-05-20 2024-06-11 瑞泽恩制药公司 Methods for breaking immune tolerance using multiple guide RNAs
MX2019001211A (en) 2016-07-29 2019-09-16 Regeneron Pharma Mice comprising mutations resulting in expression of c-truncated fibrillin-1.
MX381216B (en) 2016-09-30 2025-03-12 Regeneron Pharma NON-HUMAN ANIMALS THAT HAVE A HEXANUCLEOTIDE REPEAT EXPANSION AT A C9ORF72 LOCUS.
US11064685B2 (en) 2017-02-27 2021-07-20 Regeneron Pharmaceuticals, Inc. Non-human animal models of retinoschisis
KR102701443B1 (en) 2017-06-27 2024-09-04 리제너론 파마슈티칼스 인코포레이티드 Nonhuman animals containing the humanized ASGR1 locus
KR20200033259A (en) 2017-07-31 2020-03-27 리제너론 파마슈티칼스 인코포레이티드 Methods and compositions for evaluating CRISPR / Cas-mediated destruction or deletion in vivo and CRISPR / Cas-induced recombination with exogenous donor nucleic acids
KR20200032117A (en) 2017-07-31 2020-03-25 리제너론 파마슈티칼스 인코포레이티드 Evaluation of CRISPR / Cas-induced recombination with exogenous donor nucleic acids in vivo
US11130999B2 (en) 2017-07-31 2021-09-28 Regeneron Pharmaceuticals, Inc. Cas-ready mouse embryonic stem cells and mice and uses thereof
EP3585162B1 (en) 2017-09-29 2023-08-30 Regeneron Pharmaceuticals, Inc. Rodents comprising a humanized ttr locus and methods of use
AU2018366290B2 (en) 2017-11-10 2022-01-27 Regeneron Pharmaceuticals, Inc. Non-human animals comprising Slc30a8 mutation and methods of use
SG11202002456WA (en) 2017-11-30 2020-04-29 Regeneron Pharma Non-human animals comprising a humanized trkb locus
WO2019183123A1 (en) 2018-03-19 2019-09-26 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using crispr/cas systems
CN112969367B (en) 2018-09-13 2023-04-07 瑞泽恩制药公司 Complement factor H gene knockout rat as C3 glomerulopathy model
AU2019403015B2 (en) 2018-12-20 2024-01-18 Regeneron Pharmaceuticals, Inc. Nuclease-mediated repeat expansion
ES2966625T3 (en) 2019-04-04 2024-04-23 Regeneron Pharma Rodents comprising a humanized coagulation factor 12 locus
JP7610339B2 (en) 2019-06-04 2025-01-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Non-human animals containing a humanized TTR locus with a beta slip mutation and methods of use
CA3137764A1 (en) 2019-06-07 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus
CA3217237A1 (en) 2019-06-27 2020-12-30 Regeneration Pharmaceuticals, Inc. Modeling tdp-43 proteinopathy
WO2021108363A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Crispr/cas-mediated upregulation of humanized ttr allele
AU2021212668A1 (en) 2020-01-28 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized PNPLA3 locus and methods of use
EP4099821A1 (en) 2020-02-07 2022-12-14 Regeneron Pharmaceuticals, Inc. <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use
US20230102342A1 (en) 2020-03-23 2023-03-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
EP4171215A2 (en) 2020-06-26 2023-05-03 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ace2 locus
CN118488784A (en) 2021-11-04 2024-08-13 瑞泽恩制药公司 Non-human animals comprising modified CACNG1 loci
WO2023108047A1 (en) 2021-12-08 2023-06-15 Regeneron Pharmaceuticals, Inc. Mutant myocilin disease model and uses thereof
EP4451863A1 (en) 2021-12-20 2024-10-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci
CN113943712B (en) * 2021-12-20 2022-03-22 南京岚轩生物科技有限公司 Electrofusion buffer solution, preparation method thereof and electrofusion method
US20250194571A1 (en) 2022-02-07 2025-06-19 Regeneron Pharmaceuticals, Inc. Compositions and methods for defining optimal treatment timeframes in lysosomal disease
IL314673A (en) 2022-02-11 2024-10-01 Regeneron Pharma Compositions and methods for screening 4R tau-targeted substances
EP4531554A1 (en) 2022-05-31 2025-04-09 Regeneron Pharmaceuticals, Inc. Animal model of tdp-43 proteinopathy
EP4561348A2 (en) 2022-07-29 2025-06-04 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a modified transferrin receptor locus
KR20250044256A (en) 2022-08-05 2025-03-31 리제너론 파마슈티칼스 인코포레이티드 Aggregation-resistant mutant of TDP-43
EP4593590A1 (en) 2022-09-29 2025-08-06 Regeneron Pharmaceuticals, Inc. Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
WO2024163650A1 (en) 2023-02-01 2024-08-08 Regeneron Pharmaceuticals, Inc. Animals comprising a modified klhdc7b locus
AU2024309884A1 (en) 2023-06-30 2025-12-18 Regeneron Pharmaceuticals, Inc. Methods and compositions for increasing homology-directed repair
WO2025122754A1 (en) 2023-12-07 2025-06-12 Regeneron Pharmaceuticals, Inc. Gaa knockout non-human animals
WO2025250495A1 (en) 2024-05-28 2025-12-04 Regeneron Pharmaceuticals, Inc. Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496720A (en) * 1993-02-10 1996-03-05 Susko-Parrish; Joan L. Parthenogenic oocyte activation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
JP2001500725A (en) * 1996-08-19 2001-01-23 ユニヴァーシティー オヴ マサチューセッツ Embryonic or stem cell-like cell lines produced by interspecies nuclear transfer
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells

Also Published As

Publication number Publication date
WO1999005266A3 (en) 1999-04-15
WO1999005266B1 (en) 1999-09-23
WO1999005266A2 (en) 1999-02-04

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase