[go: up one dir, main page]

AU619512B2 - Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method - Google Patents

Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method Download PDF

Info

Publication number
AU619512B2
AU619512B2 AU27431/88A AU2743188A AU619512B2 AU 619512 B2 AU619512 B2 AU 619512B2 AU 27431/88 A AU27431/88 A AU 27431/88A AU 2743188 A AU2743188 A AU 2743188A AU 619512 B2 AU619512 B2 AU 619512B2
Authority
AU
Australia
Prior art keywords
denotes
cooh
formula
hydrogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU27431/88A
Other languages
English (en)
Other versions
AU2743188A (en
Inventor
Gerhard Breipohl
Jochen Knolle
Werner Stuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU2743188A publication Critical patent/AU2743188A/en
Application granted granted Critical
Publication of AU619512B2 publication Critical patent/AU619512B2/en
Assigned to AVENTIS PHARMA DEUTSCHLAND GMBH reassignment AVENTIS PHARMA DEUTSCHLAND GMBH Assignment by Patentee under S 187, Reg 19.1 Assignors: HOECHST AKTIENGESELLSCHAFT
Assigned to SANOFI-AVENTIS DEUTSCHLAND GMBH reassignment SANOFI-AVENTIS DEUTSCHLAND GMBH Change of Name of Patentee under Reg 10.7(1)(a)(ii) Assignors: AVENTIS PHARMA DEUTSCHLAND GMBH
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU27431/88A 1987-12-22 1988-12-21 Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method Expired AU619512B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3743620 1987-12-22
DE3743620 1987-12-22
DE3818576 1988-06-01
DE3818576 1988-06-01

Publications (2)

Publication Number Publication Date
AU2743188A AU2743188A (en) 1989-06-22
AU619512B2 true AU619512B2 (en) 1992-01-30

Family

ID=25863103

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27431/88A Expired AU619512B2 (en) 1987-12-22 1988-12-21 Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method

Country Status (12)

Country Link
US (1) US5124478A (da)
EP (1) EP0322348B1 (da)
JP (1) JP2858766B2 (da)
KR (1) KR0128341B1 (da)
AU (1) AU619512B2 (da)
CA (1) CA1341386C (da)
DE (1) DE3887670D1 (da)
DK (1) DK173320B1 (da)
ES (1) ES2061714T3 (da)
IE (1) IE62358B1 (da)
IL (1) IL88741A (da)
PT (1) PT89297B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法
EP0401797A1 (en) * 1989-06-08 1990-12-12 PerSeptive Biosystems, Inc. Active esters for solid phase peptide synthesis
US5233044A (en) * 1989-06-08 1993-08-03 Millipore Corporation Active esters for solid phase peptide synthesis
TW295589B (da) * 1990-08-30 1997-01-11 Hoechst Ag
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use
JP3134936B2 (ja) * 1992-10-16 2001-02-13 沖電気工業株式会社 衝撃センサ
DK1156059T3 (da) * 1993-06-21 2007-11-12 Aventis Pharma Inc Selektivt spaltelige linkere baseret på en methioningruppe og en estergruppe
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
DE4408533A1 (de) 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
AUPO324096A0 (en) * 1996-10-24 1996-11-21 University Of Queensland, The Linker peptide
US7524925B2 (en) * 2004-11-18 2009-04-28 Washington State University Protein interaction reporter agents and methods for using same
JP2014513923A (ja) 2011-03-04 2014-06-19 ファイザー・インク Ｅｄｎ３様ペプチドおよびその使用
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605848B2 (en) * 1987-04-08 1991-01-24 Sanofi-Aventis Deutschland Gmbh Nitrogen containing phenoxy alkanoic acids and the synthesis of peptide amides by means of a solid phase method using acid-labile anchoring groups

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1768047C3 (de) * 1968-03-26 1979-09-27 Hoechst Ag, 6000 Frankfurt Dimethoxybenthydryl-asparagin- und glutamin-derivate sowie Verfahren zur Herstellung von asparagin- und glutaminhaltigen Peptiden

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605848B2 (en) * 1987-04-08 1991-01-24 Sanofi-Aventis Deutschland Gmbh Nitrogen containing phenoxy alkanoic acids and the synthesis of peptide amides by means of a solid phase method using acid-labile anchoring groups

Also Published As

Publication number Publication date
EP0322348A3 (en) 1990-08-29
US5124478A (en) 1992-06-23
DK173320B1 (da) 2000-07-24
IL88741A0 (en) 1989-07-31
IL88741A (en) 1994-12-29
PT89297B (pt) 1994-11-30
CA1341386C (en) 2002-08-27
DK714588A (da) 1989-06-23
EP0322348A2 (de) 1989-06-28
ES2061714T3 (es) 1994-12-16
DK714588D0 (da) 1988-12-21
AU2743188A (en) 1989-06-22
IE883832L (en) 1989-06-22
KR890009973A (ko) 1989-08-05
JP2858766B2 (ja) 1999-02-17
IE62358B1 (en) 1995-01-25
EP0322348B1 (de) 1994-02-02
PT89297A (pt) 1989-12-29
DE3887670D1 (de) 1994-03-17
KR0128341B1 (ko) 1998-04-03
JPH02243A (ja) 1990-01-05

Similar Documents

Publication Publication Date Title
AU619512B2 (en) Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method
Tamiaki et al. A novel protecting group for constructing combinatorial peptide libraries
STÜBER et al. Synthesis of peptide amides by Fmoc‐solid‐phase peptide synthesis and acid labile anchor groups
US4831084A (en) Resin-linker combination for the solid-phase synthesis of peptides and intermediates
Luke et al. ‘One-pot’methylation of Fmoc amino acids
CA1337839C (en) Synthesis of peptide amides by means of a solid phase method using acid-labile anchoring groups
Chung et al. Cyclic peptide facial amphiphile preprogrammed to self-assemble into bioactive peptide capsules
EP0331073B1 (en) Benzhydrylamine derivatives
EP0475184B1 (de) Verfahren zur Herstellung von Peptiden mittels Festphasensynthese
Sivanandaiah et al. Synthesis of peptides mediated by KOBt
US5214195A (en) Allyl esters and the use thereof for the build-up of solid phase systems for solid phase reactions
US6248865B1 (en) Compounds useful for the synthesis of dolastatin analogs
DE3842378A1 (de) Saeurelabile ankergruppen zur synthese von peptidamiden mittels festphasenmethode
DK175111B1 (da) Fremgangsmåde til fremstilling af peptidamider ved fastfasedyntese, samt anvendelse af diphenylmethanderivater ved syntesen
KR820001094B1 (ko) 펜타펩타이드의 제조방법
René et al. A Convenient, Large-Scale Preparation of 2, 4-Dichlorophenyl-4-bromomethyl-phenoxyacetate Suitable for Resin Anchorage of the First Fmoc Amino Acid
JPH03290406A (ja) Ｆｍｏｃペプチド固相合成法に用いる樹脂
JPH0827156A (ja) アミノ酸誘導体の製造方法
JPH0967341A (ja) 新規トリプトファン誘導体およびその製造法

Legal Events

Date Code Title Description
PC Assignment registered

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH

Free format text: FORMER OWNER WAS: HOECHST AKTIENGESELLSCHAFT