AU2370801A - Non peptide tachykinin receptor antagonists - Google Patents

Non peptide tachykinin receptor antagonists Download PDF

Info

Publication number: AU2370801A
Authority: AU; Australia
Prior art keywords: phenyl; ylmethyl; indol; alkyl; benzofuran
Prior art date: 1999-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU23708/01A

Other languages

English (en)

Inventor

Hubert Dr. Barth

David Christopher Horwell

Russell Andrew Lewthwaite

Martin Clive Pritchard

Jennifer Raphy

Bernd Schiefermayr

Klaus Steiner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-22

Filing date

2000-12-21

Publication date

2001-07-03

2000-02-22 Priority claimed from EP00103665A external-priority patent/EP1127875A1/en

2000-12-21 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2001-07-03 Publication of AU2370801A publication Critical patent/AU2370801A/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)

AU23708/01A 1999-12-22 2000-12-21 Non peptide tachykinin receptor antagonists Abandoned AU2370801A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US17154099P	1999-12-22	1999-12-22
US60171540		1999-12-22
EP00103665		2000-02-22
EP00103665A EP1127875A1 (en)	2000-02-22	2000-02-22	Process for the preparation of alpha-dimethylaminomethyl-tryptophan methyl ester
PCT/EP2000/013349 WO2001046176A2 (en)	1999-12-22	2000-12-21	Non peptide tachykinin receptor antagonists

Publications (1)

Publication Number	Publication Date
AU2370801A true AU2370801A (en)	2001-07-03

Family

ID=26070578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU23708/01A Abandoned AU2370801A (en)	1999-12-22	2000-12-21	Non peptide tachykinin receptor antagonists

Country Status (18)

Country	Link
EP (1)	EP1244653A1 (xx)
JP (1)	JP2003518111A (xx)
KR (1)	KR20020062364A (xx)
CN (1)	CN1413206A (xx)
AP (1)	AP2002002556A0 (xx)
AU (1)	AU2370801A (xx)
BG (1)	BG106804A (xx)
BR (1)	BR0016626A (xx)
CA (1)	CA2399584A1 (xx)
IL (1)	IL150203A0 (xx)
IS (1)	IS6395A (xx)
MA (1)	MA26854A1 (xx)
MX (1)	MXPA02006282A (xx)
NO (1)	NO20022942L (xx)
OA (1)	OA12129A (xx)
PL (1)	PL357650A1 (xx)
SK (1)	SK8862002A3 (xx)
WO (1)	WO2001046176A2 (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010516731A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0655055B1 (en) *	1992-08-13	2000-11-29	Warner-Lambert Company	Tachykinin antagonists
CA2355137A1 (en) *	1998-12-18	2000-06-29	Martyn Clive Pritchard	Non-peptide nk1 receptors antagonists

2000
- 2000-12-21 KR KR1020027008007A patent/KR20020062364A/ko not_active Application Discontinuation
- 2000-12-21 SK SK886-2002A patent/SK8862002A3/sk unknown
- 2000-12-21 OA OA1200200196A patent/OA12129A/en unknown
- 2000-12-21 BR BR0016626-0A patent/BR0016626A/pt not_active Application Discontinuation
- 2000-12-21 CA CA002399584A patent/CA2399584A1/en not_active Abandoned
- 2000-12-21 CN CN00817549A patent/CN1413206A/zh active Pending
- 2000-12-21 MX MXPA02006282A patent/MXPA02006282A/es unknown
- 2000-12-21 EP EP00987477A patent/EP1244653A1/en not_active Withdrawn
- 2000-12-21 WO PCT/EP2000/013349 patent/WO2001046176A2/en active Search and Examination
- 2000-12-21 IL IL15020300A patent/IL150203A0/xx unknown
- 2000-12-21 JP JP2001547086A patent/JP2003518111A/ja active Pending
- 2000-12-21 AP APAP/P/2002/002556A patent/AP2002002556A0/en unknown
- 2000-12-21 AU AU23708/01A patent/AU2370801A/en not_active Abandoned
- 2000-12-21 PL PL00357650A patent/PL357650A1/xx not_active Application Discontinuation
2002
- 2002-05-24 IS IS6395A patent/IS6395A/is unknown
- 2002-06-10 BG BG106804A patent/BG106804A/xx unknown
- 2002-06-14 MA MA26689A patent/MA26854A1/fr unknown
- 2002-06-19 NO NO20022942A patent/NO20022942L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2003518111A (ja)	2003-06-03
OA12129A (en)	2006-05-05
WO2001046176A2 (en)	2001-06-28
KR20020062364A (ko)	2002-07-25
CA2399584A1 (en)	2001-06-28
PL357650A1 (en)	2004-07-26
MA26854A1 (fr)	2004-12-20
WO2001046176A3 (en)	2002-07-04
IS6395A (is)	2002-05-24
SK8862002A3 (en)	2002-11-06
CN1413206A (zh)	2003-04-23
AP2002002556A0 (en)	2002-06-30
BG106804A (en)	2003-03-31
MXPA02006282A (es)	2004-09-06
NO20022942D0 (no)	2002-06-19
NO20022942L (no)	2002-06-19
IL150203A0 (en)	2002-12-01
BR0016626A (pt)	2002-11-05
EP1244653A1 (en)	2002-10-02

Publication	Publication Date	Title
AU698239B2 (en)	1998-10-29	Tachykinin antagonists
JP2008531677A (ja)	2008-08-14	ペプチド様化合物及び生物活性誘導体の製造
JP3529381B2 (ja)	2004-05-24	エンドテリン変換酵素阻害剤
NO326519B1 (no)	2008-12-22	Derivater av N-(arylsulfonyl)beta-aminosyrer omfattende en substituert aminometylgruppe, fremgangsmate for fremstilling derav samt farmasoytiske preparater inneholdende de samme
EP1717226B1 (en)	2009-01-21	2,7-substituted 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octan amide derivatives as renin inhibitors for the treatment of hypertension
AU781837B2 (en)	2005-06-16	3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity
RU2185375C2 (ru)	2002-07-20	Ациламиноалкениленамидные производные, способы их получения и фармацевтическая композиция на их основе
IL203956A (en)	2014-06-30	Indole-2-on-2 derivatives are positioned in position 3, their preparation and use for drug preparation
KR20120099457A (ko)	2012-09-10	디아실글리세롤 아실트랜스퍼라제의 억제제
NO325605B1 (no)	2008-06-23	1-aryl-2-acylaminoetanforbindelser, fremgangsmate for fremstilling derav og farmasoytiske sammensetninger omfattende forbindelsene.
WO2003093234A1 (en)	2003-11-13	Melanocortin receptor ligands
US20070142638A1 (en)	2007-06-21	Ornithine derivatives as prostaglandin e2 agonists or antagonists
JP2002533338A (ja)	2002-10-08	非ペプチドｎｋ１レセプターアンタゴニスト
KR20000052921A (ko)	2000-08-25	뉴로키닌 길항제로서의 피페라지노 유도체
AU2370801A (en)	2001-07-03	Non peptide tachykinin receptor antagonists
EP1819672A1 (en)	2007-08-22	Indole-2-carboxylic acid amides
FR2665702A1 (fr)	1992-02-14	Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
MXPA99001768A (en)	1999-06-01	Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists

Legal Events

Date	Code	Title	Description
2003-08-21	MK1	Application lapsed section 142(2)(a) - no request for examination in relevant period